The Journalof

Volume 247
October-December
PHARMACOLOGY
1988 AND EXPERIMENTAL THERAPEUTICS
A Publication of The American Society
for Pharmacology and Experimental Therapeutics

Founded by John J. Abel 1909

EDITOR
Eva King Killam

ASSISTANT EDITOR
Mannfred A. Hollinger

EDITORS FOR SPECIFIC FIELDS

Analgesia and Drug Abuse Chemotherapy Immuriopharmacology
William L Dewey H. George Mandel Sydney Spector
Billy Martin Developmental Pharmacology Neuropharmacology
Autonomic Pharmacology Bernard L Mirkin Edmund G. Anderson
Robert R. Ruffolo, Jr. Drug Metabolism and Disposition David B. Bylund
Robert E. Stltzel Edward Bresnick S. J. Enna
Behavioral Pharmacology Jordan L Holtzman Charles 0. Rutledge
John A. Harvey Endocrine Pharmacology Prostoglandins and Leukotrienes
Cardiovascular Pharmacology Paula H. Stem Guy C. La Breton
Leslie E. Bailey John C. McGlff
Gastrointestinal Pharmacology
Henry R. Besch, Jr. Thomas F. Burks Pu! rnonary Pharmacology
Theodore M. Brody Mannfred A. Hollinger
Sue Piper Duckles Renal Pharmacology
Cell Pharmacology William 0. Bemdt
Toshlo Narahashi Toxicology
Ronald P. Rubln Curtis D. Klaassen
George B. Weiss

EDITORIAL ADVISORY BOARD

Margaret Acara Hugh L. Evans Roberto Levi Roger P. Smith
Martin W. Adler Jerry M. Farley George E. Undenmayer Roger D. Spealman
Edson X. Albuquerque Harold Fesnberg Horace H. Loh Janice L. Stickney
James B. Appel Gregory D. Fink Benedict A. Lucchesi John L. Sutko
Lewis Aronow Garret A. FitzGerald K. U. Malik Boris Tabakoff
William D. Atchison Ray W. Fuller Thomas A. McCalden A. E. Takemon
Albert J. Azzaro Timothy S. Gaginella Donald E. McMillan David A. Taylor
Robert L. Balster Gerard L. Gebber W. H. Morse Robert E. Ten Eick
Paul Bass James W. Gibb Hasan Mukhtar Thomas A. Tephly
Michael A. Beaven Shn N. Girl Kevin Mullane Richard E. Tessel
John A. Bevan Frank R. Goodman L. Charles Mumn Martin J. M. C. Thoolen
C. Paul Bianchi Thomas P. Green Jose M. Musacchio Pieter B. M. W. M. Timmermans
David A. Blake Garrett J. Gross Jon A. Norman Theodore J. Torphy
Alan S. Bloom A. Adron Hams Robert F. O’Dea U. Trendelenburg
Floyd E. Bloom Richard J. Head Achilles J. Pappano Norman J. Uretsky
Carl K. Buckner J. Paul Hieble Leslie V. Panse Paul M. Vanhoutte
Theodore J. Cicero Stephen G. Holtzman William A. Pettinger Ralph Vinegar
Doris H. Clouet Jerry B. Hook Larissa A. Pohorecky Larry A. Walker
Marlene L. Cohen E. H. Jeffery Garth Powis Martin A. Wasserman
Charles R. Craig Robert M. Joy Donald V. Pnola I. M. Weiner
Luigi X. Cubeddu Alain F. Junod Russell A. Prough Richard M. Welch
E. E. Daniel George J. Kaloyanides David Raebum Grant A. Wilkinson
William C. de Groat Alexander G. Karczmar Arthur Raines Michael Williams
Louis Diamond Terry Kenakin C. R. Ross Martin M. Winbury
Gerald F. DiBona Conan Kornetsky Arnold Schwartz Raymond J. Winquist
Robert J. Dinerstein Edwin A. Kroeger Lewis S. Seiden Barry B. Wolfe
Waiter R. Dixon Suzanne G. Laychock Paul J. Silver Henry I. Yamamura
J. W. Downie TonyJ.-F. Lee David J. Smith Ben G. Zimmerman
Linda Dykstra

BOARD OF PUBLICATIONS TRUSTEES

William W. Fleming, Chairman: James A. Bain, Joseph A. Bianchine, Joel G. Hardman, Eva King Killam,
Horace Loh, Jerry A. Mitchell, Marcus M. Reidenberg, Irving I. A. Tabachnick, Palmer W. Taylor, Vincent G. Zannoni

EXECUTIVE OFFICER OF THE SOCIETY

Kay A. Croker

THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (ISSN 0022-3565) is published monthly by The American Society
for Pharmacology and Experimental Therapeutics, 428 E. Preston Street, Baltimore, MD 21202-3993. Second class postage paid at Baltimore, MD and at
additional mailing offices. POSTMASTER: Send address changes to THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEU.
TICS, 428 E. Preston St., Baltimore, MD 21202-3993. Indexed by Current Contents and Index Med icus. Subscription rates $150.00 ($205.00 foreign, $302
Japan); institutions $240.00 ($295 foreign, $392.00 Japan) single copy $16.00 ($20.00 foreign). (Japanese rates include air freight.) Prices are subject to
change. Copyright © 1988 by The American Society for Pharmacology and Experimental Therapeutics.
COPYRIGHT © 1988 BY THE AMERICAN SOcIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
1988 Pharmacotherapy of Foeal Cerbral lschemla 1221

antagonist (PY 108-068) treatment may further decrease flow in ischemic areas iachemic stroke. In Cerebral Blood Flow Physiologic and Clinical Aspects, ed.
in acute stroke. J. Cerebr. Blood Flow Metab. 6: 222-229, 1986. by J. H. Wood, pp. 663-612, McGraw-Hill, New York, 1987.
WEINSTEIN, P. R., ANDERSON, G. G. AND TELLER, D. A.: Neurological deficit YOUNG, A. R., BARRY, D. I., MACKENZIE, E. T. AND ROBERT, J.-P.: Cerebro-
and cerebral infarction after temporary middle cerebral artery occlusion in circulatory effects of so-called “vasodilators” in the anaesthetized rat. Eur.
unanesthetized cats. Stroke 17: 318-327, 1986. Neurol. 22: 142-153, 1983.
Wmss, J., GOLDBERG, M. P. AND CH0I, D. W.: Ketamine protects cultured YOUNG, A. R., BOULOY, M., BOUSSARD, J.-F.. EDVINSSON, L. AND MACKENZIE,
neocortical neurons from hypoxic injury. Brain Res. 380: 186-190, 1986. E. T.: Direct vascular effects of agents used in the pharmacotberapy of
WIELOCH, T.: Hypoglycemia-induced neuronal damage prevented by an N- cerebrovascular disease on isOlated cerebral vessels. J. Cerebr. Blood Flow
methyl-D-aspartate antagonist Science (Wash. DC) 230: 681-683, 1985. Metab. 1: 117-128, 1981.
WIELOCH, T., ENGELSEN, B., WE5TERsERG, E. of theAND AuER, R.: Lesions
glutamatergic cortico-striatal projections in the rat ameliorate hypoglycemic Send reprint requests to: Dr. E. T. MacKenzie, Laboratoires d’Etudes et de
brain damage in the striaturn Neuroaci. Lett. 58: 25-30, 1985. Recherches Synth#{233}labo, 31, ave Paul Vaillant-Couturier, 92220 Bagneux, France.
YATSU, F. M., PrrnoREw, L C. AND GROTFA, J. C.: Medical therapies for acute

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