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Stevanovic 2011
Stevanovic 2011
Correspondence:
• The measurement characteristics of the Quality of Life Enjoyment and Satisfaction
Questionnaire (Q-LES-Q) for quality of life (QOL) assessments in the clinical
D. Stevanovic
settings were evaluated.
Department of Psychiatry
General Hospital Sombor • The Q-LES-Q – SF showed sound internal consistency, test–retest reliability, and
Apatinski put 38, 25000 Sombor
convergent and criterion validity, with 80% sensitivity and 100% specificity.
Serbia • The Q-LES-Q – SF could produce reliable, valid and sensitive assessments of QOL
E-mail: dejanstevanovic@eunet.rs in routine psychiatric practice.
Third assessment
Subjects and assessments
At the follow-up assessment, 4 weeks later, beside the CGIs,
All adults admitted to daily hospital for some psychiatric PGIs and the Q-LES-Q – SF, the Clinical Global Impression
treatment between December 2008 and January 2009 were improvement scale (CGIi) was completed by a clinician,
eligible. Exclusion criteria were the presence of any other from 0 – state unchanged to 6 – ideal improvement
(Endicott et al. 1993). The three indexes, CGIs, PGIs and between different people (sensitivity), and it should be able
CGIi, were the external criteria of change (anchors) and to detect QOL changes in unstable subjects (responsive-
each should significantly correlate with the Q-LES-Q – SF ness) (Fayers & Machin 2007).
(Fayers & Machin 2007). Thus, any change in the Q-LES-Q Internal consistency reliability was assessed by Cron-
– SF would be observed in the external criteria of change. bach’s alpha and it should exceed 0.7. Test–retest reliability
After the final assessment, all participants were assigned was analysed using the intraclass correlation coefficient
to two groups. The ‘unchanged’ group (n = 22) included (the two-way random method of absolute agreement) to
subjects without changes in mental health status from the derive the reliability coefficient (Streiner & Norman 2008).
first assessment and the ‘changed’ group (n = 14) included The retest took place 7 days later considering the 1-week
those subjects who improved over the study period (the time frame of the Q-LES-Q – SF. Test–retest reliability
improvement was measured as change in scores in two or should be at least 0.9 in order to evaluate the ability of the
more of the anchors used). During the follow-up period, two questionnaire in detecting changes important for individual
subjects worsened significantly, four were acutely diseased comparisons (Fayers & Machin 2007).
(a viral infection), five were discharged earlier (as a result of Eventually, the responsiveness was evaluated as the fol-
financial problems) and 10 refused to participate this time. lowing. First, the standard error of measurement (SEM)
After the approval from the Psychiatric Board about the was derived from the standard deviation of the sample,
involvement of all patients in the study activities, the Ethics from which was assessed the reliability, multiplied by
Comity of the author’s institution (General Hospital square root of (1 – the reliability) (Sprangers et al. 2002,
Sombor) approved the study. Crosby et al. 2004). For the SEM, 90% confidence inter-
vals (90% CI) were calculated around individual patient
scores, reflecting the questionnaire’s accuracy for indi-
Psychometric analysis
vidual assessments and clinical decision making (Williams
Descriptive analysis & Naylor 1992). Further, the SEM was converted into the
The number and distribution of missing data were exam- smallest detectable change (SDC) reflecting the smallest
ined to assess the acceptability of the questionnaire assum- within-individual change in score that could be interpreted
ing that this value should not be more than one-third of as a ‘real’ change, above measurement error in one indi-
unanswered items for an individual (Fayers & Machin vidual (Terwee et al. 2007). The SDC was calculated by
2007, Terwee et al. 2007). The distribution of responses for multiplying the z-score corresponding to the level of sig-
each item was assessed visually. Further, the mean, stan- nificance, the square root of 2 and the SEM. A z-score of
dard deviation, skewness and kurtosis for responses to 1.64 was chosen to reflect an acceptable 90% CI for clini-
every item were calculated (Ware & Gandek 1998). Finally, cal application to individual patients (Schmitt & Di Fabio
the percentage of responses on anchor points was exam- 2004). Finally, the minimal important difference (MID;
ined to detect floor or ceiling effects, which should not also known as minimal clinically important difference),
exceed 15% (Terwee et al. 2007). defined as the smallest difference in score perceived as
beneficial, was determined using mean change scores for
Analysis of validity patients with small but meaningful change according to
Three assumptions were considered for validity. All items some external criteria (Schmitt & Di Fabio 2004).
should be correlated minimally 0.4 to the total score cor- Change over the 4-week interval was analysed using
rected for overlap using Spearman’s correlation. These cor- three responsiveness indices at the individual patient level.
relations should not be substantially different between the Only data from all followed-up patients were used (de Vet
items, indicating that the amount of information to the total 2001, Schmitt & Di Fabio 2004). Reliable change propor-
concept being measured is similar for each item (Ware & tion – the proportion of the sample with change scores
Gandek 1998). Finally, the Q-LES-Q – SF should be signifi- exceeding the SDC, which is also sensitivity to change;
cantly correlated with the CGIs, PGIs and CGIi (P < 0.05, MID proportion – the proportion of the sample with
Spearman’s correlation) as the means of criterion validity. change scores exceeding the MID, and specificity to change
– the proportion of those who claimed perceiving no
Analysis of internal consistency reliability, test–retest change and their scores did not exceed the SDC.
reliability, sensitivity and responsiveness
It was assumed that the questionnaire should have appro-
Results
priate internally consistency reliability and it should be
stable in stable subjects (test–retest reliability, reproducibil- From the pre-testing, it was accepted that the Q-LES-Q –
ity), it should be sensitive to detect differences in QOL SF possesses culturally appropriate items with sufficient
Table 2
Distributional data of the Q-LES-Q – SF items (n = 57)
Skewness Kurtosis
Items M SD Statistic Standard error Statistic Standard error
1. physical health 3.07 1.24 -0.37 0.316 -0.94 0.62
2. mood 2.86 1.11 -0.36 0.316 -0.98 0.62
3. work 2.13 0.51 0.45 0.316 3.79 0.62
4. household activities 3.16 1.01 -0.01 0.316 -0.63 0.62
5. social relationships 2.73 1.16 0.19 0.316 -0.73 0.62
6. family relationships 3.25 1.18 -0.44 0.316 -0.66 0.62
7. leisure time activities 2.96 1.05 -0.31 0.316 -0.65 0.62
8. ability to function in daily life 2.91 1.23 0.11 0.316 -1.07 0.62
9. sexual drive. interest and/or performance 2.75 1.18 -0.25 0.316 -1.2 0.62
10. economic status 2.34 1.15 0.51 0.316 -0.67 0.62
11. living/housing situation 3.17 1.23 -0.51 0.316 -0.73 0.62
12. ability to get around physically without feeling dizzy or falling 3.18 1.23 -0.23 0.316 -0.93 0.62
13. your vision in terms of ability to do work or hobbies 2.88 1.17 0.18 0.316 -0.91 0.62
14. overall sense of well-being 2.80 1.02 0.12 0.316 -0.7 0.62
Row total (1–14 item) 37.27 9.28 -0.67 0.316 0.53 0.62
15. medication 3.55 0.94 -0.33 0.316 -0.63 0.62
16. overall life satisfaction and contentment 3.04 1.08 0.14 0.267 -0.82 0.53
Q-LES-Q – SF, The Quality of Life Enjoyment and Satisfaction Questionnaire – Short form.
between Item no. 3 (‘satisfaction with work’) and the Parameter Value
others, while no floor or ceiling effects were observed for Standard error of measurement (SEM) 2.74, 90% CI = ⫾4.49
Smallest detectable change (SDC) 6.34
the total and they were below 15% for all items. In Minimal important difference (MID) 8.95
Table 2 were given the distributional data of the Q-LES-Q Sensitivity to change 78.57%
– SF items. MID proportion 71.43%
Specificity to change 100%
Q-LES-Q – SF, The Quality of Life Enjoyment and Satisfaction
Validity Questionnaire – Short form.
general activities scale, an equivalent to the short form, are construct and predictive, were not evaluated and it were
similar between the original (0.90) (Endicott et al. 1993), not including other QOL measures, whereas such are
Czech (0.90) (Müllerová et al. 2001), Hebrew (0.95) unavailable in Serbian. Finally, the sample in overall was
(Ritsner et al. 2002), Italian (0.92) (Rucci et al. 2007) and small and this limit the generalizability of the study to
the Serbian version (0.9). However, the test–retest reliabil- other settings.
ity coefficient is highest for the Serbian Q-LES-Q – SF In summary, this preliminary analysis of the Q-LES-Q –
(0.93). Finally, the authors that validated the Q-LES-Q – SF SF demonstrated that it is appropriate QOL questionnaire
for attention deficit – hyperactivity disorder reported that for routine, clinical assessments of individuals with psychi-
the minimally important difference anchored by clinical atric illnesses. It showed that the measure could produce
ratings is 3 points on the raw score, what equals the SEM reliable, valid and sensitive assessments of the individuals’
observed in this study (Mick et al. 2008). In two studies QOL. However, with awareness of the limitations of the
with bipolar disorder and generalized anxiety disorder, the present study and the questionnaire itself, further investi-
minimum clinically important Q-LES-Q (SF) score change gations will be needed. Future research will be directed to
was identified to be 11.89 and 6.80 points, respectfully evaluate its measurement properties in samples that are
(Endicott et al. 2007, Wyrwich et al. 2009). These findings more homogeneous, with different groups of patients. In
indicate that for measures such as the Q-LES-Q (SF) the particular, the issues arose during the study will be also
magnitude of the MID may vary depending on the specific analysed. In this way, the Q-LES-Q – SF will evolve into a
population of interest and as well as of the purpose of gold standard for QOL evaluations in routine psychiatric
assessment. practice, as it is in research.
There are several limitations of the study. First, the
heterogeneity of the sample (gender, age and diagnoses)
Acknowledgments and disclosures
could explain high reliability coefficients. Second, a small
number of participants did not allowed to study changes I would like to thank Professor Jean Endicott and to all
in mental health in those who deteriorated during people with psychiatric illness included in the study. The
the study period. Third, other aspects of validity, like author has no competing interests.
Gladis M.M., Gosch E.A., Dishuk N.M., et al. Schmitt J.S. & Di Fabio R.P. (2004) Reliable
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