Government Holkar (Model, Autonomous) S Indore (M.P.) nce College, (Department of Chemistry) Part A - Introduction Programme- Degree Class — B.Sc. Vi | Year- 2023 Session- Semester i 2023-24 Course Type (Subject) — Core Group B Paper-Il 1_| Course Code CHEM4D 2_| Course Title Physical, Bio-inorganic and Organometallic Chemistry 3 | Pre—requisite (ifany) | To study this course the student must have the subject, chemistry in diploma course of B.Sc. or equivalent. 4 | Course Learning ‘On completion of this course the students will be able to ‘Outcomes (CLO) understand: * Biophysical concepts like pH, biological Learning nes (CLO) oxidation, bioenergetics. ‘+ Magnetic properties and electronic spectra of transition metal complexes. ‘* Structure and bonding analysis of organometallic compounds using the MO theory * Organometallic compounds of main groupelements and their structure and bonding analysis + Bio inorganic chemistry and role of metal ions in biological systems. 5 | Credit Value 04 (Theory) 6 | Total Marks Formative Assessment (CCE) — 40 Marks Minimum Summative Assessment (End Semester Exam) — Pass 60 Marks: Marks — Total 40+60= 100 Marks 35 ra, ' oe aia \ee 1|PageIndore (M.P.) ___ Wepartment of Chemistry) Part —B Content of the Course Government Holkar (Model, Autonomous) Science College, Total no. of lectures — As per UGC rules (1 Credit = 15 Lectures) 5. No. Topies No. of Lectures Water, pH & buffer Water as a medium for biological reaction, concept of pH in terms of biological system, effect of pH on a biomolecule, biological buffers system Bonding in biomolecules hydrogen bond, Vander Waal interaction, ionic bond hydrophobic attraction, mglycoside linkage peptide bond, phosphodiester linkage Role of different biological buffer system like -Phosphate Buffer, bicarbonate buffer protein amino acid buffer, hemoglobin buffer system Biological oxidation-definition, types of biological oxidation, reduction oxidation by direct action of oxygen,oxidation by loss of hydrogen Electron transport chain, inhibitors of ETC Oxidative phosphorylation - definition, theories inhibitors of oxidative phosphorylation, Un- couplers Bioenergetics -couple reactions, law of thermodynamics, energy, relationship between standard fice energy change and equilibrium constant, general introduction of high energy compounds Structure of ATP as universal currency of free energy in biological systems with example -in muscle contraction, free energy of ATP hydrolysis. Magnetic properties of transition metal complexes Introduction, types of magnetic behaviour: diamagnetism, paramagnetic, and ferro magnetism, antiferromagnetism, _ferrimagnetism, calculation of magnetism. methods of determining magnetic suscepti guy, Bhatnagar Mathur, Quincke's, Curie and nuclear Magnetic resonance method, magnetic moment, LS coupling, determination of ground state ‘terms symbol, orbital contribution to magnetic moments and application ‘of magnetic moment data for 3D metal complexes. An Introduction to Organometalic Compounds- Definition and Classification with appropriate examples based on nature of metal-carbon bond (ionic, s, p and multicentre bonds). ‘Metal Alkyls: Important structural features of methyl lithium (tetramer) and trialkyl aluminium (dimer), concept of multicentre bonding in these a Siro. RY \owIndore (M.P.) (Department of Chemistry) Government Holkar (Model, Autonomous) Science College, compounds. Role of triethylaluminium in polymerisation of ethene (Ziegler - Natta Catalyst). Organomagnesium compounds- Grignard reagent, _ preparations, structure and chemical reactions. Organozine compounds-Preparations and chemical reactions. Organolithium compounds- Preparations and chemical reactions. Organosulphur compounds.Nomenclature, structural characteristics. Thiol. thio-ether, sulphonic acid, sulphonamide and sulphaguanidine- methods of preparations and chemicalreactions. Vv Metal Carbonyls-18 clectron rule, electron count of mononuclear, polynuclear and substituted metal carbonyls of 3d series. General methods of preparation (direct combination, reductive carbonylation, thermal and photochemical decomposition) of mono and binuclear carbonyls of 3d series. Structures of mononuclear and binuclear carbonyls of Cr, Mn, Fe, Co and Ni using VBT. x- acceptor behaviour of CO (MO. diagram of CO to be discussed), synergic effect and use of IR data to explain extent of back bonding. Zeise's salt: Preparation and structure, evidences of synergic effect and comparison of synergic effect with that in carbonyls, Bioinorganic Chemisiry- Metal ions present in biological systems, classification of elements according to their action in biological system. Geochemical effect on the distribution of metals. Sodium / K-pump, carbonic anhydrase and carboxypeptidase. Excess and deficiency of some trace metals. Toxicity of metal ions (Hg, Pb, Cd and As), reasons for toxicity. Use of chelating agents in medicine, Iron and its application in bio-systems, Role of Mg ions in energy production and chlorophyll. Role of Ca" in blood clotting Hemoglobin; Storage and transfer of iron. Part - C Learning Resources Text Books, Reference Books, Other Resources ‘Suggested Readings: 1, Vogel, A.I. Qualitative Inorganic Analysis, Longman, 1972 36 2. Svehla, G. Vogel's Qualitative Inorganic Analysis, 7th Edition, Prentice Hall, 1996-03-07. 3. Cotton, F.A. G.; Wilkinson &Gaus, P.L. Basic Inorganic Chemistry 3rd Ed.; Wiley India, 4, Huheey, J. Es Keiter, B.A. &Keiter, RL. Inorganic Chemisty, Principles of Structure and LXV cc Q “ynfls 31Page LGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Harper Collins 1993, Pearson, 2006. 5. Sharpe, A.G. Inorganic Chemistry, 4th Indian Reprint (Pearson Education) 2005, 6., Douglas, B. E.; McDaniel, D.H. & Alexander, J.J. Concepts and Models in Inorganic Chemistry 3rd Ed., John Wiley and Sons, NY, 1994. 7. Greenwood, N.N. & Earnshaw, A. Chemistry of the Elements, Elsevier 2nd Ed, 1997 (Ziegler Natta Catalyst and Equilit 8, Lee, J.D. Concise Inorganic Chemistry Sth Reactivity 4th in Grignard Solution). John Wiley and sons 2008. 9. Powell, P. Principles of Organometallic Chemistry, Chapman and Hall, 1988. 10. Shriver, D.D. & P. Atkins, Inorganic Chemistry 2nd Ed., Oxford Ui sity Press, 1994 11. Basolo, F. & Person, R. Mechanisms of Inorganic Reactions: Study of Metal Complexes in Solution 2nd Ed., John Wiley & Sons Inc; NY. 12. Purcell, K.F, &Kotz, J.C., Inorganic Chemistry, W.B. Saunders Co. 1977 13. Miessler, G. L. & Donald, A. Tarr, Inorganic Chemistry 4th Ed,, Pearson, 2010. Collman, James P. etal. Principles and Applications of Organotransition Metal Chemistry. Mill Valley, CA: University Science Books, 1987. 14, Crabtree, Robert H. The Organometallic Chemistry of the Tran: NY: John Wiley, 2000. 15, Spessard, Gary O., &Gary L, Miessler. Organometallic Chemistry. Upper Saddle River, NJ: Prentice-Hall, 1996, 16, Elschenbroich, C., Salzer, A. Organometallics - A Concise Introduction, 2nd Edn., (VCH ion Metals. j New York, Publication, 1992), 17. Crabtree, R. H. The Organometallic Chemistry of the Transition Metals, 6th Edn., (John Wiley, 2014). 18, Powell, P. Principles of Organometallic Chemistry, 2nd Edn, (Chapman, London, 1988). 19. Bioinorganic Chemistry, Ivano Bertini, Harry B, Gray, Stephen J. Lippard, Joan Selverstone Valentine, Viva Book Private Books Limited. 20. Biophysical Chemistry, Avinash Upadhyay, Kakoli Upadhyay, Nirmalendu Nath, Himalaya Publishing House, ‘Suggested equivalent online 4lPage \yweGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (2) (Department of Chemistry) Part ~D Assessment and Evaluation Internal Assessment: Continuous Comprehensive Evaluation (CCE)/ Formative Assessment: 40 Marks Formative Assessment shall be based on — Quiz, Seminar, Presentation, Written test, Case Study, Project, Assignment etc. ‘The division of marks is as follows: External Evaluation (Summative Assessment): End Semester Exam:60 Marks Time: 03 hours Test I 20 Marks Section (A): 5 Sx1=5 Objective Questions | (1 mark each) Test IT | 20 Marks Best two test Section (B): 5 Short [5x 7=35 Questions out of eight questions (200 words each) (7 Marks each) Test IT | 20 Marks Section (©): Two [2x 10=20 Jong questions out of four questions ( 500 Words each) (10 Marks each) (CCE) Marks Total Internal Assessment 40 Marks Total External 60 Marks Evaluation (Theory) Marks (A¥B+C) Note;- For Major, Minor, Open Elective, Foundation and Vocational Courses, Part D Il be as per the scheme of marks given, ‘The student should secure 35% marks in Internal Assessment (CCE) and External Evaluation (thegty) combined. 5SlPageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) am a — oa orden : fea wan: gah. ay — 2023 ‘WA : 2023 — 2024 wen Gey UgaeH war fear: ae was A OGY 1 | urerea a: ‘S6CHEM4D 2 | agar ar site via His, Sa orordry si orden Ca 4 | yafter (Prerequisite) (aft wig a) Be USaey OT te oe & fey faqarell 7 eRe freer 4 fet / ware aaa afeicr wet 5 | Weaen sea a) wa ot @ qe eh we or ete a wer uRaferat (ert oft |} wart ehh] snees) (CLO) Se ARAN ory GA thea, Pew orefere, oa Got Var ag wae wr ecagifre lagi, qaata 7 | orifar waite Raia or soar ae wrdenfere tiPret ot eee fle det feet Rel WE Tel S ardent atte, waa err si art faxcroer aa aorta ware fas six vite wonterdt & arg arait a after | 6 | disc 4K 04 7 | Set 3a witfed RAE Gig) — | eT alF aie : 40 ae 36 armem yeaa Gift WrRey Wan) — 60 sig Get 40+ 60= 100 sine 3 %e/ Ben \nsGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Una - Touma feaaaed RAM &] Ge Ver-eqeaa- Waele Mas We A) -L-T-P: wore | fave are alter 1 vie, Cea GR awe Ger oifaw oir oF fay ye mead we S| we sore & vel A Aya aA gaa, Ga omy wy Aiea wT war, vider aoe werreh sete, vorgehngs der, teres dea, wrens wee dee PART wits ao da A yer ewe ae, agerate ape per aim eis aay, dabehfes aoe da ate anrfie oft, we omfee } vor areas — a de fe arr craic @ frecia, — arte, om va wat ym offer, sarritat or fem, an ool, are yep Gol uRada ik ura Rerie & de dade, wer Got aiPret or arma oftae Gite sonfedt Ham Gal a arbi garb wa A veh at WORT VET G TREK aiweat S wage, vet wa ages ( a aw Gul | 2 [Men Tg Weel & awa yer — gee amex & yor vfoga@ed, sqgare, dle qa, vitele gaocd yt ORY geome gasia quite st sae ser At a fata fA, qearre — ATER FAA, fades fa, za fae ve aa qaata srpre fae grrr ene, L&S gem, Te amen ef data at Puke, gee era vet gs, qaata ort 4 gam arrem, sw ang wait S fae qaaia angel site A sual 3 fard-atre aie a awa agora dy (rufa, s, p ae ag dsfa a) \/ 6 he 2/ bs” iraeGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) _ (Department of Chemistry) [| sirearffereer| ang scored & fienge fete (grr) sik gra gees vepitan (rer) at aah dere fasten, ga cite A menae arr a sen wis db ageteer A grec vegan a after Glee arr vekw) | — ord ame ‘ite frers ofiors, faa, dear sik werahe ofan | wrditia tite fas ote wera offre’ | @réfefererr zits fad ok weate sfifrat) ondaere aifite— aren, wena feeay, arate orl, gr, were ys, wears ak teorpifsigs aM @ fat six wrahta ofhirat | 4 ag oraitied 18 gelagid Man, va aIPae, agufiate aie 3 jee & sfrentta eng orifed a gcagia wrt) ad fae Ay sik faite aries ot ary Ft amare fae (reer Valor, srr prafargaters, weiter yd weprer er Trea ATTA) | Coe HT STAT Bet ET Cr, Mn, Fe, Co sik Ni & AM acar aie agate waiter Hr der | CO a yerrat ame (CO & anette der we Tal), wearer wre sie aeade oF ei ot AAEM & fay IR Ser oT sribt| oor caus Rat sie eee, etree sera Foyer ok qraificd @ uefa waa FA ger | 5 Ua cardia ware — vide da A eng od after ofae aa H orah fear S arpa ceil or afferent) ergeil B fear we anette waa | aifeay © g-dy, aie vega ie orinhitesa | Ee ga angst a oftrera afte eth erg oreti @1 farrnar (Hg, Pb, Cd, site As) faerpar 3 aren, zat A Defer wich wr eratT) aaa sie wera Ga—monferay A agah, Gat sare sik aeikifire A se 2 sre! at after | Wh Gl IaH FAM A Ca2+ H yarns SePotay ssw she RITA yu SF a _Government Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) aT — aga sea WaT Usa Ged , Ue, HRT, aT Ga WaT Ta TEATS 4. tier, wang yore sori feevor, afar, 1972 36 2. deel, of. ahrer anfeefea ensitite wrfettie, vai were, Bee eta, 1996— 03-07. 3. oun, voush, fafeous Ys ate, dive afte eit diet deer teers fach ¢fear. 4. BE, Hee, fy ok ser aeyer railie She, fiiacs cite waa we fefactl ar ys, erie sifemH 1903, flues, 2008. 5. mm, vot sede waren, then anda Grigor (ext vader) 2005 6. STH, a8, tashaa, Sea Ws easy, oe dite Us Hise 4 sxsititw diet cheer teow, wilt fael Us wer, Gray, 1904. 7. TIS, TIT oi ortail, u. SANG cite = vfericn, vedfaae 2a Wea, 1997 (arTaR aTer deferre Ys eftafefiar ga fears wie). 8. ch. US Gaga sasitie Sf sai deen, vita el vs We 2008. 9. Tide, oh. Rare sip siete dhe, atvta vs cia, 1988. 10. aeR, SS) sik O. vee, sada wars air quer wea, aires aparece, 1904. 11. arte us, ve oes, one Ado sie erie Reese rest aie Feat were S41 Uiegrt 07S) ys, vila fle Us we eH, Wad. 12 War, Sew sik alew, ok, sande arm, Set wireet wert 197, a GOs —Government Holkar (Model, Autonomous) Science College, Indore (M.P.) — __ (Department of Chemistry) 13, Pike, vive cit Sites, vey arordina ward fas die dean, faa, 2010 Pla GR A. ve set siPfgitre Aca Set } feaia oie aephT fre ach, wie afrahicl wee gau, 1987. 14. sag, tad va. = ainiefere ofr) site ¢ gifs Acca. Fae, waar ‘aif fet, 2000. 15. whe, AY sit, sik NY ye. fee oitefers weer fe, ora tsar Rae, Wael Hfew—ete, 1996. 16. udshfaa, wh, wreak, u aitalererrr wa wire Ee y/ v wy pp he 10|PageIndore (M.P.) (Department of Chemistry) Government Holkar (Model, Autonomous) Science College, ArT = — atgeifticr yeuiers fate: Q | Internal Assessment: Con ‘Comprehensive Evaluation (CCE)/ Formative Assessment: 40 Marks ‘Time: 03 hours Formative Assessment shall be based on — , Seminar, Presentation, Written test, Case Study, Project, Assignment etc. The division of marks is as follows: jous External Evaluation (Summative Assessment): End Semester Exam:60 Marks Test | 20 Marks Section (A): 5 Objective Qui | (1 mark each) SxI-5 Test ll | 20 Marks Section ( Test IT 20 Marks ‘Section (B): 5 Short Best two test | Questions out of Marks = (20+ | eight questions (200 20) words each) (7 Marks each) 5x7=35 Jong questions out of four questions ( 500 Words each) (10 Marks each) 2x 10=20 Total Internal (CCE) Marks Assessment | 40 Marks Total External Evaluation (Theory) Marks (A+B+C) 60 Marks For Major, r, Open Elective, Foundation and Vocational Courses, Part D will be as per the scheme of marks given, Note;- ‘The student should secure 35% marks in Internal Assessment (CCE) and External Evaluation (theory) combined, \we ~VAL | PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part A- Introduction Practical’s Program: Degree Class: B.Sc. VI Semester _ | Year- 2023 [ Session- 2023-24 Course Type (Subject) — Chemistry Core Practical Course Code S6CHEM4Q Course Title Synthesis and Analytical Techniques Pre-requisite (it any) To study this course, a student must have the subject chemistry in Diploma course of B.Se. or equivalent Course Learning Outcomes ‘On completion of this course, learners will be able to: (CLO) 1. How to synthesis Ferricene from FeCh. 2. How to Synthesis of Ko[Fe(C204)3} 3. How to determine pH of bio sample. 4, How to determine sugar in blood sample by photometry. Credit Value 02 (Practical) | Part B- Content of the Course Total no. of lectures — As per UGC rules Synthesis 1. To synthesize Ferrocene from FeCl. 2. To synthesize Ks{Fe(C:0:)s] complex. 3. Synthesize of Cr(CsHs)2 4. Synthesis of triphenyl methanol. 5. Synthesis of triphenyl methanol from benzoic acid using Grignard reagent Instrumentation 1. Determination of pH of the Bio sample. 2. To determine the sugar in blood sample by photometry method. 3. Determination of the Na‘, K+ ions in water sample by flame photometry Chromatography; 1, Determuination of Re values of Fe"? / Co"? / Pb"? / Ag* by column chromatography. 2. Determination of Rf values of Pb+2 / Cu+2 / Hgt2 by TLC. Polarography 1. To determine EMF of Fe"? and and Co*? ions in bio sample 2. To determine EMF of Pb*? , Cd"? and Hg ions by polarography method Key words : synthesis, ferrocene, aceto-Fe complex, Bio sample, Flame photometry, chromatography. polarography, EMF. ‘As per suggested. QyY Tie : 12|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part C- Learning Resources Textbooks, References Books, Other resources Suggested readings: 1. Advanced Inorganic chemistry practical by Gurudeep Raj, Goel publi 2. Analytical chemistry and instrumentation Bilard, willey publication 3. Environmental chemistry by AK De S chand 4, Advanced Inorganic Chemistry by Jadhav ‘Suggested Equivalent Online Course: Part D- Assessment and Evaluation Suggested Continuous Evaluation methods: _| Internal Assessment/Formative Examination(A): | 40 Marks Lab Record 15 Marks Attendance in the Lab 05 Marks Assignments (It can be in different modes) | 20 Marks End Semester External Evaluation (B): 60 Marks Viva Voce on Practical "| 10 Marks Practical Record File 10 Marks Experiments 40 Marks Total Marks (A+B) | (40 + 60 =100 Marks) VV eB Qe \re 13|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part A - Introduction Programme- Degree Class = B.Sc. VI Semester Year- 2023 | Session- 2023-24 Course Type (Subject) ~ Chemisiry Discipline Specific Elective (DSE-I1) Group A Paper-II 1 | Course Code ‘S6CHEM2D Course Title Laboratory Skill, Techniques & Management 3 | Pre— requisite (any) | To study this course, a student must have passed diploma or equivalent course/qualification with chemistry as a subject 4 | Course Learning OBJECTIVES Outcomes (CLO) This course/paper is intended for persons employed as or aspiring for employment as laboratory technician / attendant in school/college/ other scientific laboratories. MAIN LEARNING OUTCOMES At the end of the course, the learners will be- + Familiarized with the basic facilities available in laboratories, + Expected to gain knowledge of the basic skill of organization and management of science laboratories. + Enabled to expertise in the procedures of procurement and storage of laboratory equipment & material Trained in the operation and maintenance of simple instruments used in science laboratories, + Enabled to develop skills in common laboratory techniques. + Trained to adopt appropriate disposal procedures and safety methods suitable for Laboratories, 5 | Credit Value 04 6 | Total Marks Formative Assessment (CCE) - 40 Marks Minimum ‘Summative Assessment (End Semester Exam)— | Pass 60 Marks Marks ~ ‘Total 40+60= 100 Marks 38 Part — B Content of the Course ‘Total no. of lectures ~ As per UGC rules (1 Credit = 15 Lectures) ‘S.No. Topies No. of Lectures Laboratory Skills, techniques and Mangaement 1 | Unit-1 Laboratory organization and management- Science laboratory: scientific temper, scientific ing, significance | _ VS 7g 14| Page Nw °Government Holkar (Model, Autonomous) S Indore (M.P.) nce College, (Department of Chemistry) values/ accuracy/ attitude, interaction with pupil present in the lab, dignity of work of lab staff Lectures Important components of a science laboratory: features of a science laboratory, services in a science laboratory Organization of science labs: preparation room, arrangement of stores, safety provisions, Labels- a cautionary note Day-to-day management of laboratories: day to day cleaning up, routine inspection and maintenance of laboratory, cleaning of laboratory ‘and preparation rooms, colour coding of services, emergency switch services, security and vandalism. Stock control and purchase: arranging stock, naming and maintenance of stock register, receiving of goods, processing of bills, accounting, controlling budget, information about equipment & miscellaneous records, purchase rules. File and records: sources of information in the lab, filing system for chemicals, requests for equipment & special files ‘Use of computer in science laboratory: component of a computer, overall function & application software. Key words- Colour coding, Vandalism, Budget, overall function, safety provisions, stock register, purchase rules, HAZARDS IN LABORATORY & LABORATORY SAFETY- 11 _| Electricity and gas hazards: electricity hazards in the laboratory (selection of proper fuse, selection of proper flex, safe conduct, earthing & other dangers associated with electrical equipment’s), Gas hazards in the laboratory (LPG, high pressure gas hazards, detection and handling of gas leakage & low pressure gas hazards). Fire hazards: fire hazards in the laboratory, classification of fire, precaution of fire prevention & extinguishing a fire and types of fire extinguishers, Chemical hazards: classification of hazardous chemicals, handling of chemicals, storage of chemicals, transport of bulk chemicals & transfer from large containers. Personal safety: Code of behavior for the laboratory staff, personal protective devices, disposal of waste materials, check-in & shut down sequences & shifting load Accidents and first aids: acc’ in orting, procedure, first aid box, WV SED jee \eGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) general features of first aid procedure, first aid procedures for chemical accidents, first aid treatment for shock & first aid treatment of localized inj Keywords- Gas hazards, proper flex, LPG, Fire Extinguisher, code of behaviour, First aids. BASIC LABORATORY APPARATUS AND EQUIPMENT IN CHEMISTRY Wi BASIC APPARATUS: Identification of apparatus, apparatus for heating (Bunsen burner, water bath, Oil bath, hot plate & heatin ig mantle), laboratory glassware, laboratory centrifuge, use and description Measuring Apparatus: Measurement in chemistry lab, errors, preci and accuracy of measurement, volume, types of volume, measuring devices, burettes & pipettes, accuracy of burettes & pipettes, volumetric flask, mass and weight, balances analytical and electronic, pH meter and conductometer Common laboratory glassware: laboratory glass ware and its types, cleaning methods, storage and handling of glass apparatus, assembly of glass apparatus, gas pressure in glass, safety measures for storage, caring & handling of glassware Keywords- Water bath, heating mantle, centrifuge, precision, gas pressure Solutions and their preparation: Water and its types, types of solution, IV | solubility, concentration of solutions- percentage, molarity, molality, normality & ppm, calculation of mass and volumes to prepare solutions, general guidelines for preparation of solution, general methods of Preparation, labeling, exceptions to the general method, notes on other solution reagents for chemistry, bench reagents, standard solutions. Common laboratory techniques: Heating, refluxing, filtration, small scale methods, reerystallization and determination of melting point, distillation and determination of boiling point Keywords- Concentration units, labelling, bench reagents, refluxing, recrystallization, melting point, boiling point GOOD LABORATORY PRACTICES: BASIC EXERCISES y_ | Ex. 1 procedure for purchase of laboratory related items, inventory management Ex. 2 supply of gas, electricity and water in a laboratory Bx 3 fre safety measures ina —eGovernment Holkar (Model, Autonomous) S Indore (M.P.) (Department of Chemistry tion and handling of hazardous chemicals Ex. 4 Clas Ex, 5 disposal of unserviceable and obsolete items Ex. 6 safe disposal of laboratory wastes Ex, 7 attending to emergency situation Ex. 8 preparation of standard of oxalic acid solution Ex, 9 determination of strength of NaOH Ex. 10 preparation of stock solutions and dilution Ex. 11 preparation of water and alcohol based reagents (Fehling A & B, starch solutions) Ex. 12 preparation of distilled water Ex. I3preparation of buffer solution Ex. 14 determination of pH using pH paper Keywords- Inventory, unserviceable, obsolete, Fehling A & B, distilled water Part — C Learning Resources ‘Text Books, Reference Books, Other Resources ‘Suggested Readings: 1, Robert H Hill, David C Finster, " Laboratory Safety for chemistry, Willey 2, Sveinbjom gizurarson, Benjamin R, "Hand book for Laboratory Safety" Elsevier 3. Anthony A Fuscaldo, "Laboratory Safety Theory & Practice" Elsevier 4, Steven I, Brown, "Laboratory Techniques for general chemistry" Hayden Meneil 5. http://ncert.nic.in, kelm202, "Basic Laboratory Techniques" 6. Abigail," laboratory note book, Slater Press WV Bef. 17|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part—D Assessment and Evaluation Internal Assessment: Continuous External Evaluation (Summative Comprehensive Evaluation (CCE)/ Assessment): Formative Assessment: 40 Marks End Semester Exam:60 Marks 03 hours Formative Assessment shall be based on — Quiz, Seminar, Presentation, Written test, Case Study, Project, Assignment etc. ‘The division of marks is as follows: Test I 20 Marks Section (A): 5 5x5 Objective Questions f (i mark each) Testi [20 Marks Section (B): 5 Short | 5x7=35 Best two test | Questions out of Marks = (20+ | eight questions (200 20) words each) (7 Marks each) Test II 20 Marks Section (C): Two 2x10=20 long questions out of four questions ( 500 Words each) (10 C Marks each) Total Internal Assessment | 40 Marks | Total External 60 Marks (CCE) Marks Evaluation (Theory) Marks (A+B+ C) For Major, Minor, Open Elective, Foundation and Vocational Courses, Part D will be as per the scheme of marks given. The student should secure 35% marks in Internal Assessment (CCE) and External Evalugtion (theory) combined. VV Sb", a ts, Note;- 2. 18|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) ar a — WRay aren : feat war: AeA. ak — 2023 WA : 2023 — 2024 wey Wey Teme oT ver faa: WareT yy — doe — 2 Se 1 | argues oT S6CHEM2D 2 [aque oT site warrenen wlee, dart ae wae 4 | qafter (Prerequisite) | 24 Teae oT se wel & fay faqael + aft ag a) wrens fsa 4 feta werner ara afer a et 5 | Weyer sey aT Si Teas } oR Par wea ees faa uRafert @rt ahr |} fer raat or Se we aR ai: ame) (CLO) wee we vem / tee /atet / oy ashe sarin & wave cer / wesc d wa 4) fatfir ar vee & gee antral ferg 2) yea Rreror ufone urea aia 4, srivrenenstt ¥ swore after gftersit @ oA fas walrerensil ered atx weer od gPrardl Set oT TT wt oe a wie e] swabrenen Saar she wrwh at ete site ster @) wire 4 fastest & fore wary | fas waren A gear ey ae wa suet | B teres sik ve vara 4 ule) War sabrsret dertet Y eter feta oe Her | warrnensit @ fay sagm fiver wfhasit six wen fat at arrart s ferg waa 6 | eise am 04 7 | Ba oe wiifed oetate Rig) — | RA Sail sip = 40 sie 36 airere yeaa (ifs Wirex ulen) — 60 sie Bei 40 +60 oy oaIndore (M.P.) (Department of Chemistry) Government Holkar (Model, Autonomous) Science College, ung - TrewpH faraaaeg ORAM & Het Pace WMG Ae We Fh) -L-T-P: garg | fave wen 1 warren STS sie wae ffert verre : dente we, asnfe Rees, warren ner / wdlent / wa, saree 4 ahye Perla S wrer anes, vabraren afenRat & arr a afer fer warren & Feet eae fas whee a fasiwad, fasra watrenet # tay ar serene wr eitest dar oe, we DB) araeT, Wa AGH, daci~ vo daa Ate warrenensit wr fea—wfafes weerns eRe aor, Prater Pero ait et oT va waa, watreren oi dor watt St wor, 7 Vasit A er asa, sae ores Raa day, YR ote assis I ?wER Past ot ate wie A aan, ein efi oa THOR ai WS WANS, Ha wT Hea, Vel wr ween, aeia, wave o faa wen, wae shy fafa aftce @ a a aren, wie faA| wee ok Rete wit 4 ya é wa, weRHi & fey a wmgfetT sore, Bae six Pals wise } fey sae aT warren F wee or oritte Fee wl veo wT orl sik orgy wivetar ar fig — @ aS, de—wg, woe, wer ord, Gen wa, Ylo w eRe, wie PaA WANTS H GAL Ge ware GRA faoroht otk tte & wae: weitreren 4 fase & war (sft vat wT aa, Sie veer er we, Aeftiat saan, afr alte faoteh a wert 8 gs oa Ge) wae A ta S aR (erhah, 0 RS NwGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) vel a cam ta S wet, ved oi te Reve sie oa cara Te] amt @ fac) | or & wat vate Fart S GR, aT wr aie, aT aad ik om aa St aaa oie oft ere ve af ee S yer a — Tae GR Ga wR or ato, wrEAT OT WG Xa, WHR er sem, ale wal wr uRaed sie as wet Y wari afer yen lene & ahaa o fey aaex wea, a afirnat Gat rH, aofre veri wr fier, deg sie we— SIS orprH ai ots frfteT gtemy sik wefte fates gdear oe yer ear, wien, e wefte faficen I, weftre fafa wire a arara fesward, | waa gdeansit & fey meri fafa wBbary, flee smera o a fay see svar stk wre acl or mete ora 7 UR fig tao ak, ofa wees, verieh, af wre, aR a wieen, serftas ferfeocar | gharl warren Suara war fast & saa a gma) | TSW: BENT FEE, TH oe S fay woe Gam FR, dex ayy, sifvet are, die Ge aie dea Feet valreren vars day, fast wareren & ar, fea, aaa a aunfar sia ofteeat oi wétea, AT, AT} WOR, aM S ora, ae site fade, are otk fite A adied, depts vars, gam sit ac, Recwonae ote geagihe gar, tiga a Mey ox Geachiee | errs waprene ora & ada: warrenen wa oT aa oie a CS TOR, UHR d ahd, wir S sr aT Herr six ware, via d wre a onal, oie A ty or ca, eR & fay WaT, Sy, wa S WA a sera afk Wares UR fag Teva, Herica, dgiequ, uRgea, te wares fast Y ghana) walrenen catia Read aie Gaal ars Te sik wad wor, flaad d wor, yereiicn, err a arxai— wftsramn, ateea, Aeron, afferar \— y VERGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) ___ ok igs, Ree ar } fry gaa sie sie FA TORT, Rees a dar ost 3 fay wary er és, aa A war fafeai, aafeit, a erarey fat ad onrare, wares fas & fer ore Ta otrartei oy slew, da aftante, are fart We, Fae freciowr ote Temie or Paw, smart aie aero or Faker freee, were, qaertin She} DEMIR SMITE Glare HITT + Warr 1 TabTETET a Safire agai BH ale, Ye yaw & fare wieeat | weiter 2 orisha, fare re or a age Warr 3 Ue VaMTaeM A sift Geer sor + TEN 4 GCA TART oT HifeeRUT sie WaT WGP 5 squarh sik siraferd agai ar Proer + Wan 6 Waren Pay aT ales Te weit 7 orrarcrepretta fate A errata + Tan 6 sifamnfere fre fare or Ae fae Ta EA + WaNT 9 NaOH #1 Rae aT Pekar - aN 10 faces SAT Ue TAHT TaN 11 Gal sik srewteat areata oftree dar ae Ofeit v sik ah, cer faery + WENT 12 Siga Gel Ga BeAr + Wah 13 oop far da SAT + wah 14 tee day or soa ee thea wr Pekar an fag Faed, age, armafers, toeteia y oie ah, omega Tet 7 \ Nr Qy ys y ohhGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) ara — said seat Se Wea Wedd , tial, ead, aro WER Fat aha Gere 1. Yad va fe, Ss Mt eee, wa Bera S fey wakreen Yee, fact 2, Samat rae, dons om, ws gw ik dated ae ede 3. Wart y eared), walreren Gen fraia aie seer VRE 4. ST | ATS, BAT wares Peers & ferg weereren caries des Aare 5. http://ncert-nic-in] kelm202, "gfarét watrenen gate" 6. adtta, warren ae ga, Kev Fe Ze We Oy ys oe yw 23|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) am & — sgeittra yeaa fate : Internal Assessment: Continuous External Evaluation (Summative Assessment): ‘Comprehensive Evaluation (CCE)/ End Semester Exam:60 Marks Formative Assessment: 40 Marks ‘Time: 03 hours Formative Assessment shall be based on — Quiz, Seminar, Presentation, Written test, Case Study, Project, Assignment ete, ‘The division of marks is as follows: Test I 20 Marks Section (A): 5 Sx1=5 Objective Questions (mark each) Test I 20 Marks Section (B): 5 Short | 5x 7=35 Best two test | Questions out of Marks = (20+ | eight questions (200 20) words cach) (7 Marks each) Test IIT | 20 Marks Section (©): Two | 2x10=20 long questions out of four questions ( 500 Words cach) (10 ‘Marks each) Total Internal Assessment (CCE) Marks 40 Marks | Total External 60 Marks Evaluation (Theory) Marks (A+B+C) For Major, Minor, Open Elective, Foundation and Vocational Courses, Part D will be as per the scheme of marks given, Note;- The student should secure 35% marks in Internal Assessment (CCE) and External Evaluation (theory) com 24|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part A- Introduction Practical’s Program: DEGREE Glass: BSc. VI | Year- 2023 Session- | Semester 2023-24 Course Type (Subject) — DSE Practical 1 | Course Code S6CHEM2Q 2. | Course Title Exercise for Development of Lab Skills 3. | Pre-requisite (iPany) To study this course, a student must have had the subject chemistry in Diploma course of B.Se. or equivalent 4. | Course Leaming Outcomes | On completion of this course, leamers will be able to: (CLO) ‘ Handle and run any chemistry lab skillfully. Students will be able to perform general exercises like- + Preparation of standard solutions + Determination of concentration ion of MP, pH, Conductivity of stock Solutions + Preparation of various reagents 3._| Credit Value © (Practical) Part B- Content of the Course ‘Total no. of lectures ~ As per UGC rules Lab Assignments: 1. Preparation of standard of oxalic acid solution Determination of strength of NaOH Determination of concentration of solutions- percentage, molarity, molality, normality & ppm Determination of melting point Distillation Determination of boiling point Preparation of stock solutions and dilution — Preparation of water based and alcohol-based reagents (Fehling A & B, starch solutions) 9.__| Preparation of distilled water 10. | Preparation of buffer solution-Acidic and Basie Buffers 11. | Preparation of Nesseler's reagent, Molisch reagent, Schiff base 12. | Determination of pH using pH paper, pH meter 13.___| Conductometric titration-Acid Base ne [ re fs - elma oy) onlGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part C- Learning Resources Textbooks, References Books, Other resources ‘Suggested readings: 1. “A Skills Training Manual in Basic Chemical Laboratory Techniques", by Soffiantini Vic, Seller-Atlantic Publishers, Publisher: Lulu.com ISBN: 9781471090998, 9781471090998 2, 1CSE Chemistry Lab Skills - Laboratory Ethics Viva Voce, Neha Sharma, ISBN 9789388653510, 2020, Viva Education 3. Chemistry Laboratory Skills - I: Alternative to Practical, Shirly Bandarawatta, ISBN-10 : 9554114206 Summer Gate Education; 2nd edition (July 22, 2013) 4. Fundamentals of Chemistry: Laboratory Studies, Third Edition, 1975, Frank Brescia, John Arents,... Eugene Weiner, Science Direct Suggestive Digital platforms web Links: ‘Suggested Equivalent Online Course: ee ear WO NW \ oy & 26|PageIndore (M.P.) (Department of Chemistry) Government Holkar (Model, Autonomous) Science College, Part D- Assessment and Evaluation Suggested Continuous Evaluation methods: Internal Assessment/Formative Examination(A): 40 Marks: Lab Record 15 Marks ‘Attendance in the Lab 05 Marks Assignments (It can be in different modes) 7 20 Marks End Semester External Evaluation (B): 60 Marks Viva Voce on Practical 10 Marks Practical Record File 10 Marks Experiments = 40 Marks Total Marks (A*B) | 40 + 60 =100 Marks) 27 [PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part A - Introduction Programme- Degree Class ~ B.Sc.VI Semester_| Year- 2023 _ | Session- 2023-24 ‘Course Type (Subject) — Chemistry Minor (DSE-II) 1_| Course Code S6CHEM2T Course Title Pharmaceutical and Medicinal Chemistry 3 | Pre—requisite (i To study this course, a student must have passed diploma or equivalent course/qualification with chemistry as a subject. 4 | Course Learning ‘After successfully competing this course module students, Outcomes (CLO) will be able to: + Understand importance of pharmaceutical chemistry and pharmacopeia. * Learn intellectual property rights, patents trademark and copyright. + Understand Definition, Classification of the drugs with examples and structures. * Describe the structure activity relation of some important class of drugs. * Describe the overall process of drug discovery and the role played by medicinal chemistry in this process, Relate the structure and physical properties of drugs to their pharmacological activity. Explain physio-chemical properties related to QSAR 5. | Credit Vs 4 (Theory) 6 | Total Marks Formative Assessment (CCE) - 40 Marks Minimum ‘Summative Assessment (End Semester Exam) ~ | Pass 60 Marks Marks — Total 40+60= 100 Marks 35 Part—B Content of the Course Total no. of lectures ~ As per UGC rules (1 Credit = 15 Lectures) S.No. Topics No. of Lectures Introduction to pharmacy, career in pharmacy, codes of pharmaceutical | 12 ethics, importance of pharmaceutical chemistry, pharmacopeia and its 1 | history (IP, BP, USP, NF), Drug and cosmetic act with special reference to schedule M, GMP, GLP, GCP, USFDA, NDA, clinical trial. Concept of quality and total quality management, quality assurance and \wee wa Vite — WV AW bsGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) quality control, IPQA, IPQC. Documentation and maintenance of record, intellectual property rights, patents, trademark, copyright, patent act. u Defini , history, scope and development of Pharmacognosy. Classification and Sources of drugs: classification of drugs, sources and uses of natural drug products, biological (plants, animals and microbes), geographical, marine and mineral sources. Drug Receptors: Introduction to drug receptors, nature of drug receptors, different bonding involved in drug- receptor interaction, drug receptor theories. Drug absorption: routes of drug administration, absorption of drugs and. factors affecting absorption. mM Drug design and development an overview, analogues and prodrugs structure and activityrelationship between chemical (SAR), factors governing drugdesign, approaches to drug design, receptor site theory, introduction to combinatorial synthesis in drug discovery. factors affecting bioactivity. QSAR-Free-Wilson analysis, structure a biological activity Hansch analysis, relationship between Free-Wilson analysis and Hansch analysis 12 Vv Introduction, Antibiotic B-Lactam Type Penicillin, Cephalosporins, Antitubercular - Streptomycin, Broad Spectrum Antibiotics ‘Tetracyclines, Anticancer Dactinomycin (Actinomycin D) 2 Antifungal: Polyenes, _ Antibacterial-Ciprofioxacin, — Norfloxacin, Antiviral - Acyclovir Antimalarials: Chemotherapy of Malaria SAR, Chloroquine, Chloroguanideand Mefloquine. Non-steroidal Anti-inflammatory Drugs: Diclofenac Sodium, Ibuprofen and Netopam. Keywords/Tags: Pharmacopeia, patents, trademark, copyright, QA, QC, pharmacognosy, drug, design, QSAR, antibi antifungal, anti-inflammatory drugs, antimalarials 2 1 a/b 29|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part - C Learning Resources Text Books, Reference Books, Other Resources | Suggested Readings: |, "Pharmaceutical Chemistry Inorganic Vol. Chatwal G. R., Himalaya Publishing House, Mumbai, 2010. 2. "Textbook of Pharmacognosy", Wallis E., CBS Publishers and Distributors, New Delhi, 2005, Fifth Edition, 3. "Pharmaceutical Chemistry", Choudhary N. C. and Gurbani N. K., Vallabh Prakashan, New Delhi, 2014. 4, "Pharmaceutical Chemistry", Watson D. G., Churchill Livingstone Elsevier, UK, 2011. ‘Vallabh: 5. "Text Book of Professional Pharmacy", Jain N. K. and Sharma S. Prakashan, New Delhi, 2009, Fifth 6. "Pharmacognosy and Pharmacobiotechnology", Kar A., New Age International Publishers, New Delhi, 2017, Third Edition, 7. "A Primer onQSAR/QSPR Modelling: Fundamental Concepts", Roy K., Kar S., Das R. N., Springer International Publishing AG Switzerland, 2015. 8. "Medicinal Chemistry", Kar A., New Age International Publishers, New Delhi, 2007, ion, Fourth Edition 9. "An Introduction to Medi 2013, Fifth Edition. 10. "Medicinal Chemistry", Thomas G., John Wiley & Sons, Chichester, 2007, Second ial Chemistry", PatrickG. L., Oxford University Press, UK, Edition, ‘Suggested equivalent online courses: 30|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) Part — D Assessment and Evaluation Internal Assessment: Continuous External Evaluation (Summative Comprehensive Evaluation (CCE)/ Assessment): Formative Assessment: 40 Marks End Semester Exam:60 Marks ‘Time: 03 hours Formative Assessment shall be based on — Quiz, Seminar, Presentation, Written test, Case Study, Project, Assignment etc. n of marks is as follows: 20 Marks Section (A): 5 Sxl=3 Objective Questions (1 mark each) Testi | 20 Marks Section (B): 5 Short |5x7=35 Best two test | Questions out of Marks = (20+ | eight questions (200 20) words each) (7 Marks each) Test | 20 Marks Section (C): Two [2x 10=20 Jong questions out of four questions ( 500 Words each) (10 Marks each) Total Internal Assessment | 40 Marks Total External 60 Marks (CCE) Marks Evaluation (Theory) Marks (A¥B+C) For Major, Minor, Open Elective, Foundation and Vocational Courses, Part D will be as per the scheme of marks given. ‘The student should secure 35% marks in Internal Assessment combined. & Notes 31|PageGovernment Holkar (Model, Autonomous) Science College, Indore (M.P.) (Department of Chemistry) am a — oe ere : feat wer: dah. [at — 2023 ‘WA : 2023 — 2024 ye Wee Tgaea oT ver fase : wera AISA 1 | Weaer ats S6CHEM2T (DSE-II) 2 | weer oT ite warranted Bee, cals aie yee 4 | yaften (Prerequisite) | 38 TeaHa ot Geary wel & fey faqarell > fe alg &) warrraa fava 4 feet / were area afofer a el 5 | uaa seq oY BH TGIHA Fisye G1 Whee QI Gow b uRaferal (Rf aft | ae ora Pre Howe ehh: ame) (CLO) a a SRSA sie wrafottar } Heat wy 1 afer diet for, te gene ate aiinge writ BaEwT she BAR + wer qasih HY ofan, iat of et sisal & qe agcageh af & evan earerera wider oor aos aHfeTY | ste ot ater Hw fray sik ge wire atteta wart ener Peng ag after or avi RST | art #1 deen ae site WH ot sat sihela mfafaret @ waiter we) QSAR & walter Aft —rarahe qi a care Bray | 6 | ese ar 04 7 | Ee sie witfea antenic (kid) — | eat oadof ata = 40 36 35 ame youl @ifer BAeew wa) — 60 si Ga 40+ 60= 100 aH yy Wo? 32 [Page Wo, &