DRUG STUDY 1

Generic Name:
Brand Name:  Empagliflozin
Imdur, Ismo, Monoket
Classification:
Generic Name:  Sodium-glucose co-transporter 2 (SGLT2) inhibitors.
Isosorbide mononitrate
Uses:
Classification:  Reduce the risk of cardiovascular death in adult patients with both
Antianginal agents type 2 diabetes mellitus
 Established cardiovascular disease
Uses:  It lowers blood sugar by causing the kidneys to get rid of more
 To prevent angina (chest pain) caused by coronary artery glucose in the urine
disease (heart disease).
Indication:
Indication:  Empagliflozin is indicated as an adjunct to diet and exercise to
 Prevention and management of angina pectoris due to coronary improve glycemic control in adult patients with type 2 diabetes,
artery disease. either alone or in combination with metformin or linagliptin.
 Not sufficiently rapid to be useful in aborting an acute anginal
episode Contraindication:
 Not recommended if GFR is less than 45 mL/min or during the
Contraindication: second and third trimesters of pregnancy.
 Allergic to nitrates.
Mechanism of Action:
 Concomitant use of isosorbide with PDE inhibitors such as
 Empagliflozin works by inhibiting the sodium-glucose co-
sildenafil and tadalafil.
transporter-2 (SGLT-2) found in the proximal tubules in the
kidneys. Through SGLT2 inhibition,
Mechanism of Action:
 Empagliflozin reduces renal reabsorption of glucose and increases
 Isosorbide mononitrate acts as a prodrug for nitric oxid urinary excretion of glucose.
 Reduced intracellular concentrations of calcium, caused by
processes including inhibition of IP3-mediated pathway,

DRUG STUDY 2
Brand Name:
 Glyxambi, Jardiance, Synjardy, Trijardy