Mechanism of Adverse Nursing

Drug Data Indications Contraindications Drug Interaction

Action Reaction Responsibilities
Generic Name: Chronic stable  Adjust-a- Contraindications:  Drug-drug.  CNS:  Alert:
AMLODIPINE angina, dose (for all  • Contraindicated Conivaptan, headache, Monitor
vasospastic indications): in patients moderate and somnolence, patient
Brand Name: angina Adults with hypersensitive to strong CYP3A4 fatigue, carefully.
(Prinzmetal or GFR of less drug. inhibitors dizziness. Some
Norvasc
variant angina); than 30  Use cautiously (clarithromycin,  CV: edema, patients,
to reduce risk of mL/minute in patients itraconazole, flushing, especially
Classification: hospitalization shouldn't receiving other ketoconazole, palpitations. those with
Calcium because of receive the ritonavir): May severe
Channel peripheral
angina; to 875-mg vasodilators, increase obstructive
Blocker GI: nausea,
reduce risk of tablet. especially those amlodipine CAD, have
coronary vomiting,
Adults with with severe aortic plasma developed
revascularization diarrhea,
GFR of 10 stenosis or concentration. increased
procedure in to 30 Monitor patient constipation, frequency,
hypertrophic
patients with mL/minute for hypotension abdominal duration, or
cardiomyopathy
recently should with outflow and edema. cramps, rectal severity of
documented receive 250 tract obstruction,  Cyclosporine Hemorrhage angina or
CAD by or 500 mg and in patients (systemic), acute MI
angiography and every 12 with HF with tacrolimus: May GU: after
without HF or hours reduced LVEF. increase levels hematuria, initiation of
with LVEF less depending Because drug is of both drugs. nocturia, calcium
than 40% on the metabolized by Monitor levels channel
dysuria,
infection. the liver, use and patient. urinary blocker
Adults: Initially, Adults with cautiously and in Sildenafil: May therapy or at
5 to 10 mg PO frequency or
GFR of less reduced dosage increase risk of time of
daily. Most than 10 urgency, dosage
in patients with hypotension.
patients need 10 mL/minute Monitor BP
urinary increase.
severe hepatic
mg daily. should disease. closely. Respiratory:  Monitor BP
Elderly patients: receive 250  dyspnea, frequently
Initially, 5 mg
 Dialyzable drug: Simvastatin:
or 500 mg No. Overdose May increase pneumonia, during
PO daily. every 24 Bronchitis initiation of
S&S: Marked risk of
Adjust-a-dose: hours therapy.
peripheral myopathy,
For patients who depending Skin: alopecia, Because
vasodilation with including
are small or frail on the drug-induced
hypotension and rhabdomyolysis. acne, contact
or have hepatic severity of possibly reflex Simvastatin dermatitis, vasodilation
insufficiency, infection. tachycardia. dosage eczema, dry has a gradual
initially, 5 mg Adults on shouldn't skin onset, acute
PO daily. hemodialysis exceed 20 mg hypotension
should daily. is rare.
Other: taste
receive 250
loss, gingival  Notify
or 500 mg prescriber if
every 24 bleeding,
signs of HF
hours with fever, facial occur, such as
an extra dose paralysis, swelling of
both during facial or hands and
and at the generalized feet or
end of edema, flulike shortness of
dialysis. symptoms breath. Alert:
 Mild to Abrupt
moderate withdrawal of
infections of drug may
the ear, nose, increase
and throat; frequency
skin and skin and duration
structure; or of chest pain.
GU tract Taper dose
Adults and gradually
children under
weighing 40 medical
kg or more: supervision.
500 mg PO  Look alike–
every 12 sound alike:
hours or 250 Don't confuse
mg PO every amlodipine
8 hours. with
Children amiloride.
older than
age 3
months
weighing
less than 40
kg: 25
mg/kg/day
PO divided
every 12
hours or 20
mg/kg/day
PO divided
every 8
hours.
Neonates
and infants
up to age 3
months: Up
to 30
mg/kg/day
PO divided
every 12
hour