Appendix - 4

CONFIDENTIAL PROGRESS REPORT

This report details the progress made by the research scholar during the period of 01-07-2019
to 31-12-2019. It serves as a six-monthly update on the research work conducted during this
time.

1. Name of the Research Scholar: Naveen Reddy Seelam

2. Subject: Chemistry

3. Topic Registered for PhD Degree: Synthesis and Experimental Analysis of Ophthalmic
Prostaglandins (Antiglaucoma Agent) and their
Analogues

4. Name of the Supervisor: Dr. Neeta Gupta

5. Name of Co-supervisor (if any)................None...............................................

6. Description of the guidance on the topic

Period with dates the Candidates

has been with the guide for
research work (It may also
indicate the date of leave availed
by the candidate during the
above period).

Remarks of the Supervisor on the work done by the Candidate on Topic.

Fees paid vide receipt No ................ :............................Date ................................................................

Date:……………………… ……………………… Place:

…………………….. (Signature of Head of Institution where the

Candidate was registered for Ph.D. degree)

Signature of the Supervisor Address: .........................................................

………………..…………………………….

Place::…………………. …………….………………………………..
Work Done by the Candidates in this Six Months Period

Jian Li et. al, (2020): All of the reactions took place in an atmosphere with air. The
glyceraldehyde was provided by Alfa Co. Ltd.1. Terminal arylalkynes and secondary amine
substrates were made available by AladinorAlfa Co. Aside from those containing 1,2,3,4-
tetrahydroisoquinoline2a-2e. Unless otherwise specified, all commercial reagents were utilized
without further purification. Flash column chromatography was performed using silica gel
(200–300 mesh). For analytical thin-layer chromatography (254 nm), glass plates pre-coated
with 200–300 mesh silica gel impregnated with a fluorescent indicator were employed. NMR
spectra in CDCl3 or DMSO-d6 were acquired on the Bruker NMR-300 (300 MHz), NMR-400
(400 MHz), and NMR-400 (500 MHz) using TMS as an internal reference. For HRMS (ESI),
an Agilent 6540 Q-TOF mass spectrometer was employed. To gather X-ray crystallographic
data, a SMART APEX II X-ray diffractometer was used.

Yan Xu et. al, (2020): The development of novel cyclopentolate ruthenium catalysts with large
N-heterocyclic carbene (NHC) ligands has made it possible to cross-metathesize acrylamides
with common terminal olefins in a Z-selective manner. Superior reactivity and stereoselectivity
are obtained for the first time in this challenging transformation, allowing for easier access to a
crucial class of cis-Michael acceptors from widely available feedstocks. Calculations using
density functional theory indicate the mechanism underlying the kinetic preference for cross-
metathesis, which is enabled by a pivalate anionic ligand.

Johanna Revol-Cavalier et. al, (2020): For the first time, 4,11-diepi-4-F4t-neuroprostane, a
prostaglandin produced from docosahexaenoic acid with a complex lateral chain, was
completely synthesized. A novel prostaglandin cyclopentane skeleton created via an
intramolecular highly selective organocatalytic Michael sequence of a formyl-anal derivative
was used to establish the essential and unique thermodynamic trans configuration of the lipidic
lateral chains.

Jiaming Li et. al, (2019): It is discovered that the synthesis of 15-deoxy-12,14-prostaglandin

J2 is enantioselective. To create enantiopure 3-oxodicyclopentadiene, a lipase-mediated kinetic
resolution is used as the first step in the synthesis. Through a three-component coupling
followed by a retro-Diels-Alder reaction, the prostaglandin skeleton's C8 stereochemistry is
created with high enantioselectivity. Through stereo retentive olefin metathesis and a Pinnick
oxidation, the high enantiopurity 15-deoxy-12,14-prostaglandin J2 is produced.

Beside these, the candidate has explored the following studies—

 K. C. Nicolaou et. al, (2019)

 Airat M. Gimazetdinov et. al, (2022)
 Waqar Ahmed et. al, (2022)
 Hunter S. Sims et. al, (2021)
 Hunter S. Sims et. al, (2021)
 QuentinMichaudel et. al, (2022)
 Dr. Lena Trifonov et. al, (2021)
 Nikolay S. Vostrikov et. al, (2021)
 Kejie Zhu et. al, (2021)
 Samuel J. Kempel et. al, (2021)
 Fuhao Zhang et. al, (2021)
 Airat M. Gimazetdinov et. al, (2021)
 Anders Vik et. al, (2021)
 Constantin Tănase et. al, (2021)
 Karsten Donabauer et. al, (2020)
 Jana Löwe et. al, (2020)
 Xiang Li et. al, (2020)
 N. S. Vostrikov et. al, (2020)
 TaehyeongKim et. al, (2019)
 Kejie Zhu et. al, (2019)
 Kejie Zhu, Sha Hu et. al, (2019)
 Sébastien Prévost et. al, (2015)
 Steven H. Bennett et. al, (2020)
 Kejie Zhu et. al, (2021)
 Yujiro Hayashi (2021)
 Nariyoshi Umekubo (2020)
 Changcheng Jing, Varinder Aggarwal (2020)
 Bingmei Su et. al, (2020)
 Steven H. Bennett et. al, (2020)
 Zefei Xu et. al, (2020).
 Shuke Wu et. al, (2020)
 Roger A Sheldon et. al, (2020)
 Nariyoshi Umekubo Yujiro Hayashi (2020)
 Nariyoshi Umekubo Yujiro Hayashi (2020)
 Chen Hu et. al, (2020)
 Xiaofan Wu et. al, (2020)
 Freya Taday et. al, (2020)
 Jian Li et. al, (2020)
 Nariyoshi Umekubo et. al, (2020)
 Ge Qu et. al, (2019)
 Fabio Parmeggiani et. al, (2019)
  Mattia Lazzarotto et. al, (2019)
 Xumin Gong et. al, (2018)
 Harry Eastman James Ryan (2019)
 Jiaming Li et. al, (2018)
 Shaun McKinnie et. al, (2018)

 Haidi Yang et. al, (2022)

 Kerui Chen et. al, (2022)

 Fei Cheng et. al, (2021)

 Joshua W. M. MacMillan Ryan McGuir (2022)
 Bingmei Su et. al, (2020)
 Steven H. Bennett et. al, (2020)
 Zefei Xu et. al, (2020)
 Shuke Wu et. al, (2020)
 Masaaki Suzuki et. al, (2017)
 Constantin I. Tănase et. al, (2021)
 Comstantin Tănase et. al, (2021)
 Kadri et. al, (2022)
 Romi Yoo et. al, (2017)
 Ji-Hye Park et. al, (2021)
 Chan Yun Kim et. al, (2017)
 Prof David F Garway-Heath et. al, (2015)

Signature of the Candidate

Remark of the supervisor on the work done by the candidate on topic:

Signature of the Supervisor