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KREBS CYCLE Lesson 2
roxygen is available, aerobic respiration will go forward. In eukaryotic
cells the pyruvate molecules produced at the end ofgveolyas ae tans
ported into mitochondria, which are the sites of cellular respiration.
‘There, pyruvate will be transformed into an acetyl group that will be
icked up and activated bya carrier: compound called coenzyme A
(CoA). The resulting compound is called acetyl CoA. CoA is made from
vitamin B,, pantothenic acid. Acetyl CoA can be used in a variety of ways
by the cell, but its major function isto deliver the acetyl group derived
from pyruvate to the nex sage ofthe pathway in glucose catabolism.
Breakdown of Pyruvate
In order for the pyruvate from glycolysis to enter the next pathway,
the Krebs Cycle, it must undergo several changes. The conversion isa
three-step process (Figure 7.6).
i “Sample comerts prove maacety COA
inne process carbon hone released |
dnd one malecle of NADH 5 formed
SSRN FIGURES Upon erering the
bo Naor NAOH
i
cH, | o,
Pyruvate ‘Ovidaton reaction
NAD‘ isreduced