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    Chapter 12 Part 3

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    Riboswitches are segments of mRNA that bind small molecules to regulate gene expression in bacteria. They were discovered in the early 2000s and control the expression of about 5% of bacterial genes. Riboswitches can regulate transcription, translation, and mRNA stability depending on the concentration of the bound small molecule. Common examples include regulating vitamin B1 and glutamine production in bacteria through controlling mRNA structure and protein production.

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    Chapter 12 Part 3

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    ayhamm05
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    Riboswitches are segments of mRNA that bind small molecules to regulate gene expression in bacteria. They were discovered in the early 2000s and control the expression of about 5% of bacterial genes. Riboswitches can regulate transcription, translation, and mRNA stability depending on the concentration of the bound small molecule. Common examples include regulating vitamin B1 and glutamine production in bacteria through controlling mRNA structure and protein production.

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    Riboswitches are segments of mRNA that bind small molecules to regulate gene expression in bacteria. They were discovered in the early 2000s and control the expression of about 5% of bacterial genes. Riboswitches can regulate transcription, translation, and mRNA stability depending on the concentration of the bound small molecule. Common examples include regulating vitamin B1 and glutamine production in bacteria through controlling mRNA structure and protein production.

    Copyright:

    © All Rights Reserved
    Download as KEY, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as key, pdf, or txt
    2 views8 pages

    Chapter 12 Part 3

    Uploaded by

    ayhamm05
    Riboswitches are segments of mRNA that bind small molecules to regulate gene expression in bacteria. They were discovered in the early 2000s and control the expression of about 5% of bacterial genes. Riboswitches can regulate transcription, translation, and mRNA stability depending on the concentration of the bound small molecule. Common examples include regulating vitamin B1 and glutamine production in bacteria through controlling mRNA structure and protein production.

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    © All Rights Reserved
    Download as KEY, PDF, TXT or read online from Scribd
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    Download as key, pdf, or txt
    of 8

    Part

    III

    © 2016 Pearson Education, Ltd.


    12.6 Riboswitches Regulate Bacterial Transcription,
    Translation, and mRNA Stability

    Identified in the early 2000s


    A segment of the mRNA binds a small
    regulatory molecule.
    Common in bacteria
    Regulating the expression of about 5% of genes.

    © 2016 Pearson Education, Ltd.


    Riboswitch Regulation of Transcription

    Vitamin B1 (TPP) production is a common example.

    By thi operon

    In Bacillus subtilis, the thi operon uses TPP and a


    riboswitch located in the 5’-UTR of mRNA to produce
    mRNAs in two configurations that are dependent on TPP
    concentration.

    © 2016 Pearson Education, Ltd.


    © 2016 Pearson Education, Ltd.
    Riboswitch Regulation of Translation

    The regulation of TPP synthesis in E. coli also uses a


    riboswitch, but in this bacterium TPP production is
    controlled at the level of translation.

    thiMD operon in E. coli

    When TPP concentration is low, the 5 UTR region of


    mRNA folds into a secondary structure that contains a
    Shine–Dalgarno antisequestor stem loop

    © 2016 Pearson Education, Ltd.


    © 2016 Pearson Education, Ltd.
    Riboswitch Control of mRNA Stability

    In B. subtilus, transcription and translation of the glmS


    gene produces the enzyme called glutamine:fructose-6-
    phosphate amidotransferase.

    This enzyme participates in the production of a sugar


    abbreviated as GlcN6P.

    © 2016 Pearson Education, Ltd.


    © 2016 Pearson Education, Ltd.

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