PACE IIT & Medical

PACE Delhi : K.R Mangalam World School GK-II, S Block, Greater

Kailash – II, New Delhi- 110048

Test / Exam Name: Test Standard: 12TH SCIENCE Subject: BIOLOGY

Student Name: Section: Roll No.:

Questions: 140 Time: 120 Mins Marks: 140

Q 1. Purines possess nitrogen at which position? 1 Marks

A.1, 2, 4 and 6 position
B.1, 3, 5 and 7 position
C.1, 3, 7 and 9 position
D.1, 2, 6 and 8 position
Q 2. Experimental material in the study of DNA replication has been: 1 Marks
A.Escherichia coli.
B.Neurospora crassa.
C.Pneumococcus.
D.Drosophila melanogaster.

Q 3. Okazaki segments are formed during: 1 Marks

A.Replication
B.Transduction
C.Transcription
D.Translation
Q 4. For question, two statements are given-one labelled Assertion and the other labelled Reason. Select the 1 Marks
correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
Assertion: Sequences of bases in one polynucleotide chain of DNA can determine the sequence of bases in
the other chain.
Reason: In a DNA, amount of adenine equals that of thymine and amount of guanine equals that of cytosine,
i.e., A = T and C = G.
A.Both assertion and reason are true, and reason is the correct explanation of assertion.
B.Both assertion and reason are true, but reason is not the correct explanation of assertion.
C.Assertion is true, but reason is false.
D.Both assertion and reason are false.

Q 5. While analysing the DNA of an organism a total number of 5386 nucleotides were found out of which 1 Marks
the proportion of different bases were:
Adenine : 29%, Guanine : 17%, Cytosine : 32%, Thymine : 17%. Considering the Chargaff’s rule it can be
concluded that:
A.It is single stranded DNA.
B.It is a double stranded circular DNA.
C.It is a double stranded linear DNA.
D.No conclusion can be drawn.
Q 6. The central dogma of molecular biology (genetic information flow) was modified by the discovery of: 1 Marks
A.RNA polymerase.
B.DNA ligase.
C.Reverse transcriptase.
D.DNA polymerase.

Q 7. 3-D structure of RNA is called: 1 Marks

A.Clover leaf model
B.Hair pin model

1/16
 C.Helical model
D.Plate model

Q 8. The fact that a purine base always paired through hydrogen bonds with a pyrimidine base leads to, in 1 Marks
the DNA double helix.
A.Uniform width throughout DNA.
B.Uniform length in all DNA.
C.The semiconservative nature.
D.The antiparallel nature.
Q 9. Leading strand during DNA replication is formed: 1 Marks
A.Continuously.
B.In short segments.
C.First.
D.Ahead of replication.
Q 10. Operon model for regulation of transcription was proposed by.. 1 Marks
A.Meselson and Stahl.
B.Jacob and Monod.
C.Watson and Crick.
D.Hershey and Chase
Q 11. A codon in mRNA has: 1 Marks
A.3 bases
B.2 bases
C.1 base
D.Number of bases vary
Q 12. Length of one loop of B DNA is: 1 Marks
A.3.4nm
B.0.34nm
C.20nm
D.10nm
Q 13. If the sequence of bases in DNA is ATTCGATG, then the sequence of bases in its transcript will be: 1 Marks
A.CAUCGAAU
B.UAAGCUAC
C.GUAGCUUA
D.AUUCGAUG
Q 14. For question, two statements are given-one labelled Assertion and the other labelled Reason. Select 1 Marks
the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
Assertion: Same tRNA can recognise more than one codons differing only at the third position.
Reason : The specificity of a codon is particularly determined by the first two bases.
A.Both assertion and reason are true, and reason is the correct explanation of assertion.
B.Both assertion and reason are true, but reason is not the correct explanation of assertion.
C.Assertion is true, but reason is false.
D.Both assertion and reason are false
Q 15. A sample of DNA is found to have the base composition (mole ratio) of A = 40, T = 22, G = 21 and C = 1 Marks
17. This suggests:
A.DNA is circular duplex.
B.DNA is linear duplex.
C.DNA is single stranded.
D.DNA has high melting point.
Q 16. For question, two statements are given-one labelled Assertion and the other labelled Reason. Select 1 Marks
the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.

2/16
Assertion: B-DNA has a constant diameter of 20 A.
Reason: A pyrimidine always pairs with a purine.
A.Both assertion and reason are true, and reason is the correct explanation of assertion.
B.Both assertion and reason are true, but reason is not the correct explanation of assertion.
C.Assertion is true, but reason is false.
D.Both assertion and reason are false.
Q 17. Who was awarded Nobel Prize in 1959 for in vitro synthesis of polyribonucleotide? 1 Marks
A.Tatum
B.Ochoa
C.Kornberg
D.Both B and C
Q 18. For question, two statements are given-one labelled Assertion and the other labelled Reason. Select 1 Marks
the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
Assertion: Z-DNA follows a zig-zag course.
Reason: Z-DNA is left handed.
A.Both assertion and reason are true, and reason is the correct explanation of assertion.
B.Both assertion and reason are true, but reason is not the correct explanation of assertion.
C.Assertion is true, but reason is false.
D.Both assertion and reason are false.
Q 19. Sometimes the starting codon is GUG in place of AUG, GUG normally stands for: 1 Marks
A.Valine
B.Glycine
C.Methionine
D.Tyrosine
Q 20. The number of triplet codons having all the three bases same in 64 triplet codons is: 1 Marks
A.2
B.4
C.6
D.8
Q 21. The enzyme that breaks Hydrogen bonds between the 2 strands of a DNA molecule is: 1 Marks
A.Helicase
B.Topoisomerase
C.Ligase
D.Polymerase
Q 22. Which of the following is a stop codon? 1 Marks
A.AUG, GUG, UUU
B.UGA, UAG, UAA
C.UUU, UAC, CUC
D.CUC, UAC, UAA

Q 23. Which one of the following pairs are correctly matched with regard to the codon and the amino acid 1 Marks
coded by them?
A.UUA – Valine
B.AAA – Lysine
C.AUG – Cysteine
D.CCC – Alanine

Q 24. Segments of mRNA removed during splicing are called. 1 Marks

A.Introns.
B.Exons.
C.Promotor regions.
D.Integrator regions.
3/16
Q 25. One turn of the helix in a B-form DNA is approximately 1 Marks
A.3.4nm
B.2nm
C.20nm
D.0.34nm

Q 26. Both deoxyribose and ribose belong to a class of sugars called: 1 Marks
A.Trioses.
B.Hexoses.
C.Pentoses.
D.Polysaccharides.
Q 27. The RNA polymerase holoenzyme transcribes: 1 Marks
A.The structural gene and the terminator regions.
B.The structural gene only.
C.The promoter, and the.
D.The promoter, structural gene and the terminator region.

Q 28. During splicing, the exons are joined and the enzyme which catalyzes this reaction is: 1 Marks
A.RNA ligase
B.RNA catalase
C.RNA polymerase
D.RNA primase
Q 29. A codon is made up of: 1 Marks
A.Single nucleotide
B.Two nucleotides
C.Three nucleotides
D.Four nucleotides

Q 30. Which was the last human chromosome to be completely sequenced: 1 Marks
A.Chromosome 1
B.Chromosome 11
C.Chromosome 21
D.Chromosome x

Q 31. In DNA replication, the primer is: 1 Marks

A.A small deoxyribonucleotide polymer.
B.A small ribonucleotide polymer.
C.Helix destabilizing protein.
D.Enzyme taking part in joining nucleotides of new strand.

Q 32. For question, two statements are given-one labelled Assertion and the other labelled Reason. Select 1 Marks
the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
Assertion: tRNA acts as an adapter molecule.
Reason: tRNA recognizes codon sequence of mRNA during translation.
A.Both assertion and reason are true, and reason is the correct explanation of assertion.
B.Both assertion and reason are true, but reason is not the correct explanation of assertion.
C.Assertion is true, but reason is false.
D.Both assertion and reason are false

Q 33. The fact that a purine base always paired through hydrogen bonds with a pyrimidine base leads to, in 1 Marks
the DNA double helix:
A.The antiparallel nature.
B.The semiconservative nature.
C.Uniform width throughout DNA.
D.Uniform length in all DNA.

4/16
Q 34. DNA is a polymer of nucleotides which are linked to each other by 3’-5’ phosphodiester bond. To 1 Marks
prevent polymerisation of nucleotides, which of the following modifications would you choose?
A.Remove/ Replace 3' OH group in deoxy ribose.
B.Remove/ Replace 2' OH group with some other group in deoxy ribose.
C.Both ‘a’ and ‘b’.
D.Replace purine with pyrimidines.
Q 35. DNA is unique among molecules in that it can : 1 Marks
A.Form multipolymerc omplexes
B.Come apart and re-form
C.Withstand very high temperatures
D.Replicate itself

Q 36. The transcription unit extends from: 1 Marks

A.TATA box to start point
B.TATA box to stop codon
C.Start point to stop codon
D.35 sequence to start point

Q 37. If the DNA codons are ATG ATG ATG and a cytosine base is inserted at the beginning, which of the 1 Marks
following will result?
A.A non-sense mutation
B.CT TGA TGA TG
C.CAT GAT GAT G
D.C CTG ATG ATG

Q 38. The experimental system used in studies of the discovery of replication of DNA has been: 1 Marks
A.Drosophila melanogaster
B.Pneumococcus
C.Escherichia coli
D.Neurospora crassa
Q 39. In some viruses, RNA is present instead of DNA indicating that: 1 Marks
A.Their nucleic acid must combine with host DNA before replication.
B.They cannot replicate.
C.There is no hereditary information.
D.RNA can act to transfer heredity.

Q 40. In E.coli, the lac operon gets switched on when: 1 Marks

A.Lactose is present and it binds to the repressor.
B.Repressor binds to operator.
C.RNA polymerase binds to the operator.
D.Lactose is present and it binds to RNA polymerase.
Q 41. Control of gene expression takes place at the level of: 1 Marks
A.DNA-replication.
B.Transcription.
C.Translation.
D.None of the above.

Q 42. The enzyme which helps to cut one strand of DNA duplex to release tension of coiling of two strands 1 Marks
is:
A.DNA ligase
B.DNA Polymerase I
C.Topoisomerase
D.Swielases (helicase or unwindases)

Q 43. Khorana first deciphered the triplet codons of: 1 Marks

5/16
 A.Serine and isoleucine.
B.Threonine and histidine.
C.Tyrosine and tryptophan.
D.Phenylalanine and methionine.

Q 44. In some viruses, DNA is synthesised by using RNA as template. Such a DNA is called: 1 Marks
A.c DNA
B.r DNA
C.B-DNA
D.A-DNA
Q 45. The codons causing chain termination (stop codons) are: 1 Marks
A.TAG, TGA
B.GAT, AGT
C.AGT, TAG, UGA
D.UAG, UGA, UAA

Q 46. Frame shift mutation occurs when. 1 Marks

A.Base is deleted or added.
B.Base is added.
C.Base is deleted.
D.Anticodons are not present.
Q 47. Degeneracy in the genetic code was found by: 1 Marks
A.Bernfield and Nirenberg
B.Watson and Crick
C.McClintock and Creighton
D.Hedges and Jacob
E.Lagervist

Q 48. Eukaryotic RNA polymerase III catalyses the synthesis of. 1 Marks
A.mRNA.
B.rRNA.
C.hnRNA.
D.tRNA.
Q 49. In genetic coding, triplet codons make possible 64 types of codons. If the genetic code was a doublet 1 Marks
instead of a triplet codon, the number of types of codons possible would be:
A.64 types of codons
B.4 types of codons
C.24 types of codonsa
D.16 types of codons

Q 50. If a double stranded DNA has 20% of cytosine, what will be the percentage of adenine in it? 1 Marks
A.20%
B.40%
C.30%
D.60%
Q 51. The mechanism of removing introns followed by joining of the exons in a defined order during 1 Marks
transcription is called:
A.Splicing
B.Tailing
C.Transformation
D.Capping
Q 52. If the base sequence of a codon in mRNA is 5'-AUG-3', the sequence of tRNA pairing with it must be: 1 Marks
A.5' - CAU - 3'

6/16
 B.5' - AUG - 3'
C.5' - GUA - 3'
D.5' - UAC - 3'

Q 53. Transcription means synthesis of: 1 Marks

A.DNA
B.Protein
C.mRNA
D.Enzyme
Q 54. The number of base substitution possible in amino acid codons is: 1 Marks
A.261
B.264
C.535
D.549
Q 55. Which of the following is an initiation codon? 1 Marks
A.UAG
B.AUC
C.AUG
D.CCU

Q 56. DNA replication is: 1 Marks

A.Conservative and discontinuous.
B.Semi-conservative and semi-discontinuous.
C.Semi-conservative and discontinuous.
D.Conservative.
Q 57. Which of the following sets of codons contains only termination codons? 1 Marks
A.UAA, UGA, UAG.
B.UAA, UUU, UGG.
C.UAA, UAG, UAC.
D.UUU, UCC, UGG.
Q 58. Initiation codon of protein synthesis (in eukaryotes) is: 1 Marks
A.GUA
B.GCA
C.CCA
D.AUG
Q 59. A nucleoside differs from a nucleotide. It lacks the: 1 Marks
A.Phosphate group.
B.Hydroxyl group.
C.Sugar.
D.Base.

Q 60. Genetic code is a translation of the language of: 1 Marks

A.RNA into that of proteins
B.Proteins into that of RNA
C.Amino acids into that of RNA
D.RNA into that of DNA
Q 61. In the double helix model of DNA, what would be the distance between two consecutive base pairs? 1 Marks
A.3.4nm
B.2nm
C.20nm
D.0.34nm

7/16
Q 62. If genetic code is tetraplet then what is the possible number of codons which code 20 types of amino 1 Marks
acids?
A.261
B.64
C.256
D.43
Q 63. There are 64 types of codons in genetic code dictionary because: 1 Marks
A.There are 64 types of tRNA's found in cell.
B.There are 44 meaningless and 20 codons for amino acids.
C.There are 64 amino acids for coding.
D.Genetic code is triplet.
Q 64. Which of the following are the functions of RNA? 1 Marks
A.It is a carrier of genetic information from DNA to ribosomes synthesising polypeptides.
B.It carries amino acids to ribosomes.
C.It is a constituent component of ribosomes.
D.All of the above.

Q 65. DNA replication requires which of the following enzymes? 1 Marks

A.DNA polymerase only
B.DNA polymerase and ligase
C.Ligase only
D.RNA polymerase
Q 66. In some viruses, DNA is synthesised by using RNA as template. Such a DNA is called: 1 Marks
A.A-DNA.
B.B-DNA.
C.cDNA.
D.rDNA.
Q 67. Who proved that DNA is basic genetic material? 1 Marks
A.Griffith
B.Watson
C.Boveri and Sutton
D.Hershey and Chase

Q 68. Diploid chromosome number in humans is: 1 Marks

A.46
B.44
C.48
D.42

Q 69. Method by which information reaches from DNA to RNA is: 1 Marks
A.Transcription
B.Translation
C.Transformation
D.Transduction
Q 70. The most striking example of point mutation is found in a disease called. 1 Marks
A.Thalassemia.
B.Night blindness.
C.Down’s syndrome.
D.Sickle cell anaemia.
Q 71. The one aspect which is not a salient feature of genetic code is, its: 1 Marks
A.Specificity
B.Degeneracy

8/16
 C.Ambiguity
D.Relativity

Q 72. Khorana and his colleague synthesized an RNA molecule with repeating sequences of U and G bases. 1 Marks
The RNA with, UGUGUGUGUGUG produced a tetra-peptide with alternating sequences of cysteine and valine.
This proves that codon for cysteine and valine is:
A.UGG, GUU
B.UUG, GGU
C.UGU, GUG
D.GUG, UGU

Q 73. The process of transfer of genetic information from DNA to RNA/formation of RNA from DNA is: 1 Marks
A.Transversion
B.Transcription
C.Translation
D.Translocation
Q 74. Which of the following codes for stop signal? 1 Marks
A.UAA
B.UAG
C.UGA
D.All of the above
Q 75. First codon of uracil nucleotides, UUU was deciphered by: 1 Marks
A.Mathaei
B.Khorana
C.Nirenberg
D.Both A and C
Q 76. A sequence of how many nucleotides in messenger RNA makes a codon for an amino acid? 1 Marks
A.One
B.Two
C.Three
D.Four

Q 77. Which of the following help in repairing of DNA? 1 Marks

A.Ligase
B.DNA polymerase I
C.RNA primer
D.DNA polymerase III
Q 78. In bacteria, the codon AUG stands for: 1 Marks
A.Glycine
B.Methionine
C.N-formyl methionine
D.Both B and C
Q 79. Methyl guanosine triphosphate is added at 5' end of hn-RNA in a process of: 1 Marks
A.Tailing
B.Splicing
C.Capping
D.None of these

Q 80. In Drosophila, a set of homeotic genes which control body plan at the time of organ differentiation 1 Marks
is known as:
A.TATA box
B.Homeobox
C.Pribnow box

9/16
 D.All of the above
Q 81. If the base sequence of a codon in mRNA is 5'-AUG-3', the sequence of tRNA pairing with it must be: 1 Marks
A.5' - UAC - 3'.
B.5' - CAU - 3'.
C.5' - AUG - 3'.
D.5' - GUA - 3'.
Q 82. Meselson and Stahl carried out centrifugation in CsCl2 density gradient to separate: 1 Marks

a. DNA from RNA.

b. DNA from protein.

c. The normal DNA from 15N-DNA.

d. DNA from tRNA.

A.DNA from RNA.

B.DNA from protein.
C.The normal DNA from 15N-DNA.
D.DNA from tRNA.
Q 83. In eukaryotes, mRNA is synthesized with the aid of: 1 Marks
A.RNA polymerase III.
B.RNA polymerase II.
C.RNA polymerase I.
D.Reverse transcriptase.
Q 84. Both husband and wife have normal vision though their fathers were colourblind. The probability of 1 Marks
their daughter becoming colourblind is:
A.0%
B.25%
C.50%
D.75%

Q 85. Because most of the amino acids are represented by more than one codon, the genetic code is: 1 Marks
A.Overlapping
B.Wobbling
C.Degenerate
D.Generate
Q 86. Who amongst the following scientists had no contribution in the development of the double helix 1 Marks
model for the structure of DNA?
A.Rosalind Franklin.
B.Maurice Wilkins.
C.Erwin Chargaff.
D.Meselson and Stahl.

Q 87. Okazaki fragments are seen during. 1 Marks

A.Transcription
B.Translation
C.Replication
D.Transduction

Q 88. Which scientist gave wobble hypothesis? 1 Marks

A.R. W. Holley

10/16
 B.H. G. Khorana
C.M. Nirenberg
D.F. H. C. Crick
Q 89. Which of the character is not applicable to t RNA? 1 Marks
A.It is the smallest of the RNAs
B.It acts as an adapter for amino acids
C.It has a clover leaf like structure
D.It is the largest of the RNAs

Q 90. The transforming principle of Pneumococcus as found out by Avery, MacLeod and Mc Carty was: 1 Marks
A.mRNA
B.DNA
C.Protein
D.Polysaccharide
Q 91. DNA ligase helps in: 1 Marks
A.Joining segments of DNA
B.Splitting or separation of two strands of DNA
C.Renaturation
D.Denaturation
Q 92. In the base sequence, one strand of DNA is GAT, TAG, CAT, GAC. what shall be the sequence of its 1 Marks
complementary strand?
A.CAT, CTG, ATC, GTA
B.GTA, ATC, CTG, GTA
C.ATC, GTA, CTG, GTA
D.CTA, ATC, GTA, CTG

Q 93. Genetic code is: 1 Marks

A.Triplet, universal, ambiguous and degenerate.
B.Triplet, universal, non-ambiguous and nondegenerate.
C.Triplet, universal, non-ambiguous and degenerate.
D.Triplet, universal, ambiguous and non-degenerate.
Q 94. A DNA with unequal nitrogen bases would most probably be: 1 Marks
A.Single stranded.
B.Double stranded.
C.Triple stranded.
D.Four stranded.
Q 95. Degeneracy of the genetic code denotes the existence of: 1 Marks
A.Multiple codons for a single amino acid
B.Wobble hypothesis
C.Base triplets that do not code for amino acids
D.All of the above
Q 96. Formation of mRNA from DNA is called as: 1 Marks
A.Translation
B.Transcription
C.Transformation
D.Transduction
Q 97. With regard to mature mRNA in eukaryotes: 1 Marks
A.Exons and introns do not appear in the mature RNA.
B.Exons appear but introns do not appear in the mature RNA.
C.Introns appear but exons do not appear in the mature RNA.
D.Both exons and introns appear in the mature RNA.

11/16
Q 98. Lactose operon produces enzymes: 1 Marks
A.b-galactosidase, permease and glycogen synthetase.
B.b-galactosidase, permease and transacetylase.
C.Permease, glycogen synthetase and transacetylase.
D.b-galactosidase, permease and phosphor glucose isomerase.
Q 99. The sequence of nitrogen bases in a segment of a coding strand of DNA is AATGCTTAGGCA. What will 1 Marks
be the sequence of nitrogen bases in the mRNA transcribed by it?
A.UUA CGA AUC CGU.
B.AAU GCU AAC CGA.
C.AAU GCA AUC CGU.
D.AAU GCU UAG GCA.
Q 100. The scientists involved in discovery of DNA as chemical basis of heredity were: 1 Marks
A.Hershey and Chase.
B.Griffith and Avery.
C.Avery, Mac Leod and Mc Carty.
D.Watson and Crick.
Q 101. With regard to mature mRNA in eukaryotes: 1 Marks
A.Exons appear but introns do not appear in the mature RNA.
B.Exons and introns do not appear in the mature RNA.
C.Introns appear but exons do not appear in the mature RNA.
D.Both exons and introns appear in the mature RNA.
Q 102. DNA repair in prokaryotes in carried out by: 1 Marks
A.Ligase
B.DNA polymerase III
C.DNA polymerase II
D.None of the above
Q 103. DNA polymerase is needed for: 1 Marks
A.Replication of DNA
B.Synthesis of DNA
C.Elongation of DNA
D.All of the above
Q 104. Who amongst the following scientists had no contribution in the development of the double helix 1 Marks
model for the structure of DNA?
A.Meselson and Stahl.
B.Erwin Chargaff.
C.Maurice Wilkins.
D.Rosalind Franklin.
Q 105. What is the nature of the strands of the DNA duplex? 1 Marks
A.Anti-parallel and complementary.
B.Identical and complementary.
C.Anti-parallel and non-complementary.
D.Disimilar and non-complementary.
Q 106. Regulatory proteins are the accessory proteins that interact with RNA polymerase and affect its role 1 Marks
in transcription. Which of the following statements is correct about regulatory protein?
A.They only increase expression.
B.They only decrease expression.
C.They interact with RNA polymerase but do not affect the expression.
D.They can act both as activators and as repressors.

12/16
Q 107. "It has not escaped our notice that the specific pairing we have postulated immediately suggests a 1 Marks
possible copying mechanisms for the genetic material," this is written by:
A.Meselson and Stahl
B.Archibold Garrod
C.Severo Ochoa
D.Watson and Crick
E.Beadle and Tatum
Q 108. After crossing two plants, the progenies are found to be male sterile. This phenomenon is found to be 1 Marks
maternally inherited and is due to some genes which are present in:
A.Nucleus
B.Chloroplast Mitochondria Cytoplasm
C.Mitochondria
D.Cytoplasm
Q 109. Which one of the following is a base analogue? 1 Marks
A.Nitrous acid
B.Colchicine
C.5 - bromouracil
D.Caffeine
Q 110. What is the total number of nitrogenous bases in human genome estimated? 1 Marks
A.3.5 million
B.35 thousand
C.35 million
D.3.1 billion
Q 111. The usual method of DNA replication is: 1 Marks
A.Conservative
B.Dispersive
C.Non-conservative
D.Semi-conservative
Q 112. For question, two statements are given-one labelled Assertion and the other labelled Reason. Select 1 Marks
the correct answer to these questions from the codes (a), (b), (c) and (d) as given below.
Assertion: Initiation step of protein synthesis in prokaryotes and eukaryotes has several differences.
Reason: They both form mRNA - tRNA complex with smaller subunit of ribosome.
A.Both assertion and reason are true, and reason is the correct explanation of assertion.
B.Both assertion and reason are true, but reason is not the correct explanation of assertion.
C.Assertion is true, but reason is false.
D.Both assertion and reason are false
Q 113. Meselson and Stahl carried out centrifugation in CsCl2 density gradient to separate: 1 Marks
A.DNA from RNA.
B.DNA from protein.
C.The normal DNA from 15N-DNA.
D.DNA from tRNA.

Q 114. What is the process of joining together different DNA fragments often referred as? 1 Marks
A.Transcription
B.Cloning
C.Gene splicing
D.DNA amplification
Q 115. The enzyme, DNA polymerase was discovered by: 1 Marks
A.Kornberg
B.Okazaki
13/16
 C.Waston and Crick
D.Jacob and Monod
Q 116. Out of A = T, G = C pairing, bases of DNA may exist in alternate valency state owing to arrangement 1 Marks
called .
A.Analogue substitution.
B.Tautomerizational mutation.
C.Frameshift mutation.
D.Point mutation.
Q 117. Degeneracy of genetic code was discovered by: 1 Marks
A.McClintock
B.Khorana
C.Ochoa
D.Baurnfield & Nirenberg
Q 118. In split genes, the coding sequence are called. 1 Marks
A.Introns
B.Operons
C.Exons
D.Cistrons
Q 119. Regulatory proteins are the accessory proteins that interact with RNA polymerase and affect its role 1 Marks
in transcription. Which of the following statements is correct about regulatory protein?
A.They can act both as activators and as repressors.
B.They interact with RNA polymerase but do not affect the expression.
C.They only decrease expression.
D.They only increase expression.
Q 120. A distinct mechanism that usually involves a short segment of DNA with remarkable capacity to 1 Marks
move from one location in a chromosome to another. What is this called as?
A.DNA replication
B.DNA transposition
C.DNA hybridization
D.DNA recombination

Q 121. DNA directed synthesis of mRNA is called as: 1 Marks

A.Transcription
B.Translocation
C.Transduction
D.Replication
Q 122. In Escherichia coli lac Operon is induced by: 1 Marks
A.Lactose.
B.Promoter gene.
C.β-galactosidase.
D.I-gene.
Q 123. Mr. Kapoor has Bb autosomal gene pair and d allele sex-linked. What shall be proportion of Bd in 1 Marks
sperms?
A.0
B. 1
2
​
C. 1
4
​
1
D. 8 ​

Q 124. During transcription, the DNA site at which RNA polymerase binds is called as: 1 Marks
A.Promoter
B.Regulator
14/16
 C.Receptor
D.Enhancer
Q 125. Both deoxyribose and ribose belong to a class of sugars called. 1 Marks
A.Pentoses
B.Polysaccharides
C.Hexoses
D.Trioses
Q 126. Double helix model of DNA which was proposed by Watson and Crick was of: 1 Marks
A.C – DNA
B.B – DNA
C.D – DNA
D.Z – DNA

Q 127. A human gene product can be produced by genetically engineered bacteria. This is possible, because 1 Marks
the:
A.Genetic code is universal.
B.Human chromosome can replicate in bacterial cell.
C.Bacterial cell can carry out the splicing reaction.
D.Mechanism of gene regulation is identical in humans and bacteria.
Q 128. Who among the following did not provide experimental proof for the semiconservative model of DNA 1 Marks
replication?
A.Meselson & Stahl
B.Cairns
C.Watson & Crick
D.Taylor
Q 129. Which one is a hereditary disease? 1 Marks
A.Cataract
B.Leprosy
C.Blindness
D.Phenylketonuria
Q 130. The human chromosome with the highest and least number of genes in them are respectively. 1 Marks
A.Chromosome 1 and Y.
B.Chromosome 1 and X.
C.Chromosome X and Y.
D.Chromosome 21 and Y.
Q 131. Control of gene expression takes place at the level of: 1 Marks
A.Transcription.
B.Translation.
C.None of the above.
D.DNA-replication.
Q 132. While analysing the DNA of an organism a total number of 5386 nucleotides were found out of which 1 Marks
the proportion of different bases were: Adenine = 29%, Guanine = 17%, Cytosine = 32%, Thymine = 17%.
Considering the Chargaff’s rule it can be concluded that:
A.It is a double stranded circular DNA.
B.It is single stranded DNA.
C.It is a double stranded linear DNA.
D.No conclusion can be drawn.
Q 133. Assumption that genetic code is a triplet was suggested by? 1 Marks
A.Gamow
B.Beadle and Tatum

15/16
 C.S. Brenner
D.Nirenberg and Matthaei

Q 134. The two strands of DNA are held together by. 1 Marks
A.Peptide bonds.
B.Phosphodiester bonds.
C.Hydrogen bonds.
D.S-S bonds.
Q 135. Which of the following is a nucleoside? 1 Marks
A.Adenosine
B.Adenine
C.Deoxyribose
D.Adenylic acid
Q 136. The process by which DNA of nucleus passes genetic information to mRNA is called: 1 Marks
A.Translocation
B.Transcription
C.Translation
D.Transportation

Q 137. What is the name of double helix model of Watson and Crick? 1 Marks
A.C-DNA
B.B-DNA
C.Z-DNA
D.D-DNA
Q 138. Anticodon is an unpaired triplet of bases in an exposed position of: 1 Marks
A.mRNA
B.rRNA
C.tRNA
D.sRNA
Q 139. A person with 47 chromosomes due to an additional Y-chromosome suffers from a condition called: 1 Marks
A.Down’s syndrome.
B.Super female.
C.Turner’s syndrome.
D.Klinefelter’s syndrome.
Q 140. A naturally occurring coding strand composed of alternating C and U residues would result in the 1 Marks
formation of polypeptide containing:
A.Alternating leu and ser residues
B.Either leu or ser residues
C.Only leu residues
D.Only ser residues
E.Only phe residues

16/16