390 ‘TEXTBOOK OF PHYSICAL PHARMACEUTICS ‘Step 2. All soluble ingredients are dissolved in some portion ofthe ‘vehicle and added to the smooth paste in sep Ito gota sly. ‘Step 3. The sary is wansfere to graduated cylinder, the mortar ringed with successive portions of the vehicle, Step 4. Decide whether the solids ce— * suspended in a sructured vehicle or + Nosculated or + Mocculted and then suspended ‘Add the vehicle consining. the suspending agent in the order mentioned in Figure 105. ‘Sep 5. Make up the dispersion to the fina value, Large scale The sequence of steps are same. But these steps are ‘avried out sing sophisticated equipments such as dough miner, pony mixers, ete. Particle size reduction can be obained by dy milling pre {to suspension using micropuverizer, fui energy grinding or controlled ‘precipitation. Homogenizsr er ealloi mill sured for wet mln. The ‘ature and concentration of suspending agent is cial because the ‘lection of equipment depends onthe flow characteristics ofthe suspen Sion Suspending gent canbe ned wit dry Powder er upended i 8 ‘vehicle and added. elas Ghosory of Symbate 130 = Sure fee ener change <4 — Dime te pr a ~ Sedimentation vane ofthe elected sytem {f= Accegaion to pari fh = Viocorhy ofthe erin medion, 8] = Desi af he capers phe b= Density of he ders eda, B = Degre af hoccaton Yo = Inia volume (hel) othe sediment ‘Vy = Ultimate volume (igh) of te sediment aie inet WW = Work dpne to age the pariles i apes ‘a = ler tron a soi guidance Bibiogrpty 1A Maia, Swarbic and A. Cammarata, Piyicl Pharmacy, Il Eda. Nurghese Pblsing Howse, Bombay, 121 ent oF Nocculting 302 "ToxTHOOK OF PHVSICAL PuaRMACEUS 1. Fee an ides! spesion, the sedimenttion volun shoud be ‘A equal wo one Dio 5. I case of suspensions, ll sateen below are te EXCERPT tht "Xk cousins mepending spot Bi dows not cle a pearvative it ean nose prepration Dit isan rt preparsion 9 In practice, n acceptable mspension shoul! have prices: "A of meaty 1 micromeer 8 hich can be realy edlaprsible afer they see . hich should foun a cake aerating 10. For ora aiminisiaion of a mapension 10 pity which one ofthe face he mot import? "A sscepble enor and dou 3 polmorhism 1, Wie ane ofthe following properie s apt to suspensions? CC: rap eof einantion 12. Suspended parties tecome feeclated in suspension, Doct: "A atacive forces between paris ae appecie BS partes we packed clay ute fs tern pris we pei 13, Steed vehicle i inlaed in the formation of «suspension, in onder A. estes te ier enon 1 preven the eating of th sient Creve the salimenaion of pais D. redice he ae By chemical mes. 14 tthe preperton of a rived veil which ove of te filowing ‘bmnfer tad? ©: ghycein Dr ca ene 2. ALL Gennaro, Reminpon's Pharmaceicel Selenet, 18 Eda, Mack Potiting Company, Pennayvna, 190 2. ME. Atlion, Phormacras, ELBS Eda, Chachi Hongkong 1990 Livingsone Ld ‘QUESTION BANK ah question carries I mark ‘ote Encl the slg which comespnds te the singe best response 1. A weting agent snl in the formulation ofa supension,pariaaty Che the suspended particles "oar Bpdophabie 1 re more derser tha the vehicle 1. ve eer ta toon 2 For n ocala sipersion, one ofthe following citron sted cr "high iter puncte reptons 1 rng ner parle cons Sea iter prtice stration Sak inter artless 3. tm Stokes reltionship. a parameter that grey changes the welocty of ting ens theta 1 deny a parte CC rads of the parle Dy teeny ot te mem 4. The protamine zn insulin spent x pepred by # method vc, Rha pt precpiaion 3 depen sete double decomposion 1. erga solver preiitation ‘5. Met celle i a polymer, which sof we: "anole 1, mphlye ©. atomic 6. Fora Moved mapensin, the degree of Aoculain i obearved to be (te. The sadn vole sso | (one). These vals, rope, ‘ower and lower tower and pet Sipe ed per 15. Which ye of ello mail is wed carmen nthe reparation of owed voice 1 fyaropiie © tyaeeyiaie . inoaanie 16. Wen chucol powder dusted on te sufice of water, he comet age (degree) tha he charcoal ei 1, A mandi secimenttion vole willbe ebtaned when 2ta pote 8: newwal : posive D. Ser 1, A ansance is diasted in water, Th sperson has exited 2nepaive ‘ppuret tin pena. lacy the rented aastance ©. gettin 19, Calcium hydrogen phogplate fe solved ia water The apparest ata pote inal "A eenive nee postive D. bere 20, Which one ofthese reparations is NOT qualified asa susperson, ‘A ten meal fr eddiagraste we 1K calemine lato Frenne se CC procaine pein Gor amas inketon . amin 8 compl tone aso sappeen Tach question earres 2 marks TC Mit the ole of fee energy carves in he development of suspension iieo. 2. What ore sce vehicles? What we the properties that = suc ‘elle shuld possess? 3. Dyflaes smpesion Wht mining of runpeniont 4 Menton the advantages of hyerocllids as suctred vehicles ia