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MB Chapter 4.4 Eukaryotic Replication
MB Chapter 4.4 Eukaryotic Replication
30 nm Fiber
“Beads-on a-string”form of
chromatin
1. Small animal viruses (simian virus 40, 5 kb) are good mammalian models
for elongation (replication fork) but not for initiation.
• DNA pol δ : on the leading strand that replaces DNA pol α. can synthesize
long DNA
• DNA pol ε : on the lagging strand that replaces DNA pol α. synthesized
Okazaki fragments are very short (135 bp in SV40), reflecting the amount
of DNA unwound from each nucleosome
Telomerase Replication
2) Mutation
- Type of Mutation
- Causes of Mutation