DRUGS

and
The Ripley of my lung conjunctiva are
Photosensitive

Ignis Enemy
any
tmgoqobidm.ae?fibroisIdgositthotosem;.fny
{ .
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 Signs of atropinization
1. Increased heart rate
2. Urinary retention
3. Flushed skin
4. Dilated pupils
5. Basal rales on auscultation are
cleared

lots minutes
2mg every

d) Mushroom poisoning e) MysKaneriagravis

. Hypothyroid coma
. Adrenal insufficency
 MECHANISM OF ACTION — Aspirin has multiple cellular and systemic effects [2-4]:

4-
9 ●Inhibition I
of cyclooxygenase results in decreased synthesis of prostaglandins, prostacyclin, and thromboxanes. This contributes to platelet dysfunction
gastric mucosal injury.
and

●Stimulation of the chemoreceptor trigger zone in the medulla causes nausea and vomiting.

I
→ ●Activation of the respiratory center of the medulla results in hyperventilation and respiratory @
alkalosis.

4) ●Interference with cellular metabolism (eg, Krebs cycle, oxidative phosphorylation) leads to metabolic acidosis.
-

CLINICAL FEATURES OF ACUTE OVERDOSE — Early symptoms of acute aspirin toxicity include tinnitus, vertigo, nausea, vomiting, and diarrhea;
subsequent symptoms portending a more severe intoxication include altered mental status (ranging from agitation to lethargy), hyperpyrexia,
noncardiac pulmonary edema, and coma. E

Humid
any

hepatotoxicity
Thrombocytopenia
Lactate — Salicylates uncouple oxidative phosphorylation, which results in abnormal cellular energy production
.

and utilization; the cell becomes dependent upon anaerobic metabolism, resulting in accumulation of lactate

Diagnosis
eliminated almost exclusively via the
kidneys, so the serum creatinine
I HI o concentration should be checked in
all patients who present with known

dei denialfeatures or suspected salicylate toxicity.

studies , hypokalemia Renal failure is an absolute
indication for hemodialysis in the
date angulation
gap
⑧I Serum sooty
, salicylate-poisoned patient; mi
onion
Creatinine betake ,
In ,

Emert
C
A B
chorioid ,
Decontamination
-

give glucose
-

-
acidosis