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    Lecture 23, Viruses - EN

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    This document provides an overview of viruses and the viral replication cycle. It begins by defining viruses and their structure, which can include genetic material of DNA or RNA, as well as capsids and envelopes. It then describes the viral replication cycle, which involves attachment to and penetration of host cells, synthesis of viral components, assembly and packaging, and release of new virus particles. Specifically, it outlines the phases of viral replication for bacteriophage and the one-step growth curve model. It also discusses the various effects viruses can have on host cells, such as lytic and lysogenic cycles or transformation into tumor cells. The document highlights features of retroviruses, including that they contain an enzyme to reverse transcribe their RNA into

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    Lecture 23, Viruses - EN

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    This document provides an overview of viruses and the viral replication cycle. It begins by defining viruses and their structure, which can include genetic material of DNA or RNA, as well as capsids and envelopes. It then describes the viral replication cycle, which involves attachment to and penetration of host cells, synthesis of viral components, assembly and packaging, and release of new virus particles. Specifically, it outlines the phases of viral replication for bacteriophage and the one-step growth curve model. It also discusses the various effects viruses can have on host cells, such as lytic and lysogenic cycles or transformation into tumor cells. The document highlights features of retroviruses, including that they contain an enzyme to reverse transcribe their RNA into

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    This document provides an overview of viruses and the viral replication cycle. It begins by defining viruses and their structure, which can include genetic material of DNA or RNA, as well as capsids and envelopes. It then describes the viral replication cycle, which involves attachment to and penetration of host cells, synthesis of viral components, assembly and packaging, and release of new virus particles. Specifically, it outlines the phases of viral replication for bacteriophage and the one-step growth curve model. It also discusses the various effects viruses can have on host cells, such as lytic and lysogenic cycles or transformation into tumor cells. The document highlights features of retroviruses, including that they contain an enzyme to reverse transcribe their RNA into

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    10 views25 pages

    Lecture 23, Viruses - EN

    Uploaded by

    Nariopolus
    This document provides an overview of viruses and the viral replication cycle. It begins by defining viruses and their structure, which can include genetic material of DNA or RNA, as well as capsids and envelopes. It then describes the viral replication cycle, which involves attachment to and penetration of host cells, synthesis of viral components, assembly and packaging, and release of new virus particles. Specifically, it outlines the phases of viral replication for bacteriophage and the one-step growth curve model. It also discusses the various effects viruses can have on host cells, such as lytic and lysogenic cycles or transformation into tumor cells. The document highlights features of retroviruses, including that they contain an enzyme to reverse transcribe their RNA into

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    of 25

    Microbiology 2

    CU20627

    Lecture 23
    K.F. Wannee
    Viruses Lecturer Life Sciences,
    Chemistry Department,
    HZ University of Applied
    Sciences
    The Nature of Viruses
    • What Is a Virus?

    • Structure of the Virion

    The Viral Replication Cycle


    • An Overview of Viral Life Cycles

    • Animal Viruses

    • Retroviruses
    What Is a Virus?

    • Virology
    • Biosafety levels (BSL) 1 - 4
    • Draw the structure of a virus/virion.

    • How do enveloped viruses collect their envelope?

    Emma Castoldi
    What Is a Virus?
    • Viral genomes and taxonomy
    • Diverse enveloped and non-enveloped animal viruses
    Viruses
    Genome: DNA RNA RNA DNA

    Types: ssDNA dsDNA ssRNA dsRNA ssRNA


    (Retroviruses)

    (family names) (family names)


    Structure of the Virion (1)

    Ebola virus
    Structure of the Virion (2)
    • Explain the
    relatively small size
    of viral genomes
    (in comparison to
    genomes of
    organisms).
    Structure of the Virion (3)
    • Capsid

    • Nucleocapsid
    • Helical versus icosahedral symmetry
    Structure of the Virion (4)
    • Some virions contain enzymes critical to infection

    Bacteriophage
    Structure of the Virion (4)
    • Some virions contain enzymes critical to infection

    Neuraminidase
    Overview of the Virus Life Cycle

    • Phases of viral replication


    Head

    Protein coat Virions


    Virion remains outside
    DNA Viral DNA enters

    Cell (host)

    1. Attachment 2. Penetration 3. Synthesis of 4. Assembly and 5. Cell lysis and


    (adsorption of of viral viral nucleic acid packaging of release of
    phage virion) nucleic acid and protein new viruses new virions
    Overview of the Virus Life Cycle
    • One-step growth curve of virus replication
    An Overview of Animal Viruses

    • Describe the effects, which may be induced in host


    cells, following viral infection.
    An Overview of Animal Viruses
    Formation of proviral
    state and transformation
    into tumor cell
    Tumor cell Transformation
    Cell
    division
    Virus

    Death of the
    cell and release Lysis
    of the virus

    Virus
    multiplication

    Slow release of Persistent


    virus without infection
    causing cell death

    No cell lysis

    Virus present
    Latent May revert to
    but not
    replicating infection lytic infection
    An Overview of Animal Viruses

    • Cell fusion
    An Overview of Animal Viruses
    • Retroviruses
    An Overview of Animal Viruses
    • What property makes retroviruses unique with
    respect to other virus types?

    • Retrovirus genome
    • Two identical ssRNAs
    Homework assignments

    • Assignment 20
    • Deadline Sun Dec 17th

    • Study theory lecture 24

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