|t

Capillary POTASSIUM SPARING DIURETICS

NORMAL Baroreceptors
N Aldosterone
.
•
CO BP K H
y

¡
PRINCIPAL CELL Spironolactone i SIDE EFFECTS K

N N ÷ NE ( SNS) ¡
• • Mr

ii. |
.

Riri
K N
5

N Eplerenone Kidney (B ) HR (B )

I.io:41
÷
Intercalated
Contractility (B )
"

cell

N N N Esa
.
(Aldosterone blockers)
renin Hyperkalemia
µ ACE - I /ARBs
Aldosterone
H
•
H

ENACS
• A.T-II
(cautions)
K T.P.R
-

*Post - MI

Er%µ%ar
K N K ATPASE Triamterene ADH
µ
Stress Metabolic
(LV)
K
""÷÷•÷"* Cellular
K Amiloride
Es Aldosterone acidosis
"
K Channels Cellular µ^^ Afterload
adaptations
K ATPASE Blockers) adaptations
MGMPreloadpq
(ENAC + N N
la la
Kidney stones
Retention Triamterene
""'÷•••' Ventricular
(aldostrone blockers) "
A.B H'
AQ - II hypertrophy
µ
Aldosterone BV
A :{
ENAC EKG
Aldosterone K Channels Ventricular
N K ATPASE Conn syndrome dilation
.
.
.
PRINCIPAL CELL N N Peaked T-waves
Hyperaldosteronism • Kidney
Cardiac remodeling Prolonged PR interval .

stones

÷
N N N Wide QRS (> 0.12 s) AKI

:*
INDICATIONS
3N
2K ENAC HTN ST segment
NSAIDS + triamterene
K Hyperkalemia
Sine-wave pattern (more problem with
Hydrochlorothiazide BP BV Fluid overloaded NSAID)
I
N z

HCT2 + K
Loop diuretic
l z .
K Sparing
diuretic
K K
K Ventricular fibrillation
H Epithelial Sodium
Normal K > 5 meQ/l
ENAC Channel K K
A
K Channels
Balance arroz
ir
µ
N K ATPASE
K Sparing Anti-androgen

h.B@GBag.Y
Pulmonary edema .

Aldosterone H ATPASE diuretics effects

block the Aldosterone
× INTERCALATED CELL

bi!o ',E
ATP
A ADP + P
and the Androgen Erectile dysfunction
Spironolactone
-

Androgens
A.T-II H H Eplerenone
A.B
µ
N Testosterone
K H H Peripheral edema
la Gynecomastia
Borrosa N
Ci maní

/
H ATPASE
K

*¥.EE?FE,
2.G. Amenorrhea
(absence of menstruation)
2.F. .

.
.

2.A. Cellular effect

Ascites
P.C.O.S
Polycystic Ovary this drug can help in
Syndrome treat this disease

Acne
A- -- _ .
.

Potassium sparing diuretics | Mechanism of action,

indications, adverse reactions, contraindications µ iíig