Intro BME

Introduction and Overview of the Class

生物医学工程导论
李晨钟 教授
Prof. Chenzhong Li

微信:Chenzhong_li

生物光电子和生物芯片研究室
香港中文大学 ，深圳
Department of Biomedical Engineering
Chinese University of Hong Kong，Shenzhen

2023 秋课BME3001
Diagnosis of neuromuscular disorders based on
electrophysiological technologies

Speaker: Prof. Shixiong Chen

Date: Nov 21, 2023
 Self-Introduction
➢ Education Background

• 2007 – 2012: Ph.D. in Speech and Hearing Sciences, Arizona State University, USA

• 2005 – 2007: Master of Biomedical Engineering, Tsinghua University, China

• 2001 – 2005: Bachelor of Biomedical Engineering, Tsinghua University, China

➢ Work Experience

• 2020 – Present: Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

• 2015 – 2020: Associate Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

• 2012 – 2015: Assistant Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Contents

2 Background Introduction

2 My Research

2 Teaching &Training

2 Summary
 Neuromuscular system
⚫ Neuromuscular system: brain, nerves and muscles working together to control body functions
Neuromuscular electrophysiology
Disorders

Diagnosis
Depression
Epilepsy

Hearing loss
Cognitive
impairment

Rehabilitation
Dysphagia
Attention deficit
hyperactivity
disorder

Neuromuscular electrophysiology is a technology to measure electrical signals from the brain and muscles.
Neurological rehabilitation based on electrophysiology
Electrodes Neuromuscular Diagnosis and rehabilitation
Electrophysiological Technologies of neuromuscular disorders

Flexible noncontact
electrodes

Acquisition Epilepsy
Electroencephalography
System
(EEG)
Viscoelastic Dry
Electrodes

Hearing loss

Electrocardiography
Fabric electrode (ECG)
Cognitive impairment

Processing
Flexible array
electrodes Electromyography
(EMG) Dysphagia
Contents

2 Background Introduction

2 My Research

2 Teaching &Training

2 Summary
My Research: Neurological rehabilitation based on EEG & EMG

New Electrodes New Systems AI Analysis New Solution

EEG Flexible noncontact

electrodes
Epilepsy

Viscoelastic Dry
Electrodes
Hearing loss
EMG
Flexible array electrodes
Cognitive impairment

Fabric electrode

Dysphagia
EEG Application 1: Epilepsy
 Seizure
Background
➢ Epilepsy is a neurological disorder caused by sudden unusual electrical activities in the brain
epilepsy 1/4 in
Infection Tumor Genetic Metabolic
children

Permanent
Brain Damage
About 1/26 people will develop
epilepsy at some point

Ongoing Seizure EEG Measurement Determine Seizure Types & Lesion

EEG provides important information

about the problem of the brain
 Current Clinical Routines and Challenges
Long-Term EEG Manual Diagnosis, Treatment
Monitoring EEG Reading Treatment Plan Outcome
In Hospital by Specialist by Doctor Evaluation

Return

Patient
Reservation

Long-Term EEG
Monitoring

1-2 month 2-3 Days 1-2 month

Later Later Later
(limited beds (limited number (limited beds
In hospital) In hospital)
of specialist)

Treatment Adjustment?
1-2 Weeks 2-4 hours Another 1-2 Weeks
In Hospital for one report In Hospital
My research approach: A Take-Home Solution for Epileptic
Cloud

Viscoelastic Dry
Electrodes EEG

Lesion

Stimulate
！
Seizure Alert Signal Processing Feature Extraction
Self Alert ！ Msg
Wearable ！
EEG Device
Family Alert

Outcome Assessment

！
Validation Doctor Alert

Seizure Lesion Automatic Epileptic Seizure

Localization Seizure Detection Prediction
Treatments
(Medicine, operation)
A Take-Home Solution for Epileptic Diagnosis & Treatments
Cloud
24-hour EEG EEG Reading &
Recording
Viscoelastic Dry Diagnosis by AI
Electrodes At Home EEG

Lesion
（1）New Electrodes
Stimulate
！
Self Alert ！ Msg
（2）Wearable EEG Device
Seizure Alert Signal Processing Feature Extraction

Wearable ！ Real-Time
EEG Device
Family Alert Seizure Alert
to Reduce Risk
Outcome Assessment

！
Validation Doctor Alert

Seizure Lesion Epileptic Seizure Automatic

A game-changing solution for epilepsy diagnosis
Localization & treatment!!!
Seizure Detection Prediction
Treatments
(Medicine, operation)
 Technology 1: New Electrode for Long-term EEG Monitoring

➢ Challenges of EEG Electrodes in long-term recording

⚫ Challenges ⚫ Solution
Gel Electrodes Dry Electrodes Proposed Viscoelastic Dry Electrodes (VDE)
-A novel hairy skin-adaptable electrode

Nat Biomed Eng, 2019, 3, 194–205.

Sci. Adv. 2021; 7: 7432

Problems:
• Dry out and stop working
• Can cause skin allergies
Problems:
• Gap between electrode and skin
• Sensitive to motion artifact
Stable: fill all gaps between electrode & hair
Waterless: keep working all the time
Technology 1: New Electrode for Long-term EEG Monitoring
➢ Keep Recording High-quality EEG signals up to 48 days!
Production Method

CPE Gel Paste

 Technology 1: New Electrode for Long-term EEG Monitoring
➢ The proposed VDE electrode is hairy adaptive and robust to motion artifacts
Stable ECG in Chest Motion Stable EMG in Head Rotation
A Take-Home Solution for Epileptic Diagnosis & Treatments
Cloud
24-hour EEG EEG Reading &
Recording
Viscoelastic Dry Diagnosis by AI
Electrodes At Home EEG

Lesion
（1）New Electrodes
Stimulate
！
Self Alert ！ Msg
（2）Wearable EEG Device
Seizure Alert Signal Processing Feature Extraction

Wearable ！ Real-Time
EEG Device
Family Alert Seizure Alert
to Reduce Risk
Outcome Assessment

！
Validation Doctor Alert

Seizure Lesion Epileptic Seizure Automatic

A game-changing solution for epilepsy diagnosis
Localization & treatment!!!
Seizure Detection Prediction
Treatments
(Medicine, operation)
Technology 2: High-Performance Wearable EEG Device
Problem Wireless EEG Hardware A Powerful EEG Software Platform

Online
Impedance

Real-Time Auto Seizure Detection

Spectrogram
WiFi

Speech Video
aEEG Trace Trends Recognition Motion Detect

→ A Powerful Software to Interact with the Device!

A Wearable EEG Device to Take Home

⚫ High-Quality EEG at Home ⚫ 128-Ch EEG + 16-Ch Stimulation
1-2 Weeks ⚫ Connected to Cloud System ⚫ Seizure Detection & Stimulation
In Hospital ⚫ Multi-Source Info Integration
A Take-Home Solution for Epileptic Diagnosis & Treatments
Cloud
24-hour EEG EEG Reading &
Recording
Viscoelastic Dry Diagnosis by AI
Electrodes At Home EEG

Lesion

Stimulate
！
Seizure Alert Signal Processing Feature Extraction
Self Alert ！ Msg
Wearable ！ Real-Time
EEG Device
Family Alert Seizure Alert
to Reduce Risk
Outcome Assessment

！
Validation Doctor Alert

Seizure Lesion Automatic Epileptic Seizure

Localization Seizure Detection Prediction
Treatments
(Medicine, operation)
 Technology 3: AI-Based Automatic Seizure Detection using EEG
➢ An Advanced Multi-View Deep Feature Learning – An explainable AI Approach
Multi-View Deep Feature Learning

⚫ Combines frequency and time-domain features to form multi-view deep

features (MV-DF)
⚫ Interpretability is provided through explainable artificial intelligence
⚫ Most important neural biomarkers for automatic seizure detection
⚫ Aid clinicians in identifying EEG features indicative of seizures
THANK YOU!