PFAUDLER

PHARMAGLASS PPG ®

Smoother, Cleaner, More Resistant

Glasslining for Pfaudler Pharma a rate depending on

GMP and FDA Glass PPG the chemicals present
Requirements The PharmaGlass PPG & the temperatures.
was developed free of Ask for GMM Pfaudler
heavy metals, light blue WWG 9100 catalog for
PHARMA
SOLUTIONS color, with a smoother isocorrosion curves.
surface finish compared The debris of corrosion
to the conventional glass including heavy metals
PROCESS
DESIGN

and improved alkali reduces the purity of the

PPG

resistance. Active Ingredient (AI).

PROPERTY PROFILE OF PFAUDLER

Pfaudler PharmaGlass is
When the requirements PHARMAGLASS PPG practically freefrom heavy
of the Bulk Drug industry ADK α 10-7 [K-1] 97-100 metals i.e. no heavy
20-400
were recently studied in IMPACT 20-24 NM
metals can be dissolved.
context of the stringent RESISTANCE The proportionate heavy
requirements of GMP DIELECTRIC > 20 KV/MM metal content is below
and FDA, the need for STRENGTH the analytical detection
a different glass was SPECIFIC > 109 ΩCM limits preserving the
evident. Two of the ELECTRICAL purity of the AI.
RESISTANCE*
requirements of the
ADHESIVE > 100 N/
pharmaceutical industry STRENGTH MM2
are increased purity
WEAR < 6 MG
in order to comply CM-2 H-2
with the FDA and GMP *at room temperature
The properties of this new product contribute
requirements and significantly to an improved safety and efficiency of
production processes.
alternating alkali/
acid operation. The PURITY OF
process equipment PRODUCT
of the chemical Metal Free Glass CLEAN IN PLACE
and pharmaceutical During corrosive Smooth Surface
industries have so far chemical reactions When Pfaudler
been characterized glasslining corrodes at PharmaGlass PPG
by great similarity- was developed, one
especially in terms of primary challenge was
glass lined reactors and the surface quality. The
components. In light of smoother the surface,
the survey, Pfaudler’s PPG fewer the incrustations is
response was a novel to be expected.
glass tailored to tile
needs of manufacturing CrNi Pfaudler PharmaGlass
pharmaceutical products, PPG surface is three
vitamins and fine times smoother than
Pfaudler PharmaGlass PPG compared to CrNi.
chemicals. Surface structure, magnified 200 times the conventional glass
surface.
 This product incrustation is CHANGE IN ROUGHNESS OF PPG DURING CORROSION
TESTS COMPARED TO ELECTROPOLISHED STAINLESS STEEL
efficiently avoided, further
more; the time required 0,80

Ra CrNi (μm)
for cleaning is reduced
significantly. The benefits
are obvious: Shorter 0,70
and fewer downtimes,
the systems are more 0,60
productive.

The extremely high surface 0,50

quality is preserved even
after prolonged service 0,40
times. Corrosion tests have
shown that its roughness
after an acid or alkali attack 0,30
is much lower than with
commercially available 0,20
glass types. The surface
of Pfaudler PPG is much

Ra PPG (μm)
smoother even after a 0,10
corrosive attack - than that
of healthy, electro-polished 0,00
stainless steel surfaces. before HCI after before H2O after before NaOH after

PFAUDLER PHARMAGLASS PPG THE SOLUTION FOR ADDED PERFORMANCE

Resistance of PPG to water
DIN ISO 719* DIN ISO 720* Corrosion curve of Pfaudler PharmaGlass PPG
Sb < 0.01 < 0.01
200°C
As < 0.02 < 0.02
Ba < 0.001 < 0.001 180°C
Pb < 0.01 < 0.01 160°C
Cd < 0.002 < 0.002
Cr < 0.01 < 0.01 140°C
Co 0.001 0.005 120°C
Cu 0.012 0.075
Ni < 0.005 < 0.005 100°C
Sr < 0.001 <0.001 80°C
Zn < 0.01 < 0.01
Sn < 0.05 < 0.05 60°C
Analytical detection limits according to applicable DIN standards 40°C
The analysis was carried out on glass grains sized
0.3 < 0.425 mm DIN 719 -2 -1 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
0.3 < 0.500 mm DIN 720
pH value measured at room temperature max. 0.1 mm/a max. 0.2 mm/a

Improved Optical monitoring of the production the reactor with dilute

Monitoring process and alkali (1.5%-5%) at
Pfaudler PharmaGlass PPG safe verification of the temperatures below 70°C.
has a light-blue color, thus cleaning result are now The neutralization of any
increasing contrast with possible. remaining acidic mass
dark blue, white or colored will help in cleaning and
products. The light-blue color Alkali Wash validation.
also improves the lighting of With the PharmaGlass PPG
the reactor inside. Improved it is possible to wash

PFAUDLER PHARMAGLASS PPG®

IMPROVED CHEMICAL RESISTANCE TO ALKALI

Higher Resistance to Aggressive

Substances
One of the properties characteristic of glass is its resistance
to aggressive substances, even at high temperatures.
Compared to other materials, glass is extremely resistant to
acid media. The new Pfaudler PharmaGlass PPG for
the first time combined this property with a significantly
improved resistance to alkali substances. In the alkali range
PharmaGlass PPG is 2.5 times better than chemical glass
while it matches the acid resistance of WWG 9100.

Greater Application Range

Equipment lined with Pfaudler PharmaGlass PPG can
withstand varying loads, thus offering a greater application
range. Changing between stainless steel and glassed
apparatuses is practically no longer necessary. You will save
real money in terms of investment and in your day-to-day
operations.

RATE OF CORROSION 0.1 MM/A 0.2 MM/A

IN PH -1 125˚C CA. 144W˚C
IN PH 7 150-160˚C CA. 170˚C
FROM PH 13 75˚C CA. 82˚C

DEVELOPING THE OPTIMUM SOLUTION

We will be pleased offered for glass lined be pleased to provide

to give you detailed equipment and turnkey you with supporting
answers to your projects alike. documentation for your
questions on the new decision-making process.
Pfaudler PharmaGlass Right From the
PPG. Our engineer Beginning… … Up the
can visit you for a Getting us involved Operative System
detailed presentation in your planning at Implementation,
on the new glass. As a an early stage could operation and
specialist for Reactor mean benefiting maintenance are our
Systems, we will assist from the practical issues. Our specialists
you with all projects, experience of Pfaudler and their know-how
from engineering and companies worldwide. ensure the safe,
production through The use of glass may efficient and continuous
installation and add significantly to operation of apparatuses
maintenance up to the efficiency of your and entire systems.
retrofits. This service is production – we will