Professional Documents
Culture Documents
Week 2 Lecture Fatty Acid Catabolism, Ketogenesis
Week 2 Lecture Fatty Acid Catabolism, Ketogenesis
Week 2 Lecture Fatty Acid Catabolism, Ketogenesis
Semester II
Week 2
FATTY ACID CATABOLISM
KETOGENESIS
Learning goals:
Humans obtain fats in the diet, mobilze fats stored in adipose tissue, and, in the liver,
convert excess dietary carboxydrates to fats for export to other tissues, while during
the starvation recycle lipids by autophagy
Resting
• Subsequent reactions
recover more than enough
ATP to cover this cost
Oxidation or
synthesis of
membrane lipids
Medicine 2.0, Medical Biochemistry
13
(CFUBK_072), Assist. Prof. Dace Reihmane
Acyl-Carnitine/Carnitine Transport
for fatty acids with > 12 C + AMP PPi
Than fatty acid+ATP+HSCoA----------------> AcylSCoA
Fatty acid enters cytosol as free fatty acid.
Acel-SCoA reaction produces 2 ADP, because AMP
should be converted to ADP first and
only then into ATP. In this reaction 1
ATP is used. AMP+ATP--->2ADP
Of the cell
------------
Passive
Acyl-carnitine/carnitine
transporter
HOMEWORK
TASK 1:
Take a time to fill it out!
18
The - Oxidation may be acyl-CoA
Single bond
between
methylene (-CH2-) if here O2, C-C bond is weaker
is relatively stable
in comparison to
C-C between two
carbonyl carbons
Catalyzed by -hydroxyacyl-CoA
dehydrogenase
Catalyzed by acyl-CoA
acetyltransferase (thiolase)
via covalent mechanism
29
X-linked adrenoleukodystrophy
https://www.spandidos-publications.com/10.3892/etm.2019.7804
HOMEWORK
TASK 2:
Take a time to fill it out!
• Liver
• Mitochondria
• Most prominent
A third acetyl-CoA is
incorporated in the second step
pyruvate
https://spectrum.diabetesjournals.org/content/diaspect/15/1/28/T1.large.jpg
Medicine 2.0, Medical Biochemistry
46
(CFUBK_072), Assist. Prof. Dace Reihmane
Summarize your knowledge about
The Ketogenesis
HOMEWORK
TASK 3:
Take a time to fill it out!