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International Journal of Africa Nursing Sciences 14 (2021) 100289

Contents lists available at ScienceDirect

International Journal of Africa Nursing Sciences


journal homepage: www.elsevier.com/locate/ijans

The magnitude of depressive disorder and associated factors among


prisoners in Ethiopia; implications for nursing care: A systematic review
and meta-analysis
Reta Tsegaye a, *, Diriba Mulisa a, Bizuneh Wakuma a, Werku Etafa a, Getu Mosisa a, Ebisa Turi b,
Getahun Fetensa a, Adugna Oluma a, Dejene Seyoum b, Ginenus Fekadu c, Tadesse Tolossa b
a
Department of Nursing, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia
b
Department of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia
c
Department of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia

A R T I C L E I N F O A B S T R A C T

Keywords: Background: Different studies with varying magnitudes were conducted on depression among inmates and
Depressive disorder associated factors in Ethiopia. However, there is no consistent finding of the magnitude and factors associated
Inmates with it. Thus, this systematic review and meta-analysis was intended to draw the pooled magnitude of depressive
Prisoners
disorder and associated factors in Ethiopia.
Ethiopia
Methods: A number of databases such as Pub Med, Medline, HINARI, Cochrane library, the Web of Science, and
Google Scholar were searched for studies reported on depression among inmates in Ethiopia. Stata/SE V14 was
used for statistical analysis, and publication bias was assessed using the funnel plot and Egger’s test (P = 0.063).
Result: A total of 13 full-text articles were found, and 7 full articles were used for the analysis. The pooled
prevalence of depression among inmates in Ethiopia was 44.45% (95%CI: 40.28, 48.61). The factors that were
associated with depression among inmates were the age (AOR = 0.70, 95%CI: 0.59–0.82), presence of chronic
diseases (AOR = 1.70, 95%CI 1.42–2.05), and history of Khat chewing (AOR = 1.57, 95%CI 1.32–1.86), smoking
(AOR = 1.52, 95%CI 1.10–2.10), suicidal attempt (AOR = 1.66, 95%CI 1.43–1.93), and not having paid job in
the prison (AOR = 0.39, 95%CI 0.20–0.74).
Conclusion: There is a high prevalence of depression among prisoners in Ethiopia. Many of the modifiable
associated factors should be a target for intervention by stakeholders involved in prison healthcare service. This
service should be strengthened, with a focus on the identification of high-risk inmates towards more effective
prevention of depression.

1. Background million (11%) suffer from significant mental disorders, and the most
common mental health problems are depression and anxiety (Nseluke &
Mental disorders occur at high rates in all countries of the world. An Siziya, 2011; Shrestha et al., 2017).
estimated 450 million people worldwide suffer from mental or behav­ Depression is characterized by sadness, loss of interest or pleasure,
ioral disorders. These disorders are especially prevalent in prison pop­ feelings of guilt or low self-worth, disturbed sleep or appetite, tiredness,
ulations (WHO, 2019). Though prison is used to punish those inmates and poor concentration. Individuals with depression may also have
who committed a crime, it is also a place where mental illnesses like multiple physical complaints with no apparent physical cause. Depres­
depression are the most common (Rao, Manaf, & Minhat, 2018). Psy­ sion can be long lasting or recurrent, substantially impairing people’s
chiatric disorders are known to be common among inmates than in the ability to function at work or school, and cope with daily life. At its most
general population (Piwuna et al., 2019). The World Health Organiza­ severe, depression can lead to suicide (WHO, 2019)
tion estimated that, of the 9 million inmates worldwide, at least 1 In different parts of the world, the prevalence of depression among

Abbreviations: AOR, Adjusted odds ratio; CI, confidence interval; SNNP, Southern Nations, Nationalities and Peoples; WHO, World Health Organization.
* Corresponding author.
E-mail address: retatg@gmail.com (R. Tsegaye).

https://doi.org/10.1016/j.ijans.2021.100289
Received 22 June 2020; Received in revised form 17 January 2021; Accepted 25 January 2021
Available online 2 February 2021
2214-1391/© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
R. Tsegaye et al. International Journal of Africa Nursing Sciences 14 (2021) 100289

Fig 1. PRISMA flow diagram of the included studies in the systematic review and meta-analysis of depressive disorder among inmates in Ethiopia.

inmates is varied by different factors. For instance; in Cameroon Buea disorder and associated factors in Ethiopia to provide evidence for
central prison, the prevalence of depression was 93.2% (Florence, policy-makers in designing and intervening depressive disorder among
Atanga, Chu, & Abungwah, 2019). On the other hand, the magnitude of prisoners and to forward input for further research.
depressive disorder was 29% among Egyptian inmates (Assadi et al.,
2006) while it was 29% among Nigerian inmates in Port Harcourt prison 2. Methods
respectively. Being a resident of an urban area was a strong correlate of
depressive disorder (Nwaopara and Stanley, 2015). Prison settings such 2.1. Search strategy
as overcrowding, lack of privacy, violence, social isolation, inadequate
mental health facilities, and the effects of the prison sentence may in­ In this review two reviewers (RT and BW) independently searched
crease the risk of mental disorders among inmates during imprisonment electronic engine databases including Medline, Pub Med, the Web of
(Shrestha et al., 2017). Moreover, the prison environment is character­ Science, Africa Index Medicus, EMBASE and Google Scholar. Key terms
ized by overcrowding, lack of recreational activities, and a high level of used for the search were “depression”, “ depressive disorder”, “ psy­
uncertainty could increase the risk of depression (Rao et al., 2018). The chiatric disorders” combined with “prisoners“, “inmates” and
need for effective mental health care services for inmates underscores ”Ethiopia“. The key terms were used individually and in combination
the importance of the epidemiological study to determine the contrib­ through “AND” and “OR” Boolean operators. MeSH words applied with
uting factors of depression. Although depression is common among in­ an asterisk were used to get relevant articles on the title of the study.
mates, there is varied evidence of factors significantly associated with Addis Ababa University Digital Library was searched to find unpub­
depressive disorder among inmates (Rao et al., 2018). lished papers. Articles were downloaded to Endnote (version X7.2) to
In Ethiopia, several prisons or correctional facilities are found and manage citation and facilitate the review process. The presence of
large numbers of inmates are detained as well (ICPR, 2012). Several similar systematic reviews and meta-analysis was checked by using the
studies were conducted on the magnitude of depression and associated Cochrane library to avoid duplication. The search was conducted from
factors in Ethiopia. Those studies reported varying magnitudes of December 20, 2019 to January 30, 2020. We searched for articles
depression which ranges from 29.7% to 57.4% and varying determinant published between 2005 and 2019. Preferred Reporting Items of Sys­
factors (Abdu, Kabeta, Dube, Tessema, & Abera, 2018; Alemayehu, tematic Reviews and Meta-Analysis (PRISMA) checklist guideline was
Ambaw, & Gutema, 2019; Bedaso, Kediro, & Yeneabat, 2018; Beyen, used to ensure scientific consistency in reporting searched articles
Dadi, Dachew, Muluneh, & Bisetegn, 2017; Dadi, Dachew, Tariku, (David Moher, 2009) (Fig. 1)
Habitu, & Demissie, 2019; Reta et al., 2020; Shibre et al., 2014). Though
limited studies exist, the question addressing what is the extent of 2.2. Selection and eligibility criteria
depressive disorder and its determinants among inmates in Ethiopia? is
studied in the country. Therefore, this systematic review and meta- 2.2.1. Inclusion criteria
analysis was intended to draw the pooled magnitude of depressive The review included published and unpublished articles conducted

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Table 1
Summary of included Studies and magnitude of depressive disorder among inmates in Ethiopia, 2020.
Author Year of publication Town Region Study design Sample size Prevalence 95%CI

Dadi et al. (2019) 2019 Northwest Amhara Amhara Cross-sectional 662 42.90(39.13,46.67)
Reta et al. (2020) 2019 Debre Berhan town Amhara Cross-sectional 345 42.90(37.68,48.12)
Beyen et al. (2017) 2017 Northwest Amhara Amhara Cross-sectional 727 39.06(35.52,42.65)
Bedaso et al. (2018) 2018 Hawassa city SNNP Cross-sectional 335 56.42(51.11,61.73)
Alemayehu et al. (2019) 2019 Bahir Dar city Amhara Cross-sectional 422 43.36(38.64,48.09)
Abdu et al. (2018) 2018 Jimma town Oromia Cross-sectional 336 41.37(36.1,46.64)
Terefe (2007) 2007 Debremarkos town Amhara Cross-sectional 104 47.12(37.52,56.71)
Overall Weight from random effect analysis 44.45(40.28,48.61)

in the English language in Ethiopia with the aim of determining the among prisoners. Data for this outcome was extracted in a format of two-
prevalence of depression among prisoners and its determinants. This by-two tables on the Microsoft Excel spreadsheet, and then the odds
review included observational study designs mainly cross-sectional ratio for each factor was calculated. Determinant factors included in this
studies. Duplicate reports and inconsistent outcome measures were review were the age of prisoners (34 and fewer versus greater than 34),
excluded. This systematic review and meta-analysis used the COCOPOP Marital status (married versus unmarried), Educational status (formal
(Condition, Context, and Population) framework to assess the eligibility education versus No formal education), current sentence in years (five
of the articles included. The study Population (POP) was prisoners, the and less years versus greater than five years), chronic illness (chronic
Condition (CO) was the prevalence of depression and its determinants, illness versus No chronic illness), previous history of khat chewing
and the context (CO) was only studies conducted in Ethiopia. (Previous chewing versus no previous chewing), cigarette smoking his­
tory (has smoking history versus has no smoking history), suicidal
attempt history (suicidal attempted versus suicidal not attempted)and
2.3. Outcome measurement Having worked in prison (have job in prison versus have no job in
prison).
2.3.1. Study outcome
The outcome of this systematic review and meta-analysis was the 2.3.2. Quality assessment and data extraction
pooled prevalence and determinants of depression among prisoners. Initially, the citation manager (Endnote version X7.2) was used to
Depression among prisoners was assessed by Patient health question­ manage citation and to remove duplicate articles. Then, the titles and
naire (PHQ-9) which contained nine questions each measuring a prob­ abstracts of the studies were exhaustively screened based on the rele­
lem that the prisoners bothered in the last 15 days were used to measure vance of the outcome. Full-texts of the remaining articles were evaluated
depression with scale measurement ranging from zero (not at all) to for eligibility based on pre-set inclusion and exclusion criteria. The
three (nearly every day) (Kroenke, Spitzer, & Williams, 2001). HQ-9 is Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Re­
also found to be a reliable and valid tool in different countries, including view Instrument (JBI-MAStARI) was used for a critical appraisal (JBI,
Ethiopia (Gelayea et al., 2013; Kohrt, Luitel1, Acharya, & Jordans, 2016; 2017). The checklist for data extraction contains the name of authors,
Manea, Gilbody, & McMillan, 2012; Woldetensay et al., 2018) publication year, region (the area where the study was conducted),
The second outcome of this study was the determinants of depression

Fig. 2. (a) Forest plot of the pooled magnitude of depressive disorder among inmates in Ethiopia, 2020. (b) Sub-group analysis of studies included in the meta-
analysis on the magnitude of depressive disorder among inmates in Ethiopia, 2020.

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Fig. 3. Funnel plot with 95% confidence limit of the pooled Prevalence of depressive disorder among inmates in Ethiopia, 2020.

study design, the setting of the study, sample size, response rate, and 3. Results
participants with the outcome (Table 1). Two reviewers (RT and BW)
extracted data using a standardized data extraction checklist on a A total of 89 published articles were accessed from databases. Three
Microsoft Excel spreadsheet. Incongruities between two independent unpublished articles were also accessed from google scholar and google.
reviewers were resolved by a third reviewer (DM). From those first searched, 71 were removed due to duplication, and the
remaining 21 articles were screened for eligibility. Accordingly, eight of
2.4. Statistical analysis and data synthesis them were excluded by their title and abstract. Then, 13 studies were
screened for eligibility criteria based on the outcome variables related to
Extracted data on a Microsoft Excel spreadsheet format were im­ the magnitude of depressive disorders among prisoners of which six
ported to STATA version 14 for analysis. The logarithm and standard articles were excluded because of non-relevance to the current review.
error of the odds ratio (OR) for each included study were generated Finally, 7 articles fulfilled all the eligibility criteria and were included in
using the “generate” command on STATA. The pooled prevalence of this analysis (Table 1).
depression among prisoners and its determinants was presented in the From the included seven articles, a study conducted in Northwest
form of a forest plot. The presence of heterogeneity among the included Amhara had the largest sample size while a study conducted in Debre
studies was checked by Cochran’s Q test (reported as the p-value) and Markos, the Amhara region had the smallest sample size. There is high
inverse variance index (I2). A random-effect model was computed to heterogeneity in this study (I2 = 92.3%, P = 0.00), and due to this
estimate the pooled prevalence of depression among prisoners as a high random effect model was used to find the pooled depression among
degree of heterogeneity was observed. inmates in Ethiopia. Accordingly, the pooled meta-regression indicated
that the depression among inmates in Ethiopia is 44.45(95%CI:
2.5. Heterogeneity and publication bias 40.28,48.61) (Fig. 2)
We have performed the subgroup analysis based on the region where
I2-test statistics was used to check heterogeneity across studies by studies were conducted. The subgroup analysis showed that the
determining its p-values that inverse variance test statistics values of 0, magnitude of depressive disorder among inmates in the Amhara region
25, 50, and 75% were considered as no, low, moderate, and high degrees was 41.98% (95%CI: 39.83–44.13) while in SNNP and Oromia region it
of heterogeneity, respectively (Higgins & Thompson, 2002). Due to was 56.42% (95%CI: 51.11–61.73) and 41.37% (95%CI: 36.10–46.64)
heterogeneity among studies, we performed a subgroup analysis based respectively (Fig. 2b). To assess the presence of publication bias, funnel
on region. A funnel plot was used to check publication bias. Besides, plot, and Egger test at 5% significant level were computed. The funnel
Egger’s weighted regression test and Begg’s test were also used to check plot shows a shape of symmetry, and the Egger test also showed there is
the presence of statistically significant publication bias (Colin B. Begg, no statistically significant publication bias with P = 0.303 (Fig. 3).
Madhuchh, & Mazumdar, 1994). A p-value of less than 0.05 was used to To identify single study influence on the overall meta-analysis, a
declare the statistical significance of publication bias. sensitivity analysis was performed using a random effects model and the
result showed that there was no strong evidence for the effect of single
study influence on the overall meta-analysis (Fig. 4)

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Fig. 4. Sensitivity analysis for single study influence of the magnitude of depressive disorder among inmates in Ethiopia, 2020.

3.1. Factors associated with depression among inmates in Ethiopia compared to their counterparts (OR = 0.70, 95%, CI: 0.59–0.82). Fixed
effect model was used for this analysis because, the included studies
3.1.1. Association between age and depression among inmates were not exhibited heterogeneity (I2 = 0.00%, p = 0.390) (Fig. 5).
To identify the association between age and depression among in­
mates, two studies were included in this meta-analysis in which both of 3.1.2. Association between depression among inmates and chronic diseases
them had a significant association between the occurrence of depression To identify the association between having chronic diseases and
and their age (Alemayehu et al., 2019; Reta et al., 2020). From this meta- depression among inmates, three articles were included in this meta-
regression, the pooled analysis indicated that inmates whose age less analysis in which all of them were indicated a significant association
than or equal to thirty-four years were less likely to develop depression between having chronic diseases and depression (Abdu et al., 2018;

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Fig. 5. Forest plot of the association between depressive disorder among inmates and their age in Ethiopia, 2020.

Fig. 6. Forest plot of the association between depressive disorder among inmates and chronic diseases in Ethiopia, 2020.

Bedaso et al., 2018; Reta et al., 2020). The pooled analysis indicated that fixed-effect model was used (I2 = 0.53.3%, p = 0.117) (Fig. 6)
those inmates who have chronic diseases were 1.70 times more likely to
develop depression compared to those who don’t have (OR = 1.70, 95%
CI 1.42, 2.05). Since there is no heterogeneity in the included studies, a

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R. Tsegaye et al. International Journal of Africa Nursing Sciences 14 (2021) 100289

Fig. 7. Forest plot of the association between depressive disorder among inmates and history of khat chewing in Ethiopia, 2020.

Fig. 8. Forest plot of the association between depressive disorder among inmates and history of smoking in Ethiopia, 2020.

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Fig. 9. Forest plot of the association between depressive disorder among inmates and history of sucidal attempt in Ethiopia, 2020.

3.1.3. Association between depression among inmates and history of khat 3.1.5. Association between depression among inmates and history of
chewing suicidal attempt
To identify the association between inmates’ depression and the To identify the association between the occurrence of depression
history of khat chewing; two articles were included in this meta-analysis among inmates and the history of suicidal attempt; two articles were
in which both were found to have a significant association with included in this meta-analysis in which both of them have shown a
depression among inmates (Abdu et al., 2018; Bedaso et al., 2018). The significant association between the occurrence of depression among
pooled effect from this meta-analysis also indicated that there was a inmates and history of suicidal attempt (Beyen et al., 2017; Reta et al.,
positive and significant association between the occurrence of depres­ 2020). The pooled meta analysis also showed that there is a positive
sion among inmates and having a history of khat chewing. Those in­ significant association between the occurrence of depression among
mates who were having a history of khat chewing have a chance of inmates and having a history of suicidal attempts. Inmates who were
developing depression 1.57 times higher compared to their counterparts having a history of suicidal attempts in their life have 1.66 times higher
(OR = 1.57, 95% CI 1.32, 1.86). Since there is no heterogeneity in the chance of developing depression than those who were not having a
included studies, a fixed-effect model was used (I2 = 36.2%, p = 0.210) history of suicidal attempt (OR = 1.66, 95% CI 1.43, 1.93). Since there is
(Fig. 7) no heterogeneity in the included studies, a fixed-effect model was used
(I2 = 0.000%, p = 0.536) (Fig. 9)
3.1.4. Association between depression among inmates and a history of
smoking 3.1.6. Association between depression among inmates and having worked
Again to identify the association between the occurrence of depres­ in a prison
sion among inmates and the history of smoking; two articles were In this meta-regression; two articles were included to show whether
included in this meta-analysis in which both of them were indicated there is an association between having worked in the jail and the
significant association (Abdu et al., 2018; Bedaso et al., 2018). The occurrence of depression among inmates both articles showed negative
pooled finding from this meta-analysis also shown that there is a positive significant finding between the occurrence of depression and having
significant association between the occurrence of depression among paid job in prison (Abdu et al., 2018; Bedaso et al., 2018). The pooled
inmates and having a history of smoking. Inmates who were having a meta-analysis similarly indicated that inmates who have paid job in jail
history of smoking were 52% higher chance of developing depression have 61% lesser chance of developing depression than those who have
than those who had no history of smoking (OR = 1.52, 95% CI 1.10, no job (OR = 0.39, 95% CI 0.20, 0.74). Since there is heterogeneity in
2.10). Since there is heterogeneity in the included studies, a random- the included studies, a random-effect model was used (I2 = 61.5%, p =
effect model was used (I2 = 72.1%, p = 0.058) (Fig. 8) 0.107) (Fig. 10)
On the other hand, marital status, educational status and current

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Fig. 10. Forest plot of the association between depressive disorder among inmates and having work in jail in Ethiopia, 2020.

sentence in year were not associated with the occurrence of depressive This analysis had also identified the associated factors for depressive
disorder among inmates in this meta-analysis. disorders among inmates. Age was one of the significant predictors for
depressive disorder. Inmates whose age less than or equal to thirty-four
4. Discussion years were 30% less likely to develop depression than their counterparts
(OR = 0.70, 95%, CI: 0.59–0.82). This finding is consistent with a lon­
This review and meta-analysis was the first of its kind targeting in­ gitudinal cohort study in the Netherlands, in which older age was
mates with depressive disorder in Ethiopia. There is a relatively small significantly associated with a worse 2-year major depressive disorder
number of available and eligible studies for review, especially when (Schaakxs, Comjis, kok, & Penninx, 2018). This may be attributed to
compared to several potentially eligible studies in Western/more older ages are prone to chronic diseases which perhaps lead to ultimate
developed countries. Those available are inconsistent in magnitude and despair and depression (Majekodunmi, Obadeji, Oluwole, & Oyelami,
determinant factors. Thus, this systematic review and meta-analysis was 2017). This finding is different from a study conducted in Port Harcourt
mainly intended to find out the pooled magnitude of depression and Prison and another study done on older adults. Both studies had found
associated factors among inmates in Ethiopia. out that depression was less prevalent among older adults than among
In the present systematic review and meta-analysis, the pooled younger adults but can have serious consequences (Fiske, Wetherell, &
magnitude of depression among inmates in Ethiopia was 42.59%. This is Gatz, 2009; Nwaopara and Stanley, 2015). The possible difference could
nearly similar to a study conducted among Norwegian inmates (46.1%), be due to the nature of studies as this study is a systematic review while
and Nepalese prisoners (35.3%) (Shrestha et al., 2017; Værøy, 2011). those studies were cross-sectional studies.
However, this finding is lower than the magnitude of depression among Having chronic disease during imprisonment was found to be a sig­
older adult prisoners in Nigeria (59%) (Piwuna et al., 2019) and inmates nificant predictor of depression among inmates in Ethiopia. Inmates
in Cameroon (93.2%) (Florence et al., 2019) but higher than the prev­ who have chronic diseases were 1.70 times more likely to develop
alence of depression among inmates in Iran (29%) (Assadi et al., 2006). depression compared to those who do not have (OR = 1.70, 95% CI 1.42,
This difference could be attributed to the difference in the socioeco­ 2.05). Two study findings in Nigeria similarly found that known chronic
nomic status of countries, differences in prisoner handling, and variation medical condition(s) was a risk factor in developing depression among
in scales of measurement of depression between these studies. Besides inmates (Majekodunmi et al., 2017; Piwuna et al., 2019). This could be
this, in the current study, the magnitude of depressive disorder is higher because patients having chronic diseases have an additional burden of
among studies having a larger sample size. Generally, the magnitude of stress due to their health condition that may affect a person’s mobility,
depressive disorder in the current meta-analysis was relatively high change the way a person lives. These changes can be stressful and cause
which denotes prison health needs due focus on Ethiopia. a certain amount of despair which may lead to the development of

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R. Tsegaye et al. International Journal of Africa Nursing Sciences 14 (2021) 100289

depression among inmates (Simon, 2001). This implies that inmates Declaration of Competing Interest
with known chronic illnesses should be emphasized by providing regular
follow-up at the prison center to minimize the development of The authors declare that they have no known competing financial
depression. interests or personal relationships that could have appeared to influence
According to this systematic review and meta-analysis, inmates who the work reported in this paper.
have a history of khat chewing and cigarette smoking were more prone
to the development of depression. Those inmates who were having a
Acknowledgments
history of khat chewing have a chance of developing depression 1.57
times higher than their counterparts (OR = 1.57, 95% CI 1.32, 1.86)
We would like to acknowledge Wollega University for its support to
whereas inmates who were having a history of smoking were 52%
conduct this study.
higher chance of developing depression than those who had no history
of smoking (OR = 1.52, 95% CI 1.10, 2.10). This finding is consistent
with a study conducted among Norwegian inmates in which almost 70% Funding
of all inmates had a history of drug abuse including chewing khat
(Værøy, 2011). The reason for the development of depression among No funding was received to conduct this study.
smokers and khat chewers could be due to the withdrawal effects of
these substances. This implies that inmates who had a history of sub­ References
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