Contents

-Some Background
-The Chemistry of Aspirin
-Physical properties
-Synthesis
-Mechanism
-IR and NMR Spectroscopy
-Biological activity
-Brand names
- Conclusion
 Some Background

- 1897 In Germany, Bayer's Felix

Hoffmann develops and patents a
process for synthesising acetyl salicylic
acid or aspirin. First clinical trials begin.
Some Background

It would later be marketed as aspirin ‚ Äî “a” for

“acetyl” and “spirin” for Spirea, the genus
name of the source plant for salicylic acid, the
pain-relieving agent.
The Chemistry of Aspirin

Aspirin also known as acetylsalicylic acid

IUPAC Name: 2-acetyloxybenzoic acid

Molecular Formula: C9H8O4

Molecular Weight: 180.15742 g/mol
The chemical structure of aspirin:
The Chemistry of Aspirin

Stability and Reactivity :

- Stability: Stable in dry air.

- Hazardous Decomposition Products: Decomposes to acetic

acid and salicylic acids in the presence of moist air. Carbon
dioxide and carbon monoxide may form when heated to
decomposition.

- Conditions to Avoid: Moisture.

Physical properties
 Synthesis

Reaction :

According to the above reaction, Salicylic acid is treated with

acetic anhydride causing the reaction that converts the hydroxyl
group on salicylic acid into and ester functionality.

The product of this reaction will be acetyl salicylic acid (aspirin) and
acetic acid. Sulphuric acid or phosphoric acid will be used as a
catalyst.[ 9 ][ 10 ]
 Synthesis

The production of aspirin

from raw materials can be
divided into four separate
reactions. These are shown:
Mechanism
IR Spectroscopy
NMR Spectroscopy
 Biological activity

Aspirin works by reducing substances in the body that cause pain, fever,
and inflammation.

Aspirin is used to :

- kill pain

- reduce fever or inflammation

- treat or prevent heart attacks, strokes.

Brand names
 Conclusion

-Aspirin is used for kill pain, reduce fever and prevent

hearts attack.

-Preparation of aspirin by esterfication of salicylic

acid and acetic anhydride

-The structure of aspirin has been proved by

Spectroscopic instruments as IR and NMR .

- The melting point = 135 ْ

 References
1. aspirin-foundation.com/what/timeline.html
2. inventors.about.com/library/inventors/blaspirin.htm
3. mindhacks.com/2009/03/09/a-brief-history-of-aspirin
4. aspirin-foundation.com/what/chemistry.html
5. chem.uky.edu/courses/che554/0-SafetyIntro/AspirinMSDS.pdf
6. chemglue4u.com/lab-helper/organic-chem-lab-helpers/synthesis-of-acetylsalicylic-acid-aspirin/
7. The Organic Chemistry of Biological Pathways by John McMurry and Tadhg Begley
(Roberts and Company, 2005)
8. Organic Chemistry of Enzyme-Catalyzed Reactions by Richard Silverman (Academic
Press, 2002).
9. K. L. Williamson, Macroscale and Microscale Organic Experiments, 2nd Ed. 1994,
Houghton Mifflin, Boston. p379; revised 10/18/06
10. Palleros, Daniel R. (2000). Experimental Organic Chemistry. New York: John Wiley & Sons. p.
11. aspirin-foundation.com/what/reactions.html
12. Carstensen, J.T.; F Attarchi and XP Hou (1985). "Decomposition of aspirin in the solid state in
the presence of limited amounts of moisture". Journal of Pharmaceutical Sciences 77
13. stonybrook.edu
14. biosite.dk/leksikon/acetylsalicylsyre.htm
15. drugs.com/aspirin.html
 Kendriya Vidyalaya Wellington
CHEMISTRY INVESTIGATORY PROJECT

“Synthesis of Aspirin “
SESSION: 2023-24

Submitted to-
Submitted by-
Miss
G.GERSON KEVIN