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Overview ........................................................................................................................................... 4
A mucosa oral ................................................................................................................................ 6
Absorção Sublingual ...................................................................................................................... 7
Formas farmacêuticas de absorção sublingual ............................................................................. 9
FORMAS SÓLIDAS:...................................................................................................................... 9
GOMAS: .................................................................................................................................... 10
PATCHES BUCAIS: ..................................................................................................................... 10
TABLETES e COMPRIMIDOS SUBLINGUAIS: ............................................................................. 10
Aspectos Farmacológicos ............................................................................................................ 11
INTENSIFICADORES DE PENETRAÇÃO: ..................................................................................... 11
INIBIÇÃO ENZIMÁTICA: ............................................................................................................ 12
BIOADESIVOS: .......................................................................................................................... 12
MODIFICADORES DE SOLUBILIDADE:....................................................................................... 13
TOXICIDADE E IRRITAÇÃO: ....................................................................................................... 13
Compatibilidades e fármacos ...................................................................................................... 14
Fármacos com Eficácia Via Sublingual ......................................................................................... 15
Fórmulas & Técnica ......................................................................................................................... 35
EXCIPIENTE TIPO TABLETE SUBLINGUAL TASTE FREE .............................................................. 36
SPRAY SUBLINGUAL ................................................................................................................. 37
GOMA DE GELATINA ................................................................................................................ 38
FILME ORODISPERSÍVEL ............................................................... Erro! Indicador não definido.
Literatura Consultada ...................................................................................................................... 40

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 nifedipine and propranolol, by sublingual
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