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Nataly
Purpose: Tests for quantifying exercise capacity that are appli- a patient could complete quickly in a small space would be
cable in diverse settings are needed. The 1-min sit-to-stand test advantageous. The 1-min sit-to-stand test (1-MSTST), first
(1-MSTST) is such a test. This systematic review summarizes the described by Koufaki et al3 in 2002 is such an alternative as it
literature addressing 1-MSTST procedures, performance, and requires only a chair, a stopwatch, and <2 m2 of floor space.
clinimetric properties. That noted, we have not seen a synopsis of information on
Methods: Three online databases, hand searches, and an ex- the 1-MSTST in RehabMeasures4 or elsewhere. We, there-
Downloaded from http://journals.lww.com/jcrjournal by BhDMf5ePHKbH4TTImqenVHXBtH07/PgUYOA4UA5NK0GnEjTw7RD0o225r9vYRNT4cARpmUV2gCE= on 09/02/2020
pert consultant were used to identify literature relevant to the fore, conducted a systematic review of the 1-MSTST focused
aims of this review. Inclusion required that studies addressed the on test procedures, performance, and clinimetric properties.
1-MSTST, focused on adults, and were written in English.
Results: Seventeen articles were identified that met the inclu-
sion criteria. The populations assessed included adults without METHODS
identified pathologies and adults with lung disease, renal disease,
stroke, osteoporosis, or receiving palliative care. The 1-MSTST DATA SOURCES AND SEARCHES
typically involves an armless chair and the performance of as Three bibliographic databases (PubMed, CINAHL, and Sco-
many sit-to-stand actions as possible in 1 min without using the pus) were searched on August 3, 2016. The string “sit to
upper limbs. The mean number of 1-MSTST repetitions reported stand” and (1 minute or 1 min or 60 sec) was used to identify
in the literature achieved ranged from 8.1 (patients with stroke) potentially relevant articles. Where possible, the search was
to 50.0 (young men). Numerous studies supported the conver- limited to humans and adults. Thereafter, hand searches were
gent and known-groups validity and the test-retest reliability of conducted using the reference lists of relevant articles. An ex-
the test. The test has been shown to be responsive. Normative pert on the topic (Milo Puhan) was contacted to determine
reference values are available. whether we had missed any pertinent articles in our search.
Conclusions: The literature provides considerable support for
using the 1-MSTST to quantify exercise capacity. Broader use SELECTION OF STUDIES
of this test may be indicated, particularly where space and time Inclusion required that studies were published in
are limited. peer-reviewed journals. The studies had to provide a de-
Key Words: clinimetrics • functional capacity • sit-to-stand test • scription of the 1-MSTST and to address 1 or more clinimet-
validity ric properties of the test. Studies were excluded if a sit-to-
stand (STS) test other than the 1-MSTST was described (eg,
using a cycle ergometer or a treadmill; however, these devices DATA EXTRACTION AND QUALITY ASSESSMENT
are costly and not easily transported. Field tests not requir- Two authors independently examined potentially relevant
ing such devices are available; chief among them are timed articles for inclusion and exclusion—beginning with the ti-
walk tests and step tests. Timed walk tests (eg, 6-min walk tle and abstract and progressing to full text, if warranted.
test [6MWT]) are supposed to be conducted on a long cor- After each author compiled a list of articles to be retained
ridor,1 which is not available in many settings. Step tests (eg, for abstracting, they met to reconcile any differences. Once
YMCA step test) are physically demanding and cannot be they agreed upon a list of articles, each author independent-
completed by some older individuals with muscle weakness ly abstracted predetermined information from the articles.
or joint pain.2 An alternative to the aforementioned tests that That information focused on the sample tested (composi-
tion, size, and country), procedures, findings relative to the
Author Affiliation: Department of Physical Therapy, College of Pharmacy & 1-MSTST (eg, mean number of repetitions and clinimetric
Health Sciences, Campbell University, Lillington, North Carolina. properties), and notable conclusions. Quality was assessed
Supplemental digital content is available for this article. Direct URL citation independently by the 2 authors using a custom instrument
appears in the printed text and is provided in the HTML and PDF versions of (see Supplemental Digital Content 1, available at: http://
this article on the journal’s Web site (www.jcrpjournal.com). links.lww.com/JCRP/A73) adapted from similar instru-
The authors declare no conflicts of interest. ments used previously by the authors.5,6 Ratings were com-
pared and differences were reconciled by discussion.
Correspondence: Rebecca Crouch, PT, DPT, Doctoral Program of Physical
Therapy, Department of Physical Therapy, College of Pharmacy & Health
Sciences, Campbell University, Tracey F. Smith Hall, 4150 US 421 South,
Lillington, NC 27546 (rcrouch@campbell.edu). RESULTS
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. From a total of 95 nonduplicative articles identified by both
DOI: 10.1097/HCR.0000000000000336 database and hand searches and by expert advice, 17 were
deemed ultimately to be appropriate for inclusion in this 1-MSTST repetitions in the studies varied greatly—from
systematic review (Figure).3,7-22 The results of the studies 8.1 for a sample of patients with stroke10 to 50 for a pop-
are summarized in Table 1. ulation-based sample consisting of 20- to 24-y-old males.17
The composition of the samples tested using the Test validity was addressed in 14 studies. It was sup-
1-MSTST was diverse. Four samples involved groups of ported by significant correlations between 1-MSTST
adults with no highlighted pathology.7,9,12,17 The remainder performance and other measures with which such perfor-
focused on patients with pathology, with lung disease being mance might be expected to be associated. These other
the most common.9,11,12,14,16,19-22 Other patient groups stud- measures included, but were not limited to, leg press7,20
ied included those with renal disease,3,8,13 stroke,10 or osteo- and knee extension9,19,22 strength, 6MWT distance,9,20,22
porosis,18 and those in palliative care.15 Group sample sizes pulmonary disease severity scores,12,16 laboratory mea-
ranged from 9 to 6926, but only 3 studies included >100 sures of exercise capacity,21 and self-reported physical
participants. The studies were conducted in 18 countries, function.21 Validity correlation was also good for physi-
and Switzerland was the most common location. ologic changes accompanying 1-MSTST performance;
All but 1 study was conducted using a chair; the excep- among these changes were increases in dyspnea,9,22 blood
tional study used a height-adjustable plinth.10 In some stud- lactate,11 and heart rate.13 Fatigue resulting from the
ies, no chair specifics were provided.3,8,18,21 In other stud- 1-MSTST was significantly greater than fatigue accompa-
ies, the chair was referred to as a “standard” or “standard nying a 30-sec STS test. Notably, in comparisons with the
height” chair.7,15 The height of the chair was specified in 6MWT, the 1-MSTST evoked greater increases in blood
10 studies,9,11-14,16,17,19,20,22 with the height ranging from lactate11 and comparable increases in heart rate.13 Known-
44.5 to 48.0 cm. The chairs used in these same 10 studies groups validity of the 1-MSTST has been verified in several
were designated as armless. studies. Specifically, 1-MSTST repetitions have been shown
A prohibition on upper limb use during the 1-MSTST to be greater for men than for women,7,16,17 for healthy
was delineated in all but 4 of the studies.3,15,18,21 Measures controls than for patients with COPD,9,12 and for patients
taken to ensure that the upper limbs were not used includ- with COPD who survived than for patients with COPD
ed crossing the arms over the chest7,13,20 and putting hands who did not survive for 2 y after testing.16
on the hips.9,11,16,17,19,22 Regardless of upper limb use, in- Four studies in our review addressed test-retest reliabili-
structions in most studies stipulated the objective to be ty. Two studies did so by reporting coefficients of variation
the completion of as many repetitions, times, or cycles as across trials (3.8% and 12.8%)3,21 and 3 did so by reporting
possible3,8,10-12,14,16,17,19,20 or as quickly or as fast as possi- intraclass correlation coefficients (0.80-0.98).7,13,21 Respon-
ble.13,18,22 The criterion measure reported in all studies was siveness of the 1-MSTST was implied by studies showing
the number of repetitions, but some studies were more spe- significant increases in 1-MSTST repetitions by patients
cific. For example, Segura-Ortí and Martinez-Olmos13 ad- participating in exercise interventions.3,18,20 Specific indica-
dressed the issue of half-completed repetitions. Strassmann tors of responsiveness have been provided by Segura-Ortí
et al17 referred to fully completed cycles. and Martinez-Olmos,13 who reported a minimal detectable
All but 1 study reported the number of STS performed change (90%) of 4 repetitions, Radtke et al,21 who report-
by participants in 1 min.11 The mean/median number of ed minimal important differences of 5.4 (anchor-based)
Ozalevli et al9 Patients with COPD Chair: 46 cm high, armless 1-MSTST reps: 15 ± 5 (COPD), 20 ± 4 (healthy)
(n = 53) and healthy Task: With hands on hips, stood up and sat down without Validity: In COPD group, 1-MSTST reps correlated significantly with 6MWT distance (r = 0.75, P ≤ .01); pre- and post-STS
adults (n = 15) delay as many times as possible in 1 min at self- test dyspnea (r = −0.75 and −0.80, P < .05); mobility-related QOL (r = −0.63, P = .001); knee extension strength
(Turkey) selected speed. Rest periods permitted (r = 0.65, P < .05); but not with FEV1 (r = −0.22) or post-test heart rate (r = 0.04).
Score: Number of completed reps Mean 1-MSTST reps significantly lower (P = .01) for COPD group (n = 15) than for healthy group (n = 20).
Notable conclusions: “1-MSTST can be used as an alternative to the 6MWT in patients with COPD.”
Britton et al10 Patients with stroke Plinth: Height adjusted to 110% or 120% of leg length 1-MSTST reps: 8.1 ± 3.1 (control); 9.7 ± 4.7 (experimental).
Copyright © 2018 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.
Reliability: Test-retest ICC = 0.97.
Score: Number of completed or half-completed reps Responsiveness: MDC90%= 4 reps.
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Table 1
Summary of Studies of 1-Min Sit-to-Stand Test Included in Systematic Review (Continued )
Article Sample (Country) Test Description Findingsa and Conclusions
Van Gestel Patients with COPD Chair: 46.0-cm high armless chair 1-MSTST reps: 20.0 ± 6.0.
et al14 (n= 70) Task: Without support of hands, stood up and sat down “as Validity: 1-MSTST reps correlated significantly with FEV1 (r = 0.37, P = .014); mean steps/d (r = 0.51, P = .001) and total
(Switzerland) many times as possible…at a patient-defined pace.”
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energy expenditure (r = 0.50, P < .001) but not with having an inactive lifestyle.
Score: Number of reps over a 1-min period
Low et al15 Patients involved Chair: Standard 1-MSTST reps: 17.0 ± 7.0.
in palliative care Task: Stand up and sit down consecutively over a 1-min Validity: 1-MSTST reps were insignificantly correlated (r = 0.27, P = .053) with “acceptance” of “undesirable thoughts and
(n = 101) period feeling.”
(England) Score: Number of times
Puhan et al16 Patients with COPD Chair: 46- to 48-cm high armless chair 1-MSTST reps: 19.5 ± 8.7 (alive at 2 y), 11.8 ± 6.3 (deceased at 2 y).
(n = 409) Task: With hands on hips, stood up and sat down— Validity: 1-MSTST reps higher in male patients and patients with a lower GOLD stage, less dyspnea, and fewer comorbidities.
(Switzerland and Holland) performing “as many reps as possible at a self-paced Significantly (P = .004) fewer 1-MSTST reps for patients not surviving 2 y; 1-MSTST reps better predictors of mortality than
speed”; breaks allowed; notified when 15 sec remained BODE or ADO alone; 1-MSTST reps related to disease-specific quality of life but not with exacerbations.
Score: Number of reps Notable conclusions: “The 1-MSTST may be an attractive option with which to assess exercise capacity in COPD….”
Strassmann Adults (n = 6926) Chair: 46-cm high, armless Range of median scores for 1-MSTST reps: 30-50 (men 20-79 y), 27-47 (women 20-79 y).
et al17 (Switzerland) Task: With arms hanging down loosely or on hips, stood up Validity: 1-MSTST reps significantly lower (P < .001) in women, older adults, smokers, and individuals with higher BMI.
and sat down to complete as many cycles as possible Norms: Reference percentiles (ie, 2.5, 25, 50, 75, 97.5) presented separately for 12 age groups of men and women. Reference
in 1 min at self-selected speed; notified when 30 and equations provided that account for explanatory variables.
15 sec remaining Notable conclusions: 1-MSTST “is simple to perform for an adult population below age of 80 years and may be widely used to
Score: Number of fully completed cycles determine lower body muscular strength and endurance.”
Küçükçakır Women with post- Chair: Not specified 1-MSTST reps: 25.8 ± 5.6 (Pilates), 22.3 ± 4.6 (home exercise).
et al18 menopausal Task: “Stand up from a chair and then sit down as quickly Responsiveness: 1-MSTST reps increased significantly (P < .001) over the course of a home exercise program and a Pilates
osteoporosis (n = 60) as possible during 1 min.” program.
(Turkey) Score: Number of reps
Rausch-Osthoff Patients with COPD Chair: 46-cm high without arm supports 1-MSTST reps: 20 ± 7.
et al19 (n = 27) Task: “Stand up from and sitting down on the chair with Validity: After accounting for FEV1 and age, 1-MSTST reps were correlated significantly (β = .50, P = .014) with knee
(Switzerland) arms stationary on hips, repeating the procedure as extension strength.
many times as possible within 1 min at a patient defined Notable conclusions: “Quadriceps strength may be associated with exercise capacity as assessed by … the STS test….”
pace.”
Score: Number of completed reps
Zanini et al20 Patients with COPD Chair: 47-cm high armless chair. 1-MSTST reps: 24.0 ± 4.0 (strength group); 23.0 ± 5.0 (usual group).
(n = 60) Task: With upper limbs across chest, stood up and sat Validity: 1-MSTST reps correlated significantly with 6MWT distance (r = 0.48, P < .001); 1-RM leg-press (r = 0.36,
(Italy) down “as many times as possible.” P = .005); FEV1 (r = 0.46, P < .001) and VC (r = 0.48, P < .001).
Score: Number of completed cycles Compared with the 30-sec STS test, the 1-MSTST resulted in significantly (P < .001) greater fatigue but not heart rate
increase or oxygen desaturation.
Responsiveness: A pulmonary rehabilitation program incorporating resistance exercise resulted in a significant (P = .005)
increase in 1-MSTS reps.
Notable conclusions: 1-MSTST “is a valid and reliable tool to assess peripheral muscle performance of lower limbs, and is
sensitive to a specific pulmonary rehabilitation program.”
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1-Minute Sit-To-Stand Test Systematic Review
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5
and 4.9 repetitions (distribution-based), and Vaidya et
Validity: 1-MSTST reps correlated significantly with peak oxygen uptake (r = 0.63); maximum power (r = 0.73, P < .01); and
Notable conclusions: The 1-MSTST “may offer a cheap, valid, and promising alternative to assess muscle function” in patients
al,22 who reported minimal important differences of 1.9
Responsiveness: Effect size for pre- and post-rehabilitation changes in 1-MSTST = 0.7, MID = 5.4 reps (anchor-based) or
Responsiveness: 1-MSTST reps increased significantly (P < .001) over the course of pulmonary rehabilitation; MID = 3.1
Initiative for Chronic Obstructive Lung Disease classification; ICC, intraclass correlation coefficient; MDC90%, minimal detectable change 90%; MID, minimal important difference; 1-MSTST, 1-min sit-to-stand test; 1-RM, 1-repetition maximum; QOL, quality of life; reps,
Abbreviations: ADO, Age, Dyspnea, airflow Obstruction index; BMI, body mass index; BODE, Body mass index, Obstruction, Dyspnea, Exercise; COPD, chronic obstructive pulmonary disease; EMG, electromyogram; FEV1, forced expiratory volume in 1 sec; GOLD, Global
and 3.1 repetitions (distribution-based) and 2.5 repetitions
Validity: 1-MSTST reps correlated with 6MWT (r = 0.57, P < .001); age (r = 0.45, P = .001); long-term oxygen use
(anchor-based).
Reliability: Coefficient of variation for 3 tests = 03.8%, ICC = 0.98 but “learning effect” noted with repeated testing.
Only 1 study has provided normative data for the
1-MSTST. In that study, Strassmann et al17 presented sum-
mary data derived from almost 7000 Swiss adults. Sum-
mary data were presented according to 12 age strata for
men and women and as reference equations accounting for
explanatory variables.
Table 2 summarizes the quality ratings of the 16 articles.
The total rating scores ranged from 4 to 10 out of a possible
13 points.
Findingsa and Conclusions
1-MSTST reps data reported as mean ± standard deviation unless noted otherwise.
(n = 48)
Vaidya et al22
Table 3
Recommended Procedures for Conducting the 1-Min Sit-to-Stand Test
Component Procedure
Seating Use slightly padded table or armless chair of standard height (45.0-48.0 cm) that is stabilized (preferably against a wall).
Preparation Have the individual being tested come forward on seating surface far enough for feet to be flat on the floor and the calf to be well forward of
the seating surface. Cross arms over chest.
Practice Have tested individual do 1 sit-to-stand-to-sit cycle.
Instructions “When I say go, I want you to repeatedly stand all the way up and sit down as fast as you can without delay. You will do this for 1 minute. If you
need to rest, you are free to do so. However, you should resume as soon as possible as the goal is to complete as many sit-to-stand cycles
as possible in 1 minute.” Do not provide encouragement, but reminders to stand up fully are allowed. Do inform the person when 10 sec
remain.
Timing and On the command go, begin the stopwatch. Count each full stand aloud. The score is the number of complete sit-to-stand cycles completed in
counting 1 min. Give credit only for a complete sit-to-stand-to sit.