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    Etiopathogenesis: Investigation in

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    snehasishk51
    1. Malignant squamous cell carcinoma of keratinocyte cell origin presenting as a crusted or scaly patch with a proliferative nodular lesion and potentially non-healing ulcer. 2. Risk factors include sun exposure, arsenic exposure, HPV infection, immunosuppression, and actinic keratosis. 3. Microscopic examination shows keratin pearls, desmosomes, nuclear atypia with varying degrees of differentiation from well to poorly differentiated.

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    Etiopathogenesis: Investigation in

    Uploaded by

    snehasishk51
    5 views1 page
    1. Malignant squamous cell carcinoma of keratinocyte cell origin presenting as a crusted or scaly patch with a proliferative nodular lesion and potentially non-healing ulcer. 2. Risk factors include sun exposure, arsenic exposure, HPV infection, immunosuppression, and actinic keratosis. 3. Microscopic examination shows keratin pearls, desmosomes, nuclear atypia with varying degrees of differentiation from well to poorly differentiated.

    Original Description:

    It is the detailed answer of the Squamous Cell Carcinoma. It is the answer of the MBBS.

    Original Title

    SCC

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    1. Malignant squamous cell carcinoma of keratinocyte cell origin presenting as a crusted or scaly patch with a proliferative nodular lesion and potentially non-healing ulcer. 2. Risk factors include sun exposure, arsenic exposure, HPV infection, immunosuppression, and actinic keratosis. 3. Microscopic examination shows keratin pearls, desmosomes, nuclear atypia with varying degrees of differentiation from well to poorly differentiated.

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    5 views1 page

    Etiopathogenesis: Investigation in

    Uploaded by

    snehasishk51
    1. Malignant squamous cell carcinoma of keratinocyte cell origin presenting as a crusted or scaly patch with a proliferative nodular lesion and potentially non-healing ulcer. 2. Risk factors include sun exposure, arsenic exposure, HPV infection, immunosuppression, and actinic keratosis. 3. Microscopic examination shows keratin pearls, desmosomes, nuclear atypia with varying degrees of differentiation from well to poorly differentiated.

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    of 1

    .

    1 Tumor type : Malignant Squamous Cell Carcinoma


    2 . Cell
    of Origin : Keratinocytes
    .
    1 Crusted or
    scaly patch T red inflamed Base .

    .
    2 Nodular Lession Proliferative Growth
    feature
    .

    Clinical
    non-healing
    5
    . : .
    3 A ulcer
    .
    M

    Age - > 50
    years
    Presentation
    -

    Prediliction Exposed Sun Areas alw Long standing Inflamation .


    -
    ,

    Para
    neoplasticSyndrome --

    Risk factor :

    .
    4
    Etiopathogenesis : 1) X-Ray
    -> Loss
    of P53 -X
    Apoptosis d/t UU
    Exposure 1) Arsenic vI) Marjolin Uker .

    -> Mut
    of BeLc and RAS (1) UV
    ~ alt .
    Epidermal Growth factor .
    4 (v) Actinic Keratosis

    v) Immunosuppression
    Investigation in ↓
    : 4 HPV 5 and S

    · Patho-
    Biopsy ->

    Histopathology
    · radio-O Broder's
    Classification
    ·
    Micro- Y L &

    .
    6
    Microscopic Examinat :
    Diff
    Well Mod .

    diff Poorly Diff.


    1 . Keratin pearl (Keratinpear1) (single cell) (few sq .

    Cell)
    .
    2 Desmosomes
    (high power) Keratinizat Nu atypia
    Variants >
    a) Acantholytic SCC I H 2
    . .
    - CK
    , p63
    b) Spindle all SCC
    .

    7
    .

    Gross : Crusted scaly patch ,


    Nodular Lession , inflamed red Base
    .

    Ulceration (+/-)

    .
    8
    Prognosticfactors : Well
    Diff>NoMet > Better
    Prognosis
    .
    9 Treatment : -

    Interesting fact:
    and Most
    Malignancy
    10
    . Common Skin .

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