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5 2 D
B S R T
CONTENTS
-Integumentary System
-Lymphatic System
-Skeletal System
-Reproductive System
:Male Reproductive
System
:female Reproductive
System
-urinary System
-Nervous System
-Cardiovascular
System
-Digestive System
-Muscular System
-Respiratory System
-Endocrine System
-Photo Documentation
-Matching Type
-Word Search
-Crossword puzzle
-Answer Key
integumentary system
integumentary system
integumentary system
is the visible part of the hair hair shaft
that sticks out of the skin.
Synthesis of Vitamin D g l a n d s
The skin plays a crucial role in the synthesis of
vitamin D when exposed to sunlight. Vitamin D Sweat glands produce sweat, which helps regulate
is essential for maintaining healthy bones and body temperature and eliminate waste. Sebaceous
overall health. glands secrete sebum, an oily substance that helps
lubricate the skin and hair.
Roots pertaining to
Integumentary System
root:derm/o, dermat/o root:trich/o
Meaning: skin Meaning: hair
Example: dermabrassion Example: trichomycosis
Definition of Example: Definition of Example:
-Surgical procedure used - Fungal infection of the
to resurface hair
the skin and remove impe
rfections.
root:melan/o
Meaning: Dark,black, melan
DID YOU
in
Example: Melanosome
KNOW?
Definition of Example:
A small cellular body that
produces
melanin
A deficiency of
oxygen in the
root:hidr/o
Meaning: Sweat, perspira
tion blood leads to a
Example: anhidrosis
Definition of Example: decrease in skin
Absence of sweating
color that then
appears blue.
root:seb/o This process is
Meaning: - Sebum, sebaceo
Example: seborrhea
us gland known as
Definition of Example: cyanosis.
-Excess flow of sebum (ad
jective:
seborrheic)
Medical Terminologies
Cutaneous derma dermis
the layer of the skin
pertaining to the skin (from
between the epidermis
skin (from Latin Greek) and the subcutaneous
cutis, meaning tissue; the true
“skin”) skin or corium
S
b u r2n- y e a r -
arm s on h old co
sw is ll
b a r bh e n t h ef a c e , ne g e s t u
eque pro eck, dent
gas pane chest with
gril tank , an
l ex d
p l o do n t h e
ed
Margaret Donovan, a 72-year-old white female, was brought to the emergency room by
her son-in-law after falling in her bathtub. She was previously in good health, despite
leading a relatively sedentary lifestyle and having a 30-year history of cigarette
smoking. The only medication she currently takes is Inderal (propranolol) for mild
hypertension (high blood pressure). She fell upon entering the bathtub when her right
leg slipped out from under her; she landed on her right hip. There was no trauma to her
head, nor does she complain of right or left wrist pain.
“Open reduction surgery” is a procedure in which the broken bones are re-aligned and
long, thick pins are inserted lengthwise into the bone tissue. The pins are held in place by
screws drilled in from the outside of the bone.
During her long recovery, Margaret is advised by her physician to begin weight-bearing
as soon as she can. To aid her in this regard, Margaret begins light physical therapy three
times per week. 6.
In addition to the physical therapy benefits, why else might Margaret’s physician want
her to avoid prolonged bed-ridden activity. Following her recovery, Margaret was placed
on three medications: oral calcium supplements, oral estrogen and oral alendronate
sodium (Fosamax). (Fosamax is a drug which inhibits the activity of osteoclasts.)
lymphatic
System
The lymphatic system is an intricate network of
The lymphatic system
consists of various
tissues, vessels, and organs that play a vital
role in maintaining the body's immune function
and overall health. It functions by carrying
lymph fluid, which contains white blood cells
components, including:
and other immune cells, throughout the body.
This system is responsible for filtering out and
removing toxins, waste products, and foreign
substances from the body, as well as LYMPH NODES
transporting necessary nutrients and oxygen to small bean-shaped structures that act as filters,
cells. Additionally, the lymphatic system helps
trapping and destroying bacteria, viruses, and other
circulate and distribute fluids in the body,
harmful substances.
preventing the build-up of excess fluid and
maintaining a proper balance. Without a
functioning lymphatic system, the body's
immune response would be severely LYMPH VESSELS
compromised, making it more susceptible to are similar to blood vessels and transport
infections and diseases.
lymph fluid throughout the body.
Did y SPLEEN
ou located in the upper left side of the
abdomen, acts as a blood filter and helps
know fight infections.
? THYMUS GLAND
located behind the breastbone, is responsible for
producing and maturing T-cells, a type of white blood
It is the least cell important for immune function.
understood and
most undervalued
TONSILS
of all the body found at the back of the throat, help in
systems, yet if it filtering out pathogens that enter the body
stopped working through the mouth and nose.
we would die within
24-48 hours?
medical terminologies
medical terminologies
A clear fluid that circulates
Enlargement of lymph
nodes due to infection,
lmyphade-
inflammation, or cancer. nopathy
Inflammation of a
adenitis lymph node.
Lymphocytes
are a type of
white blood cell
that produces
anti-bodies for
immunity.
Thymus
is a lymphatic
organ located
between the lungs
and acts as storage
for lymphocytes.
Lymph Nodes
Superficial lymph - nodes - are small, oval-shaped
-are highly concentrated in the
nodes that occur in clusters
cervical (neck), axillary (arm pit),
throughout the body. They
and inguinal (groin) regions. These
contain lymphocytes and
are palpable and are often used as
help defend the body
indicators of infection
against infection.
Spleen
- a lymphatic organ located in the upper abdomen, behind
the stomach. Its function is to filter blood’s debris and old
red blood cells. Lymphocytes are also stored here
root:aden/o root:edema root:lymphangi/o
S
( s w eA n d e r s
l o
b y dl i n g ) i nn p r e s e
isco her n
m f o r l e g st e d w i t
t a h ed
mob and reccompa ema
ility stri
c t e dn i e d
Ms. Anderson had been leading an active and healthy lifestyle until she began experiencing
persistent fatigue, recurrent infections, and swelling in various parts of her body. Alarmed by
these symptoms, she sought medical assistance to uncover the underlying cause of her sickness.
Upon examination, Ms. Anderson presented with edema (swelling) in her legs which was
accompanied by discomfort and restricted mobility. Further investigations revealed that her
lymph nodes were enlarged and tender to touch. Her blood tests indicated elevated levels of
inflammatory markers. After extensive evaluation, Ms. Anderson was diagnosed with lymphedema
– a condition caused by compromised lymphatic drainage leading to fluid retention in tissues.
Additionally, she was found to have chronic inflammation due to an impaired immune response
within her lymphatic system. The lymphatic system plays a crucial role in maintaining fluid
balance, filtering toxins, and supporting immune function. When this intricate network of vessels
becomes compromised, as in Ms. Anderson's case, it can result in the accumulation of excess fluid
and impaired immune responses.
appendicular skeleton
This includes the bones of the upper and lower
functions of the limbs, including the shoulder girdle (clavicle and
skeletal system: scapula), arms (humerus, radius, and ulna), hands
(carpals, metacarpals, and phalanges), pelvic
girdle (hip bones), legs (femur, tibia, and fibula),
feet (tarsals, metatarsals, and phalanges), and
s u p p o r t associated structures. The appendicular skeleton
It forms the structural framework that supports the facilitates movement and supports the
body's soft tissues and organs, maintaining the body's attachment of muscles.
shape and providing a basis for movement.
axial
protection skelet
on
Bones serve as protective shields for delicate internal
organs. For example, the rib cage protects the heart
and lungs, while the skull protects the brain.
m o v e m e n t appendicu
Muscles are attached to bones, and when contract
lar
skeleton
muscles, they pull on the bones, allowing movement at
joints. Joints are where two or more bones meet and
enable various types of movement, such as bending,
rotating, and flexing. did you
blood cell production
know?
The bone marrow, found within certain bones, is
responsible for producing red blood cells, white blood
cells, and platelets through a process called hematopoiesis. The human
hand, including
mineral storage
Bones act as a reservoir for essential minerals, particularly the wrist,
calcium and phosphorus. When the body needs these minerals
for various functions, such as muscle contraction and nerve
contains 54
signaling, it can draw upon the stored minerals in the bones. bones.
skull
System
SKELETAL
The hand has 27 bones.
5 distal phalanges
mandible 4 middle phalanges
humerus
sternum
8 carpals (wrist bones)
rib cage 5
metacarpa
radius ls (palm
bones)
ulna radius ulna
carpals
Cervical spine
metacar
pals (7 vertebrae)
Lumbar spine
patella (7 vertebrae)
fibula Sacrum
Coccyx
tibia
tarsals
metatarsals
hallus (big toe) 4 distal phalanges
phalanges
4 middle
phalanges
5 proximal
did you know? phalanges
5 metatarsals
More than half your bones
are in your hands and feet
You have 206 bones in
total, and 106 of them are
in your hands and feet.
The foot has 26 bones
ANATOMICAL
TYPES OF
POSITION BONE
FRACTURE
Open (Compound)
the broken bone juts out through the
skin, or a wound leads to the fracture
site. Infection and external bleeding are
more likely.
stress
are tiny cracks in a bone. They're
closed
the broken bone has not pierced the
skin.
avulsion
muscles are anchored to bone with
tendons, a type of connective tissue.
Powerful muscle contractions can
wrench the tendon free and pull out
osteoblasts bursa
bone-forming cells a fluid-filled sac that
reduces friction near a
joint (root: burs/o)
osteocytes Diarthrosis
matured bone cells A freely movable joint; also
which helps maintain called a synovial joint
bone tissue (adjective: diarthrotic)
Osteoclasts Diaphysis
involved in breakdown of bone the shaft of a long
tissue to release needed bone
minerals; allows reshaping and
repair of damaged bone tissue.
Acetabulum Epiphysis
the bony socket in the hip bone that the irregularly
hold the head of the femur (from the
shaped end of a long
Latin word for vinegar because it
resembles the base of a vinegar cruet) bone
d i d y o u k n o w ?
The human foot contains 26 bones, and among these bones, the smallest is the stapes bone,
also known as the stirrup bone. It's a tiny bone located in the middle ear and is responsible for
transmitting sound vibrations to the inner ear. Despite its diminutive size (measuring about 3
millimeters in length), the stapes bone plays a crucial role in the process of hearing.
Fracture Resorption
break in a bone removal of bone by
breakdown and absorption
into the circulation
illium Reduction
refers to realignment of
the large, flared, superior
bone with use of rods,
portion of the pelvic bone
plates, or screws to ensure
(root: ili/o) (adjective: iliac)
proper healing.
Immobilization Suture
process of eliminating or
an immovable joint, such as
reducing motion to treat
the joints between the skull
bone fractures by use of bones
casts and splints.
Ligament Symphysis
a strong band of connective a slightly movable
tissue that joins one bone joint
to another
Periosteum Tendon
the fibrous membrane a fibrous band of
that covers a bone’s connective tissue that
surface attaches a muscle to a bone.
Roots Pertaining to Skeletal System
root:crani/o root:spondyl/o root:cost/o
Meaning:cranium Meaning:vertebra Meaning: rib
Example: craniometry Example: spondylolysis Example: costochondral
Definition of Example: Definition of Example: Definition of Example:
Measurement of the Destruction and Pertaining to a rib and its
separation of a vertebra cartilage
cranium
Margaret Donovan, a 72-year-old white female, was brought to the emergency room by
her son-in-law after falling in her bathtub. She was previously in good health, despite
leading a relatively sedentary lifestyle and having a 30-year history of cigarette
smoking. The only medication she currently takes is Inderal (propranolol) for mild
hypertension (high blood pressure). She fell upon entering the bathtub when her right
leg slipped out from under her; she landed on her right hip. There was no trauma to her
head, nor does she complain of right or left wrist pain.
“Open reduction surgery” is a procedure in which the broken bones are re-aligned and
long, thick pins are inserted lengthwise into the bone tissue. The pins are held in place by
screws drilled in from the outside of the bone.
During her long recovery, Margaret is advised by her physician to begin weight-bearing
as soon as she can. To aid her in this regard, Margaret begins light physical therapy three
times per week. 6.
In addition to the physical therapy benefits, why else might Margaret’s physician want
her to avoid prolonged bed-ridden activity. Following her recovery, Margaret was placed
on three medications: oral calcium supplements, oral estrogen and oral alendronate
sodium (Fosamax). (Fosamax is a drug which inhibits the activity of osteoclasts.)
REPRODUCTIVE
System
The major function of the reproductive testosterone
system is to ensure species’ survival. Other are manufactured in interstitial cells located
systems in the body, such as the endocrine between the tubules; regulate sex drive
and urinary systems, work continuously to (libido), bone mass, fat distribution, muscle
maintain homeostasis for the survival of the mass and strength, and the production of
individual. An individual may live red blood cells and sperm.
a long, healthy, and happy life
without producing offspring,
but if the species is to continue, estrogen
at least some individuals must increase secondary sex characteristics like
produce offspring. breasts and changes in overall body
composition (like curves).
4 FUNCTIONS Progesterone
prepare the endometrium (lining of your
To produce egg and sperm cells uterus) for a fertilized egg to implant and
grow.
Bladder
MALE REPRODUCTIVE
SYSTEM
Responsible for making
sperm and are also involved
in producing a hormone
called testosterone.
Testis
MEDICAL TERMINOLOGIES
bulbourethral gland erection
A small gland beside the urethra below The stiffening or hardening of the penis
the prostate that secretes part of the or the clitoris, usually because of sexual
seminal fluid; also called Cowper gland. excitement.
circumcision follice-stimulating
Surgical removal of the end of the prepuce hormone
(foreskin)
A hormone secreted by the anterior
pituitary that acts on the gonads; in males,
FSH stimulates Sertoli cells and promotes
coitus sperm cell development.
Sexual intercourse
gamete
ductus deferens A mature reproductive cell, the
spermatozoon in the male and the
The duct that conveys spermatozoa
ovum in the female.
from the epididymis to the ejaculatory
duct; also called vas deferens.
penis prepuce
The male organ of The fold of skin over
ejaculation copulation and urination the glans penis; the
Ejection of semen from the male (adjective: penile) foreskin.
urethra.
meiosis glans
ejaculatory duct The type of cell division that penis
forms the gametes; it
The duct formed by union of the ductus The bulbous end of the
results in cells with 23
deferens and the duct of the seminal penis
chromosomes, half the
vesicle; it carries spermatozoa and number found in other body
seminal fluid into the urethra. cells.
inguinal
canal
interstitial
The channel through
cells
epididymis which the testis descends
Cells located between the into the scrotum in the
A coiled tube on the surface of the seminiferous tubules of male.
testis that stores sperm until the testes that produce
ejaculation. hormones, mainly
testosterone.
gonads
A sex gland; testis or ovary.
roots pertaining to male reproduction
ROOT:test/o ROOT:sperm/i,
spermat/o
Meaning: Testis, testicle
Meaning:Semen, spermatozoa
Example: Testosterone
Example: Polyspermia
Definition of Example:
Definition of Example:
Hormones are produced
Secretion of excess
in the testis. semen.
ROOT:orchi/o, ROOT:epididym/o
orchid/o Meaning: Epididymis
Meaning: Testis Example: Epididymitis
Example: Anorchism Definition of Example:
Definition of Example: Inflammation of the
Absence of a testis epididymis.
ROOT:osche/o ROOT:vesicul/o
Meaning: Scrotum Meaning: Seminal Vesicle
Example: Oscheal Example:Vesiculogram
Definition of Example: Definition of Example:
Radiograph of a seminal
Pertaining to scrotum.
vesicle
ROOT:SEMIN ROOT:prostat/o
Meaning: Semen Meaning: Prostate
Example: Inseminate Example: Prostatometer
Definition of Example: Definition of Example:
To introduce semen into An instrument for
a vagina. measuring the prostate.
S E
C A Y
U D
S T Ere
Dys ctile
func
tion
R.G., a 67-year-old attorney, was at his annual appointment with his internist
when he decided to discuss what he considered an embarrassing subject, erectile
dysfunction (ED). R.G. was happily married with four grown children and had
continued to enjoy an active sexual relationship with his wife, until recently. He
was having difficulty sustaining an erection. He had seen so much media
publicity on this subject that he decided to bring it up with his physician. At the
conclusion of the appointment, the internist ruled out any psychogenic causes
or adverse effects of medications, such as an antidepressant or an
antihypertensive, that could predispose to ED. He recommended that R.G.
schedule a follow-up visit to his urologist to make certain there were no
underlying physical factors that would contribute to his impotence. R.G. made
an appointment with the urologist whom he had seen about 10 years ago when
he was diagnosed with BPH. At that time, the physician had reviewed various
therapies with R.G., so R.G. felt comfortable discussing his present concerns. The
urologist’s examination ruled out trauma, vascular disorders, or tumors. It was
decided to have R.G. try an ED medication. The physician explained that the
impotence agents work by targeting the physiologic mechanisms of erection.
They promote vasodilation to increase blood flow to the penis. Side effects of
the medications were also discussed. R.G. was relieved that he had no tumor or
other disease condition. He understood the therapy plan and left with follow-
up instructions.
Reproductive female
system
The reproductive system in females is responsible for
producing gametes (called eggs or ova), certain sex
hormones, and maintaining fertilized eggs as they
develop into mature fetuses and become ready for
delivery. A female’s reproductive years are between
menarche (the first menstrual cycle) and menopause
(cessation of menses for 12 consecutive months). During
this period, cyclical expulsion of ova from the ovary
occurs, with the potential to become fertilized by male
gametes (sperm). This cyclic expulsion of eggs is a
gfgthyyyyyy hl.
normal part of the menstrual cycle.
Healthy Female
Reproductive System
Medical Terminologies
cervix
DID YOU
corpus luteum
Neck; usually means A small yellow structure that
Ovary
Produce and store
your eggs (also called
ovum) and make
hormones that
control your
menstrual cycle and
pregnancy.
Fimbriae
A finger-like
projections on the Fallopian or
ends of your fallopian uterine tube
tubes closest to your
ovaries. Each month, An important
your fimbriae catch passageway for an egg Vagina
the egg that one of and a sperm to meet
your ovaries releases and for a fertilized egg The vagina serves three
purposes: It's where the
during ovulation. (embryo) to make its penis is inserted during
way to your uterus sexual intercourse. It's the
pathway (the birth canal)
through which a baby leaves
mammary gland
A specialized gland capable areola
ring, such
of secreting milk in the A pigmented
ea around
female. as the dark ar
the
the nipple of
menarche breast.
The first menstrual period
normally occurs during
puberty. hym
e n
A fold
menopause of mu
memb cous
Cessation of the rane t
partia hat
lly cov
menstrual cycle in the the en ers
trance
female the va of
gina
menstruation
The cyclic discharge of blood and
mucosal tissues from the lining mons pubis
of the nonpregnant uterus. The rounded, fleshy
elevation is anterior
ovarian follicle
to the pubic joint
The cluster of cells in which that is covered with
the ovum ripens in the hair after puberty.
ovary.
Root Pertaining to
the female reproductive system
root:oo root:salping/o
Meaning: Ovum, egg cell Meaning: Uterine tube, tube
Example: Oocyte Example: Salpingoplasty
Definition of Example: Definition of Example:
Cell that gives rise to an ovum. Plastic repair of a uterine tube
root:hyster/o root:episi/o
Meaning: Uterus Meaning: Vulva
Example:Hysterotomy Example: Episiotomy
Definition of Example: Definition of Example:
Incision of the uterus Incision of the Vulva
root:cervic/o root:perine/o
Meaning: Cervix, neck Meaning:Perineum
Example: Endocervical Example: Perineal
Definition of Example: Definition of Example:
Pertaining to the lining of the Pertaining to the perineum
cervix
root:colp/o root:mamm/o
Meaning: vagina Meaning: Breast, mammary gland
Example:Colpostenosis Example: Mammoplasty
Definition of Example: Definition of Example:
Narrowing of the vagina Plastic surgery of the breast
bladder diuretic
The bladder is a muscular sac that stores urine until it is
A substance that increases
voluntarily released from the body. It expands as it fills with the excretion of urine;
urine and contracts to expel the urine during the process of pertaining to diuresis
urination.
URINARY
URIN ARYSYS
SYSTEM
TEM
KIDNEY
Bean-shaped organs
located on either side of
the spine, just below
ureter
These are tubes that
the ribcage. Filter the
connect the kidneys to the
blood to remove waste
bladder. They transport
products and excess
urine from the kidneys to
substances, such as the bladder, where it is
salts and water, to form stored until it is ready to
urine. be expelled from the body.
urethra
This is a tube that carries
bladder urine from the bladder to
The bladder is a muscular sac the outside of the body. In
that stores urine until it is males, the urethra is also a
voluntarily released from part of the reproductive
the body. It expands as it fills system, as it is involved in
with urine and contracts to the transport of semen.
expel the urine during the
process of urination.
erythropoietin (EPO) kidney
A hormone produced by the kidneys
that stimulates red blood cell An organ of excretion (roots: ren/o,
production in the bone marrow nephr/o); the two kidneys filter the
blood and form urine,
which contains metabolic waste
products and other substances as
needed to regulate the water,
glomerular capsule electrolyte, and pH balance of body
The cup-shaped structure at the beginning fluids
of the nephron that surrounds the
glomerulus and receives material filtered
out of the blood; Bowman capsule
renal medulla
The kidney’s inner portion;
glomerular filtrate contains portions of the
The fluid and dissolved materials that nephrons and ducts that
filter out of the blood and enter the
transport urine
nephron through the
glomerular capsule toward the renal pelvis
glomerulus
The cluster of capillaries within the renal pelvis
glomerular capsule (plural: glomeruli)
(root: glomerul/o)
The expanded upper end of the
ureter that receives urine from
the kidney (Greek root pyel/o
means “basin”)
nephron
A microscopic functional unit of the kidney;
working with blood vessels, the nephron
filters the blood and balances the
composition of urine
micturition
The voiding of urine; urination
renal cortex
The kidney’s outer portion; urea
contains portions of the
The main nitrogenous (nitrogen-
nephrons
containing) waste product in the urine
urine
The fluid excreted by the kidneys;
it consists of water, electrolytes,
trigone
urea, other metabolic wastes, and
A triangle at the base of the bladder
formed by the openings of the two pigments; a variety of other
ureters and the urethra substances may appear in urine in
cases of disease (root: ur/o)
tubular reabsorption
The return of substances from the
glomerular filtrate to the blood through roots pertaining to the
the peritubular capillaries urinary system
root:ren/o
ureter Meaning: Kidney
The tube that carries urine from the Example: Suprarenal
kidney to the bladder (root: ureter/o) Definition of Example:
above the kidney
root:nephr/o
urethra Meaning: Kidney
The duct that carries urine out Example: Nephrosis
of the body and also Definition of Example: any
transports semen in the male noninflammatory disease
(root: urethr/o) condition of the kidney
root:pyel/o root:vesic/o
Meaning: renal pelvis Meaning: urinary bladder
Example: pyelectasis Example: intravesical
Definition of Example: Definition of Example:
dilatation of the renal pe within the urinary bladder
lvis
root:ur/o
Meaning: urine, urinary tra
ct
Example: urinalysis
Definition of Example:
laboratory study of urine
did you
know?
root:urin/o
Meaning: urine
Example: nocturia
Definition of Example:
urination during the night
(noct/i)
h e a d ult
T
u r i n ary
human
root:ureter/o
Meaning: ureter
d e r c an
Example: ureterostenosis
blad
Definition of Example:
p t o two
hold u
narrowing of the ureter
u r i n e.
f
cups o
DISORDERS
acidosis
Excessive acidity of body fluids hydronephrosis hypokalemia
Collection of urine in Deficiency of
the renal pelvis potassium in the
blood
bacteriuria caused by
obstruction; results
Presence of bacteria in the urine in distention and
renal atrophy
cast
A solid mold of a renal
hyponatremia hypoproteinemia
tubule found in the urine Deficiency of Decreased amount
sodium in the of protein in the
blood blood; may be
cystitis caused by kidney
Inflammation of the urinary damage resulting
in protein loss
bladder, usually as a result of
infection
hyperkalemia hypernatremia
dysuria Excess amount of Excess amount of
Painful or difficult urination potassium in the sodium in the
blood blood
glomerulonephritis
Inflammation of the kidney,
primarily involving the glomeruli;
the acute form usually occurs after
an infection elsewhere in the body;
oliguria proteinuria
Elimination of Presence of
the chronic form varies in cause and small amounts of protein, mainly
usually leads to renal failure urine albumin, in the
urine
hematuria
Presence of blood in the urine
S E
C A Y
U D
S T glom
erul
onep
hrit
is
His hemoglobin was 8.2, and his hematocrit was 26%. He had bilateral
lung rales. ABGs were: pH, 7.0; Paco2, 28; Pao2, 50; Hco3, 21. His BUN,
serum creatinine, and BUN/ creatinine ratio were abnormally high.
His ECG and liver enzyme studies were normal. His admission
diagnosis was ESRD, fluid overload, and metabolic acidosis.
He was typed and crossed for blood; tested for HIV, hepatitis B
antigen, and sexually transmitted disease; and sent for hemodialysis.
A bed was reserved for him on the transplant unit.
nervous
System
The nervous system includes the brain, spinal cord, and a complex network of nerves. This
system sends messages back and forth between the brain and the body. The brain is what
controls all the body's functions. The spinal cord runs from the brain down through the
back.
spin
organization of the nervous system cor al
For study purposes, the nervous system may d
be divided structurally into two parts:
NEURON
makes sense of
visual
information
Temporal
NEURON
Cerebellum
lobe
Plays a major role in
Assists with the
perception and balance and
interpretation of voluntary motor
sound skills.
Brainstem
Plays a role in the Allows the transfer of information
recognition of objects between the brain and body.
and visual memory. Plays a role in automatic functions
such as the heartbeat and
breathing.
Medical
TERMINOLOGIES
arachnoid mater
dendrite
The middle layer of the
meninges (from the Greek word A fiber of a neuron that
for spider, because this tissue conducts impulses toward
resembles a spider web) the cell body
axon
The fiber of a neuron that
dura mater
conducts impulses away from The strong, fibrous
the cell body outermost layer of the
meninges
myelin reflex
A whitish, fatty substance A simple, rapid, and
that surrounds certain automatic response
axons of the nervous to a stimulus
system
Neuron sulcus
The basic unit of the A shallow furrow or
nervous system; a groove, as on the
nerve cell surface of the
cerebrum
Nerve synapse
The junction between 2
A bundle of neuron neurons; also, the
fibers outside the junction between a
CNS motor neuron and a
muscle or gland
did you
know? tract
A bundle of neuron fibers
within the CNS
That our forehead
and fingertips are
the most sensitive
to pain because of
white matter
their greater
density of nerve Myelinated tissue
fibers which react of the nervous
to a pain trigger. system
Roots for the Nervous System
root:neur/o, neur/ root:gli/o root:gangli/o,
Meaning:nervous system, Meaning: neuroglia ganglion/o
nervous tissue, nerve Example: glial Meaning: Month,
Example: neurotrophin Definition of Example: menstruation
Definition of Example: Pertaining to Example: Premenstrual
Factor that promotes neuroglia Definition of Example:
nerve growth Before a menstrual period.
functions components
· Heart
· Blood
·-Circulates oxygen and removes CO2 in the body
-Provides cells with nutrients
-Removes the waste products of metabolism to
the excretory organs for disposal · Blood
-Protects the body against disease and infection
-Blood clotting
vessels
LEFT ATRIUM
Receives blood full of oxygen
from the lungs and then
empties the blood into the left
ventricle.
RIGHT ATRIUM
Receives blood low in oxygen
from the body and then
empties the blood into the
right ventricle. LEFT VENTRICLE
Responsible for pumping
RIGHT VENTRICLE oxygen-rich blood into your
aorta
Responsible for accepting venous
blood and propelling it to the
lungs where it is oxygenated and
its CO2 eliminated
MEDICAL
TERMINOLOGIES
aorta capillary
The largest artery; it A microscopic blood vessel
receives blood from the left through which materials are
ventricle and branches to all exchanged between the
parts of the body blood and the tissues
arteriole diastole
A small vessel that The relaxation
carries blood from the phase of the
arteries into the heartbeat cycle
capillaries
atrium endocardium
An entrance chamber, The thin membrane that
one of the two upper lines the chambers of the
receiving chambers of heart and covers the valves
the heart
heart systole
The muscular organ with four
chambers that contracts The contraction phase
rhythmically to propel blood of the heartbeat cycle
through vessels to all parts of
the body
repolarization venule
A return of electrical A small vessel that
charge to the resting carries blood from the
state in nerves or capillaries to the veins
muscles
ROOT:cardi/o ROOT:angi/o
Meaning: heart Meaning: Vessel
Example:cardiomyopathy Example: Angiography
Definition of Example: Definition of Example:
Any disease of the heart x-ray imaging of a
muscle vessel
ROOT:atri/o ROOT:arter/o,
arteri/o
Meaning: Atrium
Example: Atriotomy Meaning: Artery
Definition of Example: Example: endarterial
Surgical incision of an Definition of Example:
atrium Within an artery
ROOT:ventricul/o ROOT:arteriol/o
Meaning: Cavity, Ventricle Meaning: arteriole
Example: supraventricular Example:Arteriolar
Definition of Example: Definition of Example:
Pertaining to an arteriole
Above a ventricle
ROOT:valv/o, ROOT:aort/o
valvul/0
Meaning: valve Meaning: Aorta
Example: aortoptosis
Example:Valvulotome
Definition of Example:
Definition of Example:
Downward displacement
Instrument for incising
of the aorta
a valve
S E
C A Y
U D
S T My
s h oorc a r d i a
t l
o f hn e s s o fi n f a r c t
yper bre ion:
t a c
s e d ee n s i o nt, h a n d hh e s t p a
ntar diab as a in an
y lif etes hist d
esty , and ory
le a
Mr. Johnson, a 55-year-old male, presents to the emergency department complaining of chest
pain and shortness of breath. He has a history of hypertension, diabetes, and a sedentary lifestyle.
Mr. Johnson is a smoker and reports occasional high stress levels at work. Upon arrival, Mr.
Johnson describes a sudden onset of crushing chest pain radiating to his left arm, associated with
nausea and diaphoresis. Vital signs reveal elevated blood pressure and a rapid heart rate. An
electrocardiogram (ECG) shows ST-segment elevation in specific leads, indicating a myocardial
infarction (heart attack).
Blood tests confirm elevated cardiac biomarkers, supporting the diagnosis of a myocardial
infarction. Imaging studies, such as a coronary angiogram, reveal a significant blockage in one of
the coronary arteries. Johnson is promptly administered aspirin, nitrogylcerin, and a statin. He
undergoes emergent percutaneous coronary intervention (PCI) to restore blood flow in the
blocked coronary artery. Post-procedure, he receives medications for secondary prevention,
including beta-blockers, ACE inhibitors, and antiplatelet agents. Lifestyle modifications, such as
smoking cessation, dietary changes, and cardiac rehabilitation are emphasized.
Outcome:
Mr. Johnson responds well to treatment, and subsequent evaluations show improved cardiac
functions. He engages in a structured exercise program and adopts a heart-healthy lifestyle. This
case underscores the importance of timely intervention lifestyle modifications, and
comprehensive cardiovascular care in managing acute myocardial infarction and preventing
future cardiovascular events.
digestive
System
The digestive system is a
complex network of organs small intestine
The small intestine is where most digestion
that work together to and absorption occur. It receives digestive
break down food, absorb enzymes from the pancreas and bile from the
nutrients, and eliminate liver, which help to break down fats, proteins,
and carbohydrates.
waste from the body.
large intestine
the key parts of the The large intestine absorbs water and
digestive system electrolytes from the remaining undigested
food, and bacteria in the colon help to ferment
mouth, esophagus, stomach, and break down indigestible fibers.
mouth liver
The mouth is responsible for the initial
The liver produces bile that aids in fat digestion
breakdown of food through chewing and
and absorption.
the secretion of saliva, which contains
enzymes that begin the digestion process.
gall bladder
The gallbladder stores and concentrates bile,
esophagus releasing it into the small intestine when
The esophagus is a muscular tube that needed.
transports the chewed food from the
mouth to the stomach through peristalsis,
a series of wave like contractions.
did you
know?
stomach The small intestine
In the stomach, gastric juices and despite its name, is
enzymes further break down the food the longest part of
into a semi liquid form. the digestive tract,
measuring around
22 feet long
digestive system
digestive system
GALLBLADDER
Stores bile and releases it into
the digestive tract when
needed
LIVER
The largest internal organ,
responsible for producing bile,
filtering toxins, storing nutrients, STOMACH
and metabolizing chemicals. A muscular sac-like organ below the
diaphragm that stores food and
secretes juices that digest protein
PANCREAS
Secretes a variety of digestive
enzymes Also secretes bicarbonate to RECTUM
neutraize stomach acid and water to
The distal portion of the large
dilute food.
intestine; it stores and
eliminates undigested waste
SMALL INTESTINE
The portion of the intestine between ANUS
the stomach and the large intestine;
and almost all digestion and
The distal opening of the
absorption occur here digestive tract
MEDICAL
Terminologies
oral cavity small intestine
The mouth, where digestion The longest part of the
begins. Food is broken down digestive tract, where the
mechanically by chewing and majority of nutrient
mixed with saliva. absorption takes place.
esophagus villi
A muscular tube connecting the Tiny, finger-like projections
throat to the stomach. It lining the small intestine that
transports food from the mouth increase its surface area for
to the stomach through better absorption of nutrients.
peristalsis.
peristalsis colon
The involuntary contractions Also known as the large
of the muscles lining the intestine, it absorbs water and
digestive tract that propel electrolytes from undigested
food along its pathway. food, forming feces
stomach pancreas
A muscular organ that stores An organ that produces enzymes
and breaks down food to break down proteins,
further through the action carbohydrates, and fats, and
of gastric acid and enzymes. releases them into the small
intestine
liver diverticulitis
The largest internal organ, Inflammation or infection of
responsible for producing bile, small pouches (diverticula)
filtering toxins, storing nutrients, that develop in the colon
and metabolizing chemicals. wall, often due to low-fiber
diets.
hepatitis gastroenteritis
Inflammation of the liver Inflammation of the stomach
usually caused by viral and intestines, often caused
infection, alcohol abuse, or by viral or bacterial infection,
exposure to certain chemicals.
leading to diarrhea and
vomiting.
gastroesophageal lactose
reflux disease (GERD) intolerance
A condition where the stomach acid Inability to digest lactose, the
flows back into the esophagus, sugar found in milk and dairy
causing heartburn and other products, due to a deficiency in the
symptoms. enzyme lactase
ulcer appendicitis
A sore or lesion that forms on
the lining of the digestive tract, Inflammation of the appendix, a
often caused by bacteria (H. small appendage attached to the
pylori) or prolonged use of colon, often requiring surgical
NSAIDs. removal to prevent rupture.
Roots pertaining to Digestive System
root:amyl root:cholecyst/o root:col/o
Ethan, an active and cheerful 10-year-old, had been experiencing recurrent episodes of
abdominal pain, bloating, and irregular bowel movements for several months. Concerned about
his deteriorating health, his parents sought medical help to unravel the mystery behind his
symptoms. The first step in diagnosing Ethan's condition was to analyze his symptoms. His parents
described his abdominal pain as sharp and cramp-like, often worsening after meals. Bloating was a
constant companion, making it difficult for Ethan to enjoy normal activities. Furthermore,
irregular bowel movements oscillated between constipation and diarrhea, causing distress in his
daily life.
To determine the cause of Ethan's digestive troubles, various diagnostictests were conducted.
Blood tests revealed no abnormalities in his liver or pancreas enzymes. Stool samples were
analyzed for any signs of infection or malabsorption issues but yielded inconclusive results.
Finally, an upper gastrointestinal endoscopy and colonoscopy were performed to examine his
esophagus, stomach, small intestine, and colon for any abnormalities. After careful examination
of the test results, Ethan was diagnosed with Irritable BowelSyndrome (IBS). This common
gastrointestinal disorder affects the large intestine and causes a variety of uncomfortable
symptoms.
Treatment for IBS involves a multidimensional approach tailored to each patient's unique
needs. In Ethan's case, dietary modifications were recommended. His doctor advised him to avoid
trigger foods such as dairy products and artificial sweeteners while incorporating more fiber-rich
fruits and vegetables into his diet. Regular exercise and stress management techniques were also
suggested to alleviate symptoms. Over time, Ethan's condition improved significantly as he
diligently followed the prescribed treatment plan. His abdominal pain and bloating reduced, and
his bowel movements became more regular. With the support of his family and healthcare
professionals, Ethan regained his energy and zest for life.
muscular
System
The main characteristic of
FUNCTIONS OF MUSCULAR
muscle tissue is its ability to
SYSTEM
contract. When stimulated, Allow the body to MOVE
muscles shorten to produce Gives the body STABILITY
Helps maintain POSTURE
movement of the skeleton, vessel walls,
Controls ORGAN movement
or internal organs. Muscles may also Maintains BODY temperature
remain partially contracted to maintain
posture. In addition, the heat generated
by muscle contraction is the main source
of body heat.
important tips
to build muscle
Types of Muscle GET ENOUGH SLEEP
SKELETAL MUSCLE
Attached to bones and is CALORIE SURPLUS PROGRESSIVE
responsible for voluntary OVERLOAD
Biceps
femoris
Abdominals Flexion of
Support the trunk, Quadriceps the knee
allow movement and Extend the leg at
hold organs in place by the knee joint and
regulating internal
flex the thigh at
abdominal pressure.
the hip joint
Calf
muscles
Responsible for
plantarflexion the
foot and ankle
D I S O R D E R S
A disease caused by motor neuron degeneration resulting in
muscular weakness and atrophy; Lou Gehrig disease
The sural nerve is an easily harvested nerve graft that allows the surgeon to
implant healthy nerves to replace the damaged nerves in the brachial plexus.
Following the four-hour procedure, Thomas was admitted to the pediatric ICU.
After 6 days, he was discharged home with his right arm in a shoulder
immobilizer. The incisions from the nerve graft donor sites on his right and left
calf were healing nicely. He was given antibiotic ointment to apply for the next
week to prevent infection. He was also told to elevate his legs, for several days,
when he was sitting or in bed. Thomas received instructions on activities that he
could or could not perform and was told to see the orthopedic surgeon in 1 week
and again 3 weeks later. Physical therapy was ordered to prevent further
atrophy and to begin rebuilding the arm muscles.
At his 1-week follow-up, Thomas stated his frustration with the slow progress.
The orthopedic surgeon had said that in time, he should regain full use of his
right arm and normal activities of daily living should be restored.
Respiratory Trachea or Windpipe
system Serves as passage for air,
moistens and warms it while it
passes into the lungs, and
protects the respiratory
surface from an accumulation
of foreign particles
Nasal cavity
The uppermost part of the
respiratory system and
provides the nasal passage
for inhaled air from the
nostrils to the
nasopharynx and rest of
the respiratory tract.
Main Bronchi
Distribute the air
throughout the lungs
until reaching the
respiratory bronchioles
RESPIRATORY PROCESS:
The process begins with inhalation, where
air is drawn in through the nose and
passes through the pharynx, larynx, and
trachea. It then enters the lungs, where
oxygen is transferred to the bloodstream
while carbon dioxide
is removed. This oxygen-
rich blood is then distri
buted to the body's cells, allo
wing for the production of
energy through cellular
respiration.
Medical Terminologies
Little hollow; Pertains
to the alveolus
1 ALVEOLAR
conditions characterized by
collapse of the alveoli which
ATELECTASIS 2 prevent gas exchange in that
part of the lung
An inflammation of the
bronchial tubes, which
BRONCHITIS 4 carry air to and from the
lungs
An umbrella of diseases
CHRONIC OBSTRUCTIVE
including asthma, chronic
PULMONARY DISEASE 6 bronchitis, emphysema, and
(COPD) chronic bronchiectasis
A muscular structure
located beneath the lungs
that helps in the process of 7 DIAPHRAGM
breathing.
An accumulation of air in
the pleural space of the
PNEUMOTHORAX 10 chest causing the lungs to
collapse.
The examination of
PULMONARY
the blood vessels of 11 ANGIOGRAPHY
the lungs.
bronch(o) - bronchus
Example: bronchitis - inflammation
of the bronchial tubes
laryng(o) - larynx
Example: laryngitis - Inflammation
of the larynx, or voice box
nas(o) - nose
Example:nasopharynx -
upper part of the throat
pleur(o) - pleura
Example:pleurisy -
inflammation of the pleura
pulm(o) - lung
Example:pulmonology -
deals with diseases and
disorders of the lungs
pharyng(o) - pharynx
Example: pharyngitis
inflammation of the pharynx
thorac(o) - chest
Example: thoracotomy
incision into the chest wall
Sarah, a 38-year-old woman with no prior respiratory health issues, had been leading an
active and healthy lifestyle. She enjoyed jogging in the park every morning, relishing in the
fresh morning air. However, one fateful day, as she was out for her routine jog, she suddenly
collapsed and struggled to breathe. Sarah was rushed to the emergency department, where she
presented with severe shortness of breath and cyanosis (a bluish discoloration of the skin due
to lack of oxygen). Her respiratory rate was rapid and shallow, while her heart rate soared.
These alarming symptoms raised concerns about possible damage to her respiratory system.
Various diagnostic tests were conducted to determine the underlying cause of Sarah's
respiratory distress. Blood gas analysis revealed significantly low oxygen levels and elevated
carbon dioxide levels, indicating impaired gas exchange in the lungs. Chest X-rays showed signs
of pulmonary edema—a condition where fluid accumulates in the lungs—leading to compromised
lung function. After a thorough evaluation, Sarah was diagnosed with acute respiratory distress
syndrome(ARDS). ARDS occurs when there is significant inflammation and injury to the lungs due
to various causes including infections or injuries. In Sarah's case, it was suspected that her
vigorous exercise triggered an intense immune response leading to ARDS.
Sarah's treatment plan commenced immediately to address her critical condition. She was
placed on supplemental oxygen through a nasal cannula to increase oxygen levels in her blood.
To alleviate fluid accumulation in her lungs, diuretics were administered. Additionally, she was
prescribed anti-inflammatory medications to reduce lung inflammation. Sarah's recovery
journey was arduous but promising. With diligent medical care, her oxygen levels gradually
improved, and the fluid in her lungs subsided. Physical therapy played a crucial role in
strengthening her respiratory muscles, facilitating a faster return to normalcy. Sarah's
determination and resilience were essential during this period.
endocrine
System
The endocrine system of glands that produces and secretes hormones into the bloodstream best
describes the endocrine system. The endocrine hormones control growth, development, mood,
and metabolism. The circulatory system helps distribute oxygen and other nutrients to cells all
over the body. Consists of a widely distributed group of glands that secrete regulatory
substances called hormones. Because hormones are released into the blood, the endocrine
glands are known as the ductless glands, as compared to exocrine glands, such as sweat glands
and digestive glands, that secrete through ducts to the outside.
brain
Hypothalamus- Maintains the body’s homeostasis and
regulates body temperature, heart rate, and blood pressure.
Pineal Gland - Responsible for the production of melatonin,
which plays a major role in the body’s sleep-wake cycle.
Pituitary gland- Composed of 2 lobes: the anterior, which
secretes hormones involved in the body’s growth and
development, and the posterior, which secretes hormones
that increase the reabsorption of water into the kidneys.
thymus
Controls production of T-cells (white blood
cells) and plays a vital role in the body’s ability
to fight diseases.
thyroid
This butterfly shaped gland produces 3 major
hormones: calcitonin, triiodothyronine (T3), and
thyroxine (T4). They help regulate the body’s energy
and metabolism.
pancreas
Aids in the digestion of proteins, fats, and carbohydrates.
responsible for the production of insulin and glucagon,
which regulate the level of glucose in the blood.
adrenal gland
Produces hormones that allow the body
to react to stress, such as adrenaline and
cortisol.
ovaries
Secretes estrogen and progesterone, which
play a key role in the health of the female
reproductive system.
testis
Secretes testosterone, which is
vital for physical development,
bone density, and libido in males. .
Medical Terminologies
1
ADRENAL GLAND
A gland on the superior surface of the
kidney; the outer region (cortex) secretes
steroid hormones; the inner region (medulla)
secretes epinephrine in response to stress.
9 PROSTAGLANDIS
A group of hormones produced throughout the
body that have a variety of effects, including
stimulation of uterine contractions and
regulation of blood pressure, blood clotting, and
inflammation.
ENDOCRINE
Pertaining to a ductless gland
that secretes hormones into
the blood.
2 RECEPTOR
A site on the cell membrane or
within the cell to which a substance,
such as a hormone.
10
3 11
HYPOPHYSIS HORMONE
The pituitary gland; is named hypo meaning A secretion of an endocrine gland; a
“below” and physis, meaning “growing” substance that travels in the blood and has a
because the gland develops below the regulatory effect on tissues, organs, or
hypothalamus. glands.
4 12
HYPOTHALAMUS STEROID HORMONES
A portion of the brain that controls the A hormone made from lipids;
pituitary gland, produces hormones and is includes the sex hormones and the
active in maintaining homeostasis. hormones of the adrenal cortex.
5 13
PANCREATIC ISLET TARGET TISSUE
A cluster of endocrine cells in the pancreas The specific tissue on which a
that secretes hormones to regulate glucose hormone acts; may also be called
metabolism; also called islet of Langerhans or
islet cells.
the target organ.
6 14
PINEAL GLAND THYROID GLAND
A small gland in the brain; appears to An endocrine gland on either side of
regulate mood, daily rhythms, and sexual the larynx and upper trachea;
development in response to secretes hormones that affect
environmental light. metabolism and growth.
7 15
PITUITARY GLAND GLYCOSURIA
A small endocrine gland at the base of the brain; the
anterior lobe secretes growth hormones and
hormones that stimulate other glands; the posterior
Excess glucose in the urine.
lobe releases ADH and oxytocin manufactured in the
hypothalamus.
8 16
PARATHYROID GLAND SPHENOID BONE
A small endocrine gland on the posterior
A bone at the base of the skull
thyroid acts to increase blood calcium
levels; there are usually four to six that houses the pituitary gland.
parathyroid glands.
Root Pertaining to the
Endocrine System
endocrin/o
1
Endocrine glands or system
Example:
endocrinopathy -Any disease of
the endocrine glands.
pituitar/i
thyr/o, thyroid/o
4 Thyroid gland
Example:Thyrolytic-Destroying
the thyroid gland.
parathyr/o,
parathyroid/o
5
Parathyroid gland
Example: Hyperparathyroidism -
Overactivity of a parathyroid
gland.
adren/o, adrenal/o
andrenocortic/o
7
Adrenal cortex
Example:Adrenocorticotropic-
acting on the adrenal cortex.
insul/o
8 Pancreatic
Example: islets insular-
Pertaining to islet cells.
S E
C A Y
U D
S T Diab
etes
Trea
tmen
P u m pt w i t h a
n Ins
ulin
M.G., a 32-year-old marketing executive, was diagnosed with type 1 diabetes at the
age of 3. She vividly remembers her mother taking her to the doctor because she had an
illness that caused her to feel extremely tired very thirsty and hungry. She also had
begun to wet her bed and had a cut on her knee that would not heal. Her mother had had
gestational diabetes during her pregnancy with M.G., and at birth, M.G. was described as
having “macrosomia” because she weighed 10 lb. M.G. has managed her disease with
meticulous attention to her diet, exercise, preventive healthcare, regular blood glucose
monitoring, and twice-daily injections of regular and NPH insulin, which she rotates
among her upper arms, thighs, and abdomen.
She can administer her insulin in a continuous subcutaneous insulin infusion (CSII)
and in calculated meal bolus doses. She still has to test her blood for hyperglycemia and
hypoglycemia and her urine for ketones when her blood glucose is too high. She hopes
one day to have an islet transplantation.
What's the word that links
these four together?
Match the following terms to
its correspoding definition.
Meiosis
b where the nephrons begin
Salpingectomy
c excision of vas deferens
Peristeum
e inflammation of the vagina
Tendinitis
h membrane that covers a bone
Hypopnea
i displacement of a vertebra
Arachnoid mater
j inflammation of tendon
Syncope
k permanent contraction of a muscle
Contracture
l decreased rate of breathing
Peristalsis
m device for measuring air flow
Vulvotome
n wave-like contractions
Pneumotachometer
o type of a liver disease
Midbrain
p medical term for fainting
Spondylolisthesis
q instrument for incising a valve
Glycosuria
r contains reflex center for improved vision
and hearing
Cirrhosis
s the thin, web-like middle layer
Evaluation of the air capacity of the These are two bean-shaped organs
lungs located on either side of the spine, just
below the ribcage
Originating in the mind Downward displacement of the aorta
Also known as the large intestine, it
absorbs water and electrolytes from Refers to using pulleys and weights to
undigested food, forming feces maintain alignment of fractured bone
Cells that give rise to an ovum Means resembling a hair
B L O O D
H E A R T
L U N G S
B R A I N
MATCHING TYPE
1. C 11. S
2. D 12. P
3. E 13. K
4. B 14. N
5. A 15. Q
6. H 16. M
7. E 17. R
8. F 18. I
9. J 19. G
10. L 20. O
CROSSWORD
Across: Down:
2. Psychogenic 1.Spirometry
3. Colon
4. Oocyte
6. Vessel
5. Oscheal
7. Atlas
9. Kidneys 8. Coitus
10. Aortoptosis 11. Traction
14. Tuberculosis 12. Trichoid
15. Nephron 13. Neuron
BUTON, Ann Maxinne GRANA, Nicole E. JUEZAN, Dainty Pearl B.
M T R T 2 0 2 3