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Medsurg 8 Cardiovascular Medications
Medsurg 8 Cardiovascular Medications
Medsurg 8 Cardiovascular Medications
COMMON ANTICOAGULANTS
ANTICOAGULANTS 1. Heparin Sodium
2. Enoxaparin or Rivaroxaban
ORAL
3. Warfarin sodium
● Warfarin sodium 4. Dabigatran etexilate
● Dabigatran etexilate mesylate
● Rivaroxaban
1) HEPARIN SODIUM
● Apixaban
● Prevents thrombin from converting
PARENTERAL
fibrinogen to fibrin
LIST OF RX ● Argatroban
○ Fibrin is responsible for blood clot
● Bivalirudin
formation; Heparin prevents fibrin
● Dalteparin
DEFINITION ● Prevents thromboembolism
● Desirubin
● Therapeutic dose does not dissolve clots
● Enoxaparin
but prevents new thrombus formation.
● Fondaparinux
○ Therapeutic dose is different from
● Heparin sodium
therapeutic value
● Prevent the extension and formation of
● Monitor aPTT
clots by inhibiting factors in the clotting
○ Normal aPTT: 30-40 seconds
cascades and decreasing blood
DEFINITION ○ Therapeutic level: 1.5 - 2.5 x normal
coagulability.
value
● Very common for those disorders that have
○ Should be measured q4-6H during the
thrombus formation problems
initial infusion of therapy
● Myocardial infarction ○ If aPTT is too long, doctor may order
● Unstable angina to decrease dosage; if too short,
● Atrial fibrillation doctor may order to increase the
● Deep vein thrombosis dosage
● Pulmonary embolism ● Monitor platelet count
INDICATION ● Presence of mechanical heart valves ○ Anticoagulants can lower down
These disorders has a problem with blood clot platelet count and puts patient at risk
formation/ thrombosis formotion. With the help of INTERVENTI for bleeding
our anticoagulants it will help to decrease blood ONS ● Observe for bleeding gums, bruises,
clot formation and will prevent creating a new nosebleeds, hematuria, hematemesis, occult
clot. blood in the stool, and petechiae
Anticoagulants prolong or increase the time for ● Instruct the client regarding measures to
the blood clots to form and to prevent formation prevent bleeding
of new blood clots.When we give anticoagulants, ● The antidote to heparin is protamine sulfate
the one problem we need to monitor is the ○ Take note in giving heparin through IV
bleeding or hemorrhage. That is why it is C/I to: infusion, we must use an infusion
C/I
● Active bleeding pump to ensure a precise rate of
● Bleeding d/o or blood dyscrasias (disease) delivery and correct dosage.
● Ulcers (cause GI bleeding) ● Inject into the abdomen with ⅝ inch (16-mm)
● Liver and kidney disease or needle (25 to 28 gauge) at 90 degree
● Hemorrhagic brain injuries angle and do not aspirate or rub the injection
● Allopurinol site.
● Cimetidine
● Corticosteroids 2) ENOXAPARIN OR RIVAROXABAN
SUBSTANC ● Green, leafy vegetables and other foods
● Low-molecular-weight heparins
ES TO high in Vitamin K
● Have the same mechanism of action and
AVOID WITH ● Nonsteroidal anti-inflammatory drugs
use as heparin but are not interchangeable
ANTICOAG ● Oral hypoglycemic agents
with heparin
ULANTS ● Phenytoin
DEFINITION ○ Enoxaparin has a lower incidence of
● Salicylates
bleeding and other complications;
● Sulfonamides
Unlike heparin, it is life-threatening due
● Gingko and ginseng (herbs)
to severe adverse reaction called
Heparin-induced thrombocytopenia
Notes by: Caloocan boy :> #PogiProblems 1
○Enoxaparin is more preferred for INTERVENTI ● Same as for warfarin, except no routine
long-term use because Heparin cannot ONS monitoring is required.
be used long term, only short-term.
● Administer enoxaparin subcutaneous
injection into the anterolateral or THROMBOLYTIC MEDICATIONS
posterolateral abdominal wall ● Alteplase
● Do not expel air bubble from the prefilled LIST OF RX
● Tenecteplase
syringe or aspirate during injection ● Activate plasminogen to generate plasmin.
○ E.g., Clexane - the syringe has a small ○ Plasmin is the enzyme that dissolves
area in which we should not expel. clots.
○ so makita ni ninyo sa area if you have Note: The role of anticoagulants is to prevent or
the authority to give the medication, ACTION
decrease the blood clot formation, but for
make sure ayaw jud i-expel ang air thrombolytics; meaning there is already clot
INTERVENTI bubble para ang ato ma hatag na rate
ONS formation, so thrombolytics's role is to dissolve
or dose is fixed and precise and do not clots.
aspirate. Also do not aspirate when More on disorders that have blood clot formation
you inject. ● Myocardial infarction
● Rivaroxaban is taken orally, once daily. ● Arterial thrombosis
INDICATION
● Deep vein thrombosis
● Occluded shunts or catheters
● Pulmonary emboli
Same with anticoagulants, contraindicated for
patients who have active bleeding or those
Picture: Clexane conditions at higher risk for bleeding
● Active internal bleeding
3) WARFARIN SODIUM ● History of hemorrhagic stroke
● Suppresses coagulation by acting as an ● Intracranial problems including trauma
antagonist of vitamin K by inhibiting 4 ● Intracranial or intraspinal surgery within the
dependent clotting factors (X, IX, VII, and C/I previous two months
II). ● Thoracic, pelvic, or abdominal surgery within
○ Vitamin K helps in blood clot formation. the previous ten days
DEFINITION Warfarin prevents vitamin K. This is by ● History of hepatic or renal disease
inhibiting the 4 dependent clotting ● Uncontrolled hypertension
factors ● Recent, prolonged cardiopulmonary
● Prolongs clotting time and is monitored by resuscitation
the prothrombin time (PT) and the ● Known allergy to product or its preservatives
international normalized ratio SIDE & ● Bleeding
● Warfarin is used for long term ADVERSE ● Dysrhythmias
anticoagulation to prevent thromboembolic EFFECTS ● Allergic reactions
conditions such as: More on monitoring the bleeding
○ Thrombophlebitis ● Determine aPTT, PT, fibrinogen level,
○ Pulmonary Embolism hematocrit, and platelet count.
INDICATION ● Monitor vital signs.
○ Embolism Formation
● E.g., if our patient is using Heparin and they ● Assess pulses.
are to be discharged the next day, the ● Monitor for bleeding and check all excretions
doctor will discontinue Heparin and will start for occult blood.
Warfarin ● Monitor for neurological changes.
● Monitor PT and INR. ● Monitor for hypotension and tachycardia.
INTERVENTI
NOTE: ○ Signs of shock
ONS
● If patient is on Warfarin: PT & INR ● Avoid injections and venipunctures if possible.
● If patient is on Heparin: Only aPTT is ● Apply direct pressure over a punctuation site
important to monitor, but it does not mean we for 20 to 30 minutes.
should not check other laboratory values ● Handle the client gently when moving
● If Enoxaparin and Rivaroxban: no need to
● Instruct the client to use an electric razor for
monitor the 3 laboratory values
INTERVENTI ● shaving and to brush teeth gently.
Observe for bleeding gums, bruises,
ONS ● Withhold the medication if bleeding develops
nosebleeds, hematuria, hematemesis,
and notify the physician if bleeding occurs.
occult blood in the stool, and petechiae.
● Antidote: Aminocaproic acid
● Instruct the client regarding diet and
measures to prevent bleeding.
○ Diet: avoid food rich in vitamin K such ANTIPLATELET MEDICATIONS
as green leafy vegetables
● The antidote for warfarin is phytonadione Oral
(Vitamin K). ● Acetylsalicylic Acid
● Anagrelide
● Cilostazol
4) DABIGATRAN ETEXILATE
● Clopidogrel
● Works through direct inhibition of thrombin,
preventing the conversion of fibrinogen into LIST OF RX ● Dipyridamole
● Ticlopidine
fibrin and activation of factor XIII.
● Ticagrelor
DEFINITION ○ Factor XIII: stabilize the formation of
blood clots Parenteral
● Use for clot prevention associated with ● Abciximab
nonvalvular atrial fibrillation. ● Eptifibatide
● Tirofiban 4.
Hepatotoxicity (caused by elevated enzyme
● Inhibit the aggregation (formation) of levels)
platelets in the clotting process, thereby 5. Hypersensitivity (manifested by wheezing,
prolonging the bleeding time. shortness of breath, pruritus, urticaria,
ACTION ○ If bleeding time is prolonged, there clammy skin, and flushing)
would be slow formation of the blood 1. Positive inotropic and cardiotonic
clot so it prevents blood clot medications
formation. 2. For continuous IV infusion, administer with
● It can be used together with the an infusion pump.
anticoagulants. 3. Stop the infusion if the client’s BP drops or
IND ● Prophylaxis of long-term complications dysrhythmias occur
such as MI, coronary revascularization, 4. Monitor the apical pulse and BP
stents and stroke. 5. Monitor for hypersensitivity
● Bleeding disorders 6. Assess lung sounds if there are presence of
C/I INTERVENTI wheezing or crackles
● Hypersensitivity
1. Bruising ONS 7. Monitor for edema
SIDE & 8. Monitor for relief of heart failure
2. Hematuria
ADVERSE 9. Noted by reduction of edema, also
3. Gastrointestinal bleeding
EFFECTS lessening of dyspnea, and fatigue)
4. Tarry stools
1. A blood test may be prescribed 10. Monitor electrolyte and liver enzyme levels,
● To determine the client sensitivity to platelet count, and renal function studies
the medication before beginning the 11. This is because these medications may
administration decrease the potassium level and increase
2. Monitor the vital signs. the liver enzyme level
3. Instruct the client to take medication with 12. Consider a continuous ECG monitoring
food if gastrointestinal upset occurs
4. Monitor bleeding time CARDIAC GLYCOSIDES
5. Instruct the patient to monitor for side
INTERVENTIO
and adverse effects and in the measures DIGOXIN
NS
to prevent bleeding. ● Inhibit the sodium-potassium pump →
● If a patient is receiving increasing intracellular calcium → causes
anticoagulants, thrombolytics,and heart muscle fibers to contract more efficiently
antiplatelets; the primary concern for ● Produce a positive inotropic action →
ACTION
these 3 medications is the bleeding increases the force of myocardial contractions
time, therefore we should monitor ● Produce a negative dromotropic action →
the bleeding in our patient and/or Slows conduction velocity through the
put the patient in/as bleeding atrioventricular (AV) node
precaution. ● Heart failure
● Cardiogenic shock
IND ● Atrial tachycardia
POSITIVE INOTROPIC AND CARDIOTONIC
● Atrial fibrillation
MEDICATIONS
● Atrial flutter
● Stimulates myocardial contractility ● Ventricular dysrhythmias
○ Helps myocardium contract ● Second or third degree heart block
C/I
● Produces a positive inotropic effect ● Renal disease
○ Helps cardiac muscle contract stronger, ● Hypothyroidism
helps cardiac output back to a normal level, DIGOXIN TOXICITY
and increases amount of blood that heart ● If digoxin is used long-term and if there is
can pump out CAUSES overuse of digoxin, digoxin toxicity will
● Aids in the distribution of blood flow to other organs happen
● Helps increase myocardial contractility that would not B = Bradycardia
only improve the cardiac but also the peripheral and A = Anorexia
kidney function in our patient. N = Nausea
● Helps in increasing cardiac output and decreasing the D = Diarrhea
preload, improves blood flow to the periphery and A = Abdominal Pain
kidneys. CLINICAL V = Visual disturbance (yellow or green halos,
EXAMPLES MANIFESTA blurred vision, diplopia, photophobia)
Dobutamine TIONS
● Used for short term management of heart failure Early signs of toxicity:
● Increases myocardial contractility 1. Gastrointestinal Manifestations (anorexia,
Dopamine nausea, vomiting, diarrhea)
● Used as a short term rescue measure 2. Heart rate abnormalities
● Increases myocardial contractility
● Dilates renal blood vessels and increases renal blood flow
3. Visual disturbances
and urine output ● Monitor for toxicity
Milrinone Lactate ○ Remember the mnemonic BANDAV
● Used for short term management of heart failure; may be ● Monitor serum digoxin level, electrolyte
given before heart transplantation levels, and renal function test results
INTERVENTI
IND ● Heart Failure ○ Therapeutic range for digoxin is 0.5 -
ONS
SIDE AND 1. Dysrhythmias 2.0 mg/dl
ADVERSE 2. Hypotension ○ However a level on the low end of
EFFECTS 3. Thrombocytopenia normal, it is preferred in order to avoid
toxicity.
● Monitor potassium level especially for ● Instruct the client to take the medication in
hypokalemia the morning in order to avoid nocturia and
○ Less than 3.5/L (max) sleep interruption
○ Notify healthcare provider if ● Instruct the client in how to record the BP
hypokalemia occurs. ● Instruct the client to eat foods high in
■ High risk for digoxin toxicity potassium
● Instruct the client to avoid over-the-counter ● Instruct the client in how to take potassium
medications supplements if prescribed
● Monitor the client taking a potassium losing ● Instruct the client to take medication with
diuretic or corticosteroids closely for food in order to avoid GI upset
hypokalemia ● Instruct the client to change positions slowly
● Note that older clients are more sensitive to in order to prevent the orthostatic
digoxin toxicity. hypotension
● Advise the client to eat foods high in ● Instruct the client to use sunscreen when in
potassium such as fresh and dry fruits, fruit direct sunlight because of increased
juices, vegetables and potatoes photosensitivity
● Monitor the apical pulse for 1 full minute ● Instruct the client with diabetes mellitus to
○ Lower than 60 bpm = medication have the blood glucose checked
should be withheld; notify the periodically
physician
○ Teach the client how to measure the LOOP DIURETICS
pulse ● Loop diuretics inhibit sodium and chloride
● Antidote: Digoxin immune Fab is used in reabsorption from the loop of Henle and the
extreme toxicity distal tubule.
○ Focuses more on the sodium and
chloride.
ANTIHYPERTENSIVE MEDICATIONS: DIURETICS ● It has a little effect on the blood glucose
a. Thiazide diuretics level however they cause depletion of water
i. Chlorothiazide ACTION and electrolytes, and also they can increase
ii. Chlorthalidone the uric acid levels and excretion of calcium
iii. Hydrochlorothiazide sa px.
iv. Indapamide
● It can also cause rapid diuresis, so mas
v. Metolazone
b. Loop diuretics paspas ang excretion niya.
c. Osmotic diuretics ○ Faster excretion = decreased vascular
d. Potassium-retaining (sparing) diuretics fluid volume, decreased cardiac output,
and decreased blood pressure
THIAZIDE DIURETICS ● Hypertension - Loop diuretics can
Increases sodium and water excretion by decrease the blood pressure
ACTION inhibiting sodium reabsorption in the distal tubule ● Pulmonary Edema - If there is edema,
of the kidney. there is a lot of fluid inside the body of our
● Hypertension patient. Diuretics can help to excrete those
IND ● Peripheral edema INDICATION excess fluid volume in our patient.
NOT EFFECTIVE FOR IMMEDIATE DIURESIS. ● Hypercalcemia - It can increase the
● Lithium excretion of calcium. So if hypercalcemia
○ It can cause lithium toxicity, since inyong patient, it can help in order to lower
thiazide will excrete the sodium, less the calcium level.
sodium can increase the lithium ● Renal disease
C/I ● Digoxin
levels.
● Digoxin ● Lithium
● Corticosteroids CONTRAIND ● Aminoglycosides
● Hypoglycemic medications ICATION ● Anticoagulants
● Hypercalcemia, hyperglycemia, ● Corticosteroids
hyperuricemia ● Amphotericin B
● Hypokalemia, hyponatremia ● Hypokalemia (low potassium),
SIDE & hyponatremia (low sodium), hypocalcemia
● Hypovolemia
ADVERSE (low calcium), hypomagnesemia (low
● Hypotension
EFFECTS magnesium)
● Rashes
● Photosensitivity ● Thrombocytopenia
SIDE
● Dehydration ● Hyperuricemia
EFFECTS &
● Monitor vital signs ● as mentioned a while ago, loop diuretics
ADVERSE
● Monitor weight can increase the uric acid levels
EFFECTS
○ Very important if the patient has ● Orthostatic hypotension
edema to check if medication is ● Rash
effective in patients with edema. ● Ototoxicity and deafness
INTERVENTI ● Monitor urine output ● Thiamine deficiency
ONS ● Monitor the electrolytes, glucose, calcium. ● Dehydration
Blood urea nitrogen (BUN), creatinine, and ● Same with thiazide diuretics
uric acid levels ● Monitor electrolytes, calcium, magnesium,
● Check peripheral extremities for edema BUN, creatinine, and uric acid levels
INTERVENTI
● Monitor for signs of digoxin or lithium ● Administer IV furosemide slowly over 1 to 2
ONS
toxicity minutes
○ Because hearing loss can occur if it is
injected rapidly.
Notes by: Caloocan boy :> #PogiProblems 4
● Migraine headaches
TRANSDERMAL PATCH ● Prevention of Myocardial infarction
a. Instruct the client to remove the ointment on the skin ● Glaucoma
from the previous dose. ● Asthma
b. Instruct the client to squeeze a ribbon of ointment of ● Bradycardia
the prescribed length onto the applicator or ● Heart failure
dose-measuring paper. ● Severe renal or hepatic disease
c. Instruct the client to spread the ointment over a 2.5- ● Hyperthyroidism
by 3.5-inch (6.5 by 9 cm) area and cover with plastic ● Stroke
wrap, using the chest, back, abdomen, upper arm, or ● Diabetes Mellitus
anterior thigh. C/I
○ Can cause hypoglycemia
d. Instruct the client to rotate sites and to avoid touching ● Antihypertensive medication
the ointment when applying. ○ This medication can decrease the BP;
if an antihypertensive medication is
PATCHES AND OINTMENTS given together with beta adrenergic
a. Wear gloves when applying the patches and blockers, severe hypotension may
ointments to our patients. occur
b. Do not apply on the chest in the area of ● Bradycardia
defibrillator-cardioverter pad placement. ● Bronchospasm
○ This is because skin burns can result if the ○ tightening or narrowing of airway
pads need to be placed. ● Hypotension
● Weakness, fatigue
REMEMBER! If nitroglycerin tablets are used by the patient, ● Nausea, vomiting
we need to check the expiration date on the medication SIDE &
● Dizziness
bottle. ADVERSE
● Hyperglycemia
Not only for us nurses, but it is also important to instruct our EFFECTS
● Agranulocytosis
patient to check the medication bottle for the expiration date. ○ Severe reduction in the white blood
This is because expiration may occur within six months of cells, specifically the granulocytes
obtaining the medication and then the tablets will not relieve ● Behavioral or psychotic response
the chest pain if they're already expired. ● Depression
● Nightmares
● Monitor vital signs (especially BP)
PART 2: CARDIOVASCULAR MEDICATIONS ● Withhold the medication if the pulse or BP is
a. β-Adrenergic Blockers not within the prescribed parameters.
b. Calcium Channel Blockers ○ A decrease of PR and BP
c. Peripheral vasodilators ● Monitor For signs of heart failure or
d. Direct-acting Arterial Vasodilators worsening heart failure
e. Miscellaneous Vasodilators ● Assess for respiratory distress and for signs
● Nesiritide of wheezing and dyspnea.
f. Antidysrhythmic Medications
● Instruct the client to report dizziness,
g. Adrenergic Agonists
● Dobutamine lightheadedness, or nasal congestion.
● Dopamine ● Instruct the client not to stop the medication.
● Epinephrine ○ Because there will be rebound
● Norepinephrine hypertension, rebound tachycardia or
INTERVENT
anginal attack.
IONS
β-ADRENERGIC BLOCKERS ● Advise the client taking insulin that
●
Inhibit response to β-adrenergic B-adrenergic blocker can mask early signs of
stimulation, thus decreasing cardiac output. hypoglycemia.
If there would be decreased cardiac output, ○ Such as tachycardia and nervousness
there would also be decreased blood ● Instruct the client in taking insulin to monitor
pressure. the blood glucose level.
DEFINITION ● Instruct the client in how to take pulse and BP
● They block the release of catecholamines,
epinephrine, and norepinephrine. These ● Instruct the client to change positions slowly
can decrease heart rate & blood pressure, ○ To prevent the orthostatic hypotension
the workload of the heart, and the oxygen ● Instruct the client to avoid over-the-counter
demands. medications
Nonselective (Blockβ1 and β2) ○ especially the cold medications and
● Carvedilol nasal decongestants
● Labetalol
● Nadolol CALCIUM CHANNEL BLOCKERS
● Pindolol ● Amlodipine
● Propranolol ● Clevidipine
● Sotalol ● Diltiazem
LIST OF RX ● Felodipine
Cardioselective (Block β1)
● Acebutolol ● Isradipine
LIST OF RX
● Atenolol ● Nicardipin
● Betaxolol ● Nifedipine
● Bisoprolol ● Nimodipine
● Esmolol ● Nisoldipine
● metoprolol ● Verapamil
● Angina ● Decrease cardiac contractility and the
INDICATION ● Dysrhythmias ACTION workload of the heart, thus decreasing the
● Hypertension need for oxygen
Notes by: Caloocan boy :> #PogiProblems 7
NOREPINEPHRINE
● Stimulates the heart in cardiac arrest
● Vasoconstricts and increases the BP in hypotension and
shock