NEET PG

Educators Notes

Dr Arpit Agarwal
Pharma CAPSULE 5
Autocoid Part 2
 NEET PG
Educators Notes

1. Drug of choice in acute migraine is:

(a) NSAID
(b) Sumatriptan
(c) Dihydroergotamine
(d) Propranolol
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Educators Notes

2. Drug of choice in acute severe migraine is:

(a) NSAID
(b) Sumatriptan
(c) Dihydroergotamine
(d) Propranolol
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Educators Notes

3. Choose the CORRECT statement about sumatriptan:

(a) It activates 5-HT1A receptors
(b) It tends to suppress both pain and vomiting in migraine
(c) It does not carry risk of precipitating coronary vasospasm
(d) It is combined with ergotamine for the treatment of severe migraine
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4. Contraindication for the triptans is?

a) Ischemic heart disease
b) Epilepsy
c) Hepatic failure
d) All of the above
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Educators Notes

5. Drugs used in migraine prophylaxis are all except-

[A]. Flunarizine
[B]. Propranolol
[C]. Cyproheptadine
[D]. Sumatriptan
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6. Which of the following drugs is used for the prophylaxis of migraine

but not for angina pectoris?
(a) Verapamil
(b) Diltiazem
(c) Flunarizine
(d) Amlodipine
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Educators Notes

7. All statements are true about CGRP except:

a) CGRP is the most potent vasodilator of our body
b) It is released from trigeminal ganglion & involved in pathology of migraine
c) Telcagepant is a new drug which is inhibitor of CGRP
d) Telcagepant can lead to kidney failure , given with monitoring
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Educators Notes
CGRP inhibitors
CGRP is a potent vasodilator from :
• Trigeminal ganglion & spinal cord - involved in pain & nociception

MAB against CGRP for Px of migraine

1. MAB against CGRP receptor - Erenumab [SC once a month]

2. MAB against CGRP – “nezumab”

a) Fremanezumab, Galcanezumab–SC once a month or 3 months
b) Eptinezumab - IV once in 3 months
All SC exept Epti [E & I r vowels]

Oral CGRP receptor Blocker - Ubrogepant

• For acute migraine
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Educators Notes

8. Among NSAIDs, aspirin is unique because it:

(a) Irreversibly inhibits its target enzyme
(b) Reduces the risk of colon cancer
(c) Reduces fever
(d) Selectively inhibits COX-2 enzyme
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Educators Notes

9. NSAID lacking anti-inflammatory action:

(a) Paracetamol
(b) Ibuprofen
(c) Diclofenac sodium
(d) Celecoxib
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Educators Notes

10. NSAID proposed to be acting via inhibition of COX-3 is:

(a) Nimesulide
(b) Paracetamol
(c) Ketorolac
(d) Rofecoxib
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Educators Notes

11. A truck driver presented with a minor injury. Which NSAID should
not be prescribed?
(a) Celecoxib
(b) Indomethacin
(c) Naproxen
(d) Diclofenac sodium
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Educators Notes

12. Which of the following NSAIDs has been approved for use in
children?
(a) Indomethacin
(b) Ibuprofen
(c) Ketorolac
(d) Piroxicam
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13. Which NSAID undergoes enterohepatic circulation?

a. Phenylbutazone
b. Aspirin
c. Ibuprofen
d. Piroxicam
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14. Which NSAID is a selective COX2 inhibitor?

a. Diclofenac
b. Celecoxib
c. Ibuprofen
d. Piroxicam
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Educators Notes

15. True about COX-2 are all EXCEPT:

(a) It is constitutionally expressed on some cell surfaces
(b) Activation of COX-2 leads to ulcero-protective effect in stomach
(c) Induced at the site of inflammation
(d) Selective COX-2 inhibition leads to cardiovascular complications
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Educators Notes

16. Rofecoxib was withdrawn due to:

(a) Ischemic heart disease
(b) Renal complication
(c) Liver adenoma
(d) Gastric ulcer
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Educators Notes

17. Which of the following is a possible reason for the use of celecoxib
in the treatment of arthritis?
(a) History of rash with a sulfonamide
(b) History of gout
(c) History of peptic ulcer disease
(d) History of type 2 DM
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Educators Notes

18. Which of the following is a possible contraindication for the use of

celecoxib in the treatment of arthritis?
(a) History of Bleeding disorder
(b) History of gout
(c) History of peptic ulcer disease
(d) History of MI
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19. A patient on aspirin will have increase in:

(a) Bleeding time
(b) Clotting time
(c) Prothrombin time
(d) Activated partial thromboplastin time
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1. Antiplatelet drugs prolong the bleeding time.

2. Anticoagulant drugs prolong the clotting time.
3. Drugs interfering with intrinsic pathway (like heparin) prolong aPTT.
4. Drugs interfering with extrinsic pathway (like warfarin) prolong PT.
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20. All of the following actions of aspirin are mediated by inhibition of

prostaglandin synthesis except:
A. Analgesia
B. Closure of patent ductus arteriosus
C. Hyperventilation
D. Bleeding tendency
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Educators Notes

21. At usual therapeutic doses, Which is an expected effects of

aspirin?
(A). Efficacy greater than acetaminophen as anti-inflammatory agent
(B). Efficacy less than acetaminophen for relieving simple headache
(C). Inhibited growth of bacteria that cause fever
(D). Protection against bronchopasm in asthmatics
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22. Which statements is NOT TRUE about Aspirin?

(a) It is an irreversible inhibitor of COX enzyme.
(b) It reduces in vivo synthesis of prostaglandins.
(c) Its clearance is independent of plasma concentration
(d) Antiplatelet effect of is related to pre-systemic COX inhibition
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23. Aspirin should be avoided in select groups of patients because of

which reason:
(a) In diabetics because it can cause hyperglycemia
(b) In children with viral disease, because of acute renal failure
(c) In gout, because it can increase serum uric acid
(d) In pregnancy, because of high risk of teratogenicity
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Educators Notes

24. TRUE statement about aspirin is:

(a) In an afebrile patient, overdose of aspirin produces hypothermia
(b) Aspirin suppresses flushing associated with nicotinic acid
(c) It prevents granulomatous lesion & cardiac complications of
rheumatic fever
(d) Long term aspirin therapy increases the risk of colon cancer
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Educators Notes

25. Alcoholics have an increased risk of developing acetaminophen

hepatotoxicity. This increased sensitivity to acetaminophen's toxicity
is due to:
(a) Decrease availability of acetaldehyde dehydrogenase
(b) Decreased hepatocellular stores of glutathione
(c) Decreased activity of Cytochrome P450 enzymes
(d) Increased liver blood flow
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26. A 20 yr old female is admitted having consumed 10 g of

paracetamol together with alcohol 6 hrs earlier. A serum paracetamol
level is reported as 400 micrograms/ml. Which of the following is
correct with respect to this?
(a) Gastric lavage is mandatory
(b) Administration of activated charcoal
(c) Abnormalities of the kidney function are likely to be present
(d) Hepatotoxicity is likely to occur
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Educators Notes

27. A student is brought after taking an overdose of a non-prescription

drug. He is confused and lethargic, hyperventilating and dehydrated.
ABG analysis demonstrates metabolic acidosis. Which is NOT likely to
be of any benefit ?
(a) Alkalization of urine
(b) Correction of metabolic acidosis
(c) Gastric lavage
(d) Treatment with acetyl cysteine
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Educators Notes

28. H1 antihistaminic afford benefit in a number of conditions. All of

the following conditions are benefited by antagonism of histamine
except:
A. Dermographism
B. Insect bite
C. Common cold
D. Seasonal hay fever
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Educators Notes

29. True statement about fexofenadine is:

(a) It undergoes high first pass metabolism in liver
(b) Terfenadine is an active metabolite of this drug
(c) It does not block cardiac K+ channels
(d) It has high affinity for central H1 receptors
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Educators Notes

30. Anti-vertigo drug which modulates calcium channels and has

prominent labyrinthine suppressant property is:
(a) Cyproheptadine
(b) Cinnarizine
(c) Clemastine
(d) Cetrizine
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31. H3 receptor agonist exhibits all of the following actions EXCEPT

(a) Inhibition of H1 receptor induced wakefulness
(b) Increase in H1 mediated gastrin secretion
(c) Inhibition of H1 mediated bronchoconstriction
(d) Inverse agonist of H3 receptor (tiprolisant) is approved for
Narcolepsy
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32. Bremelanotide is used for

(A). Ca prostate
(B). Motor neuropathy
(C). Erectile dysfunction
(D). Metastatic RCC
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Educators Notes

Female hyposexual disorder [HSD]

• Flibanserin- 5HT2 antagonist and 5HT1A-agonist
• Bremelanotide melanocortin receptor agonist