BSE222/BSE612

Biochemical Engineering

ASHOK KUMAR

Department of Biological Sciences and

Bioengineering
Indian Institute of Technology Kanpur

Semester-II (2023-2024)
 BSE222/612
Biochemical Engineering
Course Contents

Biochemical engineering: Upstream and Downstream

Bioseparations and bio-processes, Downstream processing.
Characteristics of biological materials, pretreatment methods;
separation of cell biomass, adsorption, filtration, centrifugation, affinity
bases separation, polishing-crystallization, drying, case studies;
Process integration. Bioprocess integration for efficient production
and recovery, scale-up consideration, process monitoring and process
economics

Biochemical engineering: Stoichiometry and energetics of microbial

metabolism. Transport phenomena. Enzyme catalyzed reactions and
processes. Bioreactor design and applications. Sterilization.
Instrumentation and control

Environmental bioprocesses. Interaction of mixed microbial

population, applications, biological wastewater treatment, anaerobic,
digesters, bioremediation.
List of Books and suggested readings
1. Blanch, H. W. and Clark, D. S. “Biochemical Engineering”.
Marcel Dekker, Inc.,

2. Bailey, J. E. and Ollis, D. F. “Biochemical Engieering Fundamentals”.

McGraw-Hill, Inc.,

3. Belter, P. A., Cussler, E. L. and Hu, W. S. “Bioseparations:

Downstream Processing for Biotechnology”, John Wiley & Sons

4. Desai, Mohamed. A. Downstream Processing of Proteins:

Methods and Protocols. Humana Press

5. Shuler, M. L. and Kargi, F. Bioprocess Engineering- Basic Concepts

6. Protein Purification _Principles and Practice _Robert Scopes

7. Enfors Sven-Olof & Häggeström Lena, Bioprocess Technology- Fundamentals

and Applications

8. Lecture notes of the class lectures

Evaluation

1. Attendance 10%*

2. Mid sem Exam 30%

3. Quiz , assignment & presentations 20%

4. End sem Exam 40%

* Less than 50% attendance will deregister the student from course
Biochemical engineering/ Bioprocess engineering

Biochemical Engineering also known as Bioprocess Engineering is a

branch of Chemical Engineering or Biological Engineering. It is a
branch of engineering that deals with the design and construction of
unit processes that involve biological organisms or molecules.

The efficient utilization of physical, chemical and biological

processes to convert raw materials into useful products, at
minimal cost, with minimal energy consumption, and with
minimal impact on the environment.