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    MajorDepression3D Epidemiology

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    Ryan De Paulo
    The document describes a case control study examining the association between smoking and lung cancer. It shows data from the 1950 Wynder and Graham study, which found that 583 lung cancer cases were moderate to heavy smokers, compared to only 22 non-smoker or light smoker cases. Meanwhile, among the controls without lung cancer, 576 were smokers and 204 were non-smokers. The relative odds of smoking and lung cancer were calculated to be 9.4. Overall, the document discusses case control study design, provides an example study on smoking and lung cancer, and reviews strengths and limitations of case control studies.

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    MajorDepression3D Epidemiology

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    Ryan De Paulo
    7 views6 pages
    The document describes a case control study examining the association between smoking and lung cancer. It shows data from the 1950 Wynder and Graham study, which found that 583 lung cancer cases were moderate to heavy smokers, compared to only 22 non-smoker or light smoker cases. Meanwhile, among the controls without lung cancer, 576 were smokers and 204 were non-smokers. The relative odds of smoking and lung cancer were calculated to be 9.4. Overall, the document discusses case control study design, provides an example study on smoking and lung cancer, and reviews strengths and limitations of case control studies.

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    521b3cedbd10c0158076d190373c1c2f MajorDepression3D Epidemiology

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    The document describes a case control study examining the association between smoking and lung cancer. It shows data from the 1950 Wynder and Graham study, which found that 583 lung cancer cases were moderate to heavy smokers, compared to only 22 non-smoker or light smoker cases. Meanwhile, among the controls without lung cancer, 576 were smokers and 204 were non-smokers. The relative odds of smoking and lung cancer were calculated to be 9.4. Overall, the document discusses case control study design, provides an example study on smoking and lung cancer, and reviews strengths and limitations of case control studies.

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    © All Rights Reserved
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    7 views6 pages

    MajorDepression3D Epidemiology

    Uploaded by

    Ryan De Paulo
    The document describes a case control study examining the association between smoking and lung cancer. It shows data from the 1950 Wynder and Graham study, which found that 583 lung cancer cases were moderate to heavy smokers, compared to only 22 non-smoker or light smoker cases. Meanwhile, among the controls without lung cancer, 576 were smokers and 204 were non-smokers. The relative odds of smoking and lung cancer were calculated to be 9.4. Overall, the document discusses case control study design, provides an example study on smoking and lung cancer, and reviews strengths and limitations of case control studies.

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    of 6

    MAJOR DEPRESSION IN THE POPULATION:

    A PUBLIC HEALTH APPROACH

    William W. Eaton, PhD, Johns Hopkins University, 2013

    Copyright 2013, The Johns Hopkins University and William W. Eaton. This  work  is  licensed  under  the  Crea3ve  
    Commons  A7ribu3on-­‐NonCommercial-­‐NoDeriva3ves  license.  Your  use  of  this  material  cons3tutes  acceptance  of  that  
    license  and  the  condi3ons  of  use  of  materials  on  this  site.
    Section D: Case Control Studies
    Exemplar  Case  Control  Study  
    Wynder  and  Graham,  1950    
    Smoking  and  Lung  Cancer  

    Lung  Cancer   No  Lung  


    (Cases) Cancer  
    (Controls)
    Smoker  (moderate  to  chain)   583 576
    Exposed
    Non  or  Light  Smoker   22 204
    Not  Exposed

    Rela3ve  Odds:      583/576   (OR:    ad/bc  =  583*204/576*22)  =  9.4  


                                         22/204      
    3  
    Exemplar Case Control Study
    Life events associated with onset of Depression

    Number and Percent with severe events prior to onset

    Cases Controls

    One  or  more  


    52  (68%) 76  (20%)
    severe  events

    No  severe  events 24  (32%) 306  (80%)

    Number  of  
    76  (100%) 382  (100%)
    persons

    Rela3ve  Odds:      52/76   =    8.72  


                                   24/306      
    4  
    Source: Brown and Harris. (1978). Social origins of depression, pp. 57-58, 103. 4  
    Strengths & Weaknesses of the Case
    Control Study
    • Strengths
    – Requires no hypothesis
    – Cases can come from clinics
    – Small number of controls
    • Weaknesses
    – Biased recall (strength)
    – Temporality
    – Controls may not match cases (consistency)

    5  
    Strengths & Weaknesses of the Case
    Control Study
    • Strengths
    – Requires no hypothesis
    – Cases can come from clinics
    – Small number of controls
    • Weaknesses
    – Biased recall (strength)
    – Temporality
    – Controls may not match cases (consistency)

    6  

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