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DOI: 10.1111/pan.13716
1
Department of Anaesthesia, Royal
Children's Hospital Aberdeen and School Summary
of Medicine, University of Aberdeen, Critical airway incidents in children are a frequent problem in pediatric anesthesia
Aberdeen, UK
2 and remain a significant cause of morbidity and mortality. Young children are at
Department of Anesthesia, McGill
University Health Center, Montreal particular risk in the perioperative period. Delayed management of airway obstruc‐
Children's Hospital, Montreal, QC, CA
tion can quickly lead to serious complications due to the short apnea tolerance in
3
Department of Anesthesiology and
Critical Care Medicine, Children's Hospital
children. A simple, time critical, and pediatric‐specific airway management approach
of Philadelphia, Perelman School of combined with dedicated teaching, training, and frequent practice will help to reduce
Medicine at the University of Pennsylvania,
Philadelphia, PA, USA
airway‐related pediatric morbidity and mortality. There is currently no pediatric‐spe‐
4
Department of Anaesthesia, University cific universal framework available to guide practice. Current algorithms are modifi‐
Children's Hospital, Zurich, Switzerland cations of adult approaches which are often inappropriate because of differences in
5
Consultant Anaesthetist, Starship
age‐related anatomy, physiology, and neurodevelopment. A universal and pragmatic
Children’s Hospital, Auckland, New Zealand
6
Department of Anaesthesiology, University approach is required to achieve acceptance across diverse pediatric clinicians, socie‐
of Auckland, Auckland, New Zealand ties, and groups. Such a framework will also help to establish minimum standards for
7
Department of Anaesthesia, Leeds
pediatric airway equipment, personnel, and medications whenever pediatric airway
Teaching Hospitals NHS Trust, Leeds, UK
8
Anestesióloga pediátrica, Miembro
management is required.
del comité de Anestesia Pediátrica,
Sociedad Colombiana de Anestesiología y KEYWORDS
Reanimación, Anestesióloga del Instituto airway, children, framework
Rooselvelt, Bogotá, DC, Colombia
9
Medical School, The University of Western
Australia, Perth, WA, Australia
10
Department of Anaesthesia and Pain
Management, Perth Children's Hospital,
Perth, WA, Australia
11
Telethon Kid's Institute, Perth, WA,
Australia
Correspondence
Thomas Engelhardt, Department of
Anaesthesia, Royal Children's Hospital
Aberdeen and School of Medicine,
University of Aberdeen, Aberdeen, UK.
Email: t.engelhardt@nhs.net
Funding information
Departmental Resources. BvUS is partly
funded by the Perth Children's Hospital
Foundation, the Stan Perron Charitable
Trust, and the Frank Callahan Estate
Note: This distinction is important because treatments generally differ: Airway maneuvers and
adjuncts for the treatment of anatomical/ mechanical airway obstructions. Pharmacological inter‐
ventions for functional airway obstructions.
a
Preexisting copious secretions (upper respiratory tract infection) may benefit from a preinduction
anti‐sialagogue.
b
Minimal laryngospasm can initially be treated with jaw‐thrust and positive airway pressure.
c
Use epinephrine (titrate) in the periarrest situation.
relieve most upper anatomical airway obstructions. Forceful bag‐mask Intravenous epinephrine starting with low doses (1 mcg/kg)
ventilation may result in gastric distension (commonly not recognized by is highly effective to treat severe bronchospasm (“silent chest”).
inexperienced practitioners) which can impede ventilation/oxygenation Appropriately diluted intravenous epinephrine should be readily
and requires prompt decompression using an orogastric tube. Effective available at all times.23
bag‐mask ventilation can be monitored using waveform capnography. The early use of hypnotics and relaxants to overcome functional
airway obstruction instead of attempts to awaken the child is based
on the rational that the apnea tolerance in young children is too
4.3.2 | Functional airway obstruction
small to safely overcome a “cannot oxygenate‐cannot ventilate” situ‐
Functional airway obstruction can occur in the upper and lower ation.6,26-28 In addition, muscle relaxants should be used in the “can‐
airway. not oxygenate‐cannot ventilate” situation before any attempts of
Functional upper airway obstruction is common and usually surgical airway such as emergency cricothyroidotomy, needle inser‐
caused by insufficient depth of anesthesia (closure of pharynx), la‐ tion or tracheostomy are to be considered as endorsed in adults. 29
25
ryngospasm, or opioid‐induced glottic closure. Muscle relaxants overcome most functional airway obstruction per‐
Functional lower airway obstruction is induced by broncho‐ mitting facemask/ laryngeal mask ventilation and improve tracheal
spasm in children with recent respiratory tract infections, bron‐ intubation conditions. 27,28,30
chial hyperreactivity, or thoracic wall rigidity as a consequence of Patients with an expected or suspected difficult airway must
rapid and/or high‐dose opioid administration. While minimal la‐ be treated by practitioners experienced in difficult pediatric airway
ryngospasm and loss of pharyngeal tone may initially be treated management and adequeate help sought before starting a procedure
using continuous positive airway pressure (good routine basic air‐ (Figure 1).
way management);
Severe Functional Airway Obstructions are treated with drugs.
4.4 | Universal approach
Hypnotics such as propofol may be used early in otherwise
healthy, noncompromised children to overcome these acute func‐ A universally accepted and implemented framework for the difficult
tional airway problems such as insufficient depth of anesthesia and pediatric airway requires the recognition and use of local expertise,
severe laryngospasm. Careful hemodynamic monitoring is essential resources, and facilities. The following simple, “Open‐Box” algorithms
as severe hypotension may ensue. Muscle relaxants can be used can be adapted according to local expertise and facilities.
early as an effective alternative to effectively overcome functional The algorithms are separated into:
airway obstruction in children with a normal airway with the ex‐
ception of bronchospasm. Care must be excercised in patients with • Oxygenation and ventilation
known distal airway obstruction. • Tracheal intubation.
ENGELHARDT et al. | 989
While this suggested framework specifically applies to the normal pe‐ Rarely, an unexpected subglottic or tracheal obstruction needs
diatric airway, the main underlying principles can also be considered to be bypassed with a small tracheal tube or a Frova bougie and ven‐
for the expected abnormal and acutely impaired but otherwise normal tilation achieved using the VentrainR device.36 Careful lung recruit‐
pediatric airway. ment maneuvres are required to prevent atelectasis and to restore
The rare but frequently discussed need for front of neck airway optimal oxygenation and ventilation following prolonged tracheal
(FONA) in children can be attempted as a last resort in a “cannot intubation attempts.
oxygenate‐cannot intubate” situation. FONA is likely to be futile in If no anatomical or mechanical obstruction is apparent during
a child in an emergency. 31,32 It is not possible to sufficiently practice direct laryngoscopy and the trachea cannot be intubated, a supra‐
or gain experience for this situation to be useful and relied upon in glottic airway device or a nasopharyngeal tube should be used to
an emergency due to age and size range from neonates to adoles‐ overcome any potentially unrecognized anatomical upper airway
cents.33 Emergency FONA has been attempted in approximately 2% problems (Plan B). 21
of anticipated and unexpected difficult airways of the PeDI registry A supraglottic airway device (SAD) may be inserted before direct
with considerable subsequent morbidity and mortality. 2 This is in laryngoscopy; however, this may be unsuccessful in the presence of
stark contrast to the ability to almost always overcome difficult or an intraoral mechanical obstruction or limited mouth opening.
impossible facemask ventilation in this large cohort of difficult pedi‐
atric airways by the recognition and treatment of anatomical airway
4.4.2 | Tracheal intubation
obstructions such as the use of supraglottic devices or functional
airway obstructions through muscle paralysis.2 Tracheal intubation in children is usually easy in experienced hands
There is rarely a need for an emergency FONA in the otherwise but may be more difficult in infants and neonates (Figure 3). There
healthy child without history and findings for a difficult airway. It is no consensus as to which technique or device is best suited for
may occur following airway trauma, swelling, or anaphylaxis in the various clinical situations. There is continuing development of new
otherwise healthy child or rapid respiratory deterioration in a child devices, techniques, and technologies requiring frequent updates
with a known difficult airway. to recommendations by various groups involved in pediatric airway
Preventing the need for emergency FONA by identifying high management.
risk patients (preexisting concerns about the ability to oxygenate/ It is, therefore, impossible to develop and dictate a detailed algo‐
ventilate) is essential for optimal pediatric airway management. rithm that will be accepted by clinicians involved in pediatric airway
Early anticipation of a difficult pediatric airway allows organization management.
and preparation of best and appropriate ORL/ENT or surgical sup‐ Therefore, an “open‐box algorithm” based on local expertise and
port. The most experienced anesthetic and surgical (ideally ORL/ available resources is the most practical.
ENT) help should be available before induction of anesthesia ex‐ It is essential to recognize that oxygenation and ventilation as
cept in the situation of immediate threat to life. Options available suggested above saves lives and prevents avoidable harm. Simple,
are needle or surgical cricoidotomy. Rigid bronchoscopy may also effective mask ventilation and placement of supraglottic airway de‐
be successful in specific circumstances if facilities and expertise vices can be learned by all specialists involved in pediatric airway
are immediately available. There is insufficient evidence and clin‐ management.
ical experience to support any specific device or technique over Multiple tracheal intubation attempts lead to preventable harm
another.33-35 and must be avoided. 2,4
If a tracheostomy is considered as a final option after compli‐ An initial tracheal intubation plan should be the daily local
cated and failed intubation attempts and before airway trauma routine, taught, and practiced. This can be in the form of direct
makes mask ventilation impossible an emergency FONA should be laryngoscopy or videolaryngoscopy. 37,38 Failure to successfully
declared in the paralyzed patient. An unplanned (emergency) FONA intubate should necessitate a call for assistance. Consider using
should only be considered as an option in a desperate scenario a supraglottic airway device (SAD) for the procedure if tracheal
rather than a recognized effective treatment of failed airway man‐ intubation fails.
agement in children. However, elective FONA contingency planning The anesthetic should be continued and oxygenation and
in children with a known difficult airway may be considered before ventilation maintained while Plan A is implemented. This should
the start of a procedure. be an alternative laryngoscopy technique (videolaryngoscopy),
that is, locally agreed upon and regularly practiced. Failure to
secure tracheal intubation via this method should necessitate
4.4.1 | Oxygenation and ventilation
reconsidering the indication for tracheal intubation, potential
Saliva, blood, regurgitation, or supraglottic foreign bodies can also use of a supraglottic airway or if necessary abandoning the
lead to mechanical obstruction and necessitate suction and removal procedure.
under direct vision using either direct laryngoscopy or videolaryn‐ If local expertise and resources are available, flexible endoscopic
goscopy (PLAN A). A tracheal tube can be inserted if the larynx is (fibrebronchoscope) intubation (nasal, oral, or via supraglottic airway
visualized (Figure 2). device) represents Plan B.
990 | ENGELHARDT et al.
Plan A Plan B
Direct/ Video Laryngoscopy
(specify local choice) Insert Supraglottic Airway Device (SAD)
(oxygenate/anesthetize)
Fibreoptic intubation via SAD
(specify)
Plan B
Supraglottic Airway Device (SAD)
Surgical Tracheostomy or (ORL/ENT) Rigid Bronchoscopy
An emergency FONA should only be considered as an option in a desperate situation and
Emergency Front Of Neck Airway (eFONA) or (ORL/ENT) Rigid Bronchoscopy if oxygenation and ventilation are impossible
An emergency FONA should only be considered as an option in a desperate situation and
if oxygenation and ventilation are impossible
F I G U R E 3 Pediatric Tracheal Intubation Approach. Adapt
according to local expertise and facilities. If appropriate, consider
F I G U R E 2 Pediatric Oxygenation and Ventilation. Adapt
abandoning the attempted procedure (see Figure 1). A failure to
according to local expertise and facilities. If appropriate, consider
intubate should not result in an attempt at an emergency Front Of
abandoning the attempted procedure (see Figure 1) [Colour figure
Neck Airway (eFONA) if oxygenation and ventilation is possible
can be viewed at wileyonlinelibrary.com]
[Colour figure can be viewed at wileyonlinelibrary.com]
4.4.3 | Pediatric Airway Equipment
of a difficult/ emergency trolley setup is offered in the File S1 and
Safe management of the pediatric airway requires a minimum avail‐
can be arranged according to the locally adapted airway algorithm
ability of suitable equipment according to national standards or rec‐
and available facilities.
ommendations. The equipment must also meet a minimum standard
of performance and quality. Principles of standardization, redun‐
dancy, and safety cultures need to apply. Make and manufacturer 5 | S U M M A RY
are less relevant, but the equipment must be suitable for children
and acceptable to the clinician in charge.39-41 The overarching goal of an universal, consensus approach to the
Individual departments need to decide on the best options based pediatric airway is the prevention of perioperative hypoxia in chil‐
on their needs and affordability. It is essential that pediatric airway dren. Prevention of intubation‐related complications through regu‐
equipment is well maintained and that staff are trained regularly. lar practice, teaching, and training with dedicated pediatric staffing
A separate difficult/emergency airway trolley should be available and equipment is a priority. The first crucial step after encounter‐
where children's airways are managed. This should be adapted to ing difficulties is to prevent, recognize, and treat ANATOMICAL/
locally accepted difficult airway algorithms. A one‐stop “airway trol‐ MECHANICAL and FUNCTIONAL airway obstructions with skills and
ley” may be the best option for some departments, with equipment drugs, respectively.
separated according to age/weight. Other departments who have A locally accepted algorithm based on simple and common prin‐
a dedicated “difficult airway” trolley for elective procedures may ciples using local expertise with existing suitable equipment should
choose an additional simplified “airway rescue” trolley equipped ac‐ be established. Such an approach to the pediatric airway may find
cording to departmental rescue algorithms. Simplicity is the key to acceptance across specialist pediatric specialties and pediatric anes‐
success and overstocking must be avoided at all costs. An example thesia societies and groups.
ENGELHARDT et al. | 991