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Lipids and Membranes

L4 + DLA 2/3/4
Derived Lipids

Derived by hydrolysis of
simple/complex lipids

Ex. Fatty Acid and


Cholesterol

Simple Lipids Complex Lipids

TAGs Contain a non lipid component

Ex. Phospholipid
Derived Lipids

Fatty Acids - Nomenclature

Methyl End
Carboxylic end
Derived Lipids

Saturated FA (single bonds)

Animal fat/solid
Longer length = closer packing/lower mobility

Two types in humans:


Palmitic Acid (most abundant) - 16 C
Stearic Acid - 18 C
Derived Lipids
MUFAs
Unsaturated FA (Contain double bonds) - ⬆ fluidity
Oleic Acid
Found in Olive Oil
18 C (=9)

PUFAs

Omega 3s #3AED
Alpha Linolenic Acid
Eicopentanoic Acid
DHA
Omega 6s #6LACH
Linoleic Acid
Arachidonic Acid
PUFAs

Alpha Linolenic (18 C) Linoleic Acid (18 C)


Essential FA and will synthesize: Essential FA which helps make:
EPA (20 C) Arachidonic Acid (20 C)
Heart Healthy Used to make Prostaglandins
DHA (22 C)
Myelination
Simple Lipids

Most common form are TAGs

Storage form found in adipose

FAs can be either unsaturated or


FA saturated

Glycerol FA

FA
Complex Lipids

ALL complex lipids have a polar head group and 2 non-polar tails (FAs OR Non-Lipid)

FA
Phosphate head Glycerol
+ OR
Nitrogenous base Sphingosine
FA or non lipid
Simple Lipids

GlyceroPLs

Phosphatidic acid is building block of all PLs in PM

Cardiolipin in IM of mito

DPPC
Simple Lipids

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