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    Transplantasi Imunologi

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    ANNIS RAHMA KUSUMA WARDANI
    This document discusses transplantation immunology and tumor immunology. For transplantation, it describes different types of grafts and the immune response from the recipient rejecting the donor tissue due to alloantigens. The major histocompatibility complex plays a role in recognition. Strategies discussed include general immunosuppression and minimizing the allogeneic reaction. For tumor immunology, it describes how cancers arise and the immune system's role in recognizing and destroying transformed cells to prevent tumors. It also discusses classification of tumor antigens and mechanisms tumors use to escape the immune system. Vaccination is covered, describing how it stimulates protective immune responses through exposure to nonpathogenic forms of microbes.

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    Transplantasi Imunologi

    Uploaded by

    ANNIS RAHMA KUSUMA WARDANI
    6 views21 pages
    This document discusses transplantation immunology and tumor immunology. For transplantation, it describes different types of grafts and the immune response from the recipient rejecting the donor tissue due to alloantigens. The major histocompatibility complex plays a role in recognition. Strategies discussed include general immunosuppression and minimizing the allogeneic reaction. For tumor immunology, it describes how cancers arise and the immune system's role in recognizing and destroying transformed cells to prevent tumors. It also discusses classification of tumor antigens and mechanisms tumors use to escape the immune system. Vaccination is covered, describing how it stimulates protective immune responses through exposure to nonpathogenic forms of microbes.

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    12. Transplantasi Imunologi_

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    This document discusses transplantation immunology and tumor immunology. For transplantation, it describes different types of grafts and the immune response from the recipient rejecting the donor tissue due to alloantigens. The major histocompatibility complex plays a role in recognition. Strategies discussed include general immunosuppression and minimizing the allogeneic reaction. For tumor immunology, it describes how cancers arise and the immune system's role in recognizing and destroying transformed cells to prevent tumors. It also discusses classification of tumor antigens and mechanisms tumors use to escape the immune system. Vaccination is covered, describing how it stimulates protective immune responses through exposure to nonpathogenic forms of microbes.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Download as pdf or txt
    6 views21 pages

    Transplantasi Imunologi

    Uploaded by

    ANNIS RAHMA KUSUMA WARDANI
    This document discusses transplantation immunology and tumor immunology. For transplantation, it describes different types of grafts and the immune response from the recipient rejecting the donor tissue due to alloantigens. The major histocompatibility complex plays a role in recognition. Strategies discussed include general immunosuppression and minimizing the allogeneic reaction. For tumor immunology, it describes how cancers arise and the immune system's role in recognizing and destroying transformed cells to prevent tumors. It also discusses classification of tumor antigens and mechanisms tumors use to escape the immune system. Vaccination is covered, describing how it stimulates protective immune responses through exposure to nonpathogenic forms of microbes.

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    of 21

    TRANSPLANTATION

    IMMUNOLOGY
    TRANSPLANTATION

    (cells, tissues, or organs)


    Graft

    Donor Recipient
    Term
    • Syngeneic graft : graft transplanted
    between two genetically identical or
    syngeneic individuals
    • Allogeneic graft : graft transplanted
    between two genetically different
    individuals of the same species
    • Xenogeneic graft : graft transplanted
    between individuals of different species
    • Alloantigens : the molecules that are
    recognized as foreign on allografts
    • Problem  immune response of the
    recipient to the donor tissue 
    rejection
    • Recognition of transplanted cells is
    determined by polymorphic genes 
    Major histocompatibility complex
    (MHC)
    • Alloantigens elicit both cell-mediated
    and humoral immune responses
    T cells recognize allogeneic MHC
    Type of graft rejection
    Strategy
    • General immunosuppression
    • Minimizing the strength of the specific
    allogeneic reaction
    TUMOR IMMUNOLOGY
    • Cancer is a major health problem
    worldwide
    • Cancers arise from the uncontrolled
    proliferation and spread of clones of
    transformed cells
    • Immune system function 
    - recognize and destroy clones of
    transformed cells before they grow
    into tumors
    - kill tumors after they are formed
    Classification of tumor antigens
    • Tumor-specific antigens : antigens that
    are expressed on tumor cells but not
    on normal cells
    • Tumor-associated antigens : tumor
    antigens that are also expressed on
    normal cells
    Induction of T cells responses to
    tumors
    Mechanisms of tumors
    escape
    VACCINATION
    • Vaccination is the process of
    stimulating protective adaptive immune
    responses against microbes by
    exposure to nonpathogenic forms or
    components of the microbes
    • Jenner pioneered 200 years ago 
    vaccinia (cowpox virus)
    • Pasteur  rabies and anthrax
    Features of
    primary and
    secondary
    antibody
    responses
    • Vaccines have two major effects 
    - Vaccines protect individuals against
    disease
    - Herd immunity (if there are sufficient
    immune individuals in a population,
    transmission of the infection is
    prevented)
    Type of vaccine
    Adjuvant
    Immunization Schedule

    20
    THANK YOU

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