RĪGA STRADIŅŠ UNIVERSITY

STUDY PROGRAM “MEDICINE 2.0”

STUDY COURSE “MEDICAL BIOCHEMISTRY”
SEMESTER II
WEEK 1
HOMEWORK

Fill out these worksheets while listening to Lecture – Transport and storage of lipids. Biosynthesis of Cholesterol, Functions.
TASK 1
Fill out the table as described.

Type of lipoprotein
Give full name and the
abbreviation.
Composition of lipoproteins
List the types of macromolecules in order from
highest to lowest concentrations.
For the first one give exact %
Name characteristic apolipoproteins Lipid transport from → to
Start with the unique ones, if there are such
Describe the major route for each particle.
and the rest list in alphabetic order.
Example of red blood cell cycle: Bone
marrow → Blood → Spleen

TASK 2
Assignments:
 Fill out the table, giving general description of the metabolic process.

 Name/draw missing substrates, products, enzymes and cofactors in the schematic drawings.

Name of the metabolic process

Place of action in organism and in cell

 Substrate and products

Describe the major function/s of the

metabolic process

ATP gained/used
(including coenzymes)

TASK 3
Take a look at atherosclerotic plaque and answer the related questions.
Match the terms with correct number from the scheme:

_____Activated Macrophages

_____Cholesterol crystals

_____Cholesteryl esters

_____Foam cells

_____Necrotic cells

In order to prevent formation of atherosclerotic plaques drug class ____________________ can be used, which inhibits enzyme _____________________________________, thus

reducing activity of metabolic process named _______________________________.