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  • Poster - Gluconeogenesis (Horizontal)

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    Hridoy Zaman
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    Gluconeogenesis is a metabolic pathway that generates glucose from non-carbohydrate substrates like lactate, amino acids, and glycerol. It is important for supplying glucose to tissues between meals or during fasting. There are three irreversible steps in glycolysis that cannot be directly reversed, so gluconeogenesis bypasses these steps using different reactions. These include converting pyruvate to phosphoenolpyruvate, fructose 1,6-bisphosphate to fructose 6-phosphate, and glucose 6-phosphate to glucose. Gluconeogenesis is essential for maintaining blood glucose levels and supplying glucose to tissues when dietary carbohydrates are insufficient.

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    Gluconeogenesis is a metabolic pathway that generates glucose from non-carbohydrate substrates like lactate, amino acids, and glycerol. It is important for supplying glucose to tissues between meals or during fasting. There are three irreversible steps in glycolysis that cannot be directly reversed, so gluconeogenesis bypasses these steps using different reactions. These include converting pyruvate to phosphoenolpyruvate, fructose 1,6-bisphosphate to fructose 6-phosphate, and glucose 6-phosphate to glucose. Gluconeogenesis is essential for maintaining blood glucose levels and supplying glucose to tissues when dietary carbohydrates are insufficient.

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    4 views1 page

    Poster - Gluconeogenesis (Horizontal)

    Uploaded by

    Hridoy Zaman
    Gluconeogenesis is a metabolic pathway that generates glucose from non-carbohydrate substrates like lactate, amino acids, and glycerol. It is important for supplying glucose to tissues between meals or during fasting. There are three irreversible steps in glycolysis that cannot be directly reversed, so gluconeogenesis bypasses these steps using different reactions. These include converting pyruvate to phosphoenolpyruvate, fructose 1,6-bisphosphate to fructose 6-phosphate, and glucose 6-phosphate to glucose. Gluconeogenesis is essential for maintaining blood glucose levels and supplying glucose to tissues when dietary carbohydrates are insufficient.

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    of 1

    Name: Md Hridoy Zaman

    Gluconeogenesis Id: 19336007

    Introduction Importance and Significance


    Gluconeogenesis is a metabolic pathway that results in the generation of glucose from certain The brain depends on glucose as its primary
    non-carbohydrate carbon substrates (such as lactate, amino acids, and glycerol). fuel and red blood cells use only glucose as a
    The need for energy is important to sustain life. Organisms have evolved ways of producing fuel. Between meals and during longer fasts,
    substrates required for the catabolic reactions necessary to sustain life when desired substrates or after vigorous exercise,glycogen is
    are unavailable. The main source of energy for eukaryotes is glucose. When glucose is depleted. So.organisms need a method for
    unavailable, organisms are capable of metabolizing glucose from other non-carbohydrate synthesizing glucose from non carbohydrate
    precursors. The process that coverts pyruvate into glucose is called gluconeogenesis. precursors. This is accomplished by a pathway
    called gluconeogenesis. Gluconeogenesis
    Process and mechanism meets the needs of the body when
    carbohydrate is not available in sufficient
    As gluconeogenesis is aimed at reversing glycolysis, the reversible steps of the glycolysis amounts from diet. Failure of gluconeogenesis
    pathway simply run in the other direction. However, there are three irreversible steps that is usually fatal. Below a critical blood glucose
    cannot run in the other direction for energetic reasons. These steps must be circumvented concentration, there is brain dysfunction
    using three key reactions that make them more energy efficient. which can lead to coma and death.

    • Keep blood glucose level stable.


    • Remove lactate from skeletal
    muscle, RCB
    Step 1: Conversion of pyruvate Step 2: Conversion of Fructose Step 3: Conversion of G6P to
    to phosphoenolpyruvate 1,6 bisphosphate to Fructose 6 glucose • Supply glucose to active skeletal
    phosphate muscle.
    •Pyruvate+CO2+ATP+H20( • Glucose 6-phosphate
    pyruvate carboxylase) • Fructose 1,6-biphosphate+ • Replenish liver glycogen
    +H20= glucose+Pi
    =oxaloacetate+ADP+Pi+2H+
    H20=fructose 6- • Utilizes Glycerol and propionate
    •Oxaloacetate +GTP ( ΔG= -13.8 kj/mol
    phosphate+Pi from adipose tissue
    phosphoenol pyruvate)=
    Phosphoenolpyruvate+GDP+CO2 ΔG= -16.3 kj/mol • Regulate acid-base balance

    • Pyruvate is carboxylated by pyruvate carboxylase to oxaloacetate using 1 CO2 and 1


    ATP and Oxaloacetate to phosphoenolpyruvate using 1 GTP and by releasing CO2. References
    • Generation of fructose 6-phosphate from fructose 1,6-bisphosphate is catalyzed by a
    different enzyme, Mg2+ dependent fructose 1,6-bisphosphatase (FBPase-1). • Garrett, H., Reginald and Charles Grisham. Biochemistry. Boston: Twayne Publishers,
    • The third bypass is the final reaction of gluconeogenesis, the dephosphorylation of 2008.
    glucose 6-phosphate to yield glucose. • Raven, Peter. Biology. Boston: Twayne Publishers, 2005.
    • https://en.wikipedia.org/wiki/Gluconeogenesis

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