Arsenic is a naturally occurring, semimetallic element widely distributed in the

Earth’s crust. Arsenic levels in the environment can vary by locality, and it is found
in water, air, and soil.

There are two general forms of arsenic:

 Organic arsenic compounds contain carbon. There is no relation between organic arsenic
and “organic” food, which refers to food produced using no synthetic fertilizers or
pesticides.
 Inorganic arsenic compounds do not contain carbon. Research indicates that inorganic
arsenic is more toxic and its associated health effects are more severe.

All arsenic is toxic to humans and can affect people of any age or health status.

Because of its significance in global public health problems, studies of arsenic,

arsenic metabolism, and the health effects associated with arsenic exposure are
conducted by NIEHS, particularly through its Superfund Research Program (SRP).
Many scientists, pediatricians, and public health professionals are concerned about
the health effects of low-level exposures to arsenic in people. These health effects
may be barely noticeable at first, but if exposure continues, severe long-term
effects may result.

What Are Sources of Arsenic?

The most common source of arsenic in people is contaminated drinking water.

Because arsenic occurs naturally, waters that come in contact with particular rocks
and soils may contain it. Arsenic levels tend to be higher in groundwater sources,
such as wells, than surface sources, such as lakes or reservoirs.

Contamination from mining and fracking, coal-fired power plants, arsenic-treated

lumber, and arsenic-containing pesticides also contributes to increased levels of
arsenic in certain locations.

Arsenic may be found in foods, including rice and some fish, due to its presence in
soil or water. As a naturally occurring element, it is not possible to remove arsenic
entirely from the environment or food supply.

The U.S. Food and Drug Administration (FDA) monitors and regulates levels of
arsenic in certain foods. FDA prioritizes monitoring inorganic arsenic levels in
specific foods that are more likely to be eaten by young children, such as infant rice
cereal and apple juice.
Arsenic may be a component of air pollution. People could also touch dust
containing arsenic, but this is not a major way to be exposed.

The U.S. Geological Survey studies sources of arsenic to help local health officials
better manage water resources.

How Much Arsenic Can Be in Drinking Water?

This map shows estimates of how many private domestic well users in each county may be
drinking water with high levels of arsenic. (Image courtesy of USGS)

The maximum level of inorganic arsenic permitted in U.S. drinking water is 10 parts
per billion (ppb). This standard was set by the U.S. Environmental Protection Agency
(EPA). Some states, such as New Jersey, have more stringent drinking water
standards for arsenic than 10 ppb. There are no arsenic water standards for private
wells.

Because arsenic is tasteless, colorless, and odorless, testing is needed for detection.
The U.S. Geological Survey (USGS) has analyzed water samples from more than
5,000 wells across the United States and determined that at least 7 percent of the
wells had arsenic levels above the current EPA standard of 10 ppb. They estimate
that about 2.1 million people in the U.S. may be getting their drinking water from
private domestic wells considered to have high concentrations of arsenic. Arsenic
levels in the U.S. tend to be higher in rural communities in the Southwest, Midwest,
and Northeast.

How Can I Find Out Whether There Is Arsenic in My Drinking Water?

Because you cannot taste or smell arsenic, the water must be tested. If your home
is not on a public water system, you can have your water tested for arsenic. Your
state certification officer should be able to provide a list of laboratories in your area
that will perform tests on drinking water for a fee.

How Do I Remove Arsenic From My Drinking Water?

You cannot remove arsenic by boiling water. Additionally, chlorine bleach

disinfection will not remove arsenic. Water softeners are not a way to remove
arsenic from drinking water.

Certain filtration systems can remove arsenic from water. Consider water
treatment methods such as reverse osmosis, ultra-filtration, or ion exchange.
Contact your local health department for recommended procedures.

How does arsenic affect people?

Arsenic affects a broad range of organs and systems including:

 Cardiovascular system
 Endocrine system
 Immune system
 Liver, kidney, bladder organs
 Nervous system
 Prostate glands
 Respiratory system
 Skin

Fact Sheets

4
(1MB)
 Arsenic and Your Health

What Is NIEHS Doing?

Because of its significance as a global public health problem, studies of arsenic,
arsenic metabolism, and the health effects associated with arsenic exposure are a
priority for the National Institute of Environmental Health Sciences (NIEHS),
the National Toxicology Program (NTP), and several other organizations involved in
research, regulation, and health care.

NIEHS, particularly the Superfund Research Program through its grantees, and NTP
conduct arsenic research, which includes the following:

Fundamental Arsenic Research

Researchers have learned that both short-term and long-term exposure to arsenic
can cause health problems, but they are just beginning to understand how arsenic
works in the body — what is referred to as its modes of action.

For example, researchers are finding that arsenic, even at low levels, can interfere
with the body’s endocrine system. The endocrine system is what keeps our bodies
in balance and guides growth and development. In several cell culture and animal
models, arsenic has been found to act as an endocrine disruptor, which may
underlie many of its health effects. Other mechanisms are also likely contributors
to arsenic’s health effects.

Once inside the human body, arsenic can be metabolized into at least five different
chemical forms, each with very different toxicities. Understanding arsenic
metabolism is essential to understanding both the impacts of arsenic exposure on
human health and the individual variation in susceptibility to arsenic-caused
diseases. Researchers believe that genetic variation could be a determinant of
individual variation in arsenic metabolism and related toxicities. They also have
found that microbes in the human digestive system – known as the gut microbiome
– may complement a person’s ability to metabolize arsenic, particularly in the first
few weeks of life.

Arsenic and Cancer

Both forms of arsenic are known human carcinogen associated with skin, lung,
bladder, kidney, and liver cancers. A study from the NTP laboratory that replicates
how humans are exposed to arsenic through their whole lifetime found that mice
exposed to low concentrations of arsenic in drinking water developed lung cancer.
The concentrations in the drinking water given to the mice were similar to what
humans who use water from contaminated wells might consume.

Early-life Exposures to Arsenic and Development

Arsenic exposure can predispose children to health problems later in life.

Researchers supported by the SRP center at the University of California, Berkeley,
found increased incidence of lung and bladder cancers in adults exposed to arsenic
early in life, even up to 40 years after high exposures ceased. These findings
provide rare human evidence that an early-life environmental exposure can be
associated with a high risk of cancer as an adult.

Work from researchers at NIEHS has identified other effects of arsenic exposure in
animal models. Pregnant mice that drank water containing inorganic arsenic, at
concentrations relevant to human consumption and at levels that trigger tumor
growth, resulted in obesity in the male offspring. Males experienced negative
reproductive effects, such as decreased fertility.

Arsenic and Preterm Birth

Preterm birth, which occurs before 37 weeks of pregnancy, is a risk factor for
newborn mortality and adverse health effects in childhood and later in life. Using
umbilical cord blood from pregnant women in Bangladesh, NIEHS-funded
researchers identified elevated levels of several metals, including arsenic, as key
drivers of preterm birth risk. The team also constructed metrics or risk scores to
measure the effects of chemical mixtures and found that women with the highest
scores were nearly four times more likely to experience preterm birth than women
with the lowest scores.

Arsenic and Diabetes

Several studies, including a review of the literature by NTP, have suggested an

association between low-to-moderate levels of arsenic and metabolic diseases,
such as diabetes. For example, researchers at the University of North Carolina at
Chapel Hill SRP Center have shown that arsenic exposure can disrupt insulin-
secreting cells of the pancreas.

Health Disparities
Exposure can be from naturally occurring arsenic that is not removed from drinking
water or industrial processes that release arsenic into the environment. Health
disparities related to arsenic are influenced by differing protective actions taken by
individuals and communities, such as testing and treating water and soil.

Researchers at the Columbia University SRP Center found that people belonging to
racial and ethnic minorities in the U.S. are exposed to significantly higher arsenic
concentrations in their drinking water compared with non-Hispanic White
residents.

Tribal lands are affected by more than 15,000 hazardous waste sites and 7,000
abandoned mines that can release toxic metals such as arsenic and uranium. In
collaboration with tribal communities from North Dakota and South Dakota,
researchers at the Columbia University SRP Center found that Native Americans
from the Northern Plains have experienced urinary arsenic levels 2.5 to 5 times
higher than other U.S. populations, likely contributing to a higher burden of
cardiovascular disease.

The University of New Mexico Metal Exposure and Toxicity Assessment on Tribal
Lands of the Southwest (METALS) SRP Center has worked in partnership with
Indigenous partners to show that weathering of the metal mixtures in the millions
of tons of mining waste has produced potentially harmful nanoparticles. The
researcher’s health studies have shown that exposure to these metal mixtures
increases the prevalence of multiple chronic diseases.

Incarcerated people in the Southwestern U.S. are more likely to have higher levels
of arsenic in their water, and may also lack access to alternative drinking sources,
such as bottled water. A NIEHS-funded study found that the average arsenic
concentrations in correctional facility water systems were twice as high as other
systems in the region and four times higher than water systems across the U.S.

Individuals with low socioeconomic status (SES) may be more vulnerable to the
harmful effects of arsenic exposure. A study from the University of California,
Berkley SRP Center showed that arsenic-exposed residents of Chile with lower SES
were more likely to develop diabetes than those with higher SES.

Translational Research on Arsenic

(Photo courtesy of HM Shahidul Islam / Shutterstock.com)

At least 30 million people in Bangladesh are exposed to arsenic in their drinking

water. Researchers have found that arsenic education, coupled with water testing
programs, can increase knowledge in the population, and result in reduced arsenic
exposures, when safe drinking water sources are made available.

A scientific review of two randomized clinical trials found that folic acid
supplements may reduce blood arsenic levels and make it easier to get rid of
arsenic through the urine in individuals chronically exposed to arsenic-
contaminated drinking water. One of those trials showed that just 400 micrograms
a day of folic acid, the U.S. Recommended Dietary Allowance, reduced total blood
arsenic levels in a Bangladesh study population by 14%.

SRP-funded research centers have worked closely with affected communities to

address their concerns and provide them with important information regarding
potential exposure to arsenic and its health implications. For example, the SRP
center at Dartmouth College evaluated private well testing behavior, including
barriers. They worked to encourage private well testing and empower well water
users with the tools they need to keep their drinking water safe, including
a website, community toolkit, and online application.

A bill to sharply lower the drinking water limit for arsenic in New Hampshire was
signed into law in 2019. The new rule, informed by Dartmouth research and
outreach efforts, sets the state drinking water standards at 5 ppb, which is half of
the federal limit. According to the New Hampshire Department of Environmental
Services, the new limit will better protect human health by reducing the number of
arsenic-related illnesses and deaths.

Further Reading
Stories from the Environmental Factor (NIEHS newsletter)

 Path to Food Safety Requires Multidisciplinary Approach, Experts

Say (January 2023)
 Tribal Environmental Health Strengthened by NIEHS-Funded Scientist and
Her Team (September 2022)
 Webinar Recognizes Early-career Scientists' Research on Lead,
Arsenic (March 2022)
 Educational Tool Highlights COVID-19 and Arsenic Research (March 2022)
 E-cigarettes Expose Users to Toxic Metals Such As Arsenic, Lead (February 2