H.

on oepin M 0A Paracdam
pho spholi pido
J
PorcACAtamol Acsaminophun

Arachiclonic caicd penerat hehloocl -rain barier

L
wx-

Blacke wdoxu
Kujgenam lloxaun
Aspirin
PaC
Taraudamel
ha fprmaluwn ano
PGI Pan, Pa PGF2 ab| Bpcke
neloan Prostaalandin
CPae un ha anhal nrvou
syktim
-Irhilito proctalandin synihs
In hilurton produdioo prostaqlandire irduueed y HiLit he aduon erdoqeno o
eukin' (IL-1)
unthe hqpothalamue
and ukin 6 (IL-6) Toqeno onha haad-naauaun
Cotuno n hu bain
Reoet hpohala.muo aloue temp -ch pynatie J
Atparetic etec
 Mechaniom adon Hhotholipil

Inhlilin ploiet aggnagaion

Archiaprie add Co
*nHlib pain senocdon -Analaeaic ain
*Re
hupohalamao ed leuen Henperaluna
C o x -

(ela=
Anb pidi Pdon Aspiin
Rcdued coßNany per realukDeorud Rolecovir PaG
u edama -Amlamrlowy Pdon
Cox inhilbrtow Cause 'rh PGe
ilion a tox PGT
en3he ond nauda Lorueson
aia into PaG ,lu Pa oAracRAoie
Pa
PG 24PGD and ,toPCaM,Po Thromouazans A
Eo oul nhilts
twom locanuA
acddn pain&emaion-
,Ret huporalomup Analaeic
ad Leu Inb platlkto aggigotion
Pau Aeperaune
adio n oction , ntdued aAlany permealully dacnaae
and intt buts pan semalon o ul edama -Ai i
Pralae Aation
Ahamaaoloqcl Adtiomo.
analeie kd
Tha analugene d
Peiphara irhlion prDstoalandin produluon
7ay aeote dua to tha ilttn o pain shmu
a o su- w d
tGdo inBlile pain seaio mechanlsirducad yTN s
and brady nn
Pra hapolanatna acuon
Tar smdarion oDroslelardis or endoqnouo midiotoo
dtov
Apprin in
uken arolgesic an mortun ype dhu
a

Eledu aliues nfamnadhon tin riuny,nnectiuu iue crd intuspmatal paun

uondatim e n seu usard ord isch aamic pain.
sedalsn aieda ahlo hleond.
oaduprndane
-nhiliton produztibn oposdoqlardino duud by rareukin 1 )andnllu
6 CIL-6) in h
pothalomuo
Re"o Mahumonguälony 6gslun laadiie to vasiladion wd rcnaned haad lom.
A inlammaon ld
Dus toha mhi ldb ha enaymmo hud þroduer pro sdaglondin (do ygena, orCo
n

wih coruusito ora chdoniu od) to protdaa lordim, and b TxAa ud pro sda o din
 * ARA CerAMoL hhol"pds
oA ommor ne
an ant Pyniuer onalese }a
Aralgei ons a mo
Como n n Arochdonic odd
ca
rar odi
pynde ogaido,

PaG
hol octopordin the
i r jpro dudin qpro
Sdsu 6
UL-6)
slaglar din vdesd tbukr I
Rem h hapo Ahalama QUV*
pohalamne od lea tevdun
elecoá and ehonoxi
ftomaue ndin he heanmed o acleoarhilto andnhundaicl arihe,
taunu mdabdhed n hu
y k n Conmon odumeeeto on ha ade, nashs and pauiphoa)
Odana Gned ufd nenlon
lartcori
-îodua ovad decpá
Shovd--Aerm uadmwd po s praliu zain
Plastna prouin tndina n h
oloo ba u n i h (aution to p d t o uith o ain nanal Hundluor -0

wal Aaana hos uaun napoñd

Posropeaua an in maao Ocu
 Non -Steroida
i-nlarmson Aento
ohe ane alo callud non- norcoic oralesic

Non-sienoidal artr
hiomralow dugs CNSAID s) ore theqoups èua that re
PainduchLasi Heusr,andin
than nartsue analapae ighar doseo.drenam rylammaon )
îheyond uwo D
Thy edu dull a cdhung pain lud n
usu n isanal pain
Osu t trealmer postoperaliu duta)
n
haad achus tund
iaraine mandurad pain ,Munds pain sipai
hay posses norotie analaeak ordi pynclius cnd oni
non-
Jon naTuoe aralaeie Redued nlonlon on
pan uötho
Ad p d s -
aRdh neduud ehwated hody Crs dapnunign
Ardi
iflammálo 0dd to tomperaiunas
produuad sympsimatie ralie om pain .
Chalon
Non see dua cox Pa) eatal Cox- Selezue Cox-2 Anolaeie -anip=
Inhi litor inono inhonop ulh oor Ari
Vimesulfde ,Melbicamn elcoxilr,ttoneol ammalon Ad
Nabumaton
Para arinpphuro
daridiw
benpa3pun
danivaba
Pavaadamo Mearmapl
Phunctn
Propihuna2gn dopam
ropone a d Aryai Oxicom Pgeola ndole Pgaplona
durnvahL dardaue Pymol darvalan
idaot dusualuus
ACdutrac PProxiom
Teroiom
Keordoz Indpmulhacin Phan lula-
'pdiarads ojal bwndac Ongph
Arhar i aid luuaap
dunsval
Neprongriadd
Enerani aid
uroni add
 Prostaglandins (Q- =O
Tnese Ce most pieoJent_eicosanoIG
found in aLmoSt every tiGsueand
bodyflud
p'cological actiong
different tyPes 0f
PCS produce different effects

OCVs
POTE PCF and PRI CPTOstacyclin)
potent 19aSodilators.-

Fa in Bloodpzessu3e

heyade StaongeT thann Ach and

higtomine.

Thsomboxane TXA) having aS0-

-ConStyiction effect

&IT
MoSE PORS Stimuuares T Sm

s epegistassis

CauS e diauThoea
 POSE
inhibits g9staic acd
SecoetTOn a n d enhan ceS the
mUcouS f o d mation

Sothey habe pToteCtioe effect-

gostre muco60.

BTonchia muSie -

PGE and Pod StRong

bronch odilatoTS.

PO F and TXA2 Stoo ngg

bronchoconsDicto3

imbaance bIw PCS may PRecipita

Asthma.

kidn ey
PE and PE Cau S eS

Rena yasodilaion

diuesis
 Date

NerOuSSySterm 2
PORS adminiSt3aion
in CeTebaal uentricleSj

ee9ates Dody temp eTaru 92e

i
pTOduce feves.
PRS Sensitize MeTYe ending S
wh en giuen nt2ad ÉT YMa)_ ay

Pooduce PaUn

hey hage JOle in geneSiG0ff

1nfammaHOn

O Repaoductiue _System
mae
PORG aTe9| preSent in the
Semen

TO facilitate mo0emenEO2
SpeTroS into emae gedita toact

and_a So imgolved in featilization.

 Jn Femae

and PC p2oduce_6lo
POR E

OteIne COmtTaction

(Specialy duqing9 PTegnoy)

Jn late pTeqmancy

1Se ey el 0f PCKS

intiation andpOOqreSSio _
0f aboudJ

S0 Vsed_aS EcbolicS .

herapeutic uses f PS
osunae cologica 3
A Abostion .
PCRE amd PCE2-
pROduces abor tion n coseS wneE
oxytocin is insensitioe
( induce labouT i
 Pa JmOOLIeS i n i n i t í a t i o n Ond
pTOgession Of labou by ContOCHT9
OterUS

epticO c e z S

PE0Te_9ex y usefu for the

paelgention peptic wceS in
paienS high doseo1 NSA3DS.

PAStHma
PSEa 2bzonchodlatos

USe ASthma

90S odatodS

USe in hypesEens On.

poFOCnt_platel e t aggrega-
haemod ialssiS_
dUITy

Clauco ma
Sefuy 1n
PRS
as theyl0wer
OpenOngie9iaucoma
ImEa -ocuagpTessu9e