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ObsNGyn - Common Gyne Disorders Atf
ObsNGyn - Common Gyne Disorders Atf
com
GENITAL INFECTIONS
V A G I NI T I S
o Bacterial vaginosis
o Candidiais
o Trichomoniasis
BACTERIAL VAGINOSIS
PREDISPOSING FACTORS
INVESTIGATIONS
NUGENT SCORING
o on gram staining, we count the number of gram –ve rods V/S the number of
gram +ve rods
o if the score is 7 -10 ➔ then the diagnosis is surely BACTERIAL
VAGINOSIS.
TREATMENT
• Linked with –
o Preterm labor
o Preterm rupture of membrane
o Chorioamnionitis
o Endometritis
• Treat BV in pregnancy only if symptomatic.
• Do not treat if asymptomatic.
• So there is no routine screening for BV in pregnancy.
• DOC FOR BV IN PREGNANCY – metronidazole (vaginal route)
CANDIDIASIS
• MC species – C.albicans
• Predisposing factors
o Immunocompromised
o Pregnancy (MC VAGINTIS IN PREGNANCY = VAGINAL CANDIDIASIS)
o Antibiotic use
o Diabetes mellitus
• MC VAGINTIS IN PREGNANCY = VAGINAL CANDIDIASIS (bcz candida can survive
and flourish in acidic medium)
• Vaginal pH in candidiasis = <4.5 (acidic)
• This is the only vaginitis that occur in acidic environment.
CLINICAL FEATURES
INVESTIGATIONS
TREATMENT
RECURRENT CANDIDIASIS
TRICHOMONIAIS
• IT IS AN STD
• AGENT – T.vaginalis
CLINICAL FEATURES
INVESTIGATIONS
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• Saline microscopy
o Flagellated organisms (tennis racket shape appearance )
o ALSO WBC’S ARE PRESENT IN THE DISCHARGE
• Pap smear staining
• GOLD STANDARD - CULTURE
TREATMENT
• DOC = Metronidazole
o 2 grams orally single dose OR
o 500mg BD for 7 days
• PARTNER TREATMENT IS ALSO REQUIRED IN THE TRICHOMONIAISIS (STD)
CERVICITIS
• Next investigation to do is ➔
simple gram staining
o Vaginal epithelial cells seen colonized
by these gram –ve diplococci
➔ presumptive diagnosis is of gonococci.
o If gram stain doesn’t show any
bacteria ➔ make a presumptive diagnosis of Chlamydia.
• IOC for Chlamydia = NAAT (nucleic acid amplification test)
o Sample – endocervical swab / discharge , urine.
• IOC for Gonorrhea = gram staining
• GOLD STANDARD for Chlamydia ➔ culture in Mc Coy cell line.
• GOLD STANDARD for Gonorrhea ➔ culture in Thayer Martin medium
TREATMENT
• For Chlamydia →
o DOC is azithromycin 1gm orally single dose
o Doxycycline 100mg BD for 7 days
o Doxycycline is absolutely contraindicated in pregnancy
o So DOC in pregnancy ➔ AZITHROMYCIN
• For Gonorrhea
o DOC is injection ce ftriaxone 250mg i/m (preferable ) OR
o Tab cefixime 400mg orally single dose
PLUS (+)
o Azithromycin 1gm orally single dose (also take care of Chlamydia too)
Alternative treatment
• Whenever a female came with a complaint of vaginal discharge → simply began with
per-speculum examination → look for whether the discha rge is limited only to vagina
i.e. VAGINITIS or discharge is coming out of os i.e. CERVICITIS
CLINICAL FEATURES
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• Primary complain of chronic pelvic pain (lower abdominal pain) (not dysmenorrhea)
• Discharge per vaginum
• Fever
• Dysuria
PHYSICAL EXAMINATION
• On p/v examination
o tenderness of the upper genital tract +.
o Cervical motion tenderness present.
• On bimanual palpation
o Patient winces in pain.
• Fever
• Increase WBC count
Common Gynae Disorders P a g e 6 | 21
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• Mucopurulent cervicitis
• Increase CRP
• +ve test for Chlamydia / gonorrhea.
CONSEQUENCES OF PID
TREATMENT
• OPD T/t
o injection ceftriaxone 250mg i/m single dose
Plus
o Doxycycline 100mg BD orally for 14 days
o +/- metronidazole 500mg BD for 7 days
o Also treat the partner
• IPD T/t
o Whom to be admitted
▪ Pregnant female with PID
▪ If she has severe symtoms
▪ Unable to take orally
▪ h/o peritonitis
o start with inj. Cefoxitin + inj. Doxycycline + inj. Metronidazole for 48 -72
hrs → then switch to oral drugs
o alternative = inj.clindamycin + inj.gentamicin
GENITAL TUBERCULOSIS
• It is always secondary
• MC primary comes from the = LUNGS > Lymph nodes
• From lungs, it comes via hematogenous route.
PATHOLOGY
CLINICAL FEATURES
PHYSICAL FINDINGS
❖ TREATMENT ➔ ATT
Treatment- ATT
Aka LEIOMYOMA – Benign tumor arising from the smooth muscle of the uterus
• Nulliparous
• Obese women
• African American women
• +ve Family h is tory ( risk increase By 2.5 times)
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Factors decreasing the risk of fibroid –
• Parity
• Smoking (causes Breakdown of estrogen in the Body)
• OCP’ s do not increase the r is k of fibroid
GROSS APPEARANCE
T Y P E S OF F I B R O I D
Remember Body of the uterus is mostly formed of smooth muscle, whereas cervix is mostly formed of
connective tissue (only 10% muscle). So, most of the fibroids arise from the Body of the uterus and cervical
fibroid can Be present but less common.
intracavitory, sub mucous, intramural, sub serous, sub serous, pedunculated FIGO
CLASSIFICATION
CLINICAL PRESENTATION
1. MC presentation = asymptomatic
2. MC symptom = abnormal uterine Bleeding (MC- cyclical menorrhagia)
a. Incidence of bleeding, sub mucous > intramural > sub serous
b. Intermenstrual Bleeding (normal cyclical Bleeding with episodes of Bleeding in Between) is
typically seen in - FIBROID POLYP.
c. Post- coital bleeding seen with - FIBROID POLYP.
Pressure symptoms
a. Huge sub serous fibroid can press rectum => CONSTIPATION
b. Huge sub serous fibroid or cervical fibroid, can press on the urethra - urethra stretched
over the fibroid - narrowing & kinking of the urethra and lead to retention of urine
c. Anterior cervical fibroid - can press urinary bladder directly, irritation of the bladder,
increase frequency of micturition
HYALINE DEGENERATION
a. MC degeneration
B. Whorled appearance of the f i Broid is lost
CYSTIC DEGENERATION
FATTY DEGENERATION
CALCAREOUS DEGENERATION
a. MC in sub serous type
B. Aka WOMB STONE
INFECTION
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a. MC in fibroid polyp coming out of the Os > su Bmucous
NECROSIS
SARCOMATOUS DEGENRATION
a. Malignant change
B. Very rare, only 0.2 - 0.5 % cases
c. When occurs, i t is mostly seen in postmenopausal women
d. If after menopause, fibroid increases in size = highly suspicious of sarcomatous change
e. Diagnosis of leiomyosarcoma
i. Made only on HPE
ii. > 10 mitotic f i gures/ 10 hpf
B. Clinical features
i. Pain
ii. Mild fever
iii. Nausea / vomiting
PHYSICAL EXAMINATION
• On P/ V examination
Uterus is enlarged – uniformly or irregularly
Firm to feel
INVESTIGATIONS
o H e t e r o e c h o i c a r e a in t h e m y o m e t r i u m c l e a r l y d e m a r c a t e d .
• S A L IN E IN F U S IO N S O N O G R A P H Y ( SIS)
o Al s o k / a S O N O S A L P I N G O G R A P H Y ( S S G )
o B e t t e r f o r s uB m u c o u s a n d f i B r o i d p o l y p s
• HYSTEROSCOPY
o B e s t f o r s ubm u c o u s a n d fibr o i d p o l y p s
o it i s di a g n o s t ic a n d t h e r a p e u t i c a t t h e s a m e ti m e
Symptomatic
• We have to treat
• DEFINITIVE TREATMENT surgery
• Depends on the age of the patient and her desire of future pregnancy
Myomectomy
• Only removes l e io myoma
• There i s a chance of recurrence around 30 %
• Fertility is preserved
Hysterectomy
• Fertility is not preserved
• No recurrence
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INDICATIONS of hysterectomy i n fibroid uterus are:
• Post- menopausal women with increase in size of fibroid
• Multiparous female > 40 yrs. of age, when severely symptomatic
MEDICAL TREATMENT
INDICATIONS
Premenopausal woman with only mild symptoms Pre- optreatment
Surgical Management
MYOMECTOMY
• If it is sub serous, intramural, or sub mucous type 2, we have to approach via abdominal or
laproscopically
• Hysteroscopically route has slightly increased risk of recurrence than abdominal or laparoscopy, But
still preferred.
o Surgeons expertise
o Technical feasibility
o Instruments availability
o I f uterus very Big, then aBdominal route will be preferred
Advantages of laparoscopy
o Scar absent
o Pain is less
o Post op stay less
o Earlier ambulation
Before myomectomy
o Torniquets
o One is tied around the uterine artery
o Other is tied around the ovarian artery
o Intramyometrial injection of vasopressin
ADENOMYOSIS
• Definition – condition in which endometrial glands and stroma are located deep within
the myometrium. And surrounding myom etrium undergoes hyperplasia and hypertrophy.
So there occurs diffuse enlargement of the uterus.
• Most important D/D of this is FIBROID UTERUS.
THEORIES
CLINICAL FEATURES
• UTERUS
o Uniformly enlarged (in case of fibroid → irregularly enlarged)
o Globular
o Soft (fibroid have firm uterus)
o Tenderness +nt
o Enlargement is around 8 – 10 weeks’ size
INVESTIGATIONS
THEORIES
• These endometrial deposits also grow under the action of the hormones and also bleed
cyclically , but there is no exit for the blood and the blood keep collecting in these
deposits →leads to PAIN.
• Many inflammatory mediators like PGs and cytokines are also released around these
deposits →leads to PAIN.
• Also the collected blood at these areas heals by fibrosis leads to scarring →also
contributes to PAIN.
• Also during intercourse, depo sits on uterosacral ligaments →also contributes to
PAIN(DYSPAREUNIA)
GENERAL POINTS –
GENETIC BASIS
CLINICAL FEATURES
1. MC complaint ➔PAIN
o Congestive dysmenorrheal (pain starts few days before menses and last
throughout bleeding)
o Chronic pelvic pain
o Dyspareunia
o Low back pain
• Cause of pain –
o due to release of inflammatory
mediators from the deposits
o Deeply infiltrating deposits – irritate the nerves
INVESTIGATIONS
TREATMENT
• T/t of PAIN
o Medical treatment
• OCPs work by suppressing ovaries and stop ovulation and follicular growth
• OCPs are given for continuously for 4 -6 months without stopping in between =
causes amenorrhea during this time = so no bleeding ➔ NO PAIN
Other drugs
OPTIONS
• T/t of INFERTILITY
• Ovulation induction
• Ovulation induction + intra -uterine insemination
• In-vitro fertilization
Notes:
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