QUALITY CONTROL

Document code: Issue status: Effective date:

Page 1 of 2
QP/QC/02/WI-A004 01 10-07-2007
DOCUMENT TITLE:
STANDARD ANALYTICAL PROCEDURE
FOR
CALCIUM CARBONATE

PURPOSE & SCOPE:

It is established for chemical analysis of CALCIUM CARBONATE is applicable to Quality Control department.

RESPONSIBILITY:
1. Manager Quality Control.
2. Assistant Manager Quality Control.
3. Quality Control Analyst.

DESCRIPTION:
Appearance: White or almost white powder.
Solubility: Practically insoluble in water.

IDENTIFICATION:
1) Introduce into a test tube 0.1 g of the substance being examined suspended in 2 ml of water or use 2 ml of the prescribed
solution. Add 3 ml of 2M acetic acid, close the tube immediately using a stopper fitted with a glass tube bent at two right
angles. The solution or suspension effervesces evolving a colourless and odourless gas. Heat gently and collect the gas in
5 ml of 0.1M barium hydroxide. A white precipitate is produced which dissolves on addition of an excess of 7M
hydrochloric acid.
2) Treat a solution of the substance being examined with a solution of magnesium Sulphates. A white precipitate is
produced (distinction from bicarbonates).
3) Dissolve 5.0 g in 80 ml of dilute acetic acid R. When the effervescence ceases, boil for 2 min. Allow to cool, dilute to
100 ml with dilute acetic acid R and filter, if necessary, through a sintered-glass filter. To 0.2ml of this solution, add 5
ml of acetic acid R. Add 0.5 ml of potassium ferrocyanide solution R. The solution remains clear. Add about 50 mg of
ammonium chloride R. A white, crystalline precipitate is formed.
4) To 5 ml of 0.4% w/v solution of the substance being examined add 0.2 ml of a 2% w/v solution of ammonium oxalate. A
white precipitate is produced which is only sparingly soluble in 6M acetic acid but is soluble in hydrochloric acid.

TESTS:
1) Loss on drying: Not more than 2%, determined on 1.000 g by drying in an oven at 200°C ±10.

ASSAY:

Prepared by: Reviewed by: Approved by:

 QUALITY CONTROL
Document code: Issue status: Effective date:
Page 2 of 2
QP/QC/02/WI-A004 01 10-07-2007
DOCUMENT TITLE:
STANDARD ANALYTICAL PROCEDURE
FOR
CALCIUM CARBONATE

Dissolve 0.150 g in a mixture of 3 ml of dilute hydrochloric acid R and 20 ml of water R. Boil for 2 min, allow to cool and dilute to
50 ml with water R. Add 6.0 ml of strong sodium hydroxide solution R and about 15 mg of calconecarboxylic acid triturate R. Titrate
with 0.1 M sodium edetate until the colour changes from violet to full blue.
1 ml of 0.1 M sodium edetate is equivalent to 10.01 mg of CaCO3.
Limit: 98.5 ~ 100.5 %

RELATED DOCUMENTS
S.No Document Title Document Code S.No Document Title Document Code
Request for Sampling of Raw Q.C Analysis Certificate for Raw
1 QF/STR/001 4 QF/QC/003
Material. Material.
2 Raw Material Entry Register QF/QC/006 5 “Approved Raw Material” slip QF/QC/009
3 Analysis Record for Raw Materials QF/QC/017 6 “Rejected Raw Material” slip QF/QC/011

Prepared by: Reviewed by: Approved by: