2.

30%
62%
68.8%
1.5
Cummulative release (mg)

74.4%
78.6%
80%

1.0

0.5

0.0
0 20 40 60 80 100
Time (min)

Figure 1 - Effect of Percent Loading on 5-FU Drug release.

2.0 PBS
NaCl
KI
Urea
1.5 Glucose
Cummulative release (mg)

1.0

0.5

0.0
0 20 40 60 80 100
Time (min)

Figure 2 - Effect of Physiological Fluids on 5-FU Drug release.

 2.0

1.8
0
1.6 15 C
0
30 C
Cummulative release (mg)

1.4 0
45 C
1.2

1.0

0.8

0.6

0.4

0.2

0.0
0 20 40 60 80 100
Time (min)

Figure 3 - Effect of temperature on 5-FU Drug release.

 0.20 gm
2.0
0.30 gm
1.8 0.35 gm
0.40 gm
1.6
Cummulative release (mg)

1.4

1.2

1.0

0.8

0.6

0.4

0.2

0.0
0 20 40 60 80 100
Time (min)

Figure 4 - Effect of chitosan concentration on 5-FU Drug release.

1 ml
2.0 2 ml
3 ml
1.8

1.6
Cummulative release (mg)

1.4

1.2

1.0

0.8

0.6

0.4

0.2

0.0
0 20 40 60 80 100
Time (min)
Figure 5 - Effect of lactic acid concentration on 5-FU Drug release

Table 1. Kinetic analysis of release data showing the release exponent under varying experimental
conditions

S. No. Chitosan (g) Lactic acid (ml) n Mechanism

1 0.3 1 0.486 Fickian

2 0.3 3 0.535 Anomalous
3 0.2 2 0.460 Fickian
4 0.4 1 0.477 Fickian
5 0.3 2 0.493 Fickian
6 0.2 4 0.422 Non- Fickian
7 0.1 4 0.447 Non - Fickian
8 0.35 2 0.531 Anomalous
9 0.35 1 0.482 Fickian
10 0.4 3 0.533 Anomalous
11 0.1 3 0.551 Anomalous