NEET PG

Educators Notes

Dr Arpit Agarwal
PHARMA CAPSULE 7
Drugs for Diabetes
 NEET PG
Educators Notes

1. Insulin causes all except:

A. Glycogenesis
B. Glycolysis
C. Lipogenesis
D. Ketogenesis
 NEET PG
Educators Notes

2. Insulin acts by stimulation of:

A. Ionotropic receptor
B. Enzymatic receptor
C. Metabotropic receptor
D. Nuclear receptor
 NEET PG
Educators Notes

3. Glucagon acts by stimulation of:

A. Ionotropic receptor
B. Enzymatic receptor
C. Metabotropic receptor
D. Nuclear receptor
 NEET PG
Educators Notes

4. Adverse effects of insulin include all except:

A. Edema
B. Hypoglycemia
C. Lipodystrophy
D. Hyperkalemia
 NEET PG
Educators Notes

5. All insulin are rapid and short acting EXCEPT:

A. Lispro
B. Aspart
C. Glargine
D. Regular
 NEET PG
Educators Notes

6. Long acting insulin is:

A. Lente
B. Semi-lente
C. Ultra-lente
D. Lispro-insulin
 NEET PG
Educators Notes

7. Insulin with longest duration of action is:

A. Insulin glargine
B. Protamine zinc insulin
C. Insulin Degludec
D. Plain insulin Detemer
8. Identify Insulin shown with dotted blue line :
A. Insulin glargine
B. Regular insulin
C. Insulin Aspart
D. NPH
 NEET PG
Educators Notes

9. A 15-year-old type 1 DM patient presents in comatose state. Blood sugar

is 658 mg/dl, Urine is positive for glucose and ketone bodies. Which of the
following insulin types depicted in the graph below is most appropriate?

A. A

B. B

C. C

D. D
 NEET PG
Educators Notes

10. The most likely complication of insulin therapy in ketoacidosis is:

A. Dilutional hyponatremia
B. Hypoglycemia
C. Increased bleeding tendency
D. Hypokalemia
 NEET PG
Educators Notes

11. Sulfonylureas act by all except:

A. Decreasing glucagon secretion from pancreas
B. Increasing tissue sensitivity to insulin
C. Increasing gluconeogenesis
D. Increasing insulin secretion from pancreas
 NEET PG
Educators Notes

12. All are true regarding chlorpropamide except:

A. It is short acting
B. It can cause hypoglycemia in elderly
C. Causes weight gain
D. Associated with alcoholic flush
 NEET PG
Educators Notes

13. All statements about nateglinide are true except?

A. Decreases post-prandial hyperglycemia
B. Hypoglycemia is less common than with sulfonylureas
C. It decreases insulin resistance
D. It acts by releasing insulin
E. It should be avoided in liver disease
 NEET PG
Educators Notes

14. All are contraindications for the use of metformin except

a) Hypotensive state
b) Alcoholics
c) Renal failure
d) Hypokalemia
 NEET PG
Educators Notes

15. Common side effect of thiazolidinediones is:

(a) Dysguesia
(b) Hypoglycemia
(c) Water retention with weight gain
(d) Anemia
 NEET PG
Educators Notes

16. All about exenatide are true except:

A. A GLP -1 analogue given subcutaneously
B. It can be used for treatment of Type 1 and Type 2 DM
C. It decreases glucagon
D. Used as monotherapy or in combination with OHA
 NEET PG
Educators Notes

17. All are side effects of exenatide except

A. Increased Gastric emptying
B. Pancreatitis
C. Thyroid cancer
D. Weight loss
 NEET PG
Educators Notes

18. All statements about alpha-glucosidase inhibitors are true EXCEPT:

A. Reduces intestinal absorption of carbohydrates
B. Effective in both type 1 and 2 diabetes
C. Hypoglycemia is a common and serious side effect
D. Avoid in patients with IBD
 NEET PG
Educators Notes

19. A patient is receiving insulin and acarbose developed hypoglycemia.

Which should be used for hypoglycemia in this patient?
a) Sucrose
b) Galactose
c) Glucose
d) Starch
 NEET PG
Educators Notes

20. Which of the following is/ are a side effect/s of Dapaglifozin ?

a) Weight loss
b) Polyuria
c) Increased incidence of urinary tract infections
d) All the above
 NEET PG
Educators Notes

21. Anti-diabetic drugs causing weight loss are all except

A. DPP-4 Inhibitor
B. Pramlintide
C. GLP-1 agonist
D. SGLT-2 Inhibitor
 NEET PG
Educators Notes

22. Antidiabetic drugs that can be used safely in renal failure are:
(a) Metformin
(b) Glimepiride
(c) Linagliptin
(d) Exenatide
 NEET PG
Educators Notes

23. Antidiabetic drugs reducing ASCVD mortality are all except:

(a) Metformin
(b) Dapagliflozin
(c) Linagliptin
(d) Liraglutide