Professional Documents
Culture Documents
S Rheumatic Heart Disease
S Rheumatic Heart Disease
Table of Contents
1 Introduction ..................................................................................................................................... 3
1.1 Funding .................................................................................................................................. 3
1.2 Conflict of interest .................................................................................................................. 3
1.3 Development process ............................................................................................................ 3
1.4 Summary of changes ............................................................................................................. 3
2 Methodology ................................................................................................................................... 4
2.1 Topic identification ................................................................................................................. 4
2.2 Scope ..................................................................................................................................... 4
2.3 Clinical questions ................................................................................................................... 4
2.4 Search strategy ...................................................................................................................... 5
2.4.1 Keywords ........................................................................................................................... 5
2.5 Consultation ........................................................................................................................... 6
2.6 Endorsement ......................................................................................................................... 6
2.7 Citation ................................................................................................................................... 6
3 Levels of evidence .......................................................................................................................... 7
3.1 Summary recommendations .................................................................................................. 8
4 Implementation ............................................................................................................................... 9
4.1 Suggested resources ............................................................................................................. 9
4.2 Implementation measures ..................................................................................................... 9
4.2.1 Implications for implementation ......................................................................................... 9
4.2.2 QCG measures .................................................................................................................. 9
4.2.3 Hospital and Health Service measures ............................................................................. 9
4.3 Quality measures ................................................................................................................. 10
4.4 Areas for future research ..................................................................................................... 10
4.5 Safety and quality ................................................................................................................ 11
References .......................................................................................................................................... 17
List of Tables
Table 1. Summary of change ................................................................................................................ 3
Table 2. Scope framework ..................................................................................................................... 4
Table 3. Basic search strategy .............................................................................................................. 5
Table 4. Major guideline development processes ................................................................................. 6
Table 5. Levels of evidence (GRADE) ................................................................................................... 7
Table 6. GRADE strength of recommendations .................................................................................... 7
Table 7. Summary recommendations .................................................................................................... 8
Table 8. NSQHS Standard 1 ............................................................................................................... 10
Table 9. Clinical quality measures ....................................................................................................... 10
Table 10. NSQHS Criteria ................................................................................................................... 11
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives V4.0 International licence. In essence, you are free to copy and
communicate the work in its current form for non-commercial purposes, as long as you attribute Queensland Clinical Guidelines, Queensland Health and abide
by the licence terms. You may not alter or adapt the work in any way. To view a copy of this licence, visit https://creativecommons.org/licenses/by-nc-
nd/4.0/deed.en
For further information contact Queensland Clinical Guidelines, RBWH Post Office, Herston Qld 4029, email Guidelines@health.qld.gov.au, For permissions
beyond the scope of this licence contact: Intellectual Property Officer, Queensland Health, GPO Box 48, Brisbane Qld 4001, email
ip_officer@health.qld.gov.au
1 Introduction
This document is a supplement to the Queensland Clinical Guideline (QCG) Rheumatic heart
disease and pregnancy. It provides supplementary information regarding guideline development,
makes summary recommendations, suggests measures to assist implementation and quality
activities and summarises changes (if any) to the guideline since original publication. Refer to the
guideline for abbreviations, acronyms, flow charts and acknowledgements.
1.1 Funding
The development of this guideline was jointly funded by the Queensland Aboriginal and Torres Strait
Islander Rheumatic Heart Disease Action Plan 2018-2021, and Healthcare Improvement Unit,
Queensland Health. Consumer representatives were paid a standard fee. Other working party
members participated on a voluntary basis.
Publication date
Identifier Summary of major change
Endorsed by:
March 2022 First publication
Statewide Maternity and MN22.40-1-V1-R27
Neonatal Clinical Network
(Qld)
2 Methodology
Queensland Clinical Guidelines (QCG) follows a rigorous process of guideline development. This
process was endorsed by the Queensland Health Patient Safety and Quality Executive Committee in
December 2009. The guidelines are best described as ‘evidence informed consensus guidelines’ and
draw from the evidence base of existing national and international guidelines and the expert opinion
of the working party.
2.2 Scope
The scope of the guideline was determined using the following framework.
Scope framework
• Women with history of acute rheumatic fever and/or rheumatic heart disease
Population • Pregnant women with a history of or identified with acute rheumatic fever
(ARF) / rheumatic heart disease (RHD) for the first-time during pregnancy
Identify relevant evidence related to:
• The risks related to pregnancy for women with ARF or RHD
Purpose • Preconception counselling
• Assessment and management of ARF and RHD during pregnancy and
postpartum
Support:
Outcome • Early identification of pregnant women with ARF and RHD
• Best practice management during pregnancy, labour and postpartum
• Standard care as outlined in the Queensland Clinical Guidelines Standard
Care guideline
• Routine antenatal, intrapartum and postpartum care
• Primary health prevention, diagnosis and management of ARF
Exclusions
• Secondary prophylaxis and long-term monitoring of ARF
• Comprehensive information related to echocardiographic features of
RHD/ARF
• Surgical or interventional management of RHD
Step Consideration
1. Review clinical guidelines • This may include national and/or international guideline
developed by other writers, professional organisations, government
reputable groups relevant to organisations, state based groups.
the clinical speciality • This assists the guideline writer to identify:
o The scope and breadth of what others have found useful
for clinicians and informs the scope and clinical question
development
o Identify resources commonly found in guidelines such as
flowcharts, audit criteria and levels of evidence
o Identify common search and key terms
o Identify common and key references
2. Undertake a foundation • Construct a search using common search and key terms
search using key search identified during Step 1 above
terms • Search the following databases
o PubMed
o CINAHL
o Medline
o Cochrane Central Register of Controlled Trials
o EBSCO
o Embase
• Studies published in English less than or equal to 5 years
previous are reviewed in the first instance. Other years
may be searched as are relevant to the topic
• Save and document the search
• Add other databases as relevant to the clinical area
3. Develop search word list for • This may require the development of clinical sub-questions
each clinical question beyond those identified in the initial scope.
• Using the foundation search performed at Step 2 as the
baseline search framework, refine the search using the
specific terms developed for the clinical question
• Save and document the search strategy undertaken for
each clinical question
4. Other search strategies • Search the reference lists of reports and articles for
additional studies
• Access other sources for relevant literature
o Known resource sites
o Internet search engines
o Relevant textbooks
2.4.1 Keywords
The following keywords were used in the basic search strategy: Key words (rheumatic heart disease,
pregnancy, acute rheumatic fever, cardiac risk factors, cardiac lesions, mitral stenosis, aortic
stenosis, ejection fraction, risk stratification, ARF, RHD).
Other keywords may have been used for specific aspects of the guideline.
2.5 Consultation
Major consultative and development processes occurred between April and November 2021.
Process Activity
Clinical leads • The clinical leads accepted their appointment in February 2021
• Consumer participation was invited from a range of consumer focused
Consumer
organisations who had previously accepted an invitation for ongoing
participation
involvement with QCG
• An EOI for working party membership was distributed via email to
Queensland clinicians and stakeholders in September 2021
• The working party was recruited from responses received
Working party
• Working party members who participated in the working party consultation
processes are acknowledged in the guideline
• Working party consultation occurred in a virtual group via email
• Consultation was invited from Queensland clinicians and stakeholders
during November 2021
Statewide
• Feedback was received primarily via email
consultation
• All feedback was compiled and provided to the clinical leads and working
party members for review and comment
• A literature review and consultation with the clinical lead was undertaken
Review
in June–November 2021
2.6 Endorsement
The guideline was endorsed by the:
• Queensland Clinical Guidelines Steering Committee in February 2022
• Statewide Maternity and Neonatal Clinical Network (Queensland) in February 2022
2.7 Citation
The recommended citation of Queensland Clinical Guidelines is in the following format:
EXAMPLE:
Queensland Clinical Guidelines. Normal birth. Guideline No. MN17.25-V3-R22.
Queensland Health 2017. Available from: www.health.qld.gov.au/qcg.
3 Levels of evidence
The levels of evidence and strength of recommendations identified by the GRADE system1 and used
by RHD Australia and the Menzies School of Health Research2 were used to inform the summary
recommendations.
Quality of
Code Definition
evidence
Further research is very unlikely to change the level of
A High confidence in the estimate of effect. i.e.
• Several high-quality studies with consistent results
Further research is likely to have an impact in the current
confidence in the estimate of effect and may change the
B Moderate estimate. i.e.
• One high quality study
• Several studies with some limitations
Further research is very likely to have an important impact on
the level of confidence in the estimate of effect and would likely
C Low
change the estimate. i.e.
• One or more studies with significant limitations
Estimate of effect is very uncertain. i.e.
D Very low • No direct research evidence
• One or more studies with very significant limitations
Strength of
Code Implications when combined with evidence
recommendation
• 1A: Strong recommendation, applies to most patients without
reservation. Clinicians should follow a strong
recommendation unless a clear and compelling rationale for
an alternative approach is present.
• 1B: Strong recommendation, applies to most patients.
Clinicians should follow a strong recommendation unless a
1 Strong
clear and compelling rationale for an alternative approach is
present.
• 1C: Strong recommendation, applies to most patients. Some
of the evidence
o Base supporting the recommendation is, however, of low
quality
• 2A: Weak recommendation. The best action may differ
depending on circumstances of patients or societal values
• 2B: Walk recommendation. Alternative approaches likely to
2 Weak be better for some patients under some circumstances
• 2C: Very weak recommendation. Other alternatives may be
equally reasonable
• 2D: No evidence available; expert consensus judgement
Consensus
• Decreased left ventricular systolic function
• Moderate or severe aortic and/or mitral stenosis
Identify as high risk
• Pulmonary hypertension
• Mechanical valve prostheses or cardiac disorder requiring
anticoagulation
• Current heart failure or arrhythmia
• Ensure the woman is on RHD register in relevant jurisdictions
RHD register • 2B
• If not (or if not sure), contact RHD register
• Symptoms and signs requiring urgent medical assessment:
o New onset or progressive breathlessness or cough
o Need to sleep sitting up (orthopnoea)
Red flags o Significant reduction in exercise tolerance • 1C
o Syncope or presyncope
o Persistently fast heart rate (tachycardia)
o Wheeze and/or leg oedema
• Multi-disciplinary team approach • 2B
• Individualised birth plan taking account of cardiovascular and • 1C
obstetric issues
• Vaginal birth recommended unless obstetric and/or cardiovascular • 2C
conditions preclude
Labour and birth • Requirement for intrapartum intensive or invasive monitoring • 1A
should be individualised depending on severity of underlying
valvular disease
• Follow anticoagulation protocol where relevant • 1A
• Aim for early epidural analgesia when tachycardia or hypertension • 2C
may not be well tolerated because of maternal valvular disease
• Follow anticoagulation protocol where relevant • 1C
• Investigate post-partum/post-discharge dyspnoea or new-onset • 2C
Post-partum
cough promptly
• Discuss family planning and contraception • 1C
• Follow-up cardiac review according to priority • 1C
• Clinical communication follow-up with primary health • 2C
Post-discharge
services/GP/Aboriginal Medical Service and other relevant services
• Maintain high degree of suspicion for presentation of dyspnoea • 1C
4 Implementation
This guideline is applicable to all Queensland public and private maternity facilities. It can be
downloaded in Portable Document Format (PDF) from www.health.qld.gov.au/qcg
References
1. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an
emerging consensus on rating quality of evidence and strength of recommendations. British Medical
Journal 2008;336(7650):924.
2. RHDAustralia (ARF/RHD writing group). The 2020 Australian guideline for prevention, diagnosis
and management of acute rheumatic fever and rheumatic heart disease (3rd edition). [Internet]. 2020
[cited 2021 January 20]. Available from: https://www.rhdaustralia.org.au.
3. Australian Commission on Safety and Quality in Health Care. National Safety and Quality Health
Service Standards. [Internet]. 2017 [cited 2021 Nov 4]. Available from: www.safetyandquality.gov.au.
4. Snelgrove JW, Alera JM, Foster MC, Bett KCN, Bloomfield GS, Silversides CK, et al. Prevalence
of Rheumatic Heart Disease and Other Cardiac Conditions in Low-Risk Pregnancies in Kenya: A
Prospective Echocardiography Screening Study. Glob Heart 2021;16(1):10.
5. Kumar RK, Antunes MJ, Beaton A, Mirabel M, Nkomo VT, Okello E, et al. Contemporary
Diagnosis and Management of Rheumatic Heart Disease: Implications for Closing the Gap: A
Scientific Statement From the American Heart Association. Circulation 2020;142(20):e337-e57.
6. European Society of Cardiology (ESC). 2018 ESC Guidelines for the management of
cardiovascular diseases during pregnancy. European Heart Journal 2018;39:3165–241.
7. Queensland Clinical Guidelines. Standard care. Guideline No. MN18.50-V1-R23. [Internet].
Queensland Health. 2018. [cited 2021 Nov 4]. Available from: https://www.health.qld.gov.au/qcg
Acknowledgements
Queensland Clinical Guidelines gratefully acknowledge the contribution of Queensland clinicians and
other stakeholders who participated throughout the guideline development process particularly:
Clinical Leads
Professor William Parsonage, Senior Staff Cardiologist, Royal Brisbane and Women’s Hospital
Dr Sam Hillier, Cardiologist, Cairns
Dr Cecelia O’Brien, Maternal Fetal Medicine specialist, Townsville University Hospital