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    Anti-Fungal Agents

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    Guy Seb
    This document categorizes and provides examples of various antifungal drug targets and mechanisms of action. It lists 7 categories of antifungal drugs: polyenes, allylamines, azoles, echinocandins, polyoxins, chitin synthesis inhibitors, and nucleic acid analogs. Each targets a different component or process in the fungal cell, such as the membrane, ergosterol biosynthesis, glucan synthesis, chitin synthesis, microtubule formation, or nucleic acid synthesis. Examples are given for each category along with their typical route of administration.

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    Anti-Fungal Agents

    Uploaded by

    Guy Seb
    7 views1 page
    This document categorizes and provides examples of various antifungal drug targets and mechanisms of action. It lists 7 categories of antifungal drugs: polyenes, allylamines, azoles, echinocandins, polyoxins, chitin synthesis inhibitors, and nucleic acid analogs. Each targets a different component or process in the fungal cell, such as the membrane, ergosterol biosynthesis, glucan synthesis, chitin synthesis, microtubule formation, or nucleic acid synthesis. Examples are given for each category along with their typical route of administration.

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    Anti-fungal agents

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    This document categorizes and provides examples of various antifungal drug targets and mechanisms of action. It lists 7 categories of antifungal drugs: polyenes, allylamines, azoles, echinocandins, polyoxins, chitin synthesis inhibitors, and nucleic acid analogs. Each targets a different component or process in the fungal cell, such as the membrane, ergosterol biosynthesis, glucan synthesis, chitin synthesis, microtubule formation, or nucleic acid synthesis. Examples are given for each category along with their typical route of administration.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    7 views1 page

    Anti-Fungal Agents

    Uploaded by

    Guy Seb
    This document categorizes and provides examples of various antifungal drug targets and mechanisms of action. It lists 7 categories of antifungal drugs: polyenes, allylamines, azoles, echinocandins, polyoxins, chitin synthesis inhibitors, and nucleic acid analogs. Each targets a different component or process in the fungal cell, such as the membrane, ergosterol biosynthesis, glucan synthesis, chitin synthesis, microtubule formation, or nucleic acid synthesis. Examples are given for each category along with their typical route of administration.

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    © All Rights Reserved
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    of 1

    Target Category Notes Examples Usage

    Amphotericin B Oral, intravenous


    Polyene Binds to ergosterol, causing
    (Membrane Function) membrane permeability + cell death
    Nystatin Oral, topical

    Allylamine Broad-spectrum antifungal drugs


    Ergosterol (Ergosterol alteration of critical membrane Terbinafine Oral, topical
    inhibitors biosynthesis) transport activities

    Clotrimazole Topical
    Azoles Broad-spectrum antifungal drugs
    (Ergosterol alteration of critical membrane Fluconazole Oral
    biosynthesis) transport activities
    Miconazole Topical

    Blocks activity of 1,3-β-D-glucan


    synthase
    Echinocandins
    ➔ enzyme that forms β -glucan Caspofungin Intravenous
    (glucan)
    polymers in the fungal cell wall
    ➔ Treatment of Candida
    Cell Wall
    Synthesis Polyoxins Inhibits chitin biosynthesis (N-
    Polyoxin A and B Agricultural
    (chitin) acetylglucosamine)

    Chitin synthesis
    X Nikkomycin Z Experimental
    inhibitor

    Microtubule Disrupts microtubule aggregation


    Aromatic Inhibitor Griseofulvin Oral
    Formation during mitosis

    Nucleic Acid Nucleotide analog that inhibits


    Nucleic Acid Analog 5-Fluorocytosine Oral
    Synthesis nucleic acid synthesis

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