Name: Frans Mallare Bularan
Course and Section: BSN 2-YA-7
Action/
Pharmacodynamic
Brand Name: Action:
Tagamet H2 receptor antagonist
Tagamet HB cimetidine prevents histamine management of peptic ulcers,
from acting on stomach lining
Therapeutic Class: H2 receptors. Reduced gastric
Anti ulcer Agent acid output as a result aids in where it is advantageous to
the treatment of disorders like
Pharmacologic Class: gastroesophageal reflux
Histamine H2 Antagonist disease (GERD) and peptic patients, it can also be used to
ulcers.
Available Forms:
• Injectable Solution Pharmacodynamics:
(150 md/dl) Cimetidine reduces the
• Oral Solution stimulation of stomach acid
(300mg/5mL) production caused by
•Tablet histamine by competitively
(200 mg) blocking H2 receptors.
(300 mg) Cimetidine promotes ulcer
(400 mg Rx) healing and relieves
(600 mg Rx) symptoms related to high
(800 mg Rx) gastric acid by blocking the
effects of histamine and
keeping the stomach's acidity
lower.
PHARMACOLOGY DRUG STUDY
GASTROINTESTINAL TRACT - CIMETIDINE
Indication
The use of cimetidine is
recommended for the
GERD, and illnesses like
Zollinger-Ellison syndrome
reduce stomach acid
secretion. In severely ill
avoid stress ulcers.
The medication is intended to
prevent stress-related
stomach ulcers and efficiently
control reflux esophagitis
disease in addition to
managing gastric
hypersecretion.
Contraindication
• Hypersensitivity or allergy to
cimetidine or other H2
receptor antagonists.
• Impaired renal function,
particularly with a creatinine
clearance below 30 mL/min.
• Concurrent use with drugs
that rely on the same renal
pathway for elimination,
leading to potential
interactions.
• Active gastrointestinal
bleeding, as cimetidine may
not be suitable for managing
bleeding ulcers.
• History of arrhythmias or
conditions predisposing to
arrhythmias.
• Use with caution in patients
with hepatic impairment, as
cimetidine metabolism occurs
in the liver.
• Pregnancy and
breastfeeding, unless the
potential benefits outweigh the
risks.
Subject: NCMA 216
Drug Study
Nursing Consideration
Side Effects Adverse Reaction
CNS: CNS: Assess and evaluate the
• Headache • Nausea and Vomiting patients, paying particular
• Dizziness • Agitation attention to their medical
• Drowsiness • Confusion, Depression history and their liver or
• Hallucinations kidney function since it can
• Reversible Mental influence metabolism,
Impairment whereas renal impairment
• Mental Status Changes may impact medication
excretion.
CVS: CVS: Inform the patient about any
• Bradycardia • Difficulty of Breathing possible side effects
• Arrhythmias and adverse reaction.
• Hypotension Encourage patients to report
• Tachycardia any unexpected symptoms as
soon as possible.
GIT: EENT: Assess carefully for any
• Diarrhea • Blurred Vision indications of gastrointestinal
• Dry Mouth bleeding or symptoms
• Nasal Congestion associated with the underlying
• Tinnitus (Ringing in the Ear) illness.
Make sure that the patient
receives the recommended
dosage and route since when
oral cimetidine is taken with
food or an antacid, absorption
is improved, reducing the
possibility of gastrointestinal
distress and maximizing the
therapeutic outcome.
 PHARMACOLOGY DRUG STUDY
GASTROINTESTINAL TRACT - CIMETIDINE

Action/ Nursing Consideration

Pharmacodynamic Indication Contraindication Side Effects Adverse Reaction

Regularly assess renal

function, particularly in
patients who already have
renal problems. Early
identification and intervention
are ensured by keeping an
eye out for unpleasant effects,
such as disorientation,
hallucinations, or allergic
reactions.

Assess patient’s engagement

in activities that call for mental
attention. We should warn
him/her that she/she may
become dizzy or confused
since it helps in reducing the
possible dangers connected
to cimetidine use by
highlighting safety
precautions.

Make sure to schedule routine

follow-up appointments in
order to evaluate the patient's
reaction to treatment, watch
out for any adverse effects,
and modify the treatment plan
as needed.
 References:
https://www.drugs.com/ingredient/cimetidine.html
https://search.medscape.com/search/?q=cimetidine&plr=ref
https://rb.gy/lc3886
https://www.rxlist.com/tegretol-drug.htm?fbclid=IwAR0QjUj8qB5LcwjQyqVh-6hyKiB9fXyDXTTujwr__896Osj7l-_qo2KcGOQ