HIDROFOBNE INTERAKCIJE

water oil

es (“Aggregation colloids”)
3 - 50 nm
ne
Hydrophilic headgroup

Hydrophobic tail

H2O
Different shapes of micelles

What determines the shape/size of micelles...?

• Head group size ?

 the air-water interface
le size: 2. c > cmc :number:
Aggregation formation
Ionic of micelles
surfactants
The critical micelle concentration (cmc , ck)
Conductivity:
3 - 50 nm (mobility)
1 c
Air Ionic surfactants
cmc (ck) = critical micelle concentration:
2
zA = 10-170
Water
3
concentration, above which micelles areNonionic
observedsurfactants
4
zA = 30-10.000
G°mic = °mic - °solv = RT ln (cmc)
H2O The cmc decreases with increasing tailAdsorption
1. Small c: length of surfacta
because the hydrophobic character increases
the air-water interface
2. c > cmc : formation of micelles
cal micelle concentrations (CMC):
Ionic surfactants
ionic surfactants cmc = 10-3 – 10-2 M
rally higher cmc (ck) = critical micelle concentration:
ed to nonionic surfactants Nonionic surfactants
concentration, cmc
above which
= 10 micelles are observed
-4 – 10-3 M

G°mic = °
mic - °
solv = RT ln (cmc)
ceramide were studied by
and band and boundary
he dissociation of micelles
equired us to approach
mers rather than by the
sides were therefore first
weight aggregates (1-3
Me,SO. Galactosyl-N-
aminyl)galactosylgluco-
This gave a sedimenting micelle and a nonsedimenting mo-
nomer concentration of (1-2) X M (or less) which
corresponds to the critical micelle concentration value. The
mixed gangliosides revealed two micellar sizes (i.e., 10 and
4.5 S), the slower sedimenting species being formed from the
larger one with time (days). The critical micelle concentration
of the mixed gangliosides was found to be approximately
M by gel filtration, equilibrium dialysis, and band centrifu-
gation.

cribed as acylsphingosyl Table I: Literature Values for the cmc of Gangliosides

id (Klenk, 1942). It was cmc (M) ganglioside technique reference
osides ( G M I ,GD,,, GDlb,
structure, Le., N-acyl- 1X mixed surface Gammack (1963)
tension
ylgalactosaminegalactose, 1 X 10” mixed conductance Howard & Burton (1964)
N-acetylneuraminic acid 1X GM, neuraminidase Rauvala (1976)
M 3are biosynthetic pre- 7.5 X lo-’ G M ~ triiodide Yohe & Rosenberg (1972)
nal galactose and galac- method
8.5 X lo-’ G M ~ triiodide Yohe & Rosenberg (1972)
ively. method
in the binding or function 9.5 X lo-’ G D , ~ triiodide Yohe & Rosenberg (1972)
ecules, Le., cholera toxin method
n (Helting et al., 1977), 1X GT, triiodide Yohe & Rosenberg(l972)
eller, 1975), thyrotropin method
nic gonadotropin (Lee et