2/10/23, 14:38 Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study | Schizophrenia…

JOURNAL ARTICLE

Abnormalities of Regional Brain Activity

in Patients With Schizophrenia: A
Longitudinal Resting-State fMRI Study
Get access
, , , , , , , , , ... Show more

Schizophrenia Bulletin, Volume 49, Issue 5, September 2023, Pages

1336–1344, https://doi.org/10.1093/schbul/sbad054
Published: 21 April 2023

Abstract
Background
Evidence from functional and structural research suggests
that abnormal brain activity plays an important role in the
pathophysiology of schizophrenia (SZ). However, limited
studies have focused on post-treatment changes, and current
conclusions are inconsistent.

Study Design
We recruited 104 SZ patients to have resting-state functional
magnetic resonance imaging scans at baseline and 8 weeks of
treatment with second-generation antipsychotics, along
with baseline scanning of 86 healthy controls (HCs) for
comparison purposes. Individual regional homogeneity
(ReHo), amplitude of low-frequency fluctuations (ALFF), and
degree centrality values were calculated to evaluate the
functional activity. The Positive and Negative Syndrome
Scale (PANSS) and MATRICS Consensus Cognitive Battery
were applied to measure psychiatric symptoms and cognitive
impairment in SZ patients.

Results
Compared with HCs at baseline, SZ patients had higher ALFF
and ReHo values in the bilateral inferior temporal gyrus,
inferior frontal gyrus, and lower ALFF and ReHo values in
fusiform gyrus and precuneus. Following 8 weeks of
treatment, ReHo was increased in right medial region of the
superior frontal gyrus (SFGmed) and decreased in the left

https://academic.oup.com/schizophreniabulletin/article-abstract/49/5/1336/7135684?redirectedFrom=fulltext 1/3
2/10/23, 14:38 Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study | Schizophrenia…

middle occipital gyrus and the left postcentral gyrus.

Meanwhile, ReHo of the right SFGmed was increased after
treatment in the response group (the reduction rate of PANSS
≥50%). Enhanced ALFF in the dorsolateral of SFG correlated
with improvement in depressive factor score.

Conclusions
These findings provide novel evidence for the abnormal
functional activity hypothesis of SZ, suggesting that
abnormality of right SFGmed can be used as a biomarker of
treatment response in SZ.

Keywords: schizophrenia, regional homogeneity, resting-state

functional magnetic resonance imaging, prediction, treatment
response
Issue Section: Regular articles

© The Author(s) 2023. Published by Oxford University Press on behalf of the

Maryland Psychiatric Research Center. All rights reserved. For permissions,
please email: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford
University Press, Standard Journals Publication Model (https://academic.oup.c
om/pages/standard-publication-reuse-rights)

You do not currently have access to this article.

Sign in Get help with access

Schizophrenia
International Research
Society members

Sign in through society site

https://academic.oup.com/schizophreniabulletin/article-abstract/49/5/1336/7135684?redirectedFrom=fulltext 2/3
2/10/23, 14:38 Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study | Schizophrenia…

Personal account Institutional access

Sign in with email/username
Sign in through your
& password
institution
Get email alerts
Save searches Sign in with a library card
Purchase content Sign in with username /
Activate your purchase / trial password
code Recommend to your librarian

Sign in Register
Institutional account
management
Sign in as administrator

Purchase

Subscription prices and ordering for this journal

Purchasing options for books and journals across Oxford Academic

Short-term Access

To purchase short-term access, please sign in to your personal account

above.
Don't already have a personal account? Register

Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A

Longitudinal Resting-State fMRI Study - 24 Hours access

EUR €48.00 GBP £42.00 USD $52.00

Rental

This article is also available for rental through

DeepDyve.

https://academic.oup.com/schizophreniabulletin/article-abstract/49/5/1336/7135684?redirectedFrom=fulltext 3/3