SUSTAIN SUSTAIN

® ®

SUSTAIN
VetPlus Ltd
‘Animal House’, Boundary Road,
Lytham, FY8 5LT. United Kingdom
When should SUSTAIN be used? ®

In dogs experiencing sub-optimal gastrointestinal health. Customer Services

The first product to

0800 867 283
Fax
01253 797 409
Feeding instructions

combine the benefits of

SUSTAIN is a powder that can be sprinkled over
® E-mail
customer.services@vetplus.co.uk
your dog’s meals.
www.vetplusglobal.com

two licensed probiotics

SUSTAIN®
Bodyweight (Kg)
Daily Amount

One small/medium breed

References
<20 sachet daily 1. Delcenserie V. et al (2008) Immunomodulatory Effects of Probiotics
in the intestinal Tract. Current Issues in Molecular Biology 10:37-
54
20 - 40 One large breed sachet daily
2. Salminen S. et al (1998) Demonstration of safety of probiotics
— a review. International Journal of Food Microbiology 44:93-106
3. Chandler M. (2017) Probiotics in cats and dogs- uses and latest
>40 Two large breed sachets daily studies. Veterinary Times 47:44
4. Chapman C.M. et al (2011) Health benefits of probiotics: are
mixtures more effective than single strains? European Journal of
Composition Nutrition 50(1):1-17

Chicory Inulin, Porcine Liver Powder, Yeast Products (source
of Beta-Glucans), Magnesium Stearate.
Additives
• Enterococcus faecium DSM 10663/NCIMB 10415
• Bacillus subtilis C3102 DSM 15544
• L-Threonine, Zinc (Amino Acid Chelate), Calcium
D-Pantothenate, Pyridoxine Hydrochloride, Folic Acid,
Cyanocobalamin, Flavouring
SUSTAIN® is manufactured to GMP standards
5. Quigley E.M. and Quera R. (2006) Small intestinal bacterial
overgrowth: roles of antibiotics, prebiotics, and probiotics.
Gastroenterology 130(2):S78-S90
6. Hickson M. et al (2007) Use of Probiotic Lactobacillus preparation
to prevent diarrhoea associated with antibiotics: randomised double
blind placebo controlled trial. British Medical Journal 335:80
7. Dellinger E.P. et al (1999) Effect of PGG-glucan on the rate of
serious postoperative infection or death observed after high-risk
gastrointestinal operations. The Archives of Surgery 134:977–983
8. Lutgendorff F. et al (2008) The role of microbiota and probiotics
in stress-induced gastrointestinal damage. Current molecular
medicine 8(4):282-298
9. Zambori C. et al (2016) Antimicrobial Effect of Probiotic on Bacterial
Species from Dental Plaque. Journal of Infection in Developing
Countries 10(3):214-221
10. Marsella R. and Girolomoni G. (2009) Canine Models of Atopic
Dermatitis: A Useful Tool with Untapped Potential. Journal of
Investigative Dermatology 129(10):2351-2357
11. Vahjen W. and Männer K. (2003) The effect of a probiotic
Enterococcus faecium product in diets of healthy dogs on
bacteriological counts of Salmonella spp., Campylobacter spp.
and Clostridium spp. in faeces. Archives of Animal Nutrition
57(3):229-233
12. Fuller R. (1991) Probiotics in Human Medicine. Gut 32:439-442
13. Benyacoub J. et al (2003) Supplementation of food with
Enterococcus faecium (SF68) stimulates immune functions in
young dogs. The Journal of Nutrition 133(4):1158-1162
14. Jeong J.S. and Kim I.H. (2014) Effect of Bacillus subtilis C-3102
spores as a probiotic feed supplement on growth performance,
noxious gas emission, and intestinal microflora in broilers. Poultry
Science 93(12):3097-3103
15. Félix, A.P et al (2010) Digestibility and fecal characteristics of dogs
fed with Bacillus subtilis in diet. Ciencia Rural 40(10):2169-2173
16. Rychlik A. et al (2013) The effectiveness of natural and synthetic
immunomodulators in the treatment of inflammatory bowel disease
in dogs. Acta Veterinaria Hungarica 61(3):297-308
17. Beynen A.C. et al (2011) Dietary beta-1.3/1.6-glucans reduce
clinical signs of canine atopy. American Journal Animal Veterinary
Science 6(4):146-152
18. Haladová E. et al (2011) Immunomodulatory effect of glucan on
specific and nonspecific immunity after vaccination in puppies. Acta
Veterinaria Hungarica 59(1):77-86
19. Van der Beek C.M. et al (2018) The prebiotic inulin improves
substrate metabolism and promotes short-chain fatty acid
production in overweight to obese men. Metabolism. 87:25-35
20. Apanavicius C.J. et al (2007) Fructan supplementation and
infection affect food intake, fever and epithelial sloughing from
Salmonella challenge in weanling puppies. The Journal of Nutrition
137(8):1923-1930

92190.2
 SUSTAIN
®

SUSTAIN
®
The FIRST product to combine the
benefits of two licensed probiotics

Background
SUSTAIN® can be The gut mucosal barrier is colonised by a complex
used in the following population of microorganisms, known as the
situations: microbiota. This intestinal microbiota has the

• IBD / Colitis3
• Acute and chronic
diarrhoea3
Bacillus
ability to modulate innate and adaptive immune
responses, at both local and systemic levels,
through interactions with gut associated lymphoid
tissue (GALT)1.

Probiotics are live microorganisms that, when

• SIBO / Antibiotic
Responsive Diarrhoea5
• In conjunction with
or post antibiotic
treatment6
• Prior to and following
GI surgery 7
• Times of stress and
convalescence8
• Dental disease9
• Atopic dermatitis 10
subtilis
administered to the host, provide a beneficial
effect on health2. Different probiotic species
achieve this by positively modifying the
microbiota, through actions such as pathogen
Enterococcus
exclusion, secretion of antimicrobial factors and
stimulation of immune cells, which all help to
improve gastrointestinal health.
Prebiotics are non-digestible substrates,
which promote the growth and function of
faecium
both probiotic bacteria and the microbiota,
making them essential supportive ingredients.
There is now growing evidence that
combining multiple probiotic strains is more

efficacious than using a single source4.

SUSTAIN
® Enterococcus faecium is a licensed
probiotic for dogs, which has been
shown to inhibit the growth of
contains...
pathogens, such as Clostridia11.
E.faecium is a natural, commensal
bacterium that competes with
pathogens for nutrients and receptor
sites12 and has been found to
influence canine immune systems13.
Oral administration of E.faecium in
young dogs has been found
to increase and enhance lgA
production13, the most predominant
immunoglobulin within the
gastrointestinal tract.
Bacillus subtilis is another probiotic
strain licensed for use in dogs and is
unique to SUSTAIN®. This probiotic
can tolerate extreme environments,
by forming a protective endospore14,
allowing it to survive the low pH of
gastric acid. B.subtilis also creates the
optimum anaerobic environment, for
the growth of beneficial Lactobacilli
within the microbiota14.
In addition, it has been demonstrated
to improve faecal odour and
consistency in dogs15.
MacroGard® from yeast, is a L-Threonine is important for normal
unique Beta-glucan; a type of physiology of the gastrointestinal tract.
immunomodulatory molecule which has
been found to be beneficial for dogs with B-vitamins are important for enterocyte
IBD16 and atopic dermatitis17 as and immune cell metabolism.
well as improving the immune response
to vaccination18. Zinc amino acid chelate
is important for energy metabolism,
Inulin is a fructooligosaccharide prebiotic immune cell function and mucosal
that encourages production of short membrane integrity.
chain fatty acids by the microbiota,
which are essential for colonocyte health
and metabolism19. Inulin has also been
found to help protect against bacterial
infection20.