PROGESTERONE MCQ

1. The luteal phase of the menstrual cycle is associated with:

o High luteinizing hormone level
o High progesterone levels
o High prolactin level
o Low basal body temperature
o Proliferative changes in the endometrium
2. In the days after ovulation, all of the following occurs EXCEPT:
o The basal temperature rises.
o The endometrium undergoes secretory changes.
o The plasma progesterone concentration falls.
o Cervical mucous becomes more viscous & scanty.
o Corpus luteum form.
3. Which of the following is probably responsible for physiologic hyperventilation during
pregnancy?
o Large fluctuations in plasma bicarbonate.
o Increased estrogen production.
o Increased progesterone production.
o Decreased functional residual volume.
o Decreased plasma PO2.
4. The source of progesterone that maintains the pregnancy during early 1ST trimester?
o Placenta.
o Corpus luteum.
o Corpus albicans.
o Adrenal glands.
o Endometrium.
5. Regarding ovulation can be diagnosed by the following measures, EXCEPT?
o Measuring day 14 serum progesterone.
o Observing a rise in basal body temperature in the 2ND half of the menstrual cycle.
o Study of the cervical mucous.
o Endometrial histology.
o Ultrasound.
6. Progesterone maintains pregnancy by
o enhancing uterine contractions
o enhancing uterine quiescence
7. Progesterone 8% Gel is indicated for what?
o Progesterone supplementation for infertile women with progesterone deficiency.
o Progesterone replacement as part of an Assisted Reproductive Technology (“ART”)
treatment for infertile women with progesterone deficiency.
o Both of above
8. What is Progesterone 8% Gel dosing in ART for Progesterone replacement?
o Twice daily & if pregnancy occurs, treatment may be continued until placental
autonomy is achieved, up to 10-12 weeks.
 o Once daily & if pregnancy occurs, treatment may be continued until placental
autonomy is achieved, up to 10-12 weeks.
o Twice daily & if pregnancy occurs, treatment may be continued until placental
autonomy is achieved, up to 5-6 weeks.
9. Which parameters are improved in sustained release progesterone tablets?
o Absorption
o Solubility
o Bioavailability
o Reduction in Particle size
o All of above
10. Which are the gaps in conventional progesterone capsules overcome by sustained release
tablets of Progesterone?
o Poor solubility as progesterone is BCG class II drug
o Side Effects
o Vaginal route not preferred by patients
o All of above