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Key Merged
Key Merged
Khaled Elshamanhory
Prokaryotes Eukaryotes Cell Wall Plant Animal
Examples Bacteria Fungi / Plants / Animals Bacteria ✓ Cell wall ✓
Nucleus ✓ Fungi Chitin Chloroplast ✓
Membrane-bound Plants Cellulose Centrioles ✓
✓ Animals Cytokinesis Plate Furrow
organelles
DNA Circular Linear All cells: plasma membrane/cytoplasm /DNA/ribosome.
Organelles key Plasma / Cell Membrane Passive transport
Nucleus Chromatin (DNA/genes/codes)/nucleolus
Mitochondria Respiration/ATP (energy)/O2 +glucose
Chloroplast Chlorophyll/photosynthesis
Centrioles Spindles pull chromosomes from centromere
Ribosomes Protein synthesis
Golgi complex Processing/package/shipping/export/secretion
Lysosomes Digestion/hydrolysis/ apoptosis/defense
Endoplasmic reticulum Network/ smooth (lipid)/rough(protein)
Microtubules Movement (cilia/flagella)/division (centrioles) Passive transport
Microfilaments Movement (pseudopodia) • No energy/with conc. gradient
Non-membranous Ribosome/chromosome/centrioles 1. Facilitated diffusion: polar channel protein
2. Simple diffusion: non-polar bilayer
Evolution of Eukaryotes/Endosymbiosis
Active transport
• Large eukaryote engulfed smaller prokaryote
• Energy/ATP
Cell Cycle 1. Protein pump/against conc. gradient
1.Interphase 2. Vesicle transport
• G1 (growth) - Endocytosis: phago (eat) - pino (drink)
- Exocytosis: secrete – excrete
• S (DNA replicate)
• G2 (organelles duplicate)
2.Mitosis: nuclear division
3.Cytokinesis: cytoplasmic division
Cancer: error in cell cycle Prefixes:
Apoptosis: programmed cells death c = 10-2 m = 10-3 µ = 10-6 n = 10-9
Mitosis Chromosome
• Separation of identical chromosomes 1. Prophase 2 sister chromatids
• 2 identical (2n) cells produced • Nucleus disappears Centromere
• Keep chromosomal number • Chromosomes appear Genes loci
• Somatic cells
Homologous chromosomes
• Asexual reproduction/growth
• Same genes / different alleles
Human chromosomal number
2. Metaphase 3. Anaphase 4. Telophase
1. Somatic / autosomal / body cells
• Chromosomes align • Separation • 2nuclei • 2n / diploid / 46 chromosomes
• ♀: 44 + XX ♂: 44 + XY
2. Sex cells / gametes
• n / haploid / 23 chromosomes
• ♀: 22 + X ♂: 22 + X / 22 + Y
Dr. Khaled Elshamanhory 2- Biochemistry Keywords ESTII Biology
Radioactive isotopes: (extra neutrons) / C14 (fossils dating) Enzymes (-ase)
Intermolecular bonds: hydrogen bond / Van Der Waals forces Protein catalyst speed up chemical reaction
Vitamins / coenzymes: polar (BC) - non polar (KEDA) Lower activation energy (EA)
Polar / charged: water soluble / hydrophilic (salts, ions) Induced fit model
Nonpolar / not charged: fat soluble / hydrophobic (CO2 / O2 / lipids) Active site is specific to substrate
Water: cohesion / hydrogen bond and adhesion rise water in trees Denature / change 3D-shape
High temperature / chemicals
pH
Acid (H+) < (7 neutral / water) < base (OH-) / pH = 4 (H+ = 10-4)
Blood 7.4 / stomach 2 / mouth 7 / intestine 8 Aerobic cellular respiration
C6H12O6 (glucose) + 6O2 (glucose oxidation) → 6CO2 + 6H2O + 36 ATP
Metabolism Hydrogen carriers: NAD+ and FAD carry hydrogen with its high energy electrons
1. Anabolism / build up / dehydration synthesis Glycolysis in cytoplasm: glucose → pyruvates + ATP
Monomer + monomer → polymer + water (condensate) Krebs cycle in mitochondrial matrix: → ATP + ↑↑CO2
2. Catabolism / breakdown / hydrolysis Electron transport chain in inner mitochondrial membrane / crista
Polymer + water → monomer + monomer NAD+ and FAD release high energy electrons to cytochrome c
NADH2 molecule releases 3ATP ≈ 45 kj
H2 + 1/2 O2 → H2O + ↑↑ATP
Carbohydrates / C + (2H:O)
Chemiosmosis / (H+) gradient / highest amount of ATP / ATP synthetase
1. Monosaccharides C6H12O6:
Glucose (main energy source), fructose, galactose (different atoms positions) Anaerobic respiration / Fermentation / no oxygen
2. Disaccharides: 1. Alcoholic fermentation (yeast / beer / baking): glucose → CO2 + ethanol + ATP
Maltose (2 glucoses) / sucrose (glucose + fructose) / lactose (glucose + galactose) 2. Acid fermentation (bacteria / yogurt): glucose → lactic acid + ATP
3. Polysaccharides Cramp in in human muscles: low O2 during exercise / accumulating lactic acid
Starch (glucose storage in plants)
Cellulose (cell wall in plants) Photosynthesis
Glycogen (glucose storage in animals) In chloroplast: 6CO2 + 6H2O → C6H12O6 (glucose) + 6O2 (from water)
1. Light reaction in grana
Lipids / 3 fatty acid + glycerol
Light energy + chlorophyll → chemical energy / ATP
1. Fat (animal): saturated fatty acids (C-C) / long term energy storage (↑energy)
Light energy + H2O → NADPH + ↑O2
2. Oil (plant): unsaturated fatty acids (C=C)
2. Dark reaction / carbon fixation / Calvin cycle in stroma
3. Wax: cover plant leaves / cuticle / prevent water loss CO2 + (H2 & ATP from light reaction) → 2G3P → glucose
4. Steroids: cholesterol holds cell membrane / high levels cause atherosclerosis
CAM open stomata at night
C4 pathway have Kranz anatomy
Proteins
Starch is detected by iodine →blue
Polymer of amino acids monomers linked by peptide bonds
Photosynthesis in aquatic plant is measured by oxygen bubbles
Tertiary protein: 3D folding determines function Highest photosynthetic colors are red and blue
Dr. Khaled Elshamanhory 3- Molecular Biology Ketwords ESTII Biology
DNA – Watson & Crick Model Protein synthesis Triplet Codon Chart
DNA is anti-parallel double helix carry genetic code Each 3 nucleotides are translated into 1 amino acid
DNA transmit traits through generations 1- Transcription (nucleus) Start codon AUG
Intron is a non-coding DNA sequence DNA → mRNA by RNA polymerase Stop codons UAG / UGA / UAA
Exon is a coding DNA sequence A C G T A C G T T
DNA 3` 5`
Gene is a DNA nucleotide sequence
mRNA 5` 3`
U G C A U G C A A
DNA monomer (nucleotide)
Phosphate group + deoxyribose sugar + nitrogenous base Processing / splicing: remove introns and join exons
Blood groups
Sex linked recessive inheritance Sex linked dominant inheritance
Antigens (A) IA and (B) IB are dominant over recessive (O) ‘i’
Hemophilia / color blindness Carrier female is affected
A: AA / AO B: BB / BO O: OO (universal donor)
Affect males more than females Boy inherits it from mother only
AB: AB (co-dominance / universal recipient)
Genes on X chromosome not Y Girl inherits it from mother or father
AO × BO gives all phenotypes / AB parent never have O child
Boy gets hemophilia from mother XAXa × XaY → 50% of children affected
Rh+ dominant over Rh- (Rh- mother needs immediate injection after first birth)
Girl gets hemophilia from both parents
Agglutination test: antibody clumps antigen Always % of males to females is 50%
XHXh × XhY → 50% of children affected
Anti A Anti B Anti Rh
Blood group A Agglutination
Blood group B Agglutination Karyotype / metaphase Family pedigree
Blood group AB Agglutination Agglutination Photographic presentation of 1 cell
Blood group O Normal female
Normal male
Rh+ Agglutination
Rh-
Affected male Affected female
Stomata
Transpiration (water vapor) & gas exchange
Plant kingdom
Angiosperms
Phyla Example Vascular t. Seeds Flowers 1. Stem – dicot
2. Leaf – dicot
Bryophyta Mosses 3. Flower – monocot
1 2 3 4 4. Flower – dicot
Pterophyta Ferns ✓ 5. Stem – monocot
Gymnosperms Pines / cone ✓ ✓ 6. Leaf – monocot
7. Seed – dicot
Angiosperms Flowering ✓ ✓ ✓ 8. Seed - monocot
5 6 7 8
Dr. Khaled Elshamanhory 6- Physiology Keywords ESTII Biology
Circulation Digestive system Endocrine system
L. ventricle → aorta → body → vena cava → R. atrium → R. Peristalsis: movement of digestive system Anterior pituitary gland
ventricle → pulm. artery → lung → pulm. vein → L. atrium. Mouth: digest starch by amylase FSH: ♀ ovary (estrogen) / ♂ testis (testosterone)
Superior vena cava from upper body Stomach: digest protein by pepsin LH: ♀ ovulation / ♂ spermatogenesis
Pancreas Prolactin: mammary glands GH: growth hormone
Pulmonary artery to lung
Aorta to body Trypsin digests proteins into polypeptides Posterior pituitary gland / hypothalamus
Pulmonary veins Lipase digests lipids into fatty acids and glycerol ADH: ↓ urine volume ↑ urine conc. in nephron
R. atrium from lung
Amylase digests starch into maltose Oxytocin: uterine contraction during birth
from body
• L. atrium from lung Gall bladder Thyroid: thyroxin / iodine / metabolism
Store bile for breakdown of large lipids into globules Parathyroid: PTH / ↑ blood Ca++ level from bones
• R. ventricle to
• L. ventricle to aorta Large intestine / colon: absorb water Adrenal medulla: adrenaline / fear fight flight
pulmonary artery
Small intestine: absorb food by villi Adrenal cortex
Inferior vena cava from lower body Liver: secrete bile / store excess glucose as glycogen Cortisol: metabolism / anti-inflammatory
Valve: prevent backflow of blood Aldosterone: reabsorb salts from nephron
Salivary glands
• Pancreas (endocrine / exocrine)
Mouth
• Heart beat control by medulla oblongata Pharynx Insulin: ↓blood glucose / store as glycogen in liver
• Sympathetic ↑ heart rate / parasympathetic ↓ heart rate Glucagon: oppose insulin
• SA node on R. atrium / AV node on ventricles Esophagus
Diabetes: ↑ blood glucose / no insulin
Blood cells formation in bone marrow
Female reproductive system
RBCs: hemoglobin carries O2 Gall bladder Stomach
Menstrual cycle / 28 days
WBCs: immunity Pancreas
Liver FSH→ ovary→ estrogen (↑ uterine thickness)
Platelets: blood clotting
Large Small
LH (14) → ovary (ovulation / corpus luteum)
Immune system intestine intestine Corpus luteum → progesterone (keep uterine thickness)
Appendix
1st line of defense Rectum No fertilization / corpus luteum degenerates / menstruation
Inflammation / hot / red / swell / pain / histamine Anus Fertilization / fallopian tube / 14 / zygote
2nd line of defense
Nervous system Placenta
Phagocytes engulf bacteria / diapedeses
Nerve cell / neuron: sensory / motor Pass food / wastes / O2 / CO2 by diffusion / no nerve
3rd line of defense / lymphocytes
Myelin sheath: speed up electric impulse Embryo and mother blood do not mix
B-cells: attack bacteria by antibodies / memory cells
Nerve fiber thickness: speed up electric impulse Contraceptive pills
B-cells proliferate in lymph nodes
Nerve impulse / action potential: Na+/K+ channels Estrogen + progesterone to prevent uterine resorption
Killer T-cells: attack virus and cancer cells
Synapse: between nerves / acetyl choline Germ layer
Helper T-cell: activate B and killer T-cells
CNS: brain and spinal cord (reflex) Ectoderm / skin / nerve
T-cells are activated in thymus gland / ablation
Spinal nerves: dorsal sensory / ventral motor Mesoderm / viscera / muscle / bone
Active immunity / vaccine (lifelong): self-antibodies
Medulla oblongata: involuntary / autonomic Endoderm / internal organs
Passive immunity (short time): external antibodies
Dr. Khaled Elshamanhory 7- Taxonomy Keywords ESTII Biology
Number
Number
Ecological pyramid
Loss in number and biomass of individuals Hawks / 3rd
4 trophic levels
Ecosystem (biotic + abiotic factors)
Loss of heat energy through respiration by 10% Snakes / 2nd
Nitrogen cycle: decomposers → NH3 → plant → animal → death
N2 fixing bacteria (+) in legumes roots (+) fix N2 gas into nitrates or ammonia Succession Rabbits / 1st
Aerobic nitrifying bacteria: convert nitrates into ammonia Permanent organism replacement Carrots / producers
Anaerobic denitrifying bacteria: convert nitrogen compound into N2 Lichens are pioneer organisms
Biomes Behavior
Tropical rainforest: ↑ precipitation / ↑ diversity / ↑ vegetation Unlearned / innate behavior / fixed action pattern
Desert: dry / temperature fluctuation / cactus / ↓ productivity Reflexes / nervous Instinct / endocrine
Grasslands / savanna: rain and drought / main human food
Learned behavior
Deciduous forest: shed leaves / oak / maple / ↑↑ productivity
Habituation: loss of sensation Classical conditioning / Pavlov: dog bell and food
Taiga / coniferous forest: frozen winter / needle leaves pines
Operant conditioning / Skinner: rat and maze Imprinting / Konrad: duckling / gosling / mother
Tundra / coniferous / boreal: permafrost / no trees / no deep soil
Marine biome / salt: stable ecosystem / highest producer (planktons) Social behavior
Pheromones: smell from moth to find mate Activity: diurnal (day) / nocturnal (night)
Pollution
Global warming / greenhouse effect / melt of polar ice A Prey
Fossil fuel / cutting off trees / ↑CO2 / CH4 emit heat to Earth Predator A B C
Acid rains: sulfur ↓ soil pH
B
Ozone depletion: UVR / skin cancer
Eutrophication: ↑phosphate in lakes / sewage / ↑algal growth / O2 depletion
Bio-magnification (DDT / ppm): toxins accumulation in higher trophic levels Competition Predation Succession