ANTIPSYCHOTIC MEDICATION

Name of Drug Class Preparation Indication Mode of Action Side effects

Chlorpromazine Phenothiazine Tablet (10mg, 25mg, Schizophrenia and other Blockade of dopamine 2 Dyskinesia, dystonia,
antipsychotic 50mg, psychoses, mania & hypomania; receptors (D2) is responsible tremor, postural
100mg,200mg) anxiety, psychomotor agitation, for reducing the positive signs hypotension,xerostonia,
(1st generation) excitement, violent or of pyschosis & improving other insomnia, blocked nose,
Injection dangerously impulsive behavior, behaviors agitation, cardiac
( 25mg/mL) childhood schizophrenia and arrhythmias, leukopenia,
autism. Intractable hiccup. respiratory depression

Haloperidol Typical Tablet Schizophrenia, acute psychosis, competitively blocks Injection site reaction,
Antipsychotic (0.5mg, 1 mg, 2mg, Behavioral disorders, persistent post-synaptic dopamine (D2) tachycardia, hypotension,
5mg, 10mg, 20mg) nausea, intractable hiccup control receptors in the brain, hypertension,
(1st generation) of tics and vocal utterance of eliminating dopamine QT-prolongation and/or
Oral concentrate tourette’s disorder neurotransmission and leading ventricular arrhythmia.
(2mg/mL) to the relief of delusions and Torsades Pointes, EPS,
hallucinations that are hyperkinesia, tardive
Injectable solution, commonly associated with dyskinesia, akathisia,
lactate psychosis. bradykinesia, hypertonia,
5mg/mL somnolence

Injectable solution,
decanoate
50 mg/mL
100mg/mL

Amisulpride Atypical Tablet Psychoses eg acute and chronic
antipsychotic (200mg) schizophrenic disorders in which
(2nd positive symptoms ( delusions,
generation) hallucinations, thought disorder)
and/or negative symptoms
(blunted affect, emotional/social
withdrawal) are prominent
including patients characterized
by predominant negative
symptoms
Enhances dopaminergic
neurotransmission by
preferentially blocking
presynaptic D2/D3 dopamine
receptors, producing dopamine
release responsible for its
disinhibitory effects.
Hypotension, bradycardia,
QT interval prolongation,
ventricular arrhythmia,
sudden death, VTE,
Allergic reaction,
angioedema, weight gain,
urticaria, Insomnia,
anxiety, agitation,
somnolence, EPS (
tremor, rigidity,
hypokinesia,
hypersalivation, akathisia,
dyskinesia)
Aripiprazole Atypical Tablet Schizophrenia, acute manic and As a partial agonist at D2 N/V, headache, insomnia
antipsychotics (2mg, 5mg,10mg, mixed episodes associated with receptors in the mesolimbic
(2nd 15mg, 20mg, 30 mg) bipolar I disorder and dopaminergic pathway, adult constipation,
generation) maintenance therapy of bipolar I aripiprazole acts as a functional dizziness, akathisia,
Oral Suspension disorder antagonist in the mesolimbic anxiety, restlessness
(1mg/mL) dopamine pathway and
Adjunctive treatment of major reduces the extent of Children somnolence,
depressive disorder irritability dopaminergic pathway activity. EPS, fatigue, increased
associated with autistic disorder This results in reduced positive appetite and weight
Tourette’s syndrome symptoms in schizophrenia and
extrapyramidal motor side
effects.

Clozapine Atypical Tablet Treatment resistant Blocking of 5-HT2A/5-HT2C Drowsiness, dizziness,

antipsychotics schizophrenia, serious psychosis serotonin receptors and the hypersalivation, dry
(2nd (25mg, 50mg, with tardive dyskinesia, negative D1-4 dopamine receptors, with mouth, tachycardia and
generation) 100mg, 200mg ) symptoms schizophrenia, the highest affinity for the D4 sedation.
schizo-affective disorder, severe dopamine receptor. As a Constipation, headache,
Oral disintegrating manic bipolar I disorder and serotonin and D4 dopamine nausea, changes in
tablet borderline personality disorder antagonist, clozapine is able to eyesightM,
elicit its antipsychotic effects agranulocytosis, seizure,
(12.5mg, 25mg, 50 without inducing many of the CV effects, fever
mg, 150mg, 200mg) extrapyramidal motor effects
associated with D2 dopamine
Oral suspension receptor antagonists.
50mg/mL

Olanzapine Atypical Tablet Management of schizophrenia Dinds loosely to the receptor Somnolence, weight gain,
antipsychotics (2.5mg, and treatment of moderate to and dissociates easily, allowing eosinophilia, elevated
(2nd 5mg,7.5mg,10mg,15 severe mania associated with for normal dopamine prolactin, cholesterol,
generation) mg, 20mg) bipolar disorder neurotransmission. The effect glucose, and triglyceride
on the D2 receptors leads to a levels. Increased appetite,
Tablet,orally decrease in positive symptoms dizziness, akathisia,
disintegrating in patients, including parkinson's dyskinesia,
(5mg, hallucinations, delusions, and orthostatic hypotension,
10mg,15mg,20mg) disorganized speech, thought, anticholinergic effects,
and behavior. asthenia, fatigue, edema
IM injection, short
acting
(10mg)

IM injection,
 extended release
suspension
(210mg/vial,
300mg/vial,
405mg/vial)

Quetiapine Atypical Tablet , immediate Schizophrenia and bipolar Combination of antagonism at Dysarthria, dyspnea, EPS,
antipsychotics release disorder including manic and D2 receptors in the mesolimbic parkinsonia, flu-like
(2nd (25mg, 50mg, major depressive episodes in pathway and 5HT2A receptors symptoms, leukopenia,
generation) 100mg, 200mg, bipolar disorder and prevention of in the frontal cortex. orthostatic hypotension,
300mg, 400 mg) recurrence in bipolar disorder in Antagonism at D2 receptors peripheral edema, skin
patients whose manic, mixed, or relieves positive symptoms rash. Increased weight
Tablet, extended depressive episode has while antagonism at 5HT2A
release responded to quetiapine receptors relieves negative
(50mg, 150mg, treatment symptoms of schizophrenia.
200mg, 300mg,
400mg)