February 2019, Volume 42, Number 2, pp.

79–150 Editor
Moran Furman

Opinions Trends Publisher

Paige Shaklee
79 What Is the Relationship between Mark E. Walton and
Journal Manager
Dopamine and Effort? Sebastien Bouret
Fred Kop

92 Toward a Model of Interpersonal Frank Krueger and Journal Administrator

Trust Drawn from Neuroscience, Andreas Meyer-Lindenberg Patrick Scheffmann
Psychology, and Economics
Advisory Editorial Board
Silvia Arber
102 Novelty and Dopaminergic Modulation Adrian J. Duszkiewicz, Anders Björklund
of Memory Persistence: A Tale of Two Colin G. McNamara, J. Paul Bolam
Systems Tomonori Takeuchi, Sarah W. Bottjer
and Lisa Genzel Rui M. Costa
Reviews Ann Marie Craig
Barry J. Dickson
115 The Role of De Novo Noncoding Tychele N. Turner Chris Q. Doe
Craig C. Garner
Regulatory Mutations in and Evan E. Eichler Yukiko Goda
Neurodevelopmental Disorders Kenneth D. Harris
Nancy Ip
128 Mapping the Conformational David M. MacLean, Meyer Jackson
Landscape of Glutamate Receptors Ryan J. Durham, Maria Karayiorgou
Robert C. Malenka
Using Single Molecule FRET and Vasanthi Jayaraman Mark P. Mattson
Freda D. Miller
140 Synaptic, Mitochondrial, and Maria Nguyen, Yvette C. Wong, Richard G.M. Morris
Lysosomal Dysfunction in Parkinson’s Daniel Ysselstein, Alex Severino, Maiken Nedergaard
Eric Nestler
Disease and Dimitri Krainc
Anna W. Roe
Hitoshi Sakano
Greg Stuart
Marc Tessier-Lavigne
Chris A. Walsh

On The Cover: Dopamine release in the hippocampus is an important gating mechanism Editorial Inquiries
that promotes persistence of everyday memories. While axons from the ventral tegmental Trends in Neurosciences
area were traditionally thought to be the exclusive source of hippocampal dopamine, more Cell Press
recently, neurons in the noradrenergic locus coeruleus were shown to be a source of such 50 Hampshire St. 5th Floor
dopamine as well. In this issue of Trends in Neurosciences, Duszkiewicz et al. outline how Cambridge, MA 02139, USA
these two systems may be activated by two different forms of novelty depending on past Tel: 617 386 2133
experiences, and how this process may lead to formation of one of two distinct forms E-mail: tins@cell.com
of long-term memory: episodic memories rich in context or semantic memories more
schematic in nature. Cover image by the authors and iStock/portishead1, LiliGraphie,
LokFung and Panya.