Benign oral neoplasms

Case 1
• A 70-year-old woman has a labial lesion. The lesion was surgically removed and prepared for
routine histopathological examination
According to the shown clinical photo as well as histopathological photomicrographs
 Describe the clinical appearance of the lesion?
 What is the possible cause of this lesion?
 What is the main histopathological features
 State the differential diagnosis
 What is the clinical course & prognosis ?
 What is the treatment?
 Case 2
A 22-year-old patient complains of a large mass involving his tongue and interferes
with eating and mastication. A biopsy from the lesion was taken & you receive his
histopathological report.
Histopathological examination of H&E stained section revealed a connective tissue
lesion formed of many blood spaces lined by endothelial cells with intervening
collagen fibers & fibroblasts. The lesion was covered by stratified squamous
epithelium.

Diagnosis
Hemangioma
According to the shown clinical photo and histopathological
photomicrograph

 What is the nature of the lesion?

 Identify 2 histopathological features that made you reach
your answer?
 Case 3
• A 25-year-old lady has a small well circumscribed lingual swelling. The lesion was surgically
removed and prepared for routine histopathological examination
According to the shown clinical photo and histopathological photomicrograph
 Describe the clinical appearance of the lesion?
 Write a histopathological report
 What is the origin of this lesion?
 What is the histopathological differential diagnosis for this lesion?
 How to differentiate using the histopathological report?
 Case 4
A 30-year-old man has a lingual swelling. During clinical examination, brown spots on his
arms were noticed. The oral lesion was surgically removed and prepared for routine
histopathological examination.
According to the shown clinical photos and histopathological photomicrograph
 Describe the clinical appearance of the lesion?
 List the possible differential diagnosis
 What is the origin of this lesion?
 If it is a hereditary condition, what is its mode of inheritance?
 What are the possible complications of this lesion?
 Describe the main histopathological features
 Diagnosis?
 What is the predicted prognosis?
 What can be a treatment for such condition?
 Case 5
An18-year-old patient has multiple hard swellings in his face mainly involving the lower jaw.
Clinical examination shows that his skin shows multiple small swellings pre-diagnosed as
fibromas by a general pathologist. History of the patient reveals GIT problems. One of thejaw
lesions was surgically removed and One of the jaw lesions was surgically removed and you
receive the histopathological report.
Histopathological examination of H&E stained section
revealed dense bone trabeculae arranged in the form of
concentric lamellae surrounding narrow marrow spaces.
Diagnosis
Compact Osteoma

According to the shown clinical and

radiographic photos as well as histopathological
photomicrographs
 Describe the consistency of the jaw lesions?
 State one feature in the histopathological report that supports
your answer
 Describe the radiographic findings of the jaw lesions?
 What is the associated syndrome?
 What is the cause of the GIT problems?
 What are the possible complications of this syndrome?