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Unaids 99 12
Unaids 99 12
and prevalence:
natural course of the epidemic or results
of behavioural change?
© Joint United Nations Programme on HIV/AIDS (UNAIDS) 1999. All rights reserved. This document, which is not
a formal publication of UNAIDS, may be freely reviewed, quoted, reproduced or translated, in part or in full, provided
that the source is acknowledged. The document may not be sold or used in conjunction with commercial purposes
without prior written approval from UNAIDS (contact: UNAIDS Information Centre).
The designations employed and the presentation of the material in this work do not imply the expression of any
opinion whatsoever on the part of UNAIDS concerning the legal status of any country, territory, city or area or of its
authorities, or concerning the delimitation of its frontiers and boundaries.
UNAIDS
Geneva, Switzerland
1999
Contents
1. Introduction .........................................................................................................................................................................3
2. The transmission dynamics of HIV-1:
empirical and theoretical considerations .........................................................................................7
3. Group report: Assessing HIV levels and trends .....................................................................16
4. Group report: Monitoring risk behaviour and behavioural change ................20
5. Group report: Assessing programmes and interventions ...........................................23
6. Conclusions ......................................................................................................................................................................25
Annex: List of participants ............................................................................................................................27
References ........................................................................................................................................................................31
UNAIDS
1. Introduction
The current state of the HIV epidemic
Both donor agencies funding HIV prevalence/incidence of HIV are observed
control programmes, and government at the population level a number of
agencies trying to bring about changes questions arise:
need to know whether their efforts are
having an impact. 1• Are the observed changes valid in a
statistical sense?
It is important to understand changes 2• Are the observed changes a reflection
in the incidence and prevalence of HIV in of the natural progression of the
order to plan for the scale of future epidemic?
problems and to evaluate the effective- 3• Are the observed changes a product of
ness of current national strategies to limit changes in behaviour?
the spread of infection. To make confident 4• Are the observed changes a product of
statements about the course of HIV we interventions?
require confidence in both the quality of
data on the levels of infection and in our The prevalence of HIV in a particular
ability to interpret changes in prevalence population will not grow indefinitely, it will
and incidence. saturate at some level. Following the initial
spread of HIV there is likely to be a fall in
Recently in detailed analysis of some of the incidence of infection followed in turn
the most reliable HIV surveillance data in by a resultant reduction in prevalence. A
developing countries, declines in the fall in incidence is likely to precede the fall
prevalence of HIV in young people have in prevalence as the time scale over which
been observed. The decline has been the epidemic saturates is likely to be more
observed amongst young men and rapid than the time scale on which HIV
women in Uganda and in 21-year-old associated mortality increases.
male conscripts in Thailand, suggesting
some success in stemming the spread of UNAIDS and the Wellcome Trust Centre
HIV. However, this success is not mirrored for the Epidemiology of Infectious Disease
in data from surrounding countries. The organized a workshop to explore the vali-
dynamics of an epidemic mean that a dity and interpretation of observed trends
reduction in the prevalence or incidence in HIV prevalence and incidence; to deve-
of infection is not necessarily a conse- lop a better understanding of observed
quence of reduced risk amongst a epidemiological patterns; and to generate
population. When reductions in the guidelines for evaluating changes in HIV.
Objectives
è To review current evidence for declining HIV prevalence and incidence in selected sites
and to explore the reason for the decrease in particular the role of behavioural change.
è To agree on principles for surveillance methods for evaluating changes in HIV prevalence.
è To agree on a research agenda to develop methods and collect data required to interpret
changes in HIV prevalence/incidence.
3
Trends in HIV incidence and prevalence
Background
Monitoring the course of HIV epidemics
In developing HIV surveillance activity clinic patients, drug users, prisoners,
there is a trade-off between the need for soldiers and sex workers all include many
a rapid, broad assessment of HIV’s spread with unusually high risks of having
and a more detailed understanding of acquired HIV infection. While they
epidemiological pattern. A series of quick indicate whether the virus has entered a
cross sectional studies stratified by age community and the level of infection in
and sex would provide information on the the specific group they are little use in
scale of HIV spread. Many such studies determining the extent of the problem
have been collated in the US Bureau of through-out national populations. They
the Census Database, and a few are can though provide insights into the
longitudinal data sets, but very few are changing pattern of incidence within the
genuine cohort studies (US Bureau of the groups they represent and indicate
Census, 1997). whether behaviour of those with “high
risks” is altering.
Falls in HIV prevalence have been
observed in some of the best constructed Blood donors and pregnant women
studies of prevalence and incidence. The are also often used as sentinel surveillance
longitudinal community based studies groups as they are more likely to repre-
in rural Uganda, which are intensive sent the “general” population. However,
scientific studies, have observed a decline blood donors are often pre-screened for
in prevalence (Mulder et al., 1995; Wawer risks of HIV infection; this means that they
et al., 1997). One problem with this is that tend to underestimate the prevalence of
the very studies themselves are likely to infection. The situation is complex in the
have altered the course of the epidemic. case of pregnant women who are
However, declines have also been ob- believed to represent most closely the
served in recruits to the Thai army, where general population. They are in the age
conscription by lot at the age of 21 years classes where HIV is likely to be most
means that the study of HIV prevalence in common and must have recently been
young men comes from a large more or sexually active. However, it may be wrong
less random sample (Nelson et al., 1996). to assume that they overestimate HIV
prevalence. In Mwanza, Tanzania, a
More generally, a number of practical comparison of infection in a random
problems inhibit understanding of the sample of women with a sample of
extent of HIV spread globally and women attending antenatal clinics found
changes in the incidence and prevalence the prevalence of infection to be higher in
of infection. The major problem is the lack the random sample (Kigadye et al., 1993).
of representativeness of samples used to A high risk of HIV infection is associated
monitor the epidemic, which can arise for with a low risk of pregnancy for at least
a number of reasons: two reasons. First, other bacterial STDs,
which are more common in those with
Sampling biases. The majority of studies high risks of HIV infection, cause tubal
of HIV prevalence are based on conve- occlusion and hence infertility (Brunham
nience samples. Hospital patients, STD et al., 1992). Second, the pathology asso-
4
UNAIDS
ciated with HIV may include a reduction extrapolation from urban prevalence to
in fertility, either through spontaneous rural prevalence and thence to national
abortion or other less well-defined means. prevalence should be handled with
These factors cast some doubt on the extreme care.
validity of antenatal clinics as sentinel sites
for HIV surveillance. Despite the problems above global
HIV surveillance has, because of ethical,
Sample size and reliability of financial and logistic constraints, had to
diagnostic tests. Data from reviewed concentrate on sentinel surveillance of
scientific publications are not available convenience samples. As well as the cost
for many localities. In their absence, small involved in recruiting random representa-
studies, often with no diagnostic test tive samples, there is the problem of
details being reported, are relied upon to persuading study participants to undergo
indicate the course of the HIV epidemic. an invasive specimen collection procedure.
Small sample size is an important problem The development of new technology for
for two main reasons. First, in a situation saliva based sampling of antibodies may
of low HIV prevalence larger samples are have generated a more favourable climate
required to detect accurately the small for the use of more representative
fraction of the population infected. community based samples. However, the
Secondly, in situations where HIV is more problems of cost in contacting a popu-
prevalent small changes in the prevalence lation-based sample and the ethical and
of infection can only be detected with any practical problems associated with testing,
confidence by larger samples. counselling and care remain.
5
Trends in HIV incidence and prevalence
6
UNAIDS
change them, can this be seen as a workshop. First data and opinions
product of intervention/ education? presented at the outset to inform
deliberations are summarized. The
Teasing apart the underlying epidemic workshop considered three main areas in
pattern from the impact of control on the reviewing the impact of interventions.
basis of changes in HIV incidence/ First the monitoring of infection, second
prevalence requires supplementary infor- the monitoring of risk behaviour, and third
mation and careful analysis. What do we the evaluation of interventions and
need to measure to understand the national policy. This report considered
epidemiological processes and how might each in turn. In the final section of the
we approach this measurement? report the conclusions and recommen-
dations of the workshop are presented.
This report is divided into sections
reflecting the input and outcome of the
2. The transmission
dynamics of HIV-1:
empirical and theoretical considerations
The incidence and prevalence of infection
In an endemic steady state the grows the proportion of contacts of those
prevalence of infection is simply the infectious who have already been
product of incidence and the mean infected will grow. This reduces the
duration of the infection. However, in an reproductive rate of the infection slowing
epidemic situation the relationship the growth of incidence. Eventually
between prevalence and incidence varies incidence will decline, while prevalence
as the epidemic ages. The relationship continues to grow. It is only when
between, incidence, prevalence and recovery or, in the case of HIV, mortality
mortality is illustrated in Figure 1 where of those infected increases that
the flows in and out of the HIV-infected prevalence decreases or levels off. If the
population are shown schematically. The mortality rate of those infected is greater
rate of spread of HIV depends upon the than the incidence of new infection then
basic reproductive number (R0), the prevalence will decline until the two
number of new infections caused by one balance and prevalence remains
infectious individual in an entirely constant. This pattern is excellently
susceptible population. The reproductive portrayed in data from a study of
number at time t (Rt) then alters as injecting drug users in Thailand (Fig. 2,
illustrated, as the epidemic progresses. Kitayaporn et al., 1994)
Initially the incidence and prevalence of
infection are likely to grow exponentially There are a number of methods for
in the population at risk. As the epidemic estimating incidence, each with advan-
7
Trends in HIV incidence and prevalence
Figure 1
0.45
HIV prevalence
0.40
Rt>1 Rt<1 Rt=1 Incidence of HIV-associated mortality
0.35
HIV incidence
0.30
0.25
0.20
0.15
0.10
0.05
0
0 5 10 15 20 Time (years)
R0>1
Figure 2
70 Incidence/Prevalence (%)
Incidence (per year)
60
Prevalence
50
40
30
20
10
0
1987 1988 1989 1990 1991 1992 1993 Year
8
UNAIDS
Figure 3
a. HIV-1 prevalence in rural Zimbabwe, 1994 d. Pregnancy prevalence in rural Rakai, Uganda,
40 HIV prevalence (%) 1998
Honde Valley 25 Percentage pregnant (%)
35
30 Rusitu Valley 20
25 15
20 10
5 3544 823 130 316
15
10 0
No HIV HIV and HIV and Syphilis
5 or syphilis no syphilis syphilis
0 Source: Gray et al., 1998
15–19 20–24 25–29 30–34 35–39 40–49 Age group
(years)
20–29 0
15–24 25–34 35 + Age group
(years)
Source: Kigadye et al., 1993
15–19
Christian
Traditional
71%
6%
9
Trends in HIV incidence and prevalence
10
UNAIDS
risk of HIV infection or pregnancy. It may with more chance of HIV associated
also, in part, be due to those in older age morbidity having reduced fertility.
groups having been infected for longer
10
0
15–19 20–24 25–29 30–39 15–39 Age group (years)
11
Trends in HIV incidence and prevalence
In addition to the 15 to 19 year olds 1997). This will have reduced the fertility
suffering a lower level of HIV-related sub- of this age group as well as reducing HIV
fertility they are also less likely to be risk in the younger women. Thus, the
influenced by HIV-associated mortality for prevalence of HIV infection observed in
the same reason, that they are not likely antenatal clinic attenders should have
to have been infected for long. Declines in become more of an overestimate in recent
prevalence in this age group are perhaps years. The observed declines in HIV-1
the best indicator of a decline in HIV prevalence in the 15 to 19 year old
incidence. In two studies of sexual women in sentinel surveillance sites are
behaviour in urban Ugandan populations more likely to reflect reduced incidence.
in 1989 and 1995 an increase averaging 2 These were recorded in urban Uganda in
years in the age of first sexual intercourse Kampala and Jinja, where the successive
was reported (Asiimwe-Okiror et al., behavioural surveys were carried out
Figure 5
a. HIV-1 prevalence in Uganda antenatal clinic attendees
30 HIV-1 prevalence (%)
Nsambya, Kampala
25
Jinja
20
d. Number of 15 to 19 year olds with non-regular sexual partners
15
90 Percentage of sample
80 15–19 year olds
10 1989 (N=60)
70
60 15–19 year olds
5 1995 (N=69)
50
0 40
1989 1990 1991 1992 1993 1994 1995 1996 Year 30
20
10
Number of non-
0
b. Number of non-regular partners (all ages) 0 1 2–4 5+ regular sexual
90 Percentage partners
80 All 1989 (N=527)
70 All 1995 (N=725)
60
50
40
30
20
10 e. HIV-1 prevalence amongst antenatal clinic attenders
Number
0 of sexual 30 Prevalence (%)
0 1 2–4 5+
partners Jinja 1990
25
Jinja 1996
c. HIV-1 prevalence in antenatal clinic attenders 20
40 Prevalence (%) 15
35 Nsambya 1991
10
30 Nsambya 1996
25 5
20 0
15–19 20–24 25–29 30–34 35+ Age group
15
(years)
10
5
0
15–19 20–24 25–29 30–34 35+ Age group
(years)
12
UNAIDS
13
Trends in HIV incidence and prevalence
The initial indication of change carried out in 1993 (Thongthai and Guest,
came from falling rates of sexually 1995) found very different risk behaviours
transmitted infections (Rojanapithayakorn from the earlier study (Sittitrai et al., 1994)
and Hanenberg, 1996). This preceded carried out in 1990. The proportion of
changes in HIV prevalence as might be men reporting unprotected commercial
expected since treatment immediately sex fell from 15% to 2%. Although, direct
resolves bacterial sexually transmitted and indirect sex continue to report the
infections rapidly changing the observed same number of clients (Rehle et al.,
incidence of infections. While changes in 1992; OPTA, 1996) there has been a shift
the incidence and prevalence of other away from direct to indirect sex work
infections indicate a change in the where around one rather than four clients
environment for HIV spread, the per night are reported. Condom use
differences in their biology make them reported by commercial sex workers rose
unreliable as a direct measure of HIV from 14% to 90% by 1992
incidence. However in Thailand a second (Rojanapithayakorn and Hanenberg,
random sample of the general population 1996). These findings have been con-
30
25
20
15
10
0
0 1 2 to 3 4 to 10 1 2 to 3 1 Visits to sex workers
per year per year per year per month per month per week
14
UNAIDS
firmed in many studies (Rehle et al., 1992; country (Fig. 7, Jugsudee et al., 1996).
Sawanpanyalert et al., 1994; Rugpao et Studies in military conscripts have been
al., 1997). Researchers posing as clients able to show that the fall in prevalence is
have found that the reported rates of due to reduced reported risk behaviour in
condom use are only slight overestimates the conscripts (Fig. 8, Nelson et al., 1995).
(Visrutaratna et al., 1995). In behavioural A fall in prevalence amongst those
surveillance of sex workers reported seeking antenatal care was observed in
consistent condom use in 1993 was 1996 and 1997. In the North this decline
greater in direct (87%) than indirect sex started a year earlier (Surasiengsunk et al.,
worker (56%) but this difference was the 1997). While there are biases in ante-
focus of subsequent intervention activity natal prevalence data this fall is consistent
and condom use is now similar for direct with the results from the less biased
(97%) and indirect (89%) sex workers conscripts, and was consistent with an
(Mills et al., 1997). Worryingly, in the 80% reduction in transmission proba-
same study the commercial sex workers bilities in a model of HIV spread in
report low rates of consistent condom use Thailand (Surasiengsunk et al., 1997). The
with non-client partners from 1993 to observed fall in HIV prevalence can be
1996 (Mills et al., 1997). explained in terms of changes in sexual
behaviour promoted by the government
A body of evidence consistently points in Thailand. There are still problems, for
towards a reduction in unprotected example the prevalence in injecting drug
commercial sex in Thailand. This has been users has been maintained at around
translated into a rapid decline in HIV 40%, but Thailand can be viewed as a
prevalence in military conscripts in the success story, both in terms of reducing
North where the scope for change was the incidence of HIV and monitoring the
greater and a more modest reduction in changes in risk and incidence in the
the prevalence of HIV amongst 21-year- population.
old military conscripts throughout the
Figure 8 – Behavioural change and HIV/STD decline in 21-year-old men in North Thailand
70 Percentage
Visited sex worker last year
60
Did not use condom on last visit
50
Lifetime history of STDs
40
HIV infected
30
20
10
0
1991 1993 1995 Year
Source: After Nelson et al., 1996
15
Trends in HIV incidence and prevalence
3. Group report
Assessing HIV levels and trends
Every country needs to have in place Establishing presence of infection in
an effective and efficient system of HIV areas not previously affected
surveillance. The overall aim of such a
system is to provide data to guide and At the early stages of an epidemic, it is
target intervention activities. The specific most important to monitor for infection
objectives are: among subgroups of the population most
at risk. This might include sex workers,
è To establish the presence or absence of STD patients, or injecting drug users.
infection, particularly in countries or regions
where the epidemic has not yet commenced. Monitoring can be carried out by
sentinel surveillance for groups who are
è To measure the current level of infection in the
population, and to identify variations by age, seen routinely at clinic-based sites. This
sex and risk factors. includes STD patients, and sometimes sex
workers (attending special health facilities)
è To monitor the progress of the epidemic, and or drug users (attending drug treatment
to measure trends in prevalence or incidence centres). For other groups, special ad hoc
by age and sex. surveys may need to be conducted at
è To make projections of future numbers of periodic intervals.
infections and AIDS cases.
Action points:
è To measure the health burden of the epidemic, • National programmes need to:
in terms of morbidity and mortality. – identify high risk behaviours (for
è To assess the impact of HIV control measures example, the existence and location of
on the epidemic. populations engaging in sex work or
injecting drug use);
– ensure the inclusion of such groups
Methods of HIV surveillance in periodic HIV surveillance, either through
sentinel surveillance or ad hoc surveys.
Here we focus chiefly on methods to
assess levels and trends of HIV infection • Research:
(Objectives 1–3). The main approaches Tools for identifying risk behaviours
for this purpose are: (such as rapid assessment methods)
require further refinement and evaluation.
1. Sentinel surveillance
2. Cross-sectional surveys in the general Measuring current levels
population or in specific population of prevalence
subgroups
3. Cohort studies In areas where the epidemic is well-
4. Methods based on AIDS case reports established, sentinel surveillance of groups
(e.g. based on back-calculation). more representative of the general
population have been promoted as the
The use of these methods to monitor main tool for HIV surveillance. Antenatal
levels and trends is reviewed below. clinic (ANC) attenders have been used as
16
UNAIDS
the primary sentinel group for this in identifying HIV trends in the general
purpose. (In some industrialized countries, population (see below).
dried blood spots from neonates are used
as an alternative convenient method of Despite these possible sources of bias,
measuring prevalence among women ANC sentinel surveillance continues to
giving birth.) represent the most important component
of HIV surveillance in areas where the
The usefulness of ANC data for HIV epidemic is established. It is essential that
screening depends on the degree of such programmes are established and
representativeness of pregnant women sustained.
attending ANC relative to the general
population. Selection biases may vary over Continuing surveys of other groups
time, complicating analysis of trends. (for example, sex workers or drug users)
Usage of ANC services shows substantial are also likely to be necessary depending
geographical variation, with 80–90% on the local context.
coverage in many African countries,
compared with 30% or less in some parts Measuring trends in prevalence and
of Asia. incidence
The factors leading to selection biases Examination of serial data from HIV
in this group are illustrated in Figure 9. sentinel surveillance is likely to be the
most common method of monitoring
There are insufficient data on the changes in prevalence in the general
relative importance of these factors in population. The main concern is that the
different populations, or on how these selection biases referred to above may
vary over time. Studies are needed to change over time, in which case
measure these factors, and to evaluate the misleading conclusions may be drawn
performance of ANC sentinel surveillance about trends. This issue could be
Whole population
Age–sex structure of
population, age ratio
HIV cases
All adults
of reproductive age
Age–sex structure
of population, sex ratio
of HIV cases
All women Biases
of reproductive age
Age-specific fertility
of HIV-infected and
HIV-uninfected women
All pregnant women
Attendance bias age, sex,
locality, socioeconomic
Pregnant women status, education, etc.
attending
antenatal clinic
17
Trends in HIV incidence and prevalence
18
UNAIDS
To evaluate the above sources of bias, standing of the HIV epidemic, and for the
we recommend that in certain countries effective analysis and interpretation of
and settings, ongoing ANC sentinel surveillance data. Such variables include
surveillance over a period of several years the natural history of the infection
should be accompanied by periodic cross- (incubation period, survival, mortality),
sectional studies, carried out in the and associations of HIV infection with
catchmëent population of ANC clinics rates of fertility and migration. Knowledge
used for surveillance. Such studies could of these parameters is essential to validly
be used for a number of purposes: estimate incidence from prevalence data.
19
Trends in HIV incidence and prevalence
4. Group report
Monitoring risk behaviour and behavioural change
In considering the relationship between iour surveys from Thailand suggests that
interventions and changes in epidemio- the context within which antenatal
logical patterns it is useful to think in terms sentinel surveillance occurs would not be
of a “results chain”: appropriate for reliable behavioural
Chain of effect responses (Mills et al., 1997). It is
therefore suggested that behavioural
surveillance operates within the same
Programme Behavioural Change in incidence
areas as epidemiological surveillance but
input change of infection/disease
does not use the same sampling methods.
20
UNAIDS
21
Trends in HIV incidence and prevalence
22
UNAIDS
5. Group report
Assessing programmes and interventions
Introduction combination of increased condom use and a
In the assessment of interventions, reduction in sex worker patronage, and
whether at a local, a national, or a research were accompanied by a sharp decline in
programme level, a balance must be struck reported STDs. These changes are largely
between the obvious need in all countries attributed to the national “100% Condom
and communities to act without delay to try Campaign” and are evident from the results
and reduce the spread of the HIV and its of an ongoing HIV surveillance programme
impact on morbidity and mortality, and the and focused research studies. In Uganda,
need to scientifically evaluate the relative declines in HIV prevalence among women
effectiveness of different types of inter- attending antenatal clinics are attributed to
ventions in various societies or communities. broad-based behavior changes. A large
A delicate balance must be struck between randomized trial of STD control in Mwanza,
the need for action and the need to Tanzania, resulted in a 42% decline in HIV
continually and constructively evaluate incidence (Grosskurth et al., 1995).
intervention activities. In view of limited
resources and competing health priorities, it In developed countries, successful
is also important to assess cost effectiveness interventions have been demonstrated in
of HIV/AIDS interventions. Resources must San Francisco among men who have sex
obviously be used as effectively as possible with men and in Amsterdam among IDUs
in the area of HIV and AIDS control. What (Ameijden et al., 1996). Also, sharp reduc-
follows is an attempt to evaluate current tions in perinatal HIV transmission have
successes and failures at both the research resulted from the use of zidovudine.
and national levels and to identify needs
and priorities, both in the implementation of Outcome/impact indicators
interventions and the evaluation of their In assessing programmes, it is important
relative effectiveness in terms of reducing to have data on HIV prevalence and
HIV incidence and prevalence. In our incidence as well as intermediate determi-
deliberations, it was fully recognized that nants, such as behavioural change (as in
there is no single solution or single best KAP surveys), condom use, and STDs.
practice given the great heterogeneity in Information on determinants is necessary to
societal organization in different countries allow linkage between specific outcomes
an the observed variability in the pattern of and specific interventions.
development of the epidemic.
Efficacy of intervention strategies
Successes In view of the balance between efforts
In the developing world, to date, there placed on interventions and evaluations,
have been relatively few successful HIV there remains a pressing need for a limited
interventions that have been clearly number of definitive efficacy evaluations of
demonstrated through effective scientific existing interventions (e.g., HIV counselling
evaluations. Perhaps the best documented and testing). These studies must be of
example is in Thailand where recent declines sufficient size to yield clear results and
in HIV prevalence and incidence among should be designed to allow an under-
young Thai men have resulted from a standing of mechanisms/causality.
23
Trends in HIV incidence and prevalence
24
UNAIDS
6. Conclusions
1•Quality national surveillance is vital, 8•In cross-sectional and cohort studies
and not a luxury—it is essential in order to behavioural data are essential, along with
assess the continued evolution of the HIV socioeconomic data. It is particularly
epidemic. HIV seroprevalence is the key important in the assessment of interven-
variable, with appropriate stratification tions that epidemiology and behaviour
and incidence estimates where possible. are studied concomitantly.
25
Trends in HIV incidence and prevalence
simple monitoring of the intervention incidence. Sensibly used they can provide
could be more practical. a basis for trial design and evaluation.
26
UNAIDS
Annex
List of participants
Professor R. Anderson
Wellcome Trust Centre for Epidemiology of Infectious Disease (WTCEID),
University of Oxford
South Parks Road, Oxford OX1 3PS, UK
Tel. (44) 1865 281 240 – Fax (44) 1865 281 241
E-mail: roy.anderson@zoology.oxford.ac.uk
Dr. M. Anker
Statistician, Division Emerging and Other Communicable Diseases, WHO
20 avenue Appia, CH-1211 Geneva 27, Switzerland
Tel. (41) 22 791 2380
E-mail: ankerm@who.ch
Dr. E. Asamoa-Odei
Intercountry Technical Advisor
UNAIDS c/o WHO Representative's Office
55, avenue Albert Sarrault, Dakar, Senegal
Tel. (221) 23 27 69/23 19 53 – Fax (22 1) 23 32 55
Dr. S Berkeley
HIV Vaccine Research Initiative,
c/o Health Sciences Division, The Rockefeller Foundation
1133 Avenue of the Americas, New York 10036, USA
Tel. (1) 212 869 8500 – Fax (1) 212 764 3468
Dr. M. Caraël
Prevention Team Leader, Department of Policy, Strategy and Research, UNAIDS/WHO
20 avenue Appia, CH-1211 Geneva 27, Switzerland
Tel. (41) 22 791 3666 – Fax (41) 22 791 4187
E-mail: caraelm@unaids.org
Dr. E. Castilho
Ministry of Health, Brazil
Tel. (55) 61 223 4359 – Fax (55) 61 315 2519
E-mail: euclides@aids.saude.gov.br
Professor J. Cleland
Centre for Population Studies
London School of Hygiene & Tropical Medicine
99 Gower Street, London WC1E 6AZ
Fax (44) 171 388 3076
E-mail: j.cleland@lshtm.ac.uk
27
Trends in HIV incidence and prevalence
Dr. A. Fontanet
Program Manager, Ethiopian-Netherlands AIDS Research Project (ENARP),
National Research Institute of Health
PO Box 1242 Addis Ababa, Ethiopia
Tel. (251) 113 0642 – Fax (251) 175 6329
E-mail: enarp@telecom.net.et
Dr. K. Fylkesnes
Institute of Community Medicine,
9037 University of Tromsø, Norway
Tel. (47) 77 64 4816 – Fax (47) 77 64 4831
Dr. G. Garnett
Wellcome Trust Centre for Epidemiology of Infectious Disease (WTCEID),
University of Oxford
South Parks Rd, Oxford OX1 3PS, UK
Tel. (44) 1865 281 227 – Fax (44) 1865 281 245
E-mail:geoff.garnett@zoology.oxford.ac.uk
Dr. J. Glynn
Infectious Disease Epidemiology Unit,
London School Hygiene & Tropical Medicine
Keppel Street, London WC1E 7HT, UK
Tel. (44) 171 927 2423 – Fax (44) 171 436 4230
E-mail: judith.glynn@lshtm.ac.uk
Dr. S. Gregson
Wellcome Trust Centre for Epidemiology of Infectious Disease (WTCEID),
University of Oxford
South Parks Road, Oxford OX1 3PS, UK
Tel. (44) 1865 281 230 – Fax (44) 1865 281 245
E-mail: simon.gregson@zoology.oxford.ac.uk
Professor R. Hayes
Infectious Disease Epidemiology Unit
London School Hygiene & Tropical Medicine
Keppel Street, London WC1E 7HT
Tel. (44) 171 927 2243 – Fax (44) 171 436 4230
E-mail: richard.hayes@lshtm.ac.uk
Dr. T. Mastro
Director, HIV/AIDS Collaboration
88/7 Soi Bamrasnaradura
Tiwanond Road, Nonthaburi, Thailand 11000
Tel. (662) 591 5444/5 – Fax (662) 591 5443
E-mail: tdm@bangkok.em.cdc.gov
28
UNAIDS
Mr J. Potterat
Director, STD/AIDS Programs
El Paso County Department of Health and Environment
301 S. Union Boulevard, Colorado Springs, CO 80910-3123, USA
Tel. (1) 719 578 3148 – Fax (1) 719 575 8629
E-mail: smuth@rmi.net
Dr. T. Rehle
Associate Director, Evaluation Unit, AIDSCAP
2101 Wilson Boulevard, Suite 700, Arlington, VA 22201, USA
Tel. (1) 703 516 9779 – Fax (1) 703 516 9781
E-mail: Trehle@FHI.org
Dr. S. Sarkar
Coordinator, SHAKTI Project
60 Road 7/A, Dhanmondi, Dhaka 1209, Bangladesh 8802
Tel. (8802) 81 41959-8/42070-9 – Fax (8802) 814183
E-mail: carebang@bangla.net
Dr. B. Schwartländer
Senior Epidemiologist
Joint United Nations Programme on HIV/AIDS
20 avenue Appia, CH-1211 Geneva 27, Switzerland
Tel. (41) 22 791 4705 – Fax (41) 22 791 4162
E-mail: schwartlander@unaids.org
Dr. N. Sewankambo
Department of Medicine, Makarere University
Kampala, Uganda
Tel. (256) 41 530020/530022
E-mail: nsewankambo@uga.healthnet.org
Dr. M. St Louis
Chief, Epidemiology and Surveillance Branch, Division of STD Prevention
National Center for HIV, STD & TB Prevention
Centers for Disease Control and Prevention,
1600 Clifton Road NE, Atlanta, Georgia, USA
Tel. (1) 404 639 8368 – Fax (1) 404 639 8610
E-mail: MES2@cpsstd1.cm.cdc.gov
Dr. D. Tarantola
Director, International AIDS Program,
FXB Center for Health and Human Rights,
FXB Building, 7th Floor, Harvard School of Public Health
651 Huntingdon Avenue, Boston MA 02115 USA
Tel. (1) 617 432 4313 – Fax (1) 617 432 4310
E-mail: danielt@hsph.harvard.edu
29
Trends in HIV incidence and prevalence
Mr G. Tembo
Country Programme Advisor, UNAIDS, c/o UNDP Resident Representative
PO Box 30218 Nairobi, Kenya
Tel. (254) 228 7769 (ext 337) – Fax (254) 221 5534
E-mail: tembo@arcc.or.ke
Dr. P. Way
Senior Research Analyst, International Programs Center
US Bureau of the Census
Washington, DC 20233-8860, USA
Tel. (1) 301 457 1406 – Fax (1) 301 457 3034
E-mail: Peter.o.way@ccmail.census.gov
Dr. J. Whitworth
MRC Programme on AIDS, Uganda Virus Research Institute
PO Box 49, Entebbe, Uganda
Tel. (256) 42 20272/20042 – Fax (256) 42 21137
E-mail: MRC@MRCEBB.UU.IMUL.COM
Professor B. Williams
ERU, Box 30606, Braamfonteiu 2017
Republic of South Africa
Tel. (27) 403 1815 – Fax (27) 403 1285
E-mail: Brian@eru.wn.apc.org
Professor D. Wilson
Project Support Group, Psychology Department
University of Zimbabwe
PO Box MP 167, Mount Pleasant, Harare, Zimbabwe
Fax (263) 4 333 407/335 249
30
UNAIDS
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32
The Joint United Nations Programme on HIV/AIDS (UNAIDS) is the leading advocate for global
action on HIV/AIDS. It brings together seven UN agencies in a common effort to fight the epidemic:
the United Nations Children’s Fund (UNICEF), the United Nations Development Programme (UNDP),
the United Nations Population Fund (UNFPA), the United Nations International Drug Control
Programme (UNDCP), the United Nations Educational, Scientific and Cultural Organization
(UNESCO), the World Health Organization (WHO) and the World Bank.
UNAIDS both mobilizes the responses to the epidemic of its seven cosponsoring organizations and
supplements these efforts with special initiatives. Its purpose is to lead and assist an expansion of
the international response to HIV on all fronts: medical, public health, social, economic, cultural,
political and human rights. UNAIDS works with a broad range of partners – governmental and NGO,
business, scientific and lay – to share knowledge, skills and best practice across boundaries.
Joint United Nations Programme on HIV/AIDS